Bendamustine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bendamustine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bendamustine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYOF myoferlin 0.0748668
CEMIP cell migration inducing protein, hyaluronan binding 0.0711546
NAMPT nicotinamide phosphoribosyltransferase 0.0683831
TRIO trio Rho guanine nucleotide exchange factor 0.0630474
OGA O-GlcNAcase 0.0590834
MYH9 myosin, heavy chain 9, non-muscle 0.052426
SULF1 sulfatase 1 0.0492595
BCL2L1 BCL2-like 1 0.0479446
ITGA6 integrin, alpha 6 0.0476392
KDM3A lysine (K)-specific demethylase 3A 0.0449155
NRG1 neuregulin 1 0.043048
FLNB filamin B, beta 0.0427974
MEF2A myocyte enhancer factor 2A 0.0425431
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0413324
PLEC plectin 0.0395766
RICTOR RPTOR independent companion of MTOR, complex 2 0.0384248
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0380657
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0374209
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0371762
ANLN anillin, actin binding protein 0.0367733
METTL15 methyltransferase like 15 0.036474
MYO10 myosin X 0.0355134
EZR ezrin 0.0349969
POTEF POTE ankyrin domain family, member F 0.0349595
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0346285
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0344322
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0339273
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0336863
PGK1 phosphoglycerate kinase 1 0.0335871
LNPEP leucyl/cystinyl aminopeptidase 0.0325216
CUL4B cullin 4B 0.0322149
KDM6A lysine (K)-specific demethylase 6A 0.0307122
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0295947
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0295569
TNRC6A trinucleotide repeat containing 6A 0.0294584
DIDO1 death inducer-obliterator 1 0.0291606
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0290268
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0288934
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0286935
ZNF292 zinc finger protein 292 0.0275495
SMAD3 SMAD family member 3 0.0267192
RBM39 RNA binding motif protein 39 0.0263084
ANKRD33B ankyrin repeat domain 33B 0.025904
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0257626
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.025639
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0251852
HELZ helicase with zinc finger 0.0250001
ARRDC3 arrestin domain containing 3 0.0249276
KDM7A lysine (K)-specific demethylase 7A 0.0246962
EHF ets homologous factor 0.024537
KRT6A keratin 6A, type II 0.0245207
NBAS neuroblastoma amplified sequence 0.0242527
SUCO SUN domain containing ossification factor 0.0241137
RIN2 Ras and Rab interactor 2 0.0239351
PRELID2 PRELI domain containing 2 0.0238083
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0237311
CTNND1 catenin (cadherin-associated protein), delta 1 0.0228588
FAR1 fatty acyl CoA reductase 1 0.0227806
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0227214
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0226519
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0223076
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0223063
BRWD3 bromodomain and WD repeat domain containing 3 0.0221928
KIAA1217 KIAA1217 0.0217686
XPO1 exportin 1 0.0216376
RLF rearranged L-myc fusion 0.0214749
YEATS2 YEATS domain containing 2 0.0214123
FOXO1 forkhead box O1 0.0213599
NEK7 NIMA-related kinase 7 0.0213362
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0208705
MARCHF6 membrane associated ring-CH-type finger 6 0.0207265
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.020681
ANXA11 annexin A11 0.0203815
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0203341
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0202827
CKAP5 cytoskeleton associated protein 5 0.0202736
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0201979
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0201147
MATR3 matrin 3 0.0199264
TPX2 TPX2, microtubule-associated 0.0196275
ESYT2 extended synaptotagmin-like protein 2 0.0194726
ANKH ANKH inorganic pyrophosphate transport regulator 0.0193212
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.0191759
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0191499
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0190061
LMAN1 lectin, mannose-binding, 1 0.0188568
NUP58 nucleoporin 58 0.0187046
CEP170 centrosomal protein 170kDa 0.0185404
USP3 ubiquitin specific peptidase 3 0.0184796
DOCK5 dedicator of cytokinesis 5 0.0183492
BMAL2 basic helix-loop-helix ARNT like 2 0.0182982
TM9SF2 transmembrane 9 superfamily member 2 0.0182681
CEP250 centrosomal protein 250kDa 0.0182119
CD47 CD47 molecule 0.0181252
TNIP1 TNFAIP3 interacting protein 1 0.018011
ECT2 epithelial cell transforming 2 0.017987
SPATS2 spermatogenesis associated, serine-rich 2 0.0179078
SLTM SAFB-like, transcription modulator 0.0178672
