Bendamustine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bendamustine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bendamustine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.152197
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.12381
MBNL2 muscleblind-like splicing regulator 2 0.0924825
BTBD9 BTB (POZ) domain containing 9 0.0732705
RNF43 ring finger protein 43 0.0540133
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0534228
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0519285
PRELID2 PRELI domain containing 2 0.0491837
IFNGR1 interferon gamma receptor 1 0.0485964
FNDC3A fibronectin type III domain containing 3A 0.0471335
CANX calnexin 0.0446611
RHOBTB3 Rho-related BTB domain containing 3 0.0443142
RUNX1 runt-related transcription factor 1 0.043886
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0431535
PDIA3 protein disulfide isomerase family A, member 3 0.04168
ZMYM2 zinc finger, MYM-type 2 0.0391839
PHF3 PHD finger protein 3 0.0365912
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0365243
HDLBP high density lipoprotein binding protein 0.0349849
COG6 component of oligomeric golgi complex 6 0.0347811
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0343403
CALR calreticulin 0.0341823
NRIP1 nuclear receptor interacting protein 1 0.0337167
FAT1 FAT atypical cadherin 1 0.0331906
TXNIP thioredoxin interacting protein 0.0331451
MCTP2 multiple C2 domains, transmembrane 2 0.0326152
SEC24D SEC24 family member D 0.0318228
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0310852
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0310351
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0309741
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0302949
GOLGB1 golgin B1 0.0292623
PDIA4 protein disulfide isomerase family A, member 4 0.0291164
PGK1 phosphoglycerate kinase 1 0.0290975
UBAC2 UBA domain containing 2 0.0289839
ERRFI1 ERBB receptor feedback inhibitor 1 0.0286109
AKAP9 A kinase (PRKA) anchor protein 9 0.0278997
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0278199
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0277639
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0274635
EHF ets homologous factor 0.0274118
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0273455
AHNAK AHNAK nucleoprotein 0.0272071
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.026913
AHI1 Abelson helper integration site 1 0.0263869
GOLGA2 golgin A2 0.0256735
AOPEP aminopeptidase O (putative) 0.0256256
ERCC5 excision repair cross-complementation group 5 0.02548
COPA coatomer protein complex, subunit alpha 0.0249598
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0249353
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0249162
RNF149 ring finger protein 149 0.0247743
PTEN phosphatase and tensin homolog 0.0243695
ESRP1 epithelial splicing regulatory protein 1 0.0242485
USP3 ubiquitin specific peptidase 3 0.0239897
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0238994
OGA O-GlcNAcase 0.023661
ENO1 enolase 1, (alpha) 0.0236056
NEBL nebulette 0.0232201
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0230183
KDM3A lysine (K)-specific demethylase 3A 0.0229916
TM9SF2 transmembrane 9 superfamily member 2 0.0229553
COPB1 coatomer protein complex, subunit beta 1 0.0226366
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0226113
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0224015
HELZ helicase with zinc finger 0.0221564
HYOU1 hypoxia up-regulated 1 0.0221175
USPL1 ubiquitin specific peptidase like 1 0.021896
GOLGA4 golgin A4 0.0211465
SSR1 signal sequence receptor, alpha 0.0209579
MEIS2 Meis homeobox 2 0.0208017
UBL3 ubiquitin-like 3 0.0207736
TTC3 tetratricopeptide repeat domain 3 0.0207687
LCORL ligand dependent nuclear receptor corepressor-like 0.0207353
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0204807
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0204241
SORBS1 sorbin and SH3 domain containing 1 0.0203344
ZNF148 zinc finger protein 148 0.0202117
LMAN1 lectin, mannose-binding, 1 0.0202017
MXI1 MAX interactor 1, dimerization protein 0.0200298
ESYT2 extended synaptotagmin-like protein 2 0.0200141
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0194157
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0194095
RNF145 ring finger protein 145 0.0192436
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0191731
SUCO SUN domain containing ossification factor 0.0190051
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.018891
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0187998
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0187283
HGD homogentisate 1,2-dioxygenase 0.0183331
DENND4C DENN/MADD domain containing 4C 0.0182912
METTL15 methyltransferase like 15 0.0182647
IL20RA interleukin 20 receptor, alpha 0.0181885
TMED2 transmembrane emp24 domain trafficking protein 2 0.0181025
GRAMD2B GRAM domain containing 2B 0.018093
MON2 MON2 homolog (S. cerevisiae) 0.0179207
YEATS2 YEATS domain containing 2 0.017882
