Benproperine (phosphate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPC6 glypican 6 0.0617314
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0488898
NLGN1 neuroligin 1 0.0377084
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0272313
DST dystonin 0.0258832
PDE10A phosphodiesterase 10A 0.0239965
NAV3 neuron navigator 3 0.0236175
MACROD2 MACRO domain containing 2 0.0221854
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0218387
LEF1 lymphoid enhancer-binding factor 1 0.0205709
FHIT fragile histidine triad 0.0204452
SOX5 SRY (sex determining region Y)-box 5 0.0198254
CDK14 cyclin-dependent kinase 14 0.0161811
IGF1R insulin-like growth factor 1 receptor 0.0150263
LSAMP limbic system-associated membrane protein 0.0149782
ZNF704 zinc finger protein 704 0.0149131
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0145461
PDE4D phosphodiesterase 4D, cAMP-specific 0.013967
AHR aryl hydrocarbon receptor 0.013756
EXOC4 exocyst complex component 4 0.0135032
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0118906
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0116672
C1ORF21 chromosome 1 open reading frame 21 0.0115736
NEGR1 neuronal growth regulator 1 0.0115498
TNIK TRAF2 and NCK interacting kinase 0.0114105
FMN1 formin 1 0.0111517
LRMDA leucine rich melanocyte differentiation associated 0.0111286
NBEA neurobeachin 0.0111225
MEF2A myocyte enhancer factor 2A 0.0110359
RAD51B RAD51 paralog B 0.0106706
PIAS2 protein inhibitor of activated STAT, 2 0.0104696
PRKD1 protein kinase D1 0.0104094
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0101479
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0101061
PTPRM protein tyrosine phosphatase, receptor type, M 0.00997693
QKI QKI, KH domain containing, RNA binding 0.00997037
EPHA3 EPH receptor A3 0.00989479
NELL1 NEL-like 1 (chicken) 0.00986741
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0096746
NRCAM neuronal cell adhesion molecule 0.00964716
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.00950427
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.00922799
CTTNBP2 cortactin binding protein 2 0.00910401
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.00905452
MAML2 mastermind-like 2 (Drosophila) 0.0089735
RBMS3 RNA binding motif, single stranded interacting protein 3 0.00896823
ATXN1 ataxin 1 0.00896102
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0089563
CHRM3 cholinergic receptor, muscarinic 3 0.00888299
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.00879629
TSHZ1 teashirt zinc finger homeobox 1 0.0087824
ANKRD11 ankyrin repeat domain 11 0.00877084
TMEM65 transmembrane protein 65 0.00871452
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0086429
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.00857541
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0085534
MATR3 matrin 3 0.00854769
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.00852478
SARNP SAP domain containing ribonucleoprotein 0.00844875
PSD3 pleckstrin and Sec7 domain containing 3 0.00839963
ZNF292 zinc finger protein 292 0.00838916
NCOA2 nuclear receptor coactivator 2 0.00824769
WDFY2 WD repeat and FYVE domain containing 2 0.008205
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.00818285
RAB8B RAB8B, member RAS oncogene family 0.00817882
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 0.0080864
MDFIC MyoD family inhibitor domain containing 0.00804085
STXBP5 syntaxin binding protein 5 (tomosyn) 0.00803172
RUNX1 runt-related transcription factor 1 0.00800517
SNX13 sorting nexin 13 0.00796733
SUCO SUN domain containing ossification factor 0.00792949
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0078532
BNC2 basonuclin 2 0.00781622
LCORL ligand dependent nuclear receptor corepressor-like 0.00778264
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.00772747
PAWR PRKC, apoptosis, WT1, regulator 0.00764256
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.00760531
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 0.00757923
KDM6A lysine (K)-specific demethylase 6A 0.00751738
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.00747681
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.00739324
KMT2C lysine (K)-specific methyltransferase 2C 0.00728609
NEK7 NIMA-related kinase 7 0.00722616
BTBD3 BTB (POZ) domain containing 3 0.00722052
PTCHD4 patched domain containing 4 0.00719931
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.00716718
ACSL3 acyl-CoA synthetase long-chain family member 3 0.00708168
NRG1 neuregulin 1 0.00705926
MYO1B myosin IB 0.00703307
MAPK8 mitogen-activated protein kinase 8 0.00698472
GRIK5 glutamate receptor, ionotropic, kainate 5 0.00692358
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0069122
UBQLN1 ubiquilin 1 0.00683978
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00683539
EPS8 epidermal growth factor receptor pathway substrate 8 0.00679849
LIFR leukemia inhibitory factor receptor alpha 0.0067718
RYBP RING1 and YY1 binding protein 0.00676604
