Benproperine (phosphate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HELZ helicase with zinc finger 0.060806
FNDC3B fibronectin type III domain containing 3B 0.0478748
FAM13A family with sequence similarity 13, member A 0.0419276
MEF2A myocyte enhancer factor 2A 0.0351886
AKAP12 A kinase (PRKA) anchor protein 12 0.0340088
WAC WW domain containing adaptor with coiled-coil 0.0317891
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0259854
COPA coatomer protein complex, subunit alpha 0.0256259
CDC27 cell division cycle 27 0.0256013
OGA O-GlcNAcase 0.0254069
PHIP pleckstrin homology domain interacting protein 0.0252002
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0235798
CCNY cyclin Y 0.0231738
HMGB2 high mobility group box 2 0.023112
NEK7 NIMA-related kinase 7 0.0225768
TCERG1 transcription elongation regulator 1 0.0219605
TENT5A terminal nucleotidyltransferase 5A 0.0211826
KMT2C lysine (K)-specific methyltransferase 2C 0.0206582
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0204669
RNF145 ring finger protein 145 0.0201347
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0200302
NUP58 nucleoporin 58 0.019481
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0190808
NAMPT nicotinamide phosphoribosyltransferase 0.0188448
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0185773
QKI QKI, KH domain containing, RNA binding 0.0184745
AFDN afadin, adherens junction formation factor 0.0184249
SLMAP sarcolemma associated protein 0.0184127
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0182928
PICALM phosphatidylinositol binding clathrin assembly protein 0.018266
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0182027
PDS5B PDS5 cohesin associated factor B 0.0181957
PPARG peroxisome proliferator-activated receptor gamma 0.0176373
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.017568
DENND4C DENN/MADD domain containing 4C 0.0174749
DTNA dystrobrevin, alpha 0.0173506
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0172337
FXR1 fragile X mental retardation, autosomal homolog 1 0.017218
RTN4 reticulon 4 0.0170723
SOS1 son of sevenless homolog 1 (Drosophila) 0.0169401
WDR43 WD repeat domain 43 0.0169065
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0167319
PCM1 pericentriolar material 1 0.0166054
GARS1 glycyl-tRNA synthetase 1 0.016544
GPBP1 GC-rich promoter binding protein 1 0.0163773
SUCO SUN domain containing ossification factor 0.0160832
NCKAP1 NCK-associated protein 1 0.0159105
KDM6A lysine (K)-specific demethylase 6A 0.0158416
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0157261
PTK2 protein tyrosine kinase 2 0.0156585
CSNK1G1 casein kinase 1, gamma 1 0.0156054
USP3 ubiquitin specific peptidase 3 0.0155513
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0153904
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.0152374
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0151403
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0150657
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0150048
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0149216
CHD1 chromodomain helicase DNA binding protein 1 0.0148163
CDC73 cell division cycle 73 0.0148057
SOX9 SRY (sex determining region Y)-box 9 0.014758
C1ORF21 chromosome 1 open reading frame 21 0.0146433
USP9X ubiquitin specific peptidase 9, X-linked 0.0145934
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0145766
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0145176
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0144964
PDIA6 protein disulfide isomerase family A, member 6 0.0143018
ADGRG6 adhesion G protein-coupled receptor G6 0.0142099
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0141821
ARHGAP9 Rho GTPase activating protein 9 0.0141693
ZEB1 zinc finger E-box binding homeobox 1 0.0141693
MARCHF6 membrane associated ring-CH-type finger 6 0.01411
CARD16 caspase recruitment domain family, member 16 0.0140199
BIRC6 baculoviral IAP repeat containing 6 0.0137978
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 0.0137565
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0137181
BIRC2 baculoviral IAP repeat containing 2 0.0137076
SCAF4 SR-related CTD-associated factor 4 0.0137056
RIC1 RAB6A GEF complex partner 1 0.0136562
SSBP2 single-stranded DNA binding protein 2 0.0136461
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0135445
ZNF654 zinc finger protein 654 0.0135334
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0135071
WDFY2 WD repeat and FYVE domain containing 2 0.0133845
NIPBL Nipped-B homolog (Drosophila) 0.01337
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0133503
UBA6 ubiquitin-like modifier activating enzyme 6 0.013325
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0132225
ELL2 elongation factor, RNA polymerase II, 2 0.0131728
UBA2 ubiquitin-like modifier activating enzyme 2 0.0130934
NUP153 nucleoporin 153kDa 0.012998
YTHDC1 YTH domain containing 1 0.0127969
PDIA3 protein disulfide isomerase family A, member 3 0.0127613
