| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bendamustine perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bendamustine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 0.255733 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.24407 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.136448 |
| FN1 | fibronectin 1 | 0.103626 |
| DSPP | dentin sialophosphoprotein | 0.100966 |
| APOA2 | apolipoprotein A-II | 0.0920482 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0893212 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0875632 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0866173 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0855513 |
| GPC3 | glypican 3 | 0.0801963 |
| A2M | alpha-2-macroglobulin | 0.0736822 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0686778 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0669535 |
| C3 | complement component 3 | 0.0664174 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0658124 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0652471 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0538116 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0537633 |
| TRIM26 | tripartite motif containing 26 | 0.0537571 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0518393 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0503412 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0489189 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0486282 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0460292 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0452655 |
| ENO1 | enolase 1, (alpha) | 0.04328 |
| RPS23 | ribosomal protein S23 | 0.0425646 |
| CFB | complement factor B | 0.0407037 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0404904 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0402317 |
| UBC | ubiquitin C | 0.0396534 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0386949 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0381763 |
| PEG3 | paternally expressed 3 | 0.0379248 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0367909 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0360897 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0357922 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0350917 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0337107 |
| RPLP0 | ribosomal protein, large, P0 | 0.0323979 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0323107 |
| MATR3 | matrin 3 | 0.032068 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0319741 |
| RPS27A | ribosomal protein S27a | 0.0317289 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.031284 |
| HLF | hepatic leukemia factor | 0.0311468 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0311295 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0307437 |
| CTSB | cathepsin B | 0.0304391 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0303023 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0295745 |
| OSMR | oncostatin M receptor | 0.0294866 |
| AHR | aryl hydrocarbon receptor | 0.0293796 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0291044 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0290844 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0285251 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0283114 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0279219 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0268296 |
| IFNGR1 | interferon gamma receptor 1 | 0.0263782 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0263303 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.026027 |
| MBNL3 | muscleblind-like splicing regulator 3 | 0.0259725 |
| ITGAV | integrin, alpha V | 0.0256124 |
| DSTN | destrin (actin depolymerizing factor) | 0.0251235 |
| TPM4 | tropomyosin 4 | 0.0247591 |
| SVIL | supervillin | 0.0246063 |
| RPL31 | ribosomal protein L31 | 0.0244529 |
| JMJD1C | jumonji domain containing 1C | 0.0243492 |
| ITGA1 | integrin, alpha 1 | 0.0240324 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0233306 |
| TF | transferrin | 0.0229579 |
| FOXO1 | forkhead box O1 | 0.0229154 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0227045 |
| CENPF | centromere protein F, 350/400kDa | 0.0226455 |
| RPL28 | ribosomal protein L28 | 0.0226171 |
| PLAC8 | placenta-specific 8 | 0.022528 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | 0.0225277 |
| RPS24 | ribosomal protein S24 | 0.0225077 |
| BPTF | bromodomain PHD finger transcription factor | 0.0224626 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0223688 |
| KRT8 | keratin 8, type II | 0.021969 |
| RPLP2 | ribosomal protein, large, P2 | 0.0216546 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0215949 |
| FGA | fibrinogen alpha chain | 0.0214795 |
| MALT1 | MALT1 paracaspase | 0.021378 |
| PHIP | pleckstrin homology domain interacting protein | 0.0212528 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0209552 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0209037 |
| MKI67 | marker of proliferation Ki-67 | 0.0208964 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0207941 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.020702 |
| RPS25 | ribosomal protein S25 | 0.0206401 |
| PTCHD4 | patched domain containing 4 | 0.0204911 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.020309 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0202947 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0202852 |
| SERINC1 | serine incorporator 1 | 0.0200955 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0200056 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.551739 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.146254 |
| ASPH | aspartate beta-hydroxylase | -0.0763659 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0703364 |
| EHBP1 | EH domain binding protein 1 | -0.0679094 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.055999 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0547964 |
| FMNL2 | formin-like 2 | -0.0509806 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0496199 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.048732 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0429809 |
| DTNA | dystrobrevin, alpha | -0.0423104 |
| ATXN1 | ataxin 1 | -0.0418599 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0405999 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0391762 |
| FRMD5 | FERM domain containing 5 | -0.0380228 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.035402 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0345423 |
| FAM13A | family with sequence similarity 13, member A | -0.0343782 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0339629 |
| FLNB | filamin B, beta | -0.0338234 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0337836 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0328684 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0324742 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0319062 |
| SCARB1 | scavenger receptor class B, member 1 | -0.0303005 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0271203 |
| HPCAL1 | hippocalcin-like 1 | -0.0268357 |
| RPS12 | ribosomal protein S12 | -0.026577 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0264645 |
| PLIN2 | perilipin 2 | -0.0264572 |
| MSI2 | musashi RNA-binding protein 2 | -0.0264558 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0253771 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0241838 |
| QKI | QKI, KH domain containing, RNA binding | -0.0238033 |
| TLE4 | transducin-like enhancer of split 4 | -0.0235046 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0232432 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0232261 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0230105 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0229753 |
| STK17A | serine/threonine kinase 17a | -0.0229488 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0228654 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0228523 |
| MAP1B | microtubule-associated protein 1B | -0.0221097 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0218686 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0217085 |
| FOXO3 | forkhead box O3 | -0.0217021 |
| RIGI | RNA sensor RIG-I | -0.0216398 |
| HMGA1 | high mobility group AT-hook 1 | -0.021632 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -0.0214905 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0214487 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0212699 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.020878 |
| CCNL1 | cyclin L1 | -0.0208441 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.020648 |
| NABP1 | nucleic acid binding protein 1 | -0.0203951 |
| NPR2 | natriuretic peptide receptor 2 | -0.0203394 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0202524 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0201222 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.0198466 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0198362 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0196256 |
| RNF213 | ring finger protein 213 | -0.0196001 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.019538 |
| PRKCA | protein kinase C, alpha | -0.0194575 |
| DST | dystonin | -0.0194286 |
| TNS1 | tensin 1 | -0.0194186 |
| MYO1B | myosin IB | -0.0194084 |
| HDAC4 | histone deacetylase 4 | -0.0186917 |
| MCL1 | myeloid cell leukemia 1 | -0.0186129 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0185465 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.018389 |
| NDRG1 | N-myc downstream regulated 1 | -0.0183078 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0181594 |
| INTS6 | integrator complex subunit 6 | -0.0181496 |
| ATP10A | ATPase, class V, type 10A | -0.0180939 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0179455 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0178974 |
| SQSTM1 | sequestosome 1 | -0.0178148 |
| NUP58 | nucleoporin 58 | -0.0177542 |
| SGMS1 | sphingomyelin synthase 1 | -0.0174567 |
| HOMER1 | homer scaffolding protein 1 | -0.0173982 |
| BBX | bobby sox homolog (Drosophila) | -0.0172884 |
| MT2A | metallothionein 2A | -0.0171727 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.017124 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0171179 |
| RPL23 | ribosomal protein L23 | -0.0171142 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.017075 |
| USP36 | ubiquitin specific peptidase 36 | -0.0170029 |
| RYBP | RING1 and YY1 binding protein | -0.0169716 |
| FAM107B | family with sequence similarity 107, member B | -0.0169359 |
| VEGFA | vascular endothelial growth factor A | -0.0168206 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0167408 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0166375 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0165566 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0165356 |
| STC2 | stanniocalcin 2 | -0.0165083 |
| ZNF10 | zinc finger protein 10 | -0.0164934 |
| RPL18 | ribosomal protein L18 | -0.0164382 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0163977 |
