Benproperine (phosphate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0491176
PNISR PNN-interacting serine/arginine-rich protein 0.0409792
ECPAS Ecm29 proteasome adaptor and scaffold 0.0405619
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0365041
KTN1 kinectin 1 (kinesin receptor) 0.0336827
RTN4 reticulon 4 0.0310408
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0293267
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0276476
MKI67 marker of proliferation Ki-67 0.0276151
ENO1 enolase 1, (alpha) 0.0276148
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0251847
ANKRD11 ankyrin repeat domain 11 0.0249756
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.02426
SRPK2 SRSF protein kinase 2 0.0242029
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0241999
PDS5A PDS5 cohesin associated factor A 0.0236615
MED13 mediator complex subunit 13 0.0236095
SERBP1 SERPINE1 mRNA binding protein 1 0.0232322
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0230882
PFN1 profilin 1 0.0223066
SRRM2 serine/arginine repetitive matrix 2 0.0222881
CCSER1 coiled-coil serine-rich protein 1 0.0220803
HMGA1 high mobility group AT-hook 1 0.0219841
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0217942
CENPF centromere protein F, 350/400kDa 0.021738
ETNK1 ethanolamine kinase 1 0.0216214
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0215425
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0212429
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0212068
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.020954
SET SET nuclear proto-oncogene 0.020517
RBM25 RNA binding motif protein 25 0.0204441
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0203041
RPS14 ribosomal protein S14 0.0199159
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0196444
RPL35A ribosomal protein L35a 0.019586
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0193712
NEBL nebulette 0.019015
ATP5F1A ATP synthase F1 subunit alpha 0.0185972
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0184849
TOM1L2 target of myb1-like 2 (chicken) 0.0184309
PHF14 PHD finger protein 14 0.0182355
PCBP2 poly(rC) binding protein 2 0.0181134
RPL9 ribosomal protein L9 0.0181102
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0180117
FN1 fibronectin 1 0.0180088
SHLD2 shieldin complex subunit 2 0.0177801
SNX9 sorting nexin 9 0.0174936
ERBIN erbb2 interacting protein 0.0174429
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0173648
LSAMP limbic system-associated membrane protein 0.0173078
EIF4B eukaryotic translation initiation factor 4B 0.0172145
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.0171074
RPS12 ribosomal protein S12 0.017038
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 0.0169784
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0169548
ZFYVE16 zinc finger, FYVE domain containing 16 0.0167157
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0166955
UBE3A ubiquitin protein ligase E3A 0.0164666
RAB8B RAB8B, member RAS oncogene family 0.0164161
TRIM37 tripartite motif containing 37 0.0159953
NOP56 NOP56 ribonucleoprotein 0.0159822
PNN pinin, desmosome associated protein 0.0158058
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like 0.0156628
ENAH enabled homolog (Drosophila) 0.0155881
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.0155522
BIRC6 baculoviral IAP repeat containing 6 0.0154962
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.0154676
TASOR2 transcription activation suppressor family member 2 0.0153533
BCLAF1 BCL2-associated transcription factor 1 0.0153143
KIF5C kinesin family member 5C 0.0152622
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0152134
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) 0.0152017
MGA MGA, MAX dimerization protein 0.0151743
DOCK4 dedicator of cytokinesis 4 0.015094
RPL36A ribosomal protein L36a 0.0150886
TPP2 tripeptidyl peptidase II 0.0148476
CELF1 CUGBP, Elav-like family member 1 0.0148162
NF1 neurofibromin 1 0.0147738
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.0147734
LIMS1 LIM and senescent cell antigen-like domains 1 0.0147675
SLK STE20-like kinase 0.014764
S100A9 S100 calcium binding protein A9 0.0147447
NFE2L1 nuclear factor, erythroid 2-like 1 0.0146824
PEG10 paternally expressed 10 0.0146683
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0145284
RFLNA refilin A 0.0144786
DIAPH3 diaphanous-related formin 3 0.0144483
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0143725
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.0143055
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0142954
CCDC88A coiled-coil domain containing 88A 0.0142248
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0142161
RNF220 ring finger protein 220 0.0141554
TM9SF3 transmembrane 9 superfamily member 3 0.01415
ZNF207 zinc finger protein 207 0.0140887
CDC27 cell division cycle 27 0.0140382
HELLS helicase, lymphoid-specific 0.0140346
GMPS guanine monphosphate synthase 0.0140269
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0139766

decreased expression

Symbol Name Standardized Value
