Benproperine (phosphate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PHF3 PHD finger protein 3 0.0313585
ZNF608 zinc finger protein 608 0.0278668
RAD21 RAD21 homolog (S. pombe) 0.0259912
QKI QKI, KH domain containing, RNA binding 0.0238099
ARHGAP21 Rho GTPase activating protein 21 0.023175
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.022489
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0221813
TOP2B topoisomerase (DNA) II beta 180kDa 0.0218002
ALCAM activated leukocyte cell adhesion molecule 0.0216982
ZNF292 zinc finger protein 292 0.020952
HOXA3 homeobox A3 0.0209402
IL6ST interleukin 6 signal transducer 0.020918
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0206052
NAMPT nicotinamide phosphoribosyltransferase 0.0205767
UBQLN1 ubiquilin 1 0.0205665
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0203382
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0201546
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0200255
PRELID2 PRELI domain containing 2 0.0199591
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0199097
SQSTM1 sequestosome 1 0.0187441
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0185352
FGFR2 fibroblast growth factor receptor 2 0.0184971
NEK7 NIMA-related kinase 7 0.0181118
SCARB2 scavenger receptor class B, member 2 0.0180754
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0180473
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0178782
PELI1 pellino E3 ubiquitin protein ligase 1 0.0177011
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0176799
SCLT1 sodium channel and clathrin linker 1 0.0173588
TET2 tet methylcytosine dioxygenase 2 0.0173144
SOD2 superoxide dismutase 2, mitochondrial 0.0165781
BRWD3 bromodomain and WD repeat domain containing 3 0.0163264
THOC2 THO complex 2 0.0162625
IFRD1 interferon-related developmental regulator 1 0.0161146
KANTR KDM5C adjacent non-coding transcript 0.0160572
ERRFI1 ERBB receptor feedback inhibitor 1 0.0159791
CAMTA1 calmodulin binding transcription activator 1 0.0158715
WAC WW domain containing adaptor with coiled-coil 0.0155066
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0154864
VEZT vezatin, adherens junctions transmembrane protein 0.0154833
SEPTIN7 septin 7 0.01546
CCNL1 cyclin L1 0.0154324
GARS1 glycyl-tRNA synthetase 1 0.0153198
ANXA7 annexin A7 0.0152632
TTK TTK protein kinase 0.015247
SKIC3 SKI3 subunit of superkiller complex 0.0151664
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0151268
KIF20B kinesin family member 20B 0.0149671
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0148199
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0147133
ANAPC5 anaphase promoting complex subunit 5 0.014699
TCEA1 transcription elongation factor A (SII), 1 0.0145016
ANLN anillin, actin binding protein 0.0143693
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0142789
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0141291
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0140015
USP3 ubiquitin specific peptidase 3 0.0139586
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0138814
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0138658
ARL8B ADP-ribosylation factor-like 8B 0.0138318
FNBP1L formin binding protein 1-like 0.0138056
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0137618
HMGB2 high mobility group box 2 0.0137098
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0136591
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.0135131
NCKAP1 NCK-associated protein 1 0.0134704
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0134645
SRP72 signal recognition particle 72kDa 0.0132928
TRAM1 translocation associated membrane protein 1 0.0132425
FIP1L1 factor interacting with PAPOLA and CPSF1 0.013168
OSBPL8 oxysterol binding protein-like 8 0.0131567
FAM13A family with sequence similarity 13, member A 0.0131405
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.0130995
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0130964
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0130428
SNX9 sorting nexin 9 0.0129391
FXR1 fragile X mental retardation, autosomal homolog 1 0.0127708
FBXO28 F-box protein 28 0.0127651
FANCI Fanconi anemia, complementation group I 0.0127645
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0127511
MBNL2 muscleblind-like splicing regulator 2 0.012734
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0125743
WBP11 WW domain binding protein 11 0.0124478
FRS2 fibroblast growth factor receptor substrate 2 0.012438
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0124051
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0123901
LAMP2 lysosomal-associated membrane protein 2 0.0123554
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0123401
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.0123383
NUF2 NUF2, NDC80 kinetochore complex component 0.0123093
PTK2 protein tyrosine kinase 2 0.0122862
ATP11B ATPase, class VI, type 11B 0.0122401
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0122218
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0121933
