Bendamustine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bendamustine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

165 genes differentially expressed following the Bendamustine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.167567
NDRG1 N-myc downstream regulated 1 0.145552
DTNA dystrobrevin, alpha 0.145412
NAP1L1 nucleosome assembly protein 1-like 1 0.142529
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.138488
LDHA lactate dehydrogenase A 0.129978
VIM vimentin 0.116401
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.113838
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.110132
TJP1 tight junction protein 1 0.109298
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.107317
OGA O-GlcNAcase 0.103349
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0975044
MXI1 MAX interactor 1, dimerization protein 0.0968722
CANX calnexin 0.0957478
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0937349
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0915579
RBMS3 RNA binding motif, single stranded interacting protein 3 0.083301
ELL2 elongation factor, RNA polymerase II, 2 0.082668
PKM pyruvate kinase, muscle 0.0820475
HELZ helicase with zinc finger 0.0796106
MINDY2 MINDY lysine 48 deubiquitinase 2 0.079495
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0794739
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0785083
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0768055
GARS1 glycyl-tRNA synthetase 1 0.0758278
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0746588
PCM1 pericentriolar material 1 0.0730938
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0723052
RPLP2 ribosomal protein, large, P2 0.0713185
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0710892
SPAG9 sperm associated antigen 9 0.0707052
PGK1 phosphoglycerate kinase 1 0.0704584
MBNL1 muscleblind-like splicing regulator 1 0.069779
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0685355
MEF2A myocyte enhancer factor 2A 0.0678513
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.064897
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0644191
EXT1 exostosin glycosyltransferase 1 0.0636
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0582725
EFNA5 ephrin-A5 0.0579283
IGFBP3 insulin-like growth factor binding protein 3 0.0550042
PTMA prothymosin, alpha 0.054627
EIF1 eukaryotic translation initiation factor 1 0.0534085
CTBP2 C-terminal binding protein 2 0.0516712
BRWD1 bromodomain and WD repeat domain containing 1 0.0507434
NAMPT nicotinamide phosphoribosyltransferase 0.0490366
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0479985
GOLGA4 golgin A4 0.0473767
PUM1 pumilio RNA-binding family member 1 0.0468404
LOC112694756 uncharaterized LOC112694756 0.0460348
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0458097
PPME1 protein phosphatase methylesterase 1 0.0450427
UBE3A ubiquitin protein ligase E3A 0.0444539
NCKAP1 NCK-associated protein 1 0.0440717
ZMYM2 zinc finger, MYM-type 2 0.0432511
LSAMP limbic system-associated membrane protein 0.0430278
STC1 stanniocalcin 1 0.0391904
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0373011
ESYT2 extended synaptotagmin-like protein 2 0.0360521
TMSB10 thymosin beta 10 0.0330489
ZFAND3 zinc finger, AN1-type domain 3 0.0321776
EEF2 eukaryotic translation elongation factor 2 0.0308517
ANKRD17 ankyrin repeat domain 17 0.0272586
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0194591
FLNB filamin B, beta 0.0189773
SCAF11 SR-related CTD-associated factor 11 0.0178116
CCNI cyclin I 0.0178027
PTK2 protein tyrosine kinase 2 0.0172227
KMT2C lysine (K)-specific methyltransferase 2C 0.0159468
MED13 mediator complex subunit 13 0.0150388
RPS8 ribosomal protein S8 0.0148962
NALF1 NALCN channel auxiliary factor 1 0.0147682
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0146108
FNDC3A fibronectin type III domain containing 3A 0.0140139
RUNX1 runt-related transcription factor 1 0.0138363
RPL23 ribosomal protein L23 0.0123149
RPL12 ribosomal protein L12 0.0119791
VCL vinculin 0.0117598
TXNRD1 thioredoxin reductase 1 0.0107782
KMT2E lysine (K)-specific methyltransferase 2E 0.00994723
BIRC6 baculoviral IAP repeat containing 6 0.00859965
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00702954
TRIO trio Rho guanine nucleotide exchange factor 0.00647147
RPS12 ribosomal protein S12 0.00643663
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.00503834
FAM13A family with sequence similarity 13, member A 0.00451777
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00400492
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00315007
FTH1 ferritin, heavy polypeptide 1 0.00273065
PABPC1 poly(A) binding protein, cytoplasmic 1 4.46329E-4