ACBD3 acyl-CoA binding domain containing 3 0.0178787
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0178238
BIRC6 baculoviral IAP repeat containing 6 0.0177832

decreased expression

Symbol Name Standardized Value
RNF213 ring finger protein 213 -0.168181
EPSTI1 epithelial stromal interaction 1 (breast) -0.161508
EGR1 early growth response 1 -0.161465
ANXA2 annexin A2 -0.157956
VCL vinculin -0.147773
LMO7 LIM domain 7 -0.135893
MACC1 metastasis associated in colon cancer 1 -0.11297
RIGI RNA sensor RIG-I -0.112378
STAT1 signal transducer and activator of transcription 1, 91kDa -0.108639
AREG amphiregulin -0.106448
SP100 SP100 nuclear antigen -0.104477
RAB7A RAB7A, member RAS oncogene family -0.104072
INTS6 integrator complex subunit 6 -0.101721
MX1 MX dynamin-like GTPase 1 -0.0980312
C6ORF132 chromosome 6 open reading frame 132 -0.0949005
ERBIN erbb2 interacting protein -0.0945931
TJP1 tight junction protein 1 -0.0868673
STS steroid sulfatase (microsomal), isozyme S -0.0867814
MX2 MX dynamin-like GTPase 2 -0.0865729
MYO1E myosin IE -0.0835403
PLSCR1 phospholipid scramblase 1 -0.082557
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0824089
EZR ezrin -0.0797517
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0773876
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0758825
AKAP13 A kinase (PRKA) anchor protein 13 -0.0750912
GMDS GDP-mannose 4,6-dehydratase -0.0750251
TPT1 tumor protein, translationally-controlled 1 -0.0749136
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0701844
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0684735
B2M beta-2-microglobulin -0.0650202
CCNL1 cyclin L1 -0.0645765
LOC102724023 ES1 protein homolog, mitochondrial -0.0639355
VMP1 vacuole membrane protein 1 -0.0586024
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0584893
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0577651
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.054783
ZNF292 zinc finger protein 292 -0.0539253
JUN jun proto-oncogene -0.0528385
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0527264
IFI6 interferon, alpha-inducible protein 6 -0.0523251
EFNB2 ephrin-B2 -0.0515297
RABGAP1L RAB GTPase activating protein 1-like -0.0511572
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0484061
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0481183
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0480849
MCTP1 multiple C2 domains, transmembrane 1 -0.0476579
PERP PERP, TP53 apoptosis effector -0.0463886
PTMA prothymosin, alpha -0.0461931
BCL2L1 BCL2-like 1 -0.0452314
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0450422
EXT1 exostosin glycosyltransferase 1 -0.0449433
TSHZ2 teashirt zinc finger homeobox 2 -0.0439935
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0439253
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0437934
XAF1 XIAP associated factor 1 -0.0436801
ITGA6 integrin, alpha 6 -0.0435456
MCL1 myeloid cell leukemia 1 -0.0426349
LYZ lysozyme -0.0423469
PMP22 peripheral myelin protein 22 -0.0422857
LCN2 lipocalin 2 -0.0412298
TMC5 transmembrane channel-like 5 -0.0408326
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0408228
TNS4 tensin 4 -0.0402543
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0398893
KLF6 Kruppel-like factor 6 -0.0397039
NABP1 nucleic acid binding protein 1 -0.0392354
TMSB10 thymosin beta 10 -0.0392337
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0392295
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0391408
UBAP2 ubiquitin associated protein 2 -0.0388565
TM4SF19 transmembrane 4 L six family member 19 -0.0383674
ZNFX1 zinc finger, NFX1-type containing 1 -0.0381853
SQSTM1 sequestosome 1 -0.0377046
SHB Src homology 2 domain containing adaptor protein B -0.0375393
LAMA4 laminin, alpha 4 -0.0370761
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0368167
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0366057
SPATA13 spermatogenesis associated 13 -0.0359186
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0358195
DGKH diacylglycerol kinase, eta -0.035261
BLZF1 basic leucine zipper nuclear factor 1 -0.0345751
TUFT1 tuftelin 1 -0.034496
MAP7 microtubule-associated protein 7 -0.0341783
DUSP10 dual specificity phosphatase 10 -0.0340092
CLDN4 claudin 4 -0.0338613
FOSL1 FOS-like antigen 1 -0.0331932
ACTG1 actin gamma 1 -0.0326273
ANKRD10 ankyrin repeat domain 10 -0.0325365
NT5C2 5'-nucleotidase, cytosolic II -0.0324606
LPP LIM domain containing preferred translocation partner in lipoma -0.0323667
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0322457
PRKCA protein kinase C, alpha -0.0320769
PLAUR plasminogen activator, urokinase receptor -0.031837
CATSPERB catsper channel auxiliary subunit beta -0.0317668
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.031667
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0313316
DDIT3 DNA-damage-inducible transcript 3 -0.0313208
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0308729
IRS2 insulin receptor substrate 2 -0.0307478