Bendamustine_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bendamustine perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bendamustine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.0548217
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.050773
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0449156
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0383343
VEGFA vascular endothelial growth factor A 0.0296199
MSN moesin 0.0278757
FNDC3B fibronectin type III domain containing 3B 0.0268777
POTEF POTE ankyrin domain family, member F 0.0267843
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0248458
FTH1 ferritin, heavy polypeptide 1 0.0244631
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0241966
CENPF centromere protein F, 350/400kDa 0.0233987
MYH9 myosin, heavy chain 9, non-muscle 0.023013
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0218902
IL6ST interleukin 6 signal transducer 0.0208288
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0206616
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0196147
CADM1 cell adhesion molecule 1 0.019212
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.018657
EGFR epidermal growth factor receptor 0.0171567
HDAC9 histone deacetylase 9 0.0166535
EGR1 early growth response 1 0.0166239
IL6 interleukin 6 0.0158758
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0157419
ATXN1 ataxin 1 0.0152073
PGM3 phosphoglucomutase 3 0.0145873
DSPP dentin sialophosphoprotein 0.0133747
EZR ezrin 0.0129247
SFPQ splicing factor proline/glutamine-rich 0.0129009
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0125699
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.012165
ERRFI1 ERBB receptor feedback inhibitor 1 0.012149
NCOR2 nuclear receptor corepressor 2 0.0120627
C6ORF62 chromosome 6 open reading frame 62 0.0120155
NOTCH2 notch 2 0.0120047
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0119346
TMF1 TATA element modulatory factor 1 0.0115864
INHBA inhibin, beta A 0.0115731
PTEN phosphatase and tensin homolog 0.011356
VMP1 vacuole membrane protein 1 0.011285
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0110074
JARID2 jumonji, AT rich interactive domain 2 0.0109511
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0109452
PDE4D phosphodiesterase 4D, cAMP-specific 0.0107447
XRN1 5'-3' exoribonuclease 1 0.0107047
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.010566
APLP2 amyloid beta (A4) precursor-like protein 2 0.0104333
NAV2 neuron navigator 2 0.010385
ANO6 anoctamin 6 0.0101726
GDI2 GDP dissociation inhibitor 2 0.010047
SQSTM1 sequestosome 1 0.0100197
SMC4 structural maintenance of chromosomes 4 0.0100157
NFE2L1 nuclear factor, erythroid 2-like 1 0.0100048
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.00979884
SETX senataxin 0.00979365
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0097824
SAMD9 sterile alpha motif domain containing 9 0.00978072
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00972577
ARF4 ADP-ribosylation factor 4 0.00962727
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.00960823
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.00955754
GOLGB1 golgin B1 0.00954651
UBXN4 UBX domain protein 4 0.009537
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.00950493
KDM6A lysine (K)-specific demethylase 6A 0.00950211
GPC6 glypican 6 0.00947496
NLRP1 NLR family, pyrin domain containing 1 0.00940499
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.00939318
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.00939222
DST dystonin 0.00938593
KIF16B kinesin family member 16B 0.00935839
RPS18 ribosomal protein S18 0.00935371
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.00930854
STC2 stanniocalcin 2 0.00929356
HSPA8 heat shock 70kDa protein 8 0.00926683
LIMA1 LIM domain and actin binding 1 0.00918537
PICALM phosphatidylinositol binding clathrin assembly protein 0.00915639
RPL3 ribosomal protein L3 0.00898264
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.00885191
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0085662
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.00855264
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.00849278
SON SON DNA binding protein 0.00842003
EIF5 eukaryotic translation initiation factor 5 0.00837325
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00836557
CSF1 colony stimulating factor 1 (macrophage) 0.00835319
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.00823304
MYO1B myosin IB 0.00821743
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.00812916
PDGFC platelet derived growth factor C 0.00807456
MYOF myoferlin 0.00806721
USP47 ubiquitin specific peptidase 47 0.00805427
BIRC3 baculoviral IAP repeat containing 3 0.00805255
SAMD4A sterile alpha motif domain containing 4A 0.00803287
TBC1D5 TBC1 domain family, member 5 0.0078167
