Bendamustine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bendamustine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Bendamustine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.168557
AKAP12 A kinase (PRKA) anchor protein 12 0.0736299
ERRFI1 ERBB receptor feedback inhibitor 1 0.0688697
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0602362
POTEF POTE ankyrin domain family, member F 0.058044
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0562937
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0554463
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.054804
KRT18 keratin 18, type I 0.0524187
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0498616
CSDE1 cold shock domain containing E1, RNA-binding 0.0487334
TPX2 TPX2, microtubule-associated 0.0451196
CHD4 chromodomain helicase DNA binding protein 4 0.0439535
MYH9 myosin, heavy chain 9, non-muscle 0.0435123
ENO1 enolase 1, (alpha) 0.041129
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0396162
CENPF centromere protein F, 350/400kDa 0.039247
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0374348
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0374177
SFTPA2 surfactant protein A2 0.0367879
HSPA8 heat shock 70kDa protein 8 0.036391
SERINC1 serine incorporator 1 0.0349808
PCBP2 poly(rC) binding protein 2 0.0340409
KDM3A lysine (K)-specific demethylase 3A 0.0337947
PGK1 phosphoglycerate kinase 1 0.0336448
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0335781
MACF1 microtubule-actin crosslinking factor 1 0.0334547
ICAM1 intercellular adhesion molecule 1 0.0320088
PRELID2 PRELI domain containing 2 0.031872
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0315244
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0310339
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0305457
SPTBN1 spectrin, beta, non-erythrocytic 1 0.030141
BZW1 basic leucine zipper and W2 domains 1 0.0297844
CTTN cortactin 0.028858
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0287053
KIF5B kinesin family member 5B 0.0276647
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0271295
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0270482
HDGF hepatoma-derived growth factor 0.026902
MKI67 marker of proliferation Ki-67 0.026475
SET SET nuclear proto-oncogene 0.0262185
TOP2B topoisomerase (DNA) II beta 180kDa 0.0257464
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0255365
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0248138
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0246983
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0244908
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0238873
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0231554
PHF20 PHD finger protein 20 0.0230456
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.02269
ECT2 epithelial cell transforming 2 0.0222799
RPS7 ribosomal protein S7 0.0216875
CKAP5 cytoskeleton associated protein 5 0.0216544
FNDC3B fibronectin type III domain containing 3B 0.0216408
LDHA lactate dehydrogenase A 0.0216084
RYR3 ryanodine receptor 3 0.0213271
EFR3A EFR3 homolog A (S. cerevisiae) 0.0211767
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0210175
RPL3 ribosomal protein L3 0.0205915
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0200694
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0198551
KRT8 keratin 8, type II 0.0198022
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0197507
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0197315
TARDBP TAR DNA binding protein 0.0195185
TPM3 tropomyosin 3 0.0195079
RAB14 RAB14, member RAS oncogene family 0.0193688
PYGL phosphorylase, glycogen, liver 0.0188536
ITSN1 intersectin 1 (SH3 domain protein) 0.0185012
KIF23 kinesin family member 23 0.0181423
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0181305
ZYX zyxin 0.01807
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0179229
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.0178663
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 0.0177328
MKRN1 makorin ring finger protein 1 0.0177141
FMN1 formin 1 0.0176506
KIF18A kinesin family member 18A 0.0175921
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0175465
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0174958
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0174391
PTK2 protein tyrosine kinase 2 0.0173717
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.017331
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.01716
ZBTB1 zinc finger and BTB domain containing 1 0.0171553
NCAPH non-SMC condensin I complex, subunit H 0.0171441
SERBP1 SERPINE1 mRNA binding protein 1 0.0171092
SERINC3 serine incorporator 3 0.0171014
UBA2 ubiquitin-like modifier activating enzyme 2 0.016931
RRM2 ribonucleotide reductase M2 0.0167886
DSPP dentin sialophosphoprotein 0.0167778
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.0167535
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0166783
EML4 echinoderm microtubule associated protein like 4 0.0165635
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0165166