decreased expression

Symbol Name Standardized Value
DSCAM Down syndrome cell adhesion molecule -0.176968
PDE10A phosphodiesterase 10A -0.17138
SLTM SAFB-like, transcription modulator -0.163424
EGFR epidermal growth factor receptor -0.159468
MYO1E myosin IE -0.147005
TBC1D22A TBC1 domain family, member 22A -0.143834
MCL1 myeloid cell leukemia 1 -0.127876
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.123296
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.117181
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.116469
FN1 fibronectin 1 -0.113491
THSD4 thrombospondin, type I, domain containing 4 -0.106649
AKAP12 A kinase (PRKA) anchor protein 12 -0.105829
MACF1 microtubule-actin crosslinking factor 1 -0.102801
PRKCA protein kinase C, alpha -0.101151
FNDC3B fibronectin type III domain containing 3B -0.0991646
LPP LIM domain containing preferred translocation partner in lipoma -0.0879669
TTC3 tetratricopeptide repeat domain 3 -0.08652
RAD51B RAD51 paralog B -0.0856622
ITGA6 integrin, alpha 6 -0.0835555
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0752868
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0733279
ERBIN erbb2 interacting protein -0.0711234
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0697516
BBX bobby sox homolog (Drosophila) -0.0663077
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0651616
ANXA2 annexin A2 -0.063444
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0631925
RPS6 ribosomal protein S6 -0.0631557
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0629015
JMJD1C jumonji domain containing 1C -0.0624883
MYO10 myosin X -0.0574687
ENO1 enolase 1, (alpha) -0.053553
ZNF292 zinc finger protein 292 -0.053499
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0532049
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0528776
RPLP1 ribosomal protein, large, P1 -0.0520602
GPC6 glypican 6 -0.0496009
MT2A metallothionein 2A -0.0490242
LMO7 LIM domain 7 -0.0479714
TRA2A transformer 2 alpha homolog (Drosophila) -0.0473262
B2M beta-2-microglobulin -0.0472818
PRRC2C proline-rich coiled-coil 2C -0.0458846
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0401789
MYOF myoferlin -0.0399743
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0395908
ANKRD12 ankyrin repeat domain 12 -0.0384793
TPT1 tumor protein, translationally-controlled 1 -0.0353404
ASPH aspartate beta-hydroxylase -0.032602
AKAP9 A kinase (PRKA) anchor protein 9 -0.0310966
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0304566
PARD3 par-3 family cell polarity regulator -0.0294935
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0292499
RAB7A RAB7A, member RAS oncogene family -0.0276656
DST dystonin -0.0272716
INHBA inhibin, beta A -0.0261359
SBF2 SET binding factor 2 -0.025211
RAD21 RAD21 homolog (S. pombe) -0.0226104
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0218934
SRPK2 SRSF protein kinase 2 -0.0210176
POTEF POTE ankyrin domain family, member F -0.0196959
RNF145 ring finger protein 145 -0.0172608
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0168031
SLC38A1 solute carrier family 38, member 1 -0.0167636
WSB1 WD repeat and SOCS box containing 1 -0.015951
PDE4D phosphodiesterase 4D, cAMP-specific -0.0138458
KTN1 kinectin 1 (kinesin receptor) -0.0110008
SEC31A SEC31 homolog A (S. cerevisiae) -0.00996783
WAC WW domain containing adaptor with coiled-coil -0.00880096
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.00847392
ANKRD11 ankyrin repeat domain 11 -0.00708855
RICTOR RPTOR independent companion of MTOR, complex 2 -0.00377949
CXCL8 chemokine (C-X-C motif) ligand 8 -0.00260419
CD44 CD44 molecule (Indian blood group) -7.50139E-4