TARDBP TAR DNA binding protein 0.00780546
HYOU1 hypoxia up-regulated 1 0.0077684
AXL AXL receptor tyrosine kinase 0.00772905
ZFP36L1 ZFP36 ring finger protein-like 1 0.0077229
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0077136

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.410818
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.365047
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.260875
COL1A1 collagen, type I, alpha 1 -0.236197
IGFBP3 insulin-like growth factor binding protein 3 -0.181906
VIM vimentin -0.154523
MT2A metallothionein 2A -0.140432
NDRG1 N-myc downstream regulated 1 -0.130364
COL1A2 collagen, type I, alpha 2 -0.117786
TMSB10 thymosin beta 10 -0.104695
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0939591
COL6A3 collagen, type VI, alpha 3 -0.0916635
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0889008
LOXL2 lysyl oxidase-like 2 -0.0727698
TM4SF1 transmembrane 4 L six family member 1 -0.0672306
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0656455
TRIO trio Rho guanine nucleotide exchange factor -0.0652553
TGFBI transforming growth factor, beta-induced, 68kDa -0.0647783
IER3 immediate early response 3 -0.0629945
COL5A1 collagen, type V, alpha 1 -0.0561587
FBN1 fibrillin 1 -0.0557287
AHNAK AHNAK nucleoprotein -0.0556514
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0551132
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0540134
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0537364
RPS8 ribosomal protein S8 -0.053567
ANXA2 annexin A2 -0.0529079
FTL ferritin, light polypeptide -0.0522909
CAVIN1 caveolae associated protein 1 -0.0494666
ACTG1 actin gamma 1 -0.0492514
EIF1 eukaryotic translation initiation factor 1 -0.0486756
CANX calnexin -0.0479277
LOX lysyl oxidase -0.0477923
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0474516
HMGA2 high mobility group AT-hook 2 -0.045642
RPL35A ribosomal protein L35a -0.0437614
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0434498
RRBP1 ribosome binding protein 1 -0.0430136
HLA-B major histocompatibility complex, class I, B -0.0430036
PTMA prothymosin, alpha -0.0417433
MT1X metallothionein 1X -0.041077
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.039383
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0386632
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0376231
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0374062
RPL8 ribosomal protein L8 -0.0373389
COL6A2 collagen, type VI, alpha 2 -0.0368556
TPM4 tropomyosin 4 -0.0346724
RPS6 ribosomal protein S6 -0.0344789
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0343823
RLF rearranged L-myc fusion -0.0341182
TPT1 tumor protein, translationally-controlled 1 -0.0339212
GNAS GNAS complex locus -0.0337423
CALR calreticulin -0.0335957
USP3 ubiquitin specific peptidase 3 -0.03271
S100A9 S100 calcium binding protein A9 -0.0319054
NAMPT nicotinamide phosphoribosyltransferase -0.031593
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0309734
ZFAND3 zinc finger, AN1-type domain 3 -0.0307535
RPL28 ribosomal protein L28 -0.0301588
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0296218
RPL30 ribosomal protein L30 -0.0295323
S100A10 S100 calcium binding protein A10 -0.0295075
RPL26 ribosomal protein L26 -0.0294866
S100A6 S100 calcium binding protein A6 -0.0294038
WSB1 WD repeat and SOCS box containing 1 -0.0294016
MAP4 microtubule-associated protein 4 -0.0292575
PXDN peroxidasin -0.0291357
LOC112694756 uncharaterized LOC112694756 -0.0290897
RPLP1 ribosomal protein, large, P1 -0.0290847
ANKRD11 ankyrin repeat domain 11 -0.0289668
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0282923
SPAG9 sperm associated antigen 9 -0.0279924
RPL5 ribosomal protein L5 -0.0278576
CALU calumenin -0.027773
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0276206
ZNF292 zinc finger protein 292 -0.0275892
COL3A1 collagen, type III, alpha 1 -0.0274929
RPL19 ribosomal protein L19 -0.0274367
RPL32 ribosomal protein L32 -0.0273516
LMAN1 lectin, mannose-binding, 1 -0.0266501
RPL34 ribosomal protein L34 -0.0264856
RPL11 ribosomal protein L11 -0.0262162
WASF2 WAS protein family, member 2 -0.0259174
RAB2A RAB2A, member RAS oncogene family -0.0258865
COL6A1 collagen, type VI, alpha 1 -0.0258319
TMSB4X thymosin beta 4, X-linked -0.0256523
RPL36 ribosomal protein L36 -0.0254599
LMNA lamin A/C -0.0252219
GLIS3 GLIS family zinc finger 3 -0.0250378
RPS19 ribosomal protein S19 -0.0249155
RPS3 ribosomal protein S3 -0.0244646
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0244014
RPS24 ribosomal protein S24 -0.0243717
PRRC1 proline-rich coiled-coil 1 -0.0243407
ELL2 elongation factor, RNA polymerase II, 2 -0.0239212
THY1 Thy-1 cell surface antigen -0.0237787
ECE1 endothelin converting enzyme 1 -0.0237144
H1-0 H1.0 linker histone -0.0231177
FAM162A family with sequence similarity 162, member A -0.0231057