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 0.012138
CBX5 chromobox homolog 5 0.0120382
ATAD5 ATPase family, AAA domain containing 5 0.0119981
DIPK2A divergent protein kinase domain 2A 0.011972
ICE1 interactor of little elongation complex ELL subunit 1 0.0119628

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.198635
PRKG1 protein kinase, cGMP-dependent, type I -0.183294
CADM2 cell adhesion molecule 2 -0.14255
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115918
MEST mesoderm specific transcript -0.113843
HMGA2 high mobility group AT-hook 2 -0.100593
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0956548
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0875314
TSHZ2 teashirt zinc finger homeobox 2 -0.0802014
MGP matrix Gla protein -0.0776086
PEG10 paternally expressed 10 -0.0740611
ACTG1 actin gamma 1 -0.0626604
PTMA prothymosin, alpha -0.0567909
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.056365
RPS6 ribosomal protein S6 -0.0560682
RPL34 ribosomal protein L34 -0.0551469
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0541584
VEGFA vascular endothelial growth factor A -0.053766
RPS8 ribosomal protein S8 -0.051559
RPS23 ribosomal protein S23 -0.050573
MSRB3 methionine sulfoxide reductase B3 -0.0487734
TRIO trio Rho guanine nucleotide exchange factor -0.046596
SOX4 SRY (sex determining region Y)-box 4 -0.0431364
CANX calnexin -0.0406266
TCF12 transcription factor 12 -0.0394949
RPL23 ribosomal protein L23 -0.0393881
RPS10 ribosomal protein S10 -0.0383607
RPLP2 ribosomal protein, large, P2 -0.0378973
FNDC3B fibronectin type III domain containing 3B -0.0370209
LPP LIM domain containing preferred translocation partner in lipoma -0.0361189
ZFAND3 zinc finger, AN1-type domain 3 -0.0354751
RPL31 ribosomal protein L31 -0.0352783
RPS14 ribosomal protein S14 -0.0350165
HMGA1 high mobility group AT-hook 1 -0.0344652
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0343922
CUX1 cut-like homeobox 1 -0.0334425
FGFR1 fibroblast growth factor receptor 1 -0.0333658
RPL37A ribosomal protein L37a -0.0333095
RPL35A ribosomal protein L35a -0.0332759
NBEA neurobeachin -0.032642
RPL19 ribosomal protein L19 -0.032298
RPS11 ribosomal protein S11 -0.0317958
POTEF POTE ankyrin domain family, member F -0.0317718
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0315853
S100A9 S100 calcium binding protein A9 -0.0309701
KAZN kazrin, periplakin interacting protein -0.0309217
RPS24 ribosomal protein S24 -0.0308201
RACK1 receptor for activated C kinase 1 -0.0301219
BRD4 bromodomain containing 4 -0.0301104
RPL5 ribosomal protein L5 -0.0299896
SLC38A2 solute carrier family 38, member 2 -0.0295748
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0295532
ARB2A ARB2 cotranscriptional regulator A -0.0294318
MAP1B microtubule-associated protein 1B -0.0284738
MEIS2 Meis homeobox 2 -0.0284187
RPS19 ribosomal protein S19 -0.0283919
GMDS GDP-mannose 4,6-dehydratase -0.0281421
RPS13 ribosomal protein S13 -0.0278602
EEF2 eukaryotic translation elongation factor 2 -0.0273525
RPS29 ribosomal protein S29 -0.027299
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0272765
RPS3 ribosomal protein S3 -0.0272411
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0271557
RPS25 ribosomal protein S25 -0.0268548
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0265602
THSD4 thrombospondin, type I, domain containing 4 -0.0265101
PRRC2B proline-rich coiled-coil 2B -0.026399
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0263329
TPM4 tropomyosin 4 -0.0253321
ENO1 enolase 1, (alpha) -0.0251876
MT2A metallothionein 2A -0.0249791
IPO7 importin 7 -0.0248904
RSU1 Ras suppressor protein 1 -0.0248826
COL1A2 collagen, type I, alpha 2 -0.0248451
RPL28 ribosomal protein L28 -0.0247232
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0245803
TTC28 tetratricopeptide repeat domain 28 -0.0245553
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0244182
RABGAP1L RAB GTPase activating protein 1-like -0.0243855
JMJD1C jumonji domain containing 1C -0.0242336
MYOF myoferlin -0.023866
TMSB10 thymosin beta 10 -0.0236658
ANKRD11 ankyrin repeat domain 11 -0.0235833
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0235744
ZFHX3 zinc finger homeobox 3 -0.0235694
PARD3 par-3 family cell polarity regulator -0.0234795
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0234422
PKM pyruvate kinase, muscle -0.0229477
SRSF11 serine/arginine-rich splicing factor 11 -0.0228521
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0227978
BCAS3 breast carcinoma amplified sequence 3 -0.0226387
TPK1 thiamin pyrophosphokinase 1 -0.0225082
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0223077
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.02219
KPNB1 karyopherin (importin) beta 1 -0.0221692
TBCA tubulin folding cofactor A -0.0221658
RPL11 ribosomal protein L11 -0.0220268
MSI2 musashi RNA-binding protein 2 -0.0219368
FBXL7 F-box and leucine-rich repeat protein 7 -0.0217675
NIPBL Nipped-B homolog (Drosophila) -0.0216114