Benproperine (phosphate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
F3 coagulation factor III (thromboplastin, tissue factor) 0.118193
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.115988
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0975152
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0648583
SLC35F3 solute carrier family 35, member F3 0.0626202
ITPRID2 ITPR interacting domain containing 2 0.0577182
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0562986
NPSR1 neuropeptide S receptor 1 0.0559202
FTH1 ferritin, heavy polypeptide 1 0.0550793
KLK10 kallikrein-related peptidase 10 0.047431
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.047361
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0458913
SKAP2 src kinase associated phosphoprotein 2 0.0406561
LMO7 LIM domain 7 0.0402679
GARS1 glycyl-tRNA synthetase 1 0.0395429
PGK1 phosphoglycerate kinase 1 0.0394942
ADAM9 ADAM metallopeptidase domain 9 0.0391599
KRT8 keratin 8, type II 0.0383146
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0379729
MXD1 MAX dimerization protein 1 0.0365844
SULF2 sulfatase 2 0.0348989
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0343976
DIAPH2 diaphanous-related formin 2 0.0336817
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0328911
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0328083
UBE2H ubiquitin-conjugating enzyme E2H 0.0322173
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.0322021
PERP PERP, TP53 apoptosis effector 0.0304881
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0302143
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0291053
CD2AP CD2-associated protein 0.0283186
FERMT1 fermitin family member 1 0.0262326
BZW1 basic leucine zipper and W2 domains 1 0.0256458
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0255279
GRB10 growth factor receptor-bound protein 10 0.0253688
SMC3 structural maintenance of chromosomes 3 0.02536
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0252169
MUC17 mucin 17, cell surface associated 0.0251088
RABGAP1L RAB GTPase activating protein 1-like 0.0248363
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.0245391
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0245285
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0239872
PTPRK protein tyrosine phosphatase, receptor type, K 0.0237011
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 0.0234812
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0234406
EPS8 epidermal growth factor receptor pathway substrate 8 0.0234328
TXNRD1 thioredoxin reductase 1 0.022764
PTK2 protein tyrosine kinase 2 0.0225327
ZNF292 zinc finger protein 292 0.0222536
QKI QKI, KH domain containing, RNA binding 0.0222112
PDE4D phosphodiesterase 4D, cAMP-specific 0.0212163
EGFR epidermal growth factor receptor 0.0209667
LYZ lysozyme 0.0209047
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 0.0201716
SPDYA speedy/RINGO cell cycle regulator family member A 0.0200094
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0199145
NUP58 nucleoporin 58 0.0198435
USP3 ubiquitin specific peptidase 3 0.0191604
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0190624
AFTPH aftiphilin 0.0190521
GLS2 glutaminase 2 (liver, mitochondrial) 0.0188536
WSB1 WD repeat and SOCS box containing 1 0.0186693
DPY19L1 dpy-19-like 1 (C. elegans) 0.0185208
INSIG2 insulin induced gene 2 0.0184587
IGFBP3 insulin-like growth factor binding protein 3 0.0177762
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0173821
LIMA1 LIM domain and actin binding 1 0.0172767
PEAR1 platelet endothelial aggregation receptor 1 0.0168013
SLMAP sarcolemma associated protein 0.0167047
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0166535
PARP8 poly (ADP-ribose) polymerase family, member 8 0.016634
MCU mitochondrial calcium uniporter 0.0165852
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0163437
CD9 CD9 molecule 0.0162824
VRK2 vaccinia related kinase 2 0.0160915
ANO1 anoctamin 1, calcium activated chloride channel 0.0160177
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.0160149
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0159878
HMGA1 high mobility group AT-hook 1 0.015667
DSG3 desmoglein 3 0.0156582
RREB1 ras responsive element binding protein 1 0.0156509
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0155554
BAIAP2L1 BAI1-associated protein 2-like 1 0.0155036
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0153589
CD164 CD164 molecule, sialomucin 0.0153518
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0153183
EXOC4 exocyst complex component 4 0.0151396
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.0151289
SLK STE20-like kinase 0.0151025
LAMA4 laminin, alpha 4 0.0147509
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0146232
FDPS farnesyl diphosphate synthase 0.0146165
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0145118
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0143214
