Belzutifan_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Belzutifan perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Belzutifan_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.184334
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.135882
ASPH aspartate beta-hydroxylase 0.122766
EXT1 exostosin glycosyltransferase 1 0.0965444
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0959888
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0866805
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0662937
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0597899
GLIS3 GLIS family zinc finger 3 0.0597217
HIPK2 homeodomain interacting protein kinase 2 0.0563776
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0558937
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0541064
RACK1 receptor for activated C kinase 1 0.0534292
MT2A metallothionein 2A 0.0526621
EFNA5 ephrin-A5 0.0512316
EREG epiregulin 0.0511983
SEPTIN9 septin 9 0.0498045
B2M beta-2-microglobulin 0.0495967
NFE2L2 nuclear factor, erythroid 2-like 2 0.0483259
VCL vinculin 0.047994
HMGA2 high mobility group AT-hook 2 0.0456601
NTN4 netrin 4 0.0451535
TMEM156 transmembrane protein 156 0.0448306
LTBP1 latent transforming growth factor beta binding protein 1 0.0421978
RPS12 ribosomal protein S12 0.0417394
FOXP1 forkhead box P1 0.0406039
INTS6 integrator complex subunit 6 0.0396996
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0395636
RAB10 RAB10, member RAS oncogene family 0.0390076
DSG2 desmoglein 2 0.03858
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.037704
RASAL2 RAS protein activator like 2 0.0376955
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0371537
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0369231
RPL12 ribosomal protein L12 0.0366171
ENO1 enolase 1, (alpha) 0.0361933
SVIL supervillin 0.0359862
ZSWIM6 zinc finger, SWIM-type containing 6 0.0359153
PALLD palladin, cytoskeletal associated protein 0.0356034
SYT1 synaptotagmin I 0.035505
RPS3 ribosomal protein S3 0.0352039
SMAD3 SMAD family member 3 0.0351721
FTL ferritin, light polypeptide 0.0343939
NRP1 neuropilin 1 0.0338827
MBD5 methyl-CpG binding domain protein 5 0.0337595
NPAS2 neuronal PAS domain protein 2 0.0332066
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0327629
DSTN destrin (actin depolymerizing factor) 0.0325149
PDLIM5 PDZ and LIM domain 5 0.0320409
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0316295
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0313787
DST dystonin 0.0311971
RPL26 ribosomal protein L26 0.0311156
SMYD3 SET and MYND domain containing 3 0.0308012
LOC102724023 ES1 protein homolog, mitochondrial 0.0306724
PCDH7 protocadherin 7 0.0304292
NRIP1 nuclear receptor interacting protein 1 0.0303333
BASP1 brain abundant, membrane attached signal protein 1 0.0297423
IFI6 interferon, alpha-inducible protein 6 0.0295879
IL6ST interleukin 6 signal transducer 0.0293593
PXMP2 peroxisomal membrane protein 2, 22kDa 0.0291471
SFTPA2 surfactant protein A2 0.0285881
BICD1 bicaudal D homolog 1 (Drosophila) 0.0282905
OSMR oncostatin M receptor 0.0278514
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.027782
IFI16 interferon, gamma-inducible protein 16 0.0273295
RPL37A ribosomal protein L37a 0.027268
NXN nucleoredoxin 0.0271112
RPS19 ribosomal protein S19 0.0268094
AEBP2 AE binding protein 2 0.0267726
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0266795
RO60 Ro60, Y RNA binding protein 0.0266318
SQSTM1 sequestosome 1 0.0261394
FNDC3A fibronectin type III domain containing 3A 0.0256001
FHL2 four and a half LIM domains 2 0.0250801
DUSP6 dual specificity phosphatase 6 0.0250686
FRMD5 FERM domain containing 5 0.0249881
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0248704
TNNC1 troponin C type 1 (slow) 0.0246569
FAT1 FAT atypical cadherin 1 0.0244194
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0243856
CAPN2 calpain 2, (m/II) large subunit 0.0242647
APLP2 amyloid beta (A4) precursor-like protein 2 0.0242585
SP100 SP100 nuclear antigen 0.0239246
LYST lysosomal trafficking regulator 0.0236651
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0235992
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0233626
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.023322
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0230199
ENAH enabled homolog (Drosophila) 0.022878
S100A10 S100 calcium binding protein A10 0.0228335
CLIP2 CAP-GLY domain containing linker protein 2 0.0227734
ANKRD17 ankyrin repeat domain 17 0.0227486
RPL19 ribosomal protein L19 0.0224335
ZC3H12C zinc finger CCCH-type containing 12C 0.0222529
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0220899
GPATCH2L G patch domain containing 2-like 0.0218061
VCAN versican 0.0217279
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0215338
BICC1 BicC family RNA binding protein 1 0.0214728

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.138079
NDRG1 N-myc downstream regulated 1 -0.107609
