Belzutifan_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belzutifan_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.271415
VIM vimentin 0.103128
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0668318
TPT1 tumor protein, translationally-controlled 1 0.0467767
ENO1 enolase 1, (alpha) 0.0464466
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0457777
PKM pyruvate kinase, muscle 0.0422443
LDHA lactate dehydrogenase A 0.0385674
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0367239
SVIL supervillin 0.0365755
SQSTM1 sequestosome 1 0.0352172
CD44 CD44 molecule (Indian blood group) 0.0351375
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0347383
RPLP1 ribosomal protein, large, P1 0.0341753
FTH1 ferritin, heavy polypeptide 1 0.0325612
HLA-A major histocompatibility complex, class I, A 0.0323529
LOC102724023 ES1 protein homolog, mitochondrial 0.0316314
SMAD3 SMAD family member 3 0.0302019
PTMA prothymosin, alpha 0.03017
BIRC3 baculoviral IAP repeat containing 3 0.029766
NFE2L2 nuclear factor, erythroid 2-like 2 0.0291802
RPS12 ribosomal protein S12 0.0290403
TIMP1 TIMP metallopeptidase inhibitor 1 0.0288609
TXNRD1 thioredoxin reductase 1 0.0286075
RPS3 ribosomal protein S3 0.028588
PHF20 PHD finger protein 20 0.0282757
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0281914
RPL12 ribosomal protein L12 0.0276022
TXNIP thioredoxin interacting protein 0.0274519
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0271039
JMJD1C jumonji domain containing 1C 0.0268561
CSNK1A1 casein kinase 1, alpha 1 0.0265558
B2M beta-2-microglobulin 0.0262864
MACF1 microtubule-actin crosslinking factor 1 0.0255893
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.025372
SET SET nuclear proto-oncogene 0.0248239
RPS8 ribosomal protein S8 0.0241062
TPI1 triosephosphate isomerase 1 0.0239416
RPS17 ribosomal protein S17 0.0235418
IFITM3 interferon induced transmembrane protein 3 0.0233417
BRD4 bromodomain containing 4 0.0232913
MAP1B microtubule-associated protein 1B 0.0231616
TNIP1 TNFAIP3 interacting protein 1 0.0220996
PIAS1 protein inhibitor of activated STAT, 1 0.0219246
EIF1 eukaryotic translation initiation factor 1 0.0218829
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0217205
RPS13 ribosomal protein S13 0.021421
RPS6 ribosomal protein S6 0.0213268
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0212246
SEPTIN7 septin 7 0.0207878
DEK DEK proto-oncogene 0.0205284
RPL4 ribosomal protein L4 0.020232
AKAP13 A kinase (PRKA) anchor protein 13 0.0200024
POTEF POTE ankyrin domain family, member F 0.0199227
KDM2A lysine (K)-specific demethylase 2A 0.01978
S100A10 S100 calcium binding protein A10 0.019649
H3-3B H3.3 histone B 0.0195906
PNRC1 proline-rich nuclear receptor coactivator 1 0.0194859
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0193054
RPL37A ribosomal protein L37a 0.0191908
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0186307
ANKRD12 ankyrin repeat domain 12 0.018437
RPL9 ribosomal protein L9 0.0183073
IRAK2 interleukin-1 receptor-associated kinase 2 0.0182518
TMSB10 thymosin beta 10 0.0181379
UBB ubiquitin B 0.0179328
ANXA2 annexin A2 0.0178973
HLA-B major histocompatibility complex, class I, B 0.0178202
SSH2 slingshot protein phosphatase 2 0.0177227
ANGPTL4 angiopoietin-like 4 0.017652
BIRC2 baculoviral IAP repeat containing 2 0.0176423
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0173047
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0172704
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 0.0171608
RPL11 ribosomal protein L11 0.0171269
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0171032
MBNL2 muscleblind-like splicing regulator 2 0.0169196
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0167014
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0166504
OXSR1 oxidative stress responsive 1 0.016636
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0165644
HDAC9 histone deacetylase 9 0.0165384
FTL ferritin, light polypeptide 0.0164431
ACTG1 actin gamma 1 0.0163818
RSRC2 arginine/serine-rich coiled-coil 2 0.0163678
RPS25 ribosomal protein S25 0.0159752
IER3 immediate early response 3 0.0158635
YBX3 Y box binding protein 3 0.0157084
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0156336
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0155534
UBC ubiquitin C 0.015472
FMNL2 formin-like 2 0.0153617
SLC35F2 solute carrier family 35, member F2 0.0152994
ZNF292 zinc finger protein 292 0.0150643
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0149703
RPL36 ribosomal protein L36 0.0148951
LGALS1 lectin, galactoside-binding, soluble, 1 0.0147153
MT2A metallothionein 2A 0.0147062
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0146641
HLA-E major histocompatibility complex, class I, E 0.0146164

decreased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 -0.0402864
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0373745
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0336008
