Bendamustine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bendamustine perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Bendamustine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZFAND3 zinc finger, AN1-type domain 3 0.0413134
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0379299
WAC WW domain containing adaptor with coiled-coil 0.0300449
SSBP2 single-stranded DNA binding protein 2 0.0294352
HMGB2 high mobility group box 2 0.0293228
FNDC3B fibronectin type III domain containing 3B 0.0292144
MYH9 myosin, heavy chain 9, non-muscle 0.0290992
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0284413
KDM3A lysine (K)-specific demethylase 3A 0.0281338
ARHGAP9 Rho GTPase activating protein 9 0.0263946
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0255154
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0252474
UBA6 ubiquitin-like modifier activating enzyme 6 0.024887
ZMAT3 zinc finger, matrin-type 3 0.0235317
KAT6A K(lysine) acetyltransferase 6A 0.0231688
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0230311
LPIN1 lipin 1 0.022872
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0224831
UBXN7 UBX domain protein 7 0.0223888
ASXL1 additional sex combs like transcriptional regulator 1 0.0222223
HSPA8 heat shock 70kDa protein 8 0.0222163
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0218491
UBQLN1 ubiquilin 1 0.0217546
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0216553
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.02159
DIDO1 death inducer-obliterator 1 0.0214686
XPO1 exportin 1 0.0214
RNF145 ring finger protein 145 0.0210779
USP9X ubiquitin specific peptidase 9, X-linked 0.0209823
COL4A1 collagen, type IV, alpha 1 0.0207881
CCNY cyclin Y 0.0205899
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0202357
PTEN phosphatase and tensin homolog 0.020169
ETNK1 ethanolamine kinase 1 0.0200851
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.019919
KIDINS220 kinase D-interacting substrate, 220kDa 0.019758
DDR2 discoidin domain receptor tyrosine kinase 2 0.0195281
EZR ezrin 0.0193609
AMOTL1 angiomotin like 1 0.0191302
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.018978
CASC3 cancer susceptibility candidate 3 0.0187876
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0187063
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0186069
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0183417
QKI QKI, KH domain containing, RNA binding 0.0181719
ANO6 anoctamin 6 0.0181538
RAD23B RAD23 homolog B (S. cerevisiae) 0.0180456
NUP58 nucleoporin 58 0.0180359
DDB1 damage-specific DNA binding protein 1, 127kDa 0.0180118
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0179893
EVL Enah/Vasp-like 0.0179558
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0179296
TPST1 tyrosylprotein sulfotransferase 1 0.0179057
CEP85L centrosomal protein 85kDa-like 0.0178785
FRMD4A FERM domain containing 4A 0.0177198
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0176822
RANBP9 RAN binding protein 9 0.0175428
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0175239
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0172615
EXT1 exostosin glycosyltransferase 1 0.0172474
ATP13A3 ATPase type 13A3 0.0172218
ADGRG6 adhesion G protein-coupled receptor G6 0.0170532
DNM1L dynamin 1-like 0.0170039
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0169975
RIOK3 RIO kinase 3 0.016755
CRY1 cryptochrome circadian clock 1 0.0164203
CDK14 cyclin-dependent kinase 14 0.0163411
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0162772
CPNE8 copine VIII 0.0161913
KIF13A kinesin family member 13A 0.0160591
BRWD1 bromodomain and WD repeat domain containing 1 0.0160427
MORF4L1 mortality factor 4 like 1 0.0160008
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0158681
CDK17 cyclin-dependent kinase 17 0.0158567
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0157475
EIF4B eukaryotic translation initiation factor 4B 0.0157166
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.015705
NFE2L1 nuclear factor, erythroid 2-like 1 0.0156828
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0155898
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0155471
SQLE squalene epoxidase 0.0154663
AHR aryl hydrocarbon receptor 0.0154493
ENAH enabled homolog (Drosophila) 0.0153141
YY1AP1 YY1 associated protein 1 0.0152319
NAMPT nicotinamide phosphoribosyltransferase 0.0152146
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0151909
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0151638
TFRC transferrin receptor 0.0151416
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0151091
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0150701
CEP170 centrosomal protein 170kDa 0.0149477
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.0149057
SDE2 SDE2 telomere maintenance homolog (S. pombe) 0.0148304
MYO6 myosin VI 0.014776
DIAPH3 diaphanous-related formin 3 0.0147425
