Benproperine (phosphate)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCBP2 poly(rC) binding protein 2 0.0295169
USP3 ubiquitin specific peptidase 3 0.0284099
HELZ helicase with zinc finger 0.026014
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0256054
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0245384
ADAM17 ADAM metallopeptidase domain 17 0.0235259
TNIP1 TNFAIP3 interacting protein 1 0.0233015
UBA6 ubiquitin-like modifier activating enzyme 6 0.0221576
NAMPT nicotinamide phosphoribosyltransferase 0.0221022
ADAM9 ADAM metallopeptidase domain 9 0.0213241
FNDC3B fibronectin type III domain containing 3B 0.0211049
NRIP1 nuclear receptor interacting protein 1 0.0201918
ECT2 epithelial cell transforming 2 0.0201121
NUP58 nucleoporin 58 0.0201107
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0194512
NBAS neuroblastoma amplified sequence 0.0189422
NAV2 neuron navigator 2 0.0189354
SPAG9 sperm associated antigen 9 0.0189149
RB1CC1 RB1-inducible coiled-coil 1 0.0169255
WDR43 WD repeat domain 43 0.016495
TRIO trio Rho guanine nucleotide exchange factor 0.0164417
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0163653
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0162657
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0161377
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0157924
GLS2 glutaminase 2 (liver, mitochondrial) 0.0157813
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0155688
ATP13A3 ATPase type 13A3 0.0155428
ARL5B ADP-ribosylation factor-like 5B 0.0154806
AGFG1 ArfGAP with FG repeats 1 0.0151244
BIRC6 baculoviral IAP repeat containing 6 0.014868
TFG TRK-fused gene 0.0148081
USP9X ubiquitin specific peptidase 9, X-linked 0.0147134
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0145814
DGKD diacylglycerol kinase, delta 130kDa 0.014547
TBK1 TANK-binding kinase 1 0.0144331
ZNF292 zinc finger protein 292 0.0143794
SOD2 superoxide dismutase 2, mitochondrial 0.0142937
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0140502
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0138415
PRELID2 PRELI domain containing 2 0.0138099
MYO1B myosin IB 0.0137474
CASC3 cancer susceptibility candidate 3 0.0126678
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0126033
SUCO SUN domain containing ossification factor 0.0125735
VEZT vezatin, adherens junctions transmembrane protein 0.0125698
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0125686
KCTD9 potassium channel tetramerization domain containing 9 0.0125633
BIRC3 baculoviral IAP repeat containing 3 0.0124665
WAC WW domain containing adaptor with coiled-coil 0.0124254
OLA1 Obg-like ATPase 1 0.0122795
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0121863
QKI QKI, KH domain containing, RNA binding 0.012047
MATR3 matrin 3 0.0119338
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0118457
TXNRD1 thioredoxin reductase 1 0.0117646
CHD1 chromodomain helicase DNA binding protein 1 0.0117316
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0114748
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0112318
CCNL1 cyclin L1 0.0105353
ANLN anillin, actin binding protein 0.0105017
TOP2B topoisomerase (DNA) II beta 180kDa 0.0103991
ARHGAP26 Rho GTPase activating protein 26 0.0102993
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0102899
CA8 carbonic anhydrase VIII 0.0101929
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0100767
UBA2 ubiquitin-like modifier activating enzyme 2 0.0100635
RNF145 ring finger protein 145 0.0100129
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0099975
AHR aryl hydrocarbon receptor 0.00998015
FAR1 fatty acyl CoA reductase 1 0.00989081
DMXL2 Dmx-like 2 0.00987234
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00984677
ETNK1 ethanolamine kinase 1 0.0098317
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0097814
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00974147
MSN moesin 0.00973703
AHCTF1 AT hook containing transcription factor 1 0.0097219
PDZD8 PDZ domain containing 8 0.00968523
PICALM phosphatidylinositol binding clathrin assembly protein 0.00964468
NGLY1 N-glycanase 1 0.00959065
BIRC2 baculoviral IAP repeat containing 2 0.0095831
RAD23B RAD23 homolog B (S. cerevisiae) 0.00957678
MYOF myoferlin 0.00954664
GOLGA4 golgin A4 0.00937752
RTN4 reticulon 4 0.00936129
KDM6A lysine (K)-specific demethylase 6A 0.00934508
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.00928074
CNOT1 CCR4-NOT transcription complex, subunit 1 0.009265
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00917869
SFPQ splicing factor proline/glutamine-rich 0.00916237
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.00915258
INSIG2 insulin induced gene 2 0.00911376
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.00904809
