Bendamustine_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bendamustine perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bendamustine_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.100719
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0742587
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0729907
PTMA prothymosin, alpha 0.0728286
WAC WW domain containing adaptor with coiled-coil 0.0700779
POTEF POTE ankyrin domain family, member F 0.067555
MACF1 microtubule-actin crosslinking factor 1 0.0643595
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0605809
KIF5B kinesin family member 5B 0.0602715
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0586589
TNIP1 TNFAIP3 interacting protein 1 0.0534931
VIM vimentin 0.0507013
RPS8 ribosomal protein S8 0.0477585
FTH1 ferritin, heavy polypeptide 1 0.0445887
CENPF centromere protein F, 350/400kDa 0.0440821
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0434396
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0425693
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0417553
INSIG1 insulin induced gene 1 0.0412015
RPS6 ribosomal protein S6 0.0410919
NCKAP1 NCK-associated protein 1 0.0404025
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0401215
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.039929
CXCL8 chemokine (C-X-C motif) ligand 8 0.039739
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0396829
ANXA2 annexin A2 0.0393956
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0388851
NAMPT nicotinamide phosphoribosyltransferase 0.0387471
PKM pyruvate kinase, muscle 0.0376192
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0364113
QKI QKI, KH domain containing, RNA binding 0.0359881
APOLD1 apolipoprotein L domain containing 1 0.0354213
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0350724
SPAG9 sperm associated antigen 9 0.0345808
NUP58 nucleoporin 58 0.0341637
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0340382
CARD16 caspase recruitment domain family, member 16 0.0337463
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0334793
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0334376
FXR1 fragile X mental retardation, autosomal homolog 1 0.0328103
FN1 fibronectin 1 0.0327027
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0325992
GARS1 glycyl-tRNA synthetase 1 0.0323814
DIAPH3 diaphanous-related formin 3 0.0323358
ATP5F1E ATP synthase F1 subunit epsilon 0.0322894
FOXK2 forkhead box K2 0.0319023
TXNRD1 thioredoxin reductase 1 0.0317246
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.0314459
RLIM ring finger protein, LIM domain interacting 0.0314256
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0312903
DSCAM Down syndrome cell adhesion molecule 0.0312603
ESYT2 extended synaptotagmin-like protein 2 0.0312176
MBNL2 muscleblind-like splicing regulator 2 0.0310128
RAI1 retinoic acid induced 1 0.030899
ENO1 enolase 1, (alpha) 0.030186
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0301022
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0299658
CIB1 calcium and integrin binding 1 (calmyrin) 0.0299566
HSPA8 heat shock 70kDa protein 8 0.0295118
CALR calreticulin 0.0294092
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0292368
PITPNB phosphatidylinositol transfer protein, beta 0.0291197
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0287566
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.028734
RTN4 reticulon 4 0.0282729
SERINC3 serine incorporator 3 0.028207
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.028194
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.0279591
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0278489
ADAM10 ADAM metallopeptidase domain 10 0.0276096
RPS19 ribosomal protein S19 0.0272947
RAD23B RAD23 homolog B (S. cerevisiae) 0.0272619
MSN moesin 0.0272494
SMAP1 small ArfGAP 1 0.0270751
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0269664
FAR1 fatty acyl CoA reductase 1 0.0269157
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0266707
RIGI RNA sensor RIG-I 0.0265997
RPL3 ribosomal protein L3 0.0265955
GGNBP2 gametogenetin binding protein 2 0.0264449
LOC102724023 ES1 protein homolog, mitochondrial 0.0263788
GADD45B growth arrest and DNA-damage-inducible, beta 0.0263142
TRIM44 tripartite motif containing 44 0.0262631
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0262068
S100A9 S100 calcium binding protein A9 0.0261709
AKAP11 A kinase (PRKA) anchor protein 11 0.0261519
EXOC5 exocyst complex component 5 0.0260498
OXSR1 oxidative stress responsive 1 0.0259073
TPX2 TPX2, microtubule-associated 0.0257953
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0257174
PANX1 pannexin 1 0.0255754
RIOK3 RIO kinase 3 0.0255325
HILPDA hypoxia inducible lipid droplet-associated 0.025505
RPS3 ribosomal protein S3 0.0253801
RPL23 ribosomal protein L23 0.0253497
TCAF1 TRPM8 channel-associated factor 1 0.0253138
DNM1L dynamin 1-like 0.0252441
DTNA dystrobrevin, alpha 0.0251848
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.0250913
MED4 mediator complex subunit 4 0.0250144