ATL2 atlastin GTPase 2 0.0146273
CLTC clathrin, heavy chain (Hc) 0.0146096
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0145984
COPS2 COP9 signalosome subunit 2 0.0145781
CKAP5 cytoskeleton associated protein 5 0.0145395

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.395219
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.27242
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.258292
VIM vimentin -0.113638
PTPRD protein tyrosine phosphatase, receptor type, D -0.101998
RPS6 ribosomal protein S6 -0.0968629
PTMA prothymosin, alpha -0.0963713
AKAP12 A kinase (PRKA) anchor protein 12 -0.0861462
RPL19 ribosomal protein L19 -0.0803115
RPL34 ribosomal protein L34 -0.070408
RPL23 ribosomal protein L23 -0.0686227
TMSB10 thymosin beta 10 -0.0636931
TPT1 tumor protein, translationally-controlled 1 -0.0584691
RPLP1 ribosomal protein, large, P1 -0.0578167
RPS3 ribosomal protein S3 -0.0561828
RPS19 ribosomal protein S19 -0.0551829
RPL35A ribosomal protein L35a -0.0533889
B2M beta-2-microglobulin -0.0483169
RPL37A ribosomal protein L37a -0.0477112
RPS27 ribosomal protein S27 -0.04681
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.046083
EIF1 eukaryotic translation initiation factor 1 -0.0448987
FTL ferritin, light polypeptide -0.0431809
KTN1 kinectin 1 (kinesin receptor) -0.0418181
TBX2 T-box 2 -0.0414676
GNAS GNAS complex locus -0.0404574
HILPDA hypoxia inducible lipid droplet-associated -0.0403433
RPS24 ribosomal protein S24 -0.0403029
RPL27 ribosomal protein L27 -0.0390939
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0383746
RPL31 ribosomal protein L31 -0.038041
RPL12 ribosomal protein L12 -0.0379522
RPS16 ribosomal protein S16 -0.0375292
RPLP0 ribosomal protein, large, P0 -0.0372568
ACTG1 actin gamma 1 -0.0364892
RPL38 ribosomal protein L38 -0.0361148
RPL9 ribosomal protein L9 -0.0360214
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0358307
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0355155
HAND2 heart and neural crest derivatives expressed 2 -0.0353273
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0348172
RPL30 ribosomal protein L30 -0.0347958
NCAM2 neural cell adhesion molecule 2 -0.0345172
LSAMP limbic system-associated membrane protein -0.0337427
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0333786
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.03335
WDR45B WD repeat domain 45B -0.033096
NDRG1 N-myc downstream regulated 1 -0.0330109
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0327179
TLE4 transducin-like enhancer of split 4 -0.032531
MEIS2 Meis homeobox 2 -0.0322113
S100A9 S100 calcium binding protein A9 -0.0317943
ASPH aspartate beta-hydroxylase -0.0317237
RPL26 ribosomal protein L26 -0.031526
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0314916
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0313845
RPS25 ribosomal protein S25 -0.0306721
PRRC2C proline-rich coiled-coil 2C -0.0303472
BPTF bromodomain PHD finger transcription factor -0.0298722
RPL8 ribosomal protein L8 -0.029428
RPLP2 ribosomal protein, large, P2 -0.0291455
S100A6 S100 calcium binding protein A6 -0.0288362
SMYD3 SET and MYND domain containing 3 -0.0288098
RPL32 ribosomal protein L32 -0.0287471
TRIO trio Rho guanine nucleotide exchange factor -0.0285348
RPL36 ribosomal protein L36 -0.028498
RPL35 ribosomal protein L35 -0.0280901
H3-3B H3.3 histone B -0.0279428
RPL7 ribosomal protein L7 -0.0279219
CSNK1A1 casein kinase 1, alpha 1 -0.0276196
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0276046
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0273455
GOLGA4 golgin A4 -0.027321
RPL28 ribosomal protein L28 -0.0273171
EEF2 eukaryotic translation elongation factor 2 -0.0269094
RPS14 ribosomal protein S14 -0.0267996
PHF14 PHD finger protein 14 -0.0267664
RPS17 ribosomal protein S17 -0.0264222
MARCKS myristoylated alanine-rich protein kinase C substrate -0.026417
WSB1 WD repeat and SOCS box containing 1 -0.0261897
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0260829
FHIT fragile histidine triad -0.0253015
RAB7A RAB7A, member RAS oncogene family -0.0252577
NREP neuronal regeneration related protein -0.0252417
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -0.0249807
TPI1 triosephosphate isomerase 1 -0.024644
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0246316
PCDH9 protocadherin 9 -0.0243931
NBR1 neighbor of BRCA1 gene 1 -0.0242246
LDHB lactate dehydrogenase B -0.0241477
IFI16 interferon, gamma-inducible protein 16 -0.024119
RPS29 ribosomal protein S29 -0.0240243
AFMID arylformamidase -0.0235098
VEGFA vascular endothelial growth factor A -0.0234622
GATA3 GATA binding protein 3 -0.0232187
EGR1 early growth response 1 -0.0230372
TAS2R14 taste receptor, type 2, member 14 -0.0229541
NACA nascent polypeptide-associated complex alpha subunit -0.0225048
NAP1L1 nucleosome assembly protein 1-like 1 -0.0224993
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0224673