TAS2R14 taste receptor, type 2, member 14 -0.0314371
RAD51B RAD51 paralog B -0.0311109
MCL1 myeloid cell leukemia 1 -0.0266571
AHNAK AHNAK nucleoprotein -0.0265578
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0261826
ASPH aspartate beta-hydroxylase -0.0240943
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.024042
DNER delta/notch-like EGF repeat containing -0.0228268
DPYD dihydropyrimidine dehydrogenase -0.0214857
VCL vinculin -0.0214438
FLNB filamin B, beta -0.0213342
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0206728
ATXN1 ataxin 1 -0.0205276
IL1RAP interleukin 1 receptor accessory protein -0.0202291
IGFBP3 insulin-like growth factor binding protein 3 -0.0198941
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0193949
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0189214
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0179234
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0174233
ATG7 autophagy related 7 -0.0172816
SUMF1 sulfatase modifying factor 1 -0.0169996
COL5A1 collagen, type V, alpha 1 -0.0169625
SBF2 SET binding factor 2 -0.0169144
PCED1B PC-esterase domain containing 1B -0.0167919
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0167582
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0165881
FNDC3B fibronectin type III domain containing 3B -0.0165066
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0163779
RAI14 retinoic acid induced 14 -0.0163538
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0163229
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0158541
NDRG1 N-myc downstream regulated 1 -0.0156279
ATM ATM serine/threonine kinase -0.0153963
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0151949
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0147607
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.014739
TVP23C-CDRT4 TVP23C-CDRT4 readthrough -0.0146659
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0146326
PDCD6IP programmed cell death 6 interacting protein -0.0145529
PYGL phosphorylase, glycogen, liver -0.0144197
FOXO3 forkhead box O3 -0.0142934
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0140433
ARMH4 armadillo like helical domain containing 4 -0.0139972
SAMD4A sterile alpha motif domain containing 4A -0.0139584
PARD3 par-3 family cell polarity regulator -0.013601
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0135626
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0134217
NLRP1 NLR family, pyrin domain containing 1 -0.0133474
IARS1 isoleucyl-tRNA synthetase 1 -0.0132541
PRKCA protein kinase C, alpha -0.0132476
ZBTB20 zinc finger and BTB domain containing 20 -0.0128214
USP34 ubiquitin specific peptidase 34 -0.0127734
SMYD3 SET and MYND domain containing 3 -0.0126975
MYOF myoferlin -0.0126447
ACER3 alkaline ceramidase 3 -0.0124817
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0124287
CEP250 centrosomal protein 250kDa -0.0123987
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0123276
NPC1 Niemann-Pick disease, type C1 -0.0123222
INTS6 integrator complex subunit 6 -0.0122776
CHD9 chromodomain helicase DNA binding protein 9 -0.0122548
GOLGA3 golgin A3 -0.0122165
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0121989
AFDN afadin, adherens junction formation factor -0.0120932
ARHGAP26 Rho GTPase activating protein 26 -0.0120888
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0120758
FMN1 formin 1 -0.0120212
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0119554
LAMA5 laminin, alpha 5 -0.0118762
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0118587
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0118201
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0116727
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0116146
LPP LIM domain containing preferred translocation partner in lipoma -0.0115466
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0115419
PHF21A PHD finger protein 21A -0.0115223
SHB Src homology 2 domain containing adaptor protein B -0.0115044
MAML2 mastermind-like 2 (Drosophila) -0.011375
STRN3 striatin, calmodulin binding protein 3 -0.0112485
AHCTF1 AT hook containing transcription factor 1 -0.0111976
CDC73 cell division cycle 73 -0.0111517
HOOK2 hook microtubule-tethering protein 2 -0.0111053
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0110362
ZC3H12B zinc finger CCCH-type containing 12B -0.0109733
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.010963
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0108875
CMIP c-Maf inducing protein -0.0108816
RIN2 Ras and Rab interactor 2 -0.010762
AEBP2 AE binding protein 2 -0.0106946
KIAA1328 KIAA1328 -0.0106611
NINL ninein-like -0.0106491
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0106157
ARHGAP5 Rho GTPase activating protein 5 -0.0106153
CLIC4 chloride intracellular channel 4 -0.0105711
FN1 fibronectin 1 -0.0105247
SREBF2 sterol regulatory element binding transcription factor 2 -0.0105132
PICALM phosphatidylinositol binding clathrin assembly protein -0.0104745