Belzutifan_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belzutifan_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.187646
PDE4D phosphodiesterase 4D, cAMP-specific 0.0811415
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0580969
RPL37A ribosomal protein L37a 0.053698
PKM pyruvate kinase, muscle 0.0536948
RPS8 ribosomal protein S8 0.0532889
RPS3 ribosomal protein S3 0.0520865
RPL31 ribosomal protein L31 0.0472122
RPS6 ribosomal protein S6 0.043398
RPL12 ribosomal protein L12 0.042751
RACK1 receptor for activated C kinase 1 0.0409201
PDGFC platelet derived growth factor C 0.038161
RPS12 ribosomal protein S12 0.037612
ZNF608 zinc finger protein 608 0.0370345
RPL13A ribosomal protein L13a 0.0350791
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0334072
RPS2 ribosomal protein S2 0.0330083
RPL9 ribosomal protein L9 0.0328185
RPS19 ribosomal protein S19 0.0326484
ANXA1 annexin A1 0.0316783
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0307421
RPL36 ribosomal protein L36 0.0306708
EEF2 eukaryotic translation elongation factor 2 0.0301979
RPL11 ribosomal protein L11 0.0293013
RAB27B RAB27B, member RAS oncogene family 0.0291513
SQSTM1 sequestosome 1 0.0282522
RPS27A ribosomal protein S27a 0.0273591
RPLP0 ribosomal protein, large, P0 0.0268237
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0251139
TPT1 tumor protein, translationally-controlled 1 0.0247557
RPS23 ribosomal protein S23 0.0246018
ACTG1 actin gamma 1 0.0243872
RPL35A ribosomal protein L35a 0.0243701
RPL4 ribosomal protein L4 0.0242686
USP47 ubiquitin specific peptidase 47 0.0242002
RPLP1 ribosomal protein, large, P1 0.0239265
RPL3 ribosomal protein L3 0.0235815
RPS29 ribosomal protein S29 0.0233534
RPS17 ribosomal protein S17 0.0228615
S100A10 S100 calcium binding protein A10 0.0228462
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0228134
RPL26 ribosomal protein L26 0.0227623
RPL19 ribosomal protein L19 0.022514
RPS11 ribosomal protein S11 0.0222156
DSCAM Down syndrome cell adhesion molecule 0.0216717
B2M beta-2-microglobulin 0.0215952
LDHA lactate dehydrogenase A 0.0212843
UHMK1 U2AF homology motif (UHM) kinase 1 0.0211149
EIF1 eukaryotic translation initiation factor 1 0.020794
RPL34 ribosomal protein L34 0.0204731
MACROD2 MACRO domain containing 2 0.0204104
RPL18 ribosomal protein L18 0.0203109
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 0.0199116
S100A11 S100 calcium binding protein A11 0.0192195
RPL5 ribosomal protein L5 0.0190613
RPS14 ribosomal protein S14 0.018767
NAMPT nicotinamide phosphoribosyltransferase 0.0187092
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0186585
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0185278
RPL27 ribosomal protein L27 0.0183731
RPS13 ribosomal protein S13 0.0182436
RPL23 ribosomal protein L23 0.0180829
PDCD6IP programmed cell death 6 interacting protein 0.0177146
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 0.0169948
RTN4 reticulon 4 0.0169433
LRRC7 leucine rich repeat containing 7 0.0166401
NAP1L1 nucleosome assembly protein 1-like 1 0.0165896
ARHGAP25 Rho GTPase activating protein 25 0.0164586
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0163825
GARS1 glycyl-tRNA synthetase 1 0.0162913
SSBP2 single-stranded DNA binding protein 2 0.0161775
SEC24B SEC24 family member B 0.016054
ANK2 ankyrin 2, neuronal 0.0158722
RPS25 ribosomal protein S25 0.0158127
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0157024
RPS15 ribosomal protein S15 0.0152748
RPS27 ribosomal protein S27 0.0149751
FAM120B family with sequence similarity 120B 0.0149444
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.0148698
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0148078
BBS9 Bardet-Biedl syndrome 9 0.0147589
KPNA6 karyopherin alpha 6 (importin alpha 7) 0.0146736
ATF4 activating transcription factor 4 0.0144738
RPLP2 ribosomal protein, large, P2 0.0144142
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0143815
RPL7 ribosomal protein L7 0.0142704
LDHB lactate dehydrogenase B 0.0141211
RPS5 ribosomal protein S5 0.0141102
EZR ezrin 0.0139892
FBXL17 F-box and leucine-rich repeat protein 17 0.0139112
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0138408
TMEM41B transmembrane protein 41B 0.0137534
RPL8 ribosomal protein L8 0.0137412
RARS1 arginyl-tRNA synthetase 1 0.0137328
NCEH1 neutral cholesterol ester hydrolase 1 0.0137262
TACC2 transforming, acidic coiled-coil containing protein 2 0.0136826
ZNF655 zinc finger protein 655 0.0134755
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0134633
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.0132465
FAM13A family with sequence similarity 13, member A 0.0131875

decreased expression

Symbol Name Standardized Value
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.181243
PTMA prothymosin, alpha -0.148627
PDE4B phosphodiesterase 4B, cAMP-specific -0.136331
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.128325
