Bendamustine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bendamustine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bendamustine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.068465
CXCL8 chemokine (C-X-C motif) ligand 8 0.0548708
FTH1 ferritin, heavy polypeptide 1 0.0529818
TRIO trio Rho guanine nucleotide exchange factor 0.051244
PARD3 par-3 family cell polarity regulator 0.0511174
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0504728
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0412998
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0398241
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0375901
ZNF395 zinc finger protein 395 0.037107
RSF1 remodeling and spacing factor 1 0.0353938
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0353176
PBX3 pre-B-cell leukemia homeobox 3 0.0329558
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0325007
IL6 interleukin 6 0.0318767
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0312292
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0307775
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0301524
CARD16 caspase recruitment domain family, member 16 0.0294156
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0292598
PRRC2C proline-rich coiled-coil 2C 0.0288199
RAB7A RAB7A, member RAS oncogene family 0.0281878
ZNF638 zinc finger protein 638 0.0277964
NCOR2 nuclear receptor corepressor 2 0.0275232
DLG1 discs, large homolog 1 (Drosophila) 0.0273587
DSCAM Down syndrome cell adhesion molecule 0.0273149
TPM3 tropomyosin 3 0.0272433
SNX13 sorting nexin 13 0.0270129
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0269417
RPS12 ribosomal protein S12 0.0265163
EEF2 eukaryotic translation elongation factor 2 0.0264475
FLNB filamin B, beta 0.0263441
UBA6 ubiquitin-like modifier activating enzyme 6 0.0261005
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0259915
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0258211
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0257914
RPS17 ribosomal protein S17 0.0255498
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0254289
ZMIZ1 zinc finger, MIZ-type containing 1 0.025332
CCDC14 coiled-coil domain containing 14 0.0250949
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0249745
S100A6 S100 calcium binding protein A6 0.0247717
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0244436
VEGFA vascular endothelial growth factor A 0.0241196
SRRM2 serine/arginine repetitive matrix 2 0.0240654
METTL15 methyltransferase like 15 0.0238985
FXR1 fragile X mental retardation, autosomal homolog 1 0.0234889
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0234684
CABIN1 calcineurin binding protein 1 0.0232753
SEC23A Sec23 homolog A (S. cerevisiae) 0.0230155
PRELID2 PRELI domain containing 2 0.0229702
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0229423
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0227727
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0227143
JMJD1C jumonji domain containing 1C 0.0227089
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0226975
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0225064
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0223503
NRG1 neuregulin 1 0.0223049
USP33 ubiquitin specific peptidase 33 0.0222815
ZFAND3 zinc finger, AN1-type domain 3 0.0222076
DOCK5 dedicator of cytokinesis 5 0.0219107
FOSL1 FOS-like antigen 1 0.0218535
CTSA cathepsin A 0.0218158
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0216486
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0216083
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0215973
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 0.0215223
COPS8 COP9 signalosome subunit 8 0.0214851
ATP11A ATPase, class VI, type 11A 0.021466
EEF1G eukaryotic translation elongation factor 1 gamma 0.0213231
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0213055
YAP1 Yes-associated protein 1 0.0212633
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0210221
AKAP12 A kinase (PRKA) anchor protein 12 0.020826
CCNL1 cyclin L1 0.0207647
ABI2 abl-interactor 2 0.0207536
RAB18 RAB18, member RAS oncogene family 0.0205428
EPS8 epidermal growth factor receptor pathway substrate 8 0.0203982
MCFD2 multiple coagulation factor deficiency 2 0.0203924
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0203268
GOLGA2 golgin A2 0.0203038
DSPP dentin sialophosphoprotein 0.0202813
CCNC cyclin C 0.0202388
PDE4D phosphodiesterase 4D, cAMP-specific 0.0201835
RBM25 RNA binding motif protein 25 0.0201796
COPA coatomer protein complex, subunit alpha 0.0201439
TLN1 talin 1 0.0201405
KMT2C lysine (K)-specific methyltransferase 2C 0.0199552
RPS6 ribosomal protein S6 0.0198209
NAV2 neuron navigator 2 0.0197888
RNF169 ring finger protein 169 0.0197798
RPLP0 ribosomal protein, large, P0 0.0197634
RIOK2 RIO kinase 2 0.0196471
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0196195
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0195539
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0195041