CYLD cylindromatosis (turban tumor syndrome) 0.00898019
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00896666
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.00894196
PRPF8 pre-mRNA processing factor 8 0.00892803
CDC73 cell division cycle 73 0.00880123
CEP192 centrosomal protein 192kDa 0.00873303

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.211022
VIM vimentin -0.181912
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.176997
PDE4D phosphodiesterase 4D, cAMP-specific -0.163779
ACTG1 actin gamma 1 -0.147125
AKAP12 A kinase (PRKA) anchor protein 12 -0.135538
TPT1 tumor protein, translationally-controlled 1 -0.115125
RPS19 ribosomal protein S19 -0.104295
IGFBP3 insulin-like growth factor binding protein 3 -0.103537
NDRG1 N-myc downstream regulated 1 -0.0932587
EIF1 eukaryotic translation initiation factor 1 -0.0931261
RPS6 ribosomal protein S6 -0.0914618
RPLP1 ribosomal protein, large, P1 -0.0892962
PTMA prothymosin, alpha -0.0885377
FTL ferritin, light polypeptide -0.0847468
IGFBP4 insulin-like growth factor binding protein 4 -0.0784754
ANXA2 annexin A2 -0.0717141
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0710466
EFNA5 ephrin-A5 -0.0668904
RPS16 ribosomal protein S16 -0.0640869
MT2A metallothionein 2A -0.0639326
RPS27A ribosomal protein S27a -0.0593163
RPL37A ribosomal protein L37a -0.0582318
S100A6 S100 calcium binding protein A6 -0.0578757
BASP1 brain abundant, membrane attached signal protein 1 -0.0574092
KRT81 keratin 81, type II -0.0567546
RPS8 ribosomal protein S8 -0.0567064
RPL19 ribosomal protein L19 -0.0558548
RPL26 ribosomal protein L26 -0.0558197
RPL23 ribosomal protein L23 -0.0548056
RPL35A ribosomal protein L35a -0.0543204
RPS24 ribosomal protein S24 -0.0542785
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0539067
CA12 carbonic anhydrase XII -0.0538103
RPS13 ribosomal protein S13 -0.0522086
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.051976
RPL31 ribosomal protein L31 -0.0513226
TM4SF1 transmembrane 4 L six family member 1 -0.0509547
RPLP2 ribosomal protein, large, P2 -0.0487235
RPS3 ribosomal protein S3 -0.0472689
EXT1 exostosin glycosyltransferase 1 -0.0472368
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0461339
RPS29 ribosomal protein S29 -0.0460132
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0458296
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0457999
DOCK5 dedicator of cytokinesis 5 -0.0457226
MYO1E myosin IE -0.045163
RNF213 ring finger protein 213 -0.0445224
STC1 stanniocalcin 1 -0.0440813
RPL28 ribosomal protein L28 -0.0439946
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.043603
S100A10 S100 calcium binding protein A10 -0.0417899
THSD4 thrombospondin, type I, domain containing 4 -0.0405044
RPL12 ribosomal protein L12 -0.0399536
PDE10A phosphodiesterase 10A -0.0394153
IFI6 interferon, alpha-inducible protein 6 -0.0388809
HLA-B major histocompatibility complex, class I, B -0.0386124
SP100 SP100 nuclear antigen -0.038201
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0379008
RPL34 ribosomal protein L34 -0.0377397
RPL38 ribosomal protein L38 -0.0372544
ANXA4 annexin A4 -0.0368104
MCL1 myeloid cell leukemia 1 -0.0366226
RPS17 ribosomal protein S17 -0.0365661
RPS11 ribosomal protein S11 -0.0363401
EHBP1 EH domain binding protein 1 -0.0355695
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0353991
ACTN4 actinin, alpha 4 -0.0353742
RPS23 ribosomal protein S23 -0.0349181
RPL13A ribosomal protein L13a -0.0346227
RPL7A ribosomal protein L7a -0.0345123
AHNAK AHNAK nucleoprotein -0.0341437
SQSTM1 sequestosome 1 -0.033947
ZBTB20 zinc finger and BTB domain containing 20 -0.0338811
FBXO11 F-box protein 11 -0.0336499
RPS14 ribosomal protein S14 -0.0333454
AKR1C2 aldo-keto reductase family 1, member C2 -0.033293
ALCAM activated leukocyte cell adhesion molecule -0.0329957
IGFBP1 insulin-like growth factor binding protein 1 -0.0328337
EGFR epidermal growth factor receptor -0.0327426
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0325378
GOLGB1 golgin B1 -0.0324351
LMNA lamin A/C -0.0320631
BTG1 B-cell translocation gene 1, anti-proliferative -0.0317277
MAML3 mastermind-like 3 (Drosophila) -0.03119
B2M beta-2-microglobulin -0.0310297
RPL36A ribosomal protein L36a -0.0306646
RPL8 ribosomal protein L8 -0.0305921
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0304388
VCL vinculin -0.0302135
RPS27 ribosomal protein S27 -0.0299457
RPS12 ribosomal protein S12 -0.0298193
RIN2 Ras and Rab interactor 2 -0.0293039
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.029023
TPM4 tropomyosin 4 -0.0290149
RPL37 ribosomal protein L37 -0.0289503
RPS25 ribosomal protein S25 -0.0289461
PRKCA protein kinase C, alpha -0.0282924
ZMYND8 zinc finger, MYND-type containing 8 -0.0282238
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0281295