XPO6 exportin 6 0.0127255
TOP2B topoisomerase (DNA) II beta 180kDa 0.0126161
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0125128
SNX13 sorting nexin 13 0.0124201
FBXO7 F-box protein 7 0.012331
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0123206
PSD3 pleckstrin and Sec7 domain containing 3 0.0122837

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.250751
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.24447
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.144952
VCL vinculin -0.0941059
LSAMP limbic system-associated membrane protein -0.0927193
RPL23 ribosomal protein L23 -0.0803172
RPL19 ribosomal protein L19 -0.0775181
PTPRD protein tyrosine phosphatase, receptor type, D -0.0733084
VIM vimentin -0.0726726
BPTF bromodomain PHD finger transcription factor -0.06832
ACTG1 actin gamma 1 -0.0647723
RPS6 ribosomal protein S6 -0.0643623
TLE4 transducin-like enhancer of split 4 -0.0631694
RPL35A ribosomal protein L35a -0.0612003
RPLP1 ribosomal protein, large, P1 -0.0611826
SYT1 synaptotagmin I -0.0577024
TPT1 tumor protein, translationally-controlled 1 -0.056568
NALF1 NALCN channel auxiliary factor 1 -0.0500786
RPL37A ribosomal protein L37a -0.048671
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0461486
BCAS3 breast carcinoma amplified sequence 3 -0.0439949
EIF1 eukaryotic translation initiation factor 1 -0.0437103
B2M beta-2-microglobulin -0.0425057
IFI16 interferon, gamma-inducible protein 16 -0.0424759
RPL38 ribosomal protein L38 -0.0424372
EGR1 early growth response 1 -0.0423037
FMN1 formin 1 -0.0422056
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0420369
RPS19 ribosomal protein S19 -0.0403152
TRIB2 tribbles pseudokinase 2 -0.0401005
RNF213 ring finger protein 213 -0.0394715
PTMA prothymosin, alpha -0.0362742
TMSB10 thymosin beta 10 -0.0360621
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0359547
RPS3 ribosomal protein S3 -0.0355272
RPL34 ribosomal protein L34 -0.0353292
ZBTB20 zinc finger and BTB domain containing 20 -0.034502
MEIS2 Meis homeobox 2 -0.0338729
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0330755
RPS23 ribosomal protein S23 -0.033035
RPS29 ribosomal protein S29 -0.0317452
RPL26 ribosomal protein L26 -0.0313519
TPM1 tropomyosin 1 (alpha) -0.0312413
RPL12 ribosomal protein L12 -0.0307526
SLIT2 slit homolog 2 (Drosophila) -0.0303023
FTL ferritin, light polypeptide -0.0295912
GATA3 GATA binding protein 3 -0.0293614
RIGI RNA sensor RIG-I -0.0290734
PRRC2C proline-rich coiled-coil 2C -0.0289731
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0287349
RPL32 ribosomal protein L32 -0.0285656
FNDC3A fibronectin type III domain containing 3A -0.0274492
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0272896
RPS12 ribosomal protein S12 -0.027168
RAB7A RAB7A, member RAS oncogene family -0.0267808
RPL37 ribosomal protein L37 -0.0265033
RPL7A ribosomal protein L7a -0.0263215
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0263094
LPP LIM domain containing preferred translocation partner in lipoma -0.0259588
RPL31 ribosomal protein L31 -0.0259037
PLPP1 phospholipid phosphatase 1 -0.0253668
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0251337
RPLP2 ribosomal protein, large, P2 -0.024757
CUX1 cut-like homeobox 1 -0.0247413
RPL13A ribosomal protein L13a -0.0244921
TTC17 tetratricopeptide repeat domain 17 -0.024472
RPS27 ribosomal protein S27 -0.0244648
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0242252
EEF2 eukaryotic translation elongation factor 2 -0.0241229
RPS24 ribosomal protein S24 -0.0240967
VMP1 vacuole membrane protein 1 -0.0240405
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0238334
ZNF804A zinc finger protein 804A -0.0237144
RPLP0 ribosomal protein, large, P0 -0.0235589
COL1A1 collagen, type I, alpha 1 -0.0235095
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0232021
S100A9 S100 calcium binding protein A9 -0.0231018
RPL36 ribosomal protein L36 -0.0230274
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0225059
RPS27A ribosomal protein S27a -0.0222011
GLCCI1 glucocorticoid induced 1 -0.0221305
RHOBTB3 Rho-related BTB domain containing 3 -0.022067
SIK2 salt-inducible kinase 2 -0.0216331
N4BP2L2 NEDD4 binding protein 2-like 2 -0.02159
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0214238
RPS8 ribosomal protein S8 -0.0212348
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0211067
RPL35 ribosomal protein L35 -0.0210957
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0207729
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0206716
DNAH14 dynein, axonemal, heavy chain 14 -0.0206273
MCL1 myeloid cell leukemia 1 -0.0204759
FHIT fragile histidine triad -0.0204457
RPS14 ribosomal protein S14 -0.0204038
CCDC47 coiled-coil domain containing 47 -0.0203841
PTPRM protein tyrosine phosphatase, receptor type, M -0.0202418
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0202234
TPI1 triosephosphate isomerase 1 -0.0201992
RPL30 ribosomal protein L30 -0.0201594
TBX2 T-box 2 -0.0201455