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0194692
RIOK3 RIO kinase 3 0.0193391
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0193205

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.326466
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.200136
TGFBI transforming growth factor, beta-induced, 68kDa -0.173008
VIM vimentin -0.130192
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.125365
HLA-B major histocompatibility complex, class I, B -0.119914
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.117461
FN1 fibronectin 1 -0.108204
COL6A3 collagen, type VI, alpha 3 -0.0971898
B2M beta-2-microglobulin -0.0966191
TMSB10 thymosin beta 10 -0.0944626
COL1A2 collagen, type I, alpha 2 -0.0904528
HLA-C major histocompatibility complex, class I, C -0.086887
COL1A1 collagen, type I, alpha 1 -0.0829572
CALU calumenin -0.0815248
COL6A2 collagen, type VI, alpha 2 -0.0795313
LOXL2 lysyl oxidase-like 2 -0.0716977
CAVIN1 caveolae associated protein 1 -0.0705738
MT2A metallothionein 2A -0.0693708
SDC4 syndecan 4 -0.0676598
CD44 CD44 molecule (Indian blood group) -0.066624
PTMA prothymosin, alpha -0.0644953
HLA-A major histocompatibility complex, class I, A -0.0643258
AHNAK AHNAK nucleoprotein -0.0620577
TPT1 tumor protein, translationally-controlled 1 -0.0596685
PSD3 pleckstrin and Sec7 domain containing 3 -0.0586338
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0583316
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0576381
CANX calnexin -0.0567579
STC1 stanniocalcin 1 -0.0534487
NAMPT nicotinamide phosphoribosyltransferase -0.0534441
LOX lysyl oxidase -0.0533711
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0516707
RRBP1 ribosome binding protein 1 -0.0511397
OGA O-GlcNAcase -0.0475582
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0462135
SEC24D SEC24 family member D -0.0461034
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0456078
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0452967
S100A10 S100 calcium binding protein A10 -0.0450398
LMAN1 lectin, mannose-binding, 1 -0.0439018
F3 coagulation factor III (thromboplastin, tissue factor) -0.0433135
DPYD dihydropyrimidine dehydrogenase -0.0431915
ENO1 enolase 1, (alpha) -0.0424864
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0413458
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.041166
FAM20C family with sequence similarity 20, member C -0.0408388
MYOF myoferlin -0.0402252
IGFBP7 insulin-like growth factor binding protein 7 -0.0401539
PRSS23 protease, serine, 23 -0.0401407
COL6A1 collagen, type VI, alpha 1 -0.0400474
TM4SF1 transmembrane 4 L six family member 1 -0.0399585
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0399471
SEPTIN7 septin 7 -0.0387909
FUS FUS RNA binding protein -0.0387382
ELL2 elongation factor, RNA polymerase II, 2 -0.0386242
EMP1 epithelial membrane protein 1 -0.0386122
LDHA lactate dehydrogenase A -0.0381864
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0375131
SOD2 superoxide dismutase 2, mitochondrial -0.0374805
GLG1 golgi glycoprotein 1 -0.0373146
VDAC1 voltage-dependent anion channel 1 -0.0371164
TENT5A terminal nucleotidyltransferase 5A -0.0368206
COL5A1 collagen, type V, alpha 1 -0.0363503
RPS23 ribosomal protein S23 -0.0353599
MAP1B microtubule-associated protein 1B -0.035205
FKBP10 FK506 binding protein 10, 65 kDa -0.0350416
LOC112694756 uncharaterized LOC112694756 -0.0348133
RPL34 ribosomal protein L34 -0.0342429
SAR1A secretion associated, Ras related GTPase 1A -0.034174
MORF4L2 mortality factor 4 like 2 -0.0333546
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0331675
GNAS GNAS complex locus -0.0329023
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0328393
HDLBP high density lipoprotein binding protein -0.0327208
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.032516
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0318168
EIF1 eukaryotic translation initiation factor 1 -0.0317903
MACF1 microtubule-actin crosslinking factor 1 -0.0316304
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0311548
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0310098
MARCHF6 membrane associated ring-CH-type finger 6 -0.0308832
FTL ferritin, light polypeptide -0.030868
TMEM263 transmembrane protein 263 -0.0306754
RPL28 ribosomal protein L28 -0.0303864
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0302985
RTN4 reticulon 4 -0.030234
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0301526
COL7A1 collagen, type VII, alpha 1 -0.0299437
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0297741
AUTS2 autism susceptibility candidate 2 -0.0297044
MBD5 methyl-CpG binding domain protein 5 -0.0296112
THY1 Thy-1 cell surface antigen -0.0295937
STK17A serine/threonine kinase 17a -0.0295874
EXT1 exostosin glycosyltransferase 1 -0.0295237
CDH13 cadherin 13 -0.0294492
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.029196
RAB10 RAB10, member RAS oncogene family -0.0290601
EGFR epidermal growth factor receptor -0.0288168
RHOA ras homolog family member A -0.0286427