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.105679
NPAS3 neuronal PAS domain protein 3 -0.0814797
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0741267
ZNF608 zinc finger protein 608 -0.0683462
FMNL2 formin-like 2 -0.065091
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0614792
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0511188
TENM3 teneurin transmembrane protein 3 -0.0503367
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0476206
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0449367
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0443152
RAD51B RAD51 paralog B -0.0440782
ATP11A ATPase, class VI, type 11A -0.0439449
ARB2A ARB2 cotranscriptional regulator A -0.0428575
VMP1 vacuole membrane protein 1 -0.0422358
FOXO3 forkhead box O3 -0.0390095
NGLY1 N-glycanase 1 -0.0377215
ACTG1 actin gamma 1 -0.0364033
KDM3A lysine (K)-specific demethylase 3A -0.0358784
CADM2 cell adhesion molecule 2 -0.0355737
RAP1B RAP1B, member of RAS oncogene family -0.0355126
OSBPL10 oxysterol binding protein-like 10 -0.0339335
TPD52 tumor protein D52 -0.0312387
SLF1 SMC5-SMC6 complex localization factor 1 -0.0312235
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0311626
RERE arginine-glutamic acid dipeptide (RE) repeats -0.031022
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0309353
FBXO11 F-box protein 11 -0.0308437
DPYSL2 dihydropyrimidinase-like 2 -0.0306063
ZFAND3 zinc finger, AN1-type domain 3 -0.0303539
NFIA nuclear factor I/A -0.0297869
WSB1 WD repeat and SOCS box containing 1 -0.0293919
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0292224
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0289986
MXI1 MAX interactor 1, dimerization protein -0.0279366
FOXJ3 forkhead box J3 -0.0276527
GNAS GNAS complex locus -0.0271513
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0271449
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.027012
ARFGEF3 ARFGEF family member 3 -0.0268304
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0268131
CDK19 cyclin-dependent kinase 19 -0.0263144
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0262019
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0260698
GLG1 golgi glycoprotein 1 -0.0259095
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0259037
SUN1 Sad1 and UNC84 domain containing 1 -0.0257119
APP amyloid beta (A4) precursor protein -0.0255364
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.025499
RPL13A ribosomal protein L13a -0.0254919
FAM13A family with sequence similarity 13, member A -0.025422
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 -0.025383
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0249163
NXN nucleoredoxin -0.0248681
ZNF544 zinc finger protein 544 -0.024858
ELF2 E74-like factor 2 (ets domain transcription factor) -0.02468
TTC3 tetratricopeptide repeat domain 3 -0.024552
RIGI RNA sensor RIG-I -0.0244481
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0242178
NBEAL1 neurobeachin-like 1 -0.0238546
COL5A2 collagen, type V, alpha 2 -0.0233136
GRID2 glutamate receptor, ionotropic, delta 2 -0.0231697
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0231653
WDPCP WD repeat containing planar cell polarity effector -0.0231215
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0231011
KDM7A lysine (K)-specific demethylase 7A -0.0230725
JARID2 jumonji, AT rich interactive domain 2 -0.0230627
MCTP1 multiple C2 domains, transmembrane 1 -0.0230294
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0225815
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.022461
HDLBP high density lipoprotein binding protein -0.0222922
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0219772
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0219196
ADGRG6 adhesion G protein-coupled receptor G6 -0.0216293
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.021364
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0213442
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0211845
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0211716
MLIP muscular LMNA-interacting protein -0.0211346
DST dystonin -0.0210823
ATRN attractin -0.0209228
CFDP1 craniofacial development protein 1 -0.0206263
CABIN1 calcineurin binding protein 1 -0.0206088
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0205526
KDM5B lysine (K)-specific demethylase 5B -0.0203743
NFIB nuclear factor I/B -0.0203591
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0203473
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0203461
RPS20 ribosomal protein S20 -0.020329
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.020053
BRWD3 bromodomain and WD repeat domain containing 3 -0.0198608
TAS2R14 taste receptor, type 2, member 14 -0.0198564
POU2F1 POU class 2 homeobox 1 -0.0198462
RPL27A ribosomal protein L27a -0.0197781
ZNF33A zinc finger protein 33A -0.0195859
TAOK1 TAO kinase 1 -0.0195581
AHCYL2 adenosylhomocysteinase-like 2 -0.019407
ZFHX3 zinc finger homeobox 3 -0.0192481
STRBP spermatid perinuclear RNA binding protein -0.0191714
CHSY1 chondroitin sulfate synthase 1 -0.0190452