BMP10 bone morphogenetic protein 10 -0.111933
MKI67 marker of proliferation Ki-67 -0.103826
FOXP1 forkhead box P1 -0.0916914
TOP2A topoisomerase (DNA) II alpha 170kDa -0.085543
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0840448
VCL vinculin -0.0792229
NBEA neurobeachin -0.0773261
CENPF centromere protein F, 350/400kDa -0.0757967
DLG1 discs, large homolog 1 (Drosophila) -0.0742127
NAV2 neuron navigator 2 -0.0731362
DIAPH3 diaphanous-related formin 3 -0.0730685
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0705155
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0630808
TJP1 tight junction protein 1 -0.0581328
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0580451
SMC4 structural maintenance of chromosomes 4 -0.0558514
LPP LIM domain containing preferred translocation partner in lipoma -0.0545158
TTC28 tetratricopeptide repeat domain 28 -0.0528143
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0514287
DPYD dihydropyrimidine dehydrogenase -0.0504707
GLI3 GLI family zinc finger 3 -0.0494347
EFNA5 ephrin-A5 -0.0480601
AHNAK AHNAK nucleoprotein -0.0476067
CUX1 cut-like homeobox 1 -0.0473279
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0470023
PARD3 par-3 family cell polarity regulator -0.0468783
CAMKMT calmodulin-lysine N-methyltransferase -0.0462574
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0461885
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0447114
HJURP Holliday junction recognition protein -0.0446864
SOX6 SRY (sex determining region Y)-box 6 -0.0432715
TMSB4X thymosin beta 4, X-linked -0.0418493
NFIA nuclear factor I/A -0.0415774
TPX2 TPX2, microtubule-associated -0.041171
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0402451
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0401005
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0400837
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0395757
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0394606
SBF2 SET binding factor 2 -0.0385427
ADAM10 ADAM metallopeptidase domain 10 -0.0384484
FNDC3B fibronectin type III domain containing 3B -0.0380411
SDK1 sidekick cell adhesion molecule 1 -0.0375019
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0371504
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0362866
ECT2 epithelial cell transforming 2 -0.0359196
SEPTIN11 septin 11 -0.0358041
EVI5 ecotropic viral integration site 5 -0.035395
WSB1 WD repeat and SOCS box containing 1 -0.0351334
SCLT1 sodium channel and clathrin linker 1 -0.0348847
ANLN anillin, actin binding protein -0.034691
TXNRD1 thioredoxin reductase 1 -0.0338807
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0335605
GLI2 GLI family zinc finger 2 -0.0329493
RFC3 replication factor C (activator 1) 3, 38kDa -0.0327217
PRELID2 PRELI domain containing 2 -0.0326585
CENPE centromere protein E, 312kDa -0.0324451
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0323606
DENND1A DENN/MADD domain containing 1A -0.0315777
CD47 CD47 molecule -0.0314622
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0304923
CKAP5 cytoskeleton associated protein 5 -0.0304135
CAMTA1 calmodulin binding transcription activator 1 -0.030395
ZEB1 zinc finger E-box binding homeobox 1 -0.0301718
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0301022
ANKRD11 ankyrin repeat domain 11 -0.0297574
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.029136
BIRC6 baculoviral IAP repeat containing 6 -0.0288924
BMP2K BMP2 inducible kinase -0.0288042
PSIP1 PC4 and SFRS1 interacting protein 1 -0.0284888
EBNA1BP2 EBNA1 binding protein 2 -0.0284226
TUBB tubulin, beta class I -0.0277808
RRM2 ribonucleotide reductase M2 -0.027626
GCLM glutamate-cysteine ligase, modifier subunit -0.0274011
KIF5B kinesin family member 5B -0.0273213
PLCE1 phospholipase C, epsilon 1 -0.0271168
PDE7B phosphodiesterase 7B -0.0268528
LCORL ligand dependent nuclear receptor corepressor-like -0.0266154
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0265198
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.026455
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0259756
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0258628
MBNL1 muscleblind-like splicing regulator 1 -0.0257893
MYO5A myosin VA (heavy chain 12, myoxin) -0.025531
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0255187
NEBL nebulette -0.0253442
RRBP1 ribosome binding protein 1 -0.0251635
AFG2A AFG2 AAA ATPase homolog A -0.0251019
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0250787
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0250679
SMYD3 SET and MYND domain containing 3 -0.0250076
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0248631
KPNB1 karyopherin (importin) beta 1 -0.0245936
ATAD2 ATPase family, AAA domain containing 2 -0.0245669
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0245614
FAF1 Fas (TNFRSF6) associated factor 1 -0.0241039