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.131022
SMYD3 SET and MYND domain containing 3 -0.0882096
TAS2R14 taste receptor, type 2, member 14 -0.0713113
CD44 CD44 molecule (Indian blood group) -0.0670946
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0667882
RBM39 RNA binding motif protein 39 -0.0614742
SMAD3 SMAD family member 3 -0.0576569
AKAP13 A kinase (PRKA) anchor protein 13 -0.05683
MT2A metallothionein 2A -0.0537521
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0521594
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.052064
OSMR oncostatin M receptor -0.0516887
GPATCH8 G patch domain containing 8 -0.048285
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0462293
CANX calnexin -0.0451086
TM4SF1 transmembrane 4 L six family member 1 -0.0449481
NCEH1 neutral cholesterol ester hydrolase 1 -0.0446143
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0440469
MBD5 methyl-CpG binding domain protein 5 -0.0440333
IGFBP3 insulin-like growth factor binding protein 3 -0.0416665
AHNAK AHNAK nucleoprotein -0.0416526
ATM ATM serine/threonine kinase -0.0414248
HMGA2 high mobility group AT-hook 2 -0.0409461
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0404405
EFNA5 ephrin-A5 -0.0402191
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0400079
KMT2E lysine (K)-specific methyltransferase 2E -0.0399256
THSD4 thrombospondin, type I, domain containing 4 -0.0396673
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0394129
ZC3H13 zinc finger CCCH-type containing 13 -0.0389172
APLP2 amyloid beta (A4) precursor-like protein 2 -0.037629
GPATCH2L G patch domain containing 2-like -0.0374257
FAF2 Fas associated factor family member 2 -0.0367762
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -0.0367668
DPYD dihydropyrimidine dehydrogenase -0.0365569
DST dystonin -0.0365458
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0365267
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0362956
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0361874
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0361277
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0358046
IL1RAP interleukin 1 receptor accessory protein -0.0353209
COMMD10 COMM domain containing 10 -0.035313
RPL4 ribosomal protein L4 -0.0349922
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.034702
EGR1 early growth response 1 -0.0346823
PCNX4 pecanex 4 -0.0346296
PDE8A phosphodiesterase 8A -0.03449
CEP290 centrosomal protein 290kDa -0.0344665
CFDP1 craniofacial development protein 1 -0.0335442
FNIP1 folliculin interacting protein 1 -0.033358
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0327803
ATRN attractin -0.0322575
PRH1 proline-rich protein HaeIII subfamily 1 -0.0321562
AKAP8L A kinase (PRKA) anchor protein 8-like -0.0320685
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0318806
ARB2A ARB2 cotranscriptional regulator A -0.0317235
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0316742
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0316125
GPC6 glypican 6 -0.0314055
TNRC18 trinucleotide repeat containing 18 -0.0307905
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0304543
PRPF8 pre-mRNA processing factor 8 -0.030187
FUS FUS RNA binding protein -0.0301666
PDE10A phosphodiesterase 10A -0.030151
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0299503
TLK1 tousled-like kinase 1 -0.0299481
CIRSR corepressor of RBPJ and splicing regulator -0.0297547
SEPTIN9 septin 9 -0.0296709
PHF14 PHD finger protein 14 -0.0296042
ZC3H6 zinc finger CCCH-type containing 6 -0.0295776
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.029483
LOC112694756 uncharaterized LOC112694756 -0.0294611
IARS1 isoleucyl-tRNA synthetase 1 -0.0292569
ZC3H11A zinc finger CCCH-type containing 11A -0.0291217
NUP214 nucleoporin 214kDa -0.029114
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0289574
RPL37A ribosomal protein L37a -0.0287566
RNF169 ring finger protein 169 -0.0286551
VCL vinculin -0.0285402
ADIPOR2 adiponectin receptor 2 -0.0283041
HELZ helicase with zinc finger -0.0282934
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0282312
GCC2 GRIP and coiled-coil domain containing 2 -0.0281883
ZBTB20 zinc finger and BTB domain containing 20 -0.0281835
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0280404
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0279236
RRBP1 ribosome binding protein 1 -0.0277838
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0277774
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0274716
CLASP2 cytoplasmic linker associated protein 2 -0.0274588
BTG1 B-cell translocation gene 1, anti-proliferative -0.0274291
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0274251
EPAS1 endothelial PAS domain protein 1 -0.0273303
PIBF1 progesterone immunomodulatory binding factor 1 -0.0272697
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0272429
JMJD1C jumonji domain containing 1C -0.0272401
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.027187
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0269971
CUL3 cullin 3 -0.0268749