FN1 fibronectin 1 -0.107025
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0913069
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0763704
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0725815
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0725705
PTMA prothymosin, alpha -0.0707644
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0608887
MRPS6 mitochondrial ribosomal protein S6 -0.0585974
SPAG9 sperm associated antigen 9 -0.0570247
HILPDA hypoxia inducible lipid droplet-associated -0.0552413
COPA coatomer protein complex, subunit alpha -0.0516008
VEGFA vascular endothelial growth factor A -0.0503057
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0493615
CD109 CD109 molecule -0.0437034
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0412814
ZNF292 zinc finger protein 292 -0.0379438
CALR calreticulin -0.0363183
FNDC3B fibronectin type III domain containing 3B -0.0361133
CANX calnexin -0.0360149
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0354617
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0352231
WDR45B WD repeat domain 45B -0.0335751
S100A6 S100 calcium binding protein A6 -0.0330123
RNF145 ring finger protein 145 -0.032697
NAMPT nicotinamide phosphoribosyltransferase -0.0318406
TRIO trio Rho guanine nucleotide exchange factor -0.0316097
PDIA3 protein disulfide isomerase family A, member 3 -0.0315915
CADM1 cell adhesion molecule 1 -0.0302127
CTBP2 C-terminal binding protein 2 -0.0293365
RAB6A RAB6A, member RAS oncogene family -0.0291422
HELZ helicase with zinc finger -0.0288368
ARF4 ADP-ribosylation factor 4 -0.0286535
KDM5B lysine (K)-specific demethylase 5B -0.0285683
BIRC6 baculoviral IAP repeat containing 6 -0.0285183
SEC23A Sec23 homolog A (S. cerevisiae) -0.0284954
SUCO SUN domain containing ossification factor -0.0280261
KMT2E lysine (K)-specific methyltransferase 2E -0.0273598
TFG TRK-fused gene -0.0268912
TMSB4X thymosin beta 4, X-linked -0.0267938
SOD2 superoxide dismutase 2, mitochondrial -0.0267738
KDM3A lysine (K)-specific demethylase 3A -0.0264065
DENND4C DENN/MADD domain containing 4C -0.0261482
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0259424
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0257678
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.02571
XPO1 exportin 1 -0.0253978
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0251787
GOLGA4 golgin A4 -0.0250261
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0250069
BHLHE40 basic helix-loop-helix family, member e40 -0.0249483
ESYT2 extended synaptotagmin-like protein 2 -0.0248664
ZFP36L1 ZFP36 ring finger protein-like 1 -0.024685
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0246798
NUP58 nucleoporin 58 -0.0245907
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0242546
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0241369
COG5 component of oligomeric golgi complex 5 -0.0239406
KPNB1 karyopherin (importin) beta 1 -0.023899
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0237632
TGFA transforming growth factor, alpha -0.0237131
ZNF207 zinc finger protein 207 -0.0236218
ACBD3 acyl-CoA binding domain containing 3 -0.0235706
HMGA1 high mobility group AT-hook 1 -0.0235441
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0235217
KLHL24 kelch-like family member 24 -0.0234906
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.0234591
LCORL ligand dependent nuclear receptor corepressor-like -0.0233211
ADAM9 ADAM metallopeptidase domain 9 -0.0230075
TMEM165 transmembrane protein 165 -0.0227723
POTEF POTE ankyrin domain family, member F -0.0225948
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0225399
KCTD9 potassium channel tetramerization domain containing 9 -0.0224511
GRB10 growth factor receptor-bound protein 10 -0.0219704
HDGF hepatoma-derived growth factor -0.0217738
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0216982
FOS FBJ murine osteosarcoma viral oncogene homolog -0.021645
ZCCHC7 zinc finger, CCHC domain containing 7 -0.021605
RPL35A ribosomal protein L35a -0.0212369
SEC31A SEC31 homolog A (S. cerevisiae) -0.0211223
IGFBP3 insulin-like growth factor binding protein 3 -0.0208935
INSIG2 insulin induced gene 2 -0.0207329
PDIA6 protein disulfide isomerase family A, member 6 -0.0204938
ATN1 atrophin 1 -0.0204487
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.020435
MON2 MON2 homolog (S. cerevisiae) -0.0203009
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0202137
PLIN2 perilipin 2 -0.0201773
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0199344
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0199319
OGA O-GlcNAcase -0.0198926
MORF4L2 mortality factor 4 like 2 -0.0198769
RTN4 reticulon 4 -0.0197494
RAB1A RAB1A, member RAS oncogene family -0.0194482
GARS1 glycyl-tRNA synthetase 1 -0.0193422
LOC112694756 uncharaterized LOC112694756 -0.0192236
KMT2C lysine (K)-specific methyltransferase 2C -0.0187082
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0185859
RBM39 RNA binding motif protein 39 -0.0184788