Benproperine (phosphate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NEK7 NIMA-related kinase 7 0.0242995
ERRFI1 ERBB receptor feedback inhibitor 1 0.0234889
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0232154
CELF2 CUGBP, Elav-like family member 2 0.0229195
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0226754
ADGRG6 adhesion G protein-coupled receptor G6 0.0192299
TENM3 teneurin transmembrane protein 3 0.0158504
GASK1B golgi associated kinase 1B 0.0150551
ETNK1 ethanolamine kinase 1 0.0149287
BIRC2 baculoviral IAP repeat containing 2 0.0140236
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0135834
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0129559
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0123302
THOC1 THO complex 1 0.0117528
CLDN1 claudin 1 0.0114317
OXR1 oxidation resistance 1 0.0113403
CXADR coxsackie virus and adenovirus receptor 0.0109157
ECT2 epithelial cell transforming 2 0.0104354
PTBP3 polypyrimidine tract binding protein 3 0.0101143
PDGFC platelet derived growth factor C 0.00994417
NCKAP1 NCK-associated protein 1 0.00970917
CEP95 centrosomal protein 95kDa 0.00963063
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0096148
WDR43 WD repeat domain 43 0.00915489
ZNF217 zinc finger protein 217 0.00908967
NUP153 nucleoporin 153kDa 0.00906714
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.00860576
USP24 ubiquitin specific peptidase 24 0.00823245
LMO7 LIM domain 7 0.00818909
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.00792159
TIGAR TP53 induced glycolysis regulatory phosphatase 0.00781316
BIRC3 baculoviral IAP repeat containing 3 0.00771512
ZNF519 zinc finger protein 519 0.00771171
SP3 Sp3 transcription factor 0.00754176
CDK17 cyclin-dependent kinase 17 0.00753993
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00749336
FAR1 fatty acyl CoA reductase 1 0.00740646
GMDS GDP-mannose 4,6-dehydratase 0.00740022
RNF145 ring finger protein 145 0.00736508
QKI QKI, KH domain containing, RNA binding 0.00733282
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.00719041
IL6ST interleukin 6 signal transducer 0.00687314
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.00686382
AHCTF1 AT hook containing transcription factor 1 0.00678826
MED21 mediator complex subunit 21 0.00673666
AHR aryl hydrocarbon receptor 0.00661542
EDN1 endothelin 1 0.00660081
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.00653933
HEATR1 HEAT repeat containing 1 0.00649934
TMEM167A transmembrane protein 167A 0.00645037
CARD16 caspase recruitment domain family, member 16 0.00643291
FBXL4 F-box and leucine-rich repeat protein 4 0.00635752
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0063422
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.00633249
RICTOR RPTOR independent companion of MTOR, complex 2 0.00626341
PARD6B par-6 family cell polarity regulator beta 0.00624857
XPO1 exportin 1 0.00622029
LRRC8C leucine rich repeat containing 8 family, member C 0.00617012
SERINC1 serine incorporator 1 0.00612725
BRWD3 bromodomain and WD repeat domain containing 3 0.00611222
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.00610273
ARL5B ADP-ribosylation factor-like 5B 0.00600768
MAPK8 mitogen-activated protein kinase 8 0.00599867
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.00598677
CAND1 cullin-associated and neddylation-dissociated 1 0.00596443
CD46 CD46 molecule, complement regulatory protein 0.00585602
KIF3A kinesin family member 3A 0.00585469
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 0.00583285
SOCS5 suppressor of cytokine signaling 5 0.00576576
VGLL4 vestigial-like family member 4 0.00567995
NAMPT nicotinamide phosphoribosyltransferase 0.00566577
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.00566118
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.00565156
ADAM17 ADAM metallopeptidase domain 17 0.00564464
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 0.00559355
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.00557386
PDE4B phosphodiesterase 4B, cAMP-specific 0.00556582
CDYL chromodomain protein, Y-like 0.00553086
UCK2 uridine-cytidine kinase 2 0.00542324
TNPO1 transportin 1 0.00535903
PAWR PRKC, apoptosis, WT1, regulator 0.00529257
SLC49A4 solute carrier family 49 member 4 0.00527801
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 0.00524046
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.00523941
MATR3 matrin 3 0.00520084
CHD7 chromodomain helicase DNA binding protein 7 0.00514883
DDHD1 DDHD domain containing 1 0.00510577
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.00510507
CASC3 cancer susceptibility candidate 3 0.0051043
CCNL1 cyclin L1 0.00510149
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0050839
PLK2 polo-like kinase 2 0.00507746
OCLN occludin 0.00506092
FAM76B family with sequence similarity 76, member B 0.00505608
SNX13 sorting nexin 13 0.00505217
IPO5 importin 5 0.00503068