POU2F1 POU class 2 homeobox 1 0.0143014
ZFP36L1 ZFP36 ring finger protein-like 1 0.014291
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0142878
MAML2 mastermind-like 2 (Drosophila) 0.0142653
BCL10 B-cell CLL/lymphoma 10 0.0142599
SREK1IP1 SREK1-interacting protein 1 0.0142065

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.242029
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.177713
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.147331
ERRFI1 ERBB receptor feedback inhibitor 1 -0.131215
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120166
RPS2 ribosomal protein S2 -0.114998
AKAP12 A kinase (PRKA) anchor protein 12 -0.104843
SMAD3 SMAD family member 3 -0.0947662
EFNA5 ephrin-A5 -0.0925115
DOCK5 dedicator of cytokinesis 5 -0.0882423
PLEC plectin -0.0829314
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0750344
DSG2 desmoglein 2 -0.0727366
LMTK2 lemur tyrosine kinase 2 -0.0703659
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0668342
MYH9 myosin, heavy chain 9, non-muscle -0.0660146
UBC ubiquitin C -0.0655107
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0601472
CDCP1 CUB domain containing protein 1 -0.0585685
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0585078
SDC4 syndecan 4 -0.0560021
CAB39 calcium binding protein 39 -0.0558668
KTN1 kinectin 1 (kinesin receptor) -0.0526816
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0508892
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0507293
S100A10 S100 calcium binding protein A10 -0.0501982
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.049122
RPS3 ribosomal protein S3 -0.047931
DSPP dentin sialophosphoprotein -0.0475233
VCL vinculin -0.0474854
LAMC2 laminin, gamma 2 -0.0460167
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0451708
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0449441
RPS8 ribosomal protein S8 -0.0448162
GOLGA4 golgin A4 -0.0444409
RPL26 ribosomal protein L26 -0.0441059
MYOF myoferlin -0.0439235
HSPA8 heat shock 70kDa protein 8 -0.0438717
CAPN2 calpain 2, (m/II) large subunit -0.0437376
RTN4 reticulon 4 -0.0435333
ITGA6 integrin, alpha 6 -0.0426162
FLNB filamin B, beta -0.0418807
CTSB cathepsin B -0.0415177
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0412754
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0411063
EXT1 exostosin glycosyltransferase 1 -0.0406666
RPLP2 ribosomal protein, large, P2 -0.0398359
CHD1 chromodomain helicase DNA binding protein 1 -0.0393401
JMJD1C jumonji domain containing 1C -0.0384847
MYO1E myosin IE -0.0383342
ARHGAP5 Rho GTPase activating protein 5 -0.0374779
HPCAL1 hippocalcin-like 1 -0.0373845
ZEB1 zinc finger E-box binding homeobox 1 -0.0370875
PRRC2C proline-rich coiled-coil 2C -0.0369804
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0365781
CLIP2 CAP-GLY domain containing linker protein 2 -0.0365597
ASPH aspartate beta-hydroxylase -0.0364605
BCL2L1 BCL2-like 1 -0.0363086
SEPTIN9 septin 9 -0.0362961
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0359445
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0359388
RPS12 ribosomal protein S12 -0.03577
RPL7 ribosomal protein L7 -0.0356898
EIF1 eukaryotic translation initiation factor 1 -0.0356033
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0355917
IPO7 importin 7 -0.0351245
TGM2 transglutaminase 2 -0.0346219
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0343979
SAMD4A sterile alpha motif domain containing 4A -0.0342935
RPLP1 ribosomal protein, large, P1 -0.0341841
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0341071
KIF5B kinesin family member 5B -0.0340512
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0339071
TLN1 talin 1 -0.0338501
CORO1C coronin, actin binding protein, 1C -0.0336255
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.033402
STK4 serine/threonine kinase 4 -0.0333186
TRIO trio Rho guanine nucleotide exchange factor -0.0329843
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0327532
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0325996
KDM3A lysine (K)-specific demethylase 3A -0.0320768
NAP1L1 nucleosome assembly protein 1-like 1 -0.0319025
B2M beta-2-microglobulin -0.0318968
WWC1 WW and C2 domain containing 1 -0.0318662
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 -0.0316056
TPT1 tumor protein, translationally-controlled 1 -0.0314948
RUNX1 runt-related transcription factor 1 -0.0312632
NUP98 nucleoporin 98kDa -0.0311823
OGA O-GlcNAcase -0.0309649
ANO6 anoctamin 6 -0.0309055
MAPK8 mitogen-activated protein kinase 8 -0.0308511
CLTC clathrin, heavy chain (Hc) -0.0308329
NPC1 Niemann-Pick disease, type C1 -0.0307654
MTDH metadherin -0.030596
AHNAK AHNAK nucleoprotein -0.0302843
CSNK1A1 casein kinase 1, alpha 1 -0.0301314
TUFT1 tuftelin 1 -0.0301062
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0300685
DGKD diacylglycerol kinase, delta 130kDa -0.0299881
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.029974