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0164987
CXADR coxsackie virus and adenovirus receptor 0.0164651
PFKP phosphofructokinase, platelet 0.0164419
AURKA aurora kinase A 0.0164348

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.263974
EGR1 early growth response 1 -0.137006
TMSB10 thymosin beta 10 -0.133089
TFPI2 tissue factor pathway inhibitor 2 -0.0980573
YBX3 Y box binding protein 3 -0.0798983
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0691045
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0621633
EEF2 eukaryotic translation elongation factor 2 -0.0584763
RPS8 ribosomal protein S8 -0.0561915
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0548582
RAD51B RAD51 paralog B -0.0521607
RPL35A ribosomal protein L35a -0.0510199
TMEM165 transmembrane protein 165 -0.0510041
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0499571
PFN1 profilin 1 -0.0491022
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0467489
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0453877
RAB7A RAB7A, member RAS oncogene family -0.0443046
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0434711
CCNL1 cyclin L1 -0.0432431
RBM25 RNA binding motif protein 25 -0.0425871
PDE4D phosphodiesterase 4D, cAMP-specific -0.0423373
COG5 component of oligomeric golgi complex 5 -0.0422311
KTN1 kinectin 1 (kinesin receptor) -0.0396166
RPL34 ribosomal protein L34 -0.039149
NABP1 nucleic acid binding protein 1 -0.0390974
SMC4 structural maintenance of chromosomes 4 -0.0384891
RPS19 ribosomal protein S19 -0.0383534
RPLP2 ribosomal protein, large, P2 -0.0379578
ANKRD11 ankyrin repeat domain 11 -0.0376905
NIPBL Nipped-B homolog (Drosophila) -0.0375163
RPLP1 ribosomal protein, large, P1 -0.037267
WNK1 WNK lysine deficient protein kinase 1 -0.0370448
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0370441
SLC38A2 solute carrier family 38, member 2 -0.0367024
PRKCE protein kinase C, epsilon -0.0362797
AKAP9 A kinase (PRKA) anchor protein 9 -0.0359956
WASF2 WAS protein family, member 2 -0.0356986
VMP1 vacuole membrane protein 1 -0.0355003
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0354796
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0349251
BRD2 bromodomain containing 2 -0.0349
RPS21 ribosomal protein S21 -0.0348903
JMJD1C jumonji domain containing 1C -0.0345209
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0340814
TAS2R14 taste receptor, type 2, member 14 -0.0331058
CAMKMT calmodulin-lysine N-methyltransferase -0.0330859
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0325637
MT2A metallothionein 2A -0.0317082
RTN4 reticulon 4 -0.0315991
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0314621
SBF2 SET binding factor 2 -0.0307763
CSNK1A1 casein kinase 1, alpha 1 -0.0306995
FHL2 four and a half LIM domains 2 -0.030416
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0303641
RPL37A ribosomal protein L37a -0.0302359
RPS6 ribosomal protein S6 -0.0300581
MON2 MON2 homolog (S. cerevisiae) -0.0300433
PIBF1 progesterone immunomodulatory binding factor 1 -0.0296865
HLA-B major histocompatibility complex, class I, B -0.0295302
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0293606
ELL2 elongation factor, RNA polymerase II, 2 -0.0291008
TSC22D2 TSC22 domain family, member 2 -0.0290329
RPL37 ribosomal protein L37 -0.0289667
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0286461
OSMR oncostatin M receptor -0.0285481
PCLO piccolo presynaptic cytomatrix protein -0.0284526
EIF1 eukaryotic translation initiation factor 1 -0.0282527
BPTF bromodomain PHD finger transcription factor -0.0282498
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0282351
ATXN2 ataxin 2 -0.0281553
WDR70 WD repeat domain 70 -0.0281387
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0280411
KMT2D lysine (K)-specific methyltransferase 2D -0.0280402
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0279916
TPM2 tropomyosin 2 (beta) -0.0277187
EIF5B eukaryotic translation initiation factor 5B -0.0277137
FAF1 Fas (TNFRSF6) associated factor 1 -0.027298
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0272099
RPS10 ribosomal protein S10 -0.0270964
RPS3 ribosomal protein S3 -0.026811
HMGA1 high mobility group AT-hook 1 -0.0267734
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0265985
TUT4 terminal uridylyl transferase 4 -0.0264495
BSG basigin (Ok blood group) -0.0264044
ATP11A ATPase, class VI, type 11A -0.0264025
RPL9 ribosomal protein L9 -0.0262553
RPL26 ribosomal protein L26 -0.0262426
GPHN gephyrin -0.0261841
BRD4 bromodomain containing 4 -0.0260898
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0260855
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0259579
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0259326
USP36 ubiquitin specific peptidase 36 -0.0257397
RPL13A ribosomal protein L13a -0.0255255
RPL5 ribosomal protein L5 -0.0254822
PER1 period circadian clock 1 -0.025004
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.02488
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0248115
IFI6 interferon, alpha-inducible protein 6 -0.0248