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 0.00501223
GMPS guanine monphosphate synthase 0.00498285
RPS7 ribosomal protein S7 0.00496951
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.00496647

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.306039
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.207362
TMSB10 thymosin beta 10 -0.123492
AREG amphiregulin -0.120653
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.103439
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0864882
PTMA prothymosin, alpha -0.0788686
ACTG1 actin gamma 1 -0.0734962
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0728841
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.072638
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0713745
RPS27A ribosomal protein S27a -0.066667
FTL ferritin, light polypeptide -0.065562
RAB7A RAB7A, member RAS oncogene family -0.05858
MMP12 matrix metallopeptidase 12 -0.0508229
NAP1L1 nucleosome assembly protein 1-like 1 -0.0507678
UBC ubiquitin C -0.0502297
HMGA2 high mobility group AT-hook 2 -0.0498038
RPS8 ribosomal protein S8 -0.0472763
ANXA1 annexin A1 -0.0469675
EHBP1 EH domain binding protein 1 -0.0451423
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0419256
JMJD1C jumonji domain containing 1C -0.0414053
ANKRD12 ankyrin repeat domain 12 -0.0408993
EGR1 early growth response 1 -0.0408168
TPT1 tumor protein, translationally-controlled 1 -0.0392519
CALR calreticulin -0.0390703
USP34 ubiquitin specific peptidase 34 -0.0388835
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0387027
VMP1 vacuole membrane protein 1 -0.038237
ENO1 enolase 1, (alpha) -0.0379659
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0365206
EEF2 eukaryotic translation elongation factor 2 -0.0359778
RPS3 ribosomal protein S3 -0.0348141
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0340141
RPS12 ribosomal protein S12 -0.0334083
RPS6 ribosomal protein S6 -0.0321523
RPL19 ribosomal protein L19 -0.0313738
ASPH aspartate beta-hydroxylase -0.0311307
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0307459
RPL37A ribosomal protein L37a -0.030731
TUBA1B tubulin, alpha 1b -0.0305711
TPI1 triosephosphate isomerase 1 -0.0303635
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0296057
SMC4 structural maintenance of chromosomes 4 -0.029338
RPL23 ribosomal protein L23 -0.0292206
CANX calnexin -0.0290377
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0281242
AKAP12 A kinase (PRKA) anchor protein 12 -0.0278611
NHSL1 NHS-like 1 -0.0275455
MYL12B myosin, light chain 12B, regulatory -0.0273807
RPLP2 ribosomal protein, large, P2 -0.0272957
TPM4 tropomyosin 4 -0.0272648
AHNAK AHNAK nucleoprotein -0.0270111
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0269934
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0267536
TAS2R14 taste receptor, type 2, member 14 -0.0267403
S100A6 S100 calcium binding protein A6 -0.0266975
RPL35A ribosomal protein L35a -0.0266628
HSPB1 heat shock 27kDa protein 1 -0.0265422
RPS13 ribosomal protein S13 -0.0264006
SLC38A1 solute carrier family 38, member 1 -0.0261079
RPS29 ribosomal protein S29 -0.0260673
RPLP1 ribosomal protein, large, P1 -0.0259171
PFN1 profilin 1 -0.0258635
RPS19 ribosomal protein S19 -0.0257212
EIF1 eukaryotic translation initiation factor 1 -0.025713
BPTF bromodomain PHD finger transcription factor -0.0256086
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0256082
KPNB1 karyopherin (importin) beta 1 -0.0254589
MKI67 marker of proliferation Ki-67 -0.0246281
NLGN1 neuroligin 1 -0.0240994
RPL8 ribosomal protein L8 -0.0237744
ADIPOR2 adiponectin receptor 2 -0.0236285
ZNF638 zinc finger protein 638 -0.0232443
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0230709
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0228159
RRM2 ribonucleotide reductase M2 -0.0226006
GNAS GNAS complex locus -0.0224632
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0224149
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0221604
RPS23 ribosomal protein S23 -0.0221465
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0221172
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0220753
PDIA3 protein disulfide isomerase family A, member 3 -0.0220318
YAP1 Yes-associated protein 1 -0.0219483
RPL31 ribosomal protein L31 -0.0218339
PDIA6 protein disulfide isomerase family A, member 6 -0.0217667
RPL12 ribosomal protein L12 -0.0215998
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0214923
LOC102724023 ES1 protein homolog, mitochondrial -0.0214785
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0214442
TPM3 tropomyosin 3 -0.0214001
CSNK1A1 casein kinase 1, alpha 1 -0.0213848
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0213412
MACF1 microtubule-actin crosslinking factor 1 -0.020974
ANKRD17 ankyrin repeat domain 17 -0.0209324
DDIT3 DNA-damage-inducible transcript 3 -0.0209323
CUX1 cut-like homeobox 1 -0.0209242
PCBP2 poly(rC) binding protein 2 -0.0207481