RASA2 RAS p21 protein activator 2 0.0067377
ZFYVE16 zinc finger, FYVE domain containing 16 0.00671313
MYOF myoferlin 0.00668722

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.340884
VIM vimentin -0.242588
MT2A metallothionein 2A -0.102516
FN1 fibronectin 1 -0.0896722
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0882776
ENO1 enolase 1, (alpha) -0.0836335
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.071477
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0645602
S100A6 S100 calcium binding protein A6 -0.064481
LOC112694756 uncharaterized LOC112694756 -0.0630782
PDIA4 protein disulfide isomerase family A, member 4 -0.0593773
IFI16 interferon, gamma-inducible protein 16 -0.0583476
UBC ubiquitin C -0.0571663
TMSB10 thymosin beta 10 -0.0554594
PKM pyruvate kinase, muscle -0.0517238
ACTG1 actin gamma 1 -0.0488738
CALU calumenin -0.0480806
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0470915
NDRG1 N-myc downstream regulated 1 -0.0468529
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0440769
TAGLN2 transgelin 2 -0.0434739
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0426162
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0418729
RPLP1 ribosomal protein, large, P1 -0.0390537
HLA-B major histocompatibility complex, class I, B -0.0384454
EEF2 eukaryotic translation elongation factor 2 -0.0380157
LDHA lactate dehydrogenase A -0.0379147
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0378613
IFRD1 interferon-related developmental regulator 1 -0.0375711
PTMA prothymosin, alpha -0.0364352
P4HB prolyl 4-hydroxylase, beta polypeptide -0.03457
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0333133
WSB1 WD repeat and SOCS box containing 1 -0.03282
VGF VGF nerve growth factor inducible -0.0327143
CALR calreticulin -0.0322563
DDIT4 DNA-damage-inducible transcript 4 -0.0318027
ICAM1 intercellular adhesion molecule 1 -0.0317465
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0307396
LMNA lamin A/C -0.0302691
IER3 immediate early response 3 -0.0302486
RPL37A ribosomal protein L37a -0.0295209
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0293874
ANXA2 annexin A2 -0.0293747
HILPDA hypoxia inducible lipid droplet-associated -0.0293082
TPR translocated promoter region, nuclear basket protein -0.028866
MT1X metallothionein 1X -0.0288238
IGFBP3 insulin-like growth factor binding protein 3 -0.0283315
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0280074
ASPH aspartate beta-hydroxylase -0.0278291
IGFBP5 insulin-like growth factor binding protein 5 -0.0274494
S100A9 S100 calcium binding protein A9 -0.0272441
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0270007
ZMYND8 zinc finger, MYND-type containing 8 -0.0267514
AKAP12 A kinase (PRKA) anchor protein 12 -0.0263677
RPLP2 ribosomal protein, large, P2 -0.0261318
TAC4 tachykinin 4 (hemokinin) -0.0253474
FTL ferritin, light polypeptide -0.0253417
ZYX zyxin -0.0248002
COG5 component of oligomeric golgi complex 5 -0.0247091
AHNAK AHNAK nucleoprotein -0.0243749
KMT2E lysine (K)-specific methyltransferase 2E -0.0242096
MCL1 myeloid cell leukemia 1 -0.0240197
LOC102724023 ES1 protein homolog, mitochondrial -0.0237712
IFITM3 interferon induced transmembrane protein 3 -0.0234759
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.022844
RPS8 ribosomal protein S8 -0.0222261
POTEF POTE ankyrin domain family, member F -0.0220754
PDIA3 protein disulfide isomerase family A, member 3 -0.0219511
SRPK2 SRSF protein kinase 2 -0.0219409
FLNB filamin B, beta -0.0217693
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0216357
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.02104
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0210387
RPS19 ribosomal protein S19 -0.0208971
EIF1 eukaryotic translation initiation factor 1 -0.0207678
APP amyloid beta (A4) precursor protein -0.020698
B2M beta-2-microglobulin -0.0206004
FUS FUS RNA binding protein -0.0204063
CABIN1 calcineurin binding protein 1 -0.020079
RPS3 ribosomal protein S3 -0.0200752
PGK1 phosphoglycerate kinase 1 -0.0200302
RPL26 ribosomal protein L26 -0.0199886
RPS27A ribosomal protein S27a -0.0196968
UGP2 UDP-glucose pyrophosphorylase 2 -0.0196518
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0196336
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0195654
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0195652
RPS12 ribosomal protein S12 -0.0195533
TPT1 tumor protein, translationally-controlled 1 -0.0195213
WDR45B WD repeat domain 45B -0.0194223
KDM3A lysine (K)-specific demethylase 3A -0.0194095
GOLGA4 golgin A4 -0.0190701
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0189571
JUN jun proto-oncogene -0.0189571
TM4SF1 transmembrane 4 L six family member 1 -0.0188713
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.018782
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.018481
FAM162A family with sequence similarity 162, member A -0.0178936
KTN1 kinectin 1 (kinesin receptor) -0.0176357
RPL19 ribosomal protein L19 -0.0176171