BIRC2 baculoviral IAP repeat containing 2 0.0178563
TMEM39A transmembrane protein 39A 0.0177012

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.325476
TIMP3 TIMP metallopeptidase inhibitor 3 -0.246394
PDLIM5 PDZ and LIM domain 5 -0.129124
TMSB10 thymosin beta 10 -0.113896
MT2A metallothionein 2A -0.102364
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0980086
LMO7 LIM domain 7 -0.0939484
PDE4D phosphodiesterase 4D, cAMP-specific -0.0931334
DPYD dihydropyrimidine dehydrogenase -0.0914191
B2M beta-2-microglobulin -0.0893869
TPT1 tumor protein, translationally-controlled 1 -0.087596
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0868961
INTS6 integrator complex subunit 6 -0.0866265
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0842523
SLC35F3 solute carrier family 35, member F3 -0.0799193
RPS6 ribosomal protein S6 -0.0757788
ALCAM activated leukocyte cell adhesion molecule -0.0720594
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0713561
PSD3 pleckstrin and Sec7 domain containing 3 -0.0706399
PALM2AKAP2 PALM2 and AKAP2 fusion -0.066782
RPS19 ribosomal protein S19 -0.0662102
RASAL2 RAS protein activator like 2 -0.0647934
RPS8 ribosomal protein S8 -0.0637429
RPLP2 ribosomal protein, large, P2 -0.0628213
RIGI RNA sensor RIG-I -0.0621632
PLS3 plastin 3 -0.0586638
HSPG2 heparan sulfate proteoglycan 2 -0.0580396
RABGAP1L RAB GTPase activating protein 1-like -0.0564412
RPLP1 ribosomal protein, large, P1 -0.0561123
PTMA prothymosin, alpha -0.0557818
NDRG1 N-myc downstream regulated 1 -0.0550499
HMGA2 high mobility group AT-hook 2 -0.0547363
RPS13 ribosomal protein S13 -0.0539274
HLA-B major histocompatibility complex, class I, B -0.0537228
PALLD palladin, cytoskeletal associated protein -0.0531101
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0529944
RPL35A ribosomal protein L35a -0.0526135
RPS3 ribosomal protein S3 -0.0516963
IFI6 interferon, alpha-inducible protein 6 -0.0515429
EGR1 early growth response 1 -0.0515132
EFNA5 ephrin-A5 -0.0509778
PODXL podocalyxin-like -0.0509132
RPL37 ribosomal protein L37 -0.0504546
IFITM3 interferon induced transmembrane protein 3 -0.0503593
SQSTM1 sequestosome 1 -0.0500465
RPS12 ribosomal protein S12 -0.0497366
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0478152
PRSS23 protease, serine, 23 -0.0462612
RPS21 ribosomal protein S21 -0.0461902
RPL37A ribosomal protein L37a -0.0453882
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0451238
IFITM1 interferon induced transmembrane protein 1 -0.0450308
RCOR1 REST corepressor 1 -0.044752
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0445821
ANO1 anoctamin 1, calcium activated chloride channel -0.0444573
RPL12 ribosomal protein L12 -0.0439658
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0439163
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0434961
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0430759
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0421721
GNAS GNAS complex locus -0.0416054
LDHA lactate dehydrogenase A -0.0415572
RPL30 ribosomal protein L30 -0.0413054
RAB7A RAB7A, member RAS oncogene family -0.0407119
SP100 SP100 nuclear antigen -0.0404112
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0402193
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0396412
RPL34 ribosomal protein L34 -0.039463
RPS16 ribosomal protein S16 -0.0391129
RPL11 ribosomal protein L11 -0.0391079
AKAP13 A kinase (PRKA) anchor protein 13 -0.0390432
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0388851
S100A9 S100 calcium binding protein A9 -0.0386334
PRRC2C proline-rich coiled-coil 2C -0.038263
RPS24 ribosomal protein S24 -0.0380696
FTL ferritin, light polypeptide -0.0378964
ABI3BP ABI family, member 3 (NESH) binding protein -0.0377558
BCAR3 breast cancer anti-estrogen resistance 3 -0.0375685
TMSB4X thymosin beta 4, X-linked -0.0369906
S100A11 S100 calcium binding protein A11 -0.0366137
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0365408
CDK6 cyclin-dependent kinase 6 -0.0355245
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0354335
JMJD1C jumonji domain containing 1C -0.0341853
EGFR epidermal growth factor receptor -0.0341611
CLIC4 chloride intracellular channel 4 -0.0334367
RPL31 ribosomal protein L31 -0.0323145
AGO2 argonaute RISC catalytic component 2 -0.0321782
HDAC9 histone deacetylase 9 -0.0320088
WARS1 tryptophanyl-tRNA synthetase 1 -0.0318587
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0318405
KLF5 Kruppel-like factor 5 (intestinal) -0.0316677
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0315814
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0314237
S100A10 S100 calcium binding protein A10 -0.0313987
SULF2 sulfatase 2 -0.0309838
IFI27 interferon, alpha-inducible protein 27 -0.0309028
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0308197
RPS27 ribosomal protein S27 -0.0307944
RPL23 ribosomal protein L23 -0.0307331