Benproperine (phosphate)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CCDC146 coiled-coil domain containing 146 0.0171777
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0171246
NPSR1 neuropeptide S receptor 1 0.0162182
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.015706
LMO7 LIM domain 7 0.0142667
SCFD1 sec1 family domain containing 1 0.0133531
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.013042
IGFBP3 insulin-like growth factor binding protein 3 0.0129495
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0128545
FNIP1 folliculin interacting protein 1 0.0127416
SEC24A SEC24 family member A 0.0125419
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0125029
SP3 Sp3 transcription factor 0.0120439
ADIPOR2 adiponectin receptor 2 0.0119705
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0118949
FKBP9 FK506 binding protein 9, 63 kDa 0.0118347
GOLGA2 golgin A2 0.0114795
BAIAP2L1 BAI1-associated protein 2-like 1 0.0114375
MON2 MON2 homolog (S. cerevisiae) 0.0113707
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0107856
SAMD4A sterile alpha motif domain containing 4A 0.0107302
MBNL2 muscleblind-like splicing regulator 2 0.0106292
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0104129
PLIN2 perilipin 2 0.0103875
COG6 component of oligomeric golgi complex 6 0.0102771
ESYT2 extended synaptotagmin-like protein 2 0.0102545
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0101437
CLTC clathrin, heavy chain (Hc) 0.0100489
ADAM20 ADAM metallopeptidase domain 20 0.00997324
KDM5B lysine (K)-specific demethylase 5B 0.00992216
SLK STE20-like kinase 0.0098855
EHBP1 EH domain binding protein 1 0.00982261
ZSWIM6 zinc finger, SWIM-type containing 6 0.00976213
FOXB1 forkhead box B1 0.00963852
NEK7 NIMA-related kinase 7 0.00961919
TRIP11 thyroid hormone receptor interactor 11 0.00946988
ZNF432 zinc finger protein 432 0.00943321
FTH1 ferritin, heavy polypeptide 1 0.00940551
USP53 ubiquitin specific peptidase 53 0.00938289
FDPS farnesyl diphosphate synthase 0.00929722
ZNF395 zinc finger protein 395 0.00921497
CNOT11 CCR4-NOT transcription complex, subunit 11 0.00920912
ANXA1 annexin A1 0.0091718
GOSR1 golgi SNAP receptor complex member 1 0.00905217
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0089919
COPA coatomer protein complex, subunit alpha 0.0089658
GRK3 G protein-coupled receptor kinase 3 0.00890794
CRY1 cryptochrome circadian clock 1 0.00889088
STS steroid sulfatase (microsomal), isozyme S 0.00887511
PRPF4B pre-mRNA processing factor 4B 0.00886068
MEF2A myocyte enhancer factor 2A 0.00882574
GMDS GDP-mannose 4,6-dehydratase 0.00882357
RARS2 arginyl-tRNA synthetase 2, mitochondrial 0.00878962
A1CF APOBEC1 complementation factor 0.00873708
PCED1B PC-esterase domain containing 1B 0.00870027
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00868291
DAPK2 death-associated protein kinase 2 0.00866151
FAF2 Fas associated factor family member 2 0.00857661
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.00856052
RNMT RNA (guanine-7-) methyltransferase 0.00854054
MCTP1 multiple C2 domains, transmembrane 1 0.00841681
KAT6B K(lysine) acetyltransferase 6B 0.00835012
DIABLO diablo, IAP-binding mitochondrial protein 0.00826456
GOLGA3 golgin A3 0.0082161
POF1B premature ovarian failure, 1B 0.00802694
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 0.00802584
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 0.00787205
CLMN calmin (calponin-like, transmembrane) 0.00783988
TTLL10 tubulin tyrosine ligase-like family member 10 0.00783128
UBA6 ubiquitin-like modifier activating enzyme 6 0.00773419
IKZF2 IKAROS family zinc finger 2 (Helios) 0.00768933
SORBS2 sorbin and SH3 domain containing 2 0.00763274
SCARB1 scavenger receptor class B, member 1 0.00762553
DYNC2I1 dynein 2 intermediate chain 1 0.00757263
TMEM65 transmembrane protein 65 0.00756451
XYLT1 xylosyltransferase I 0.00751421
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.00749948
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.00749212
TUT7 terminal uridylyl transferase 7 0.00746136
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.00745593
RAB2A RAB2A, member RAS oncogene family 0.00743157
NFX1 nuclear transcription factor, X-box binding 1 0.00742069
ACOX1 acyl-CoA oxidase 1, palmitoyl 0.0072917
CFAP20DC CFAP20 domain containing 0.00723751
RAB22A RAB22A, member RAS oncogene family 0.00721039
ZNF33A zinc finger protein 33A 0.007197
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.00717189
SRP9 signal recognition particle 9kDa 0.00715804
ERMP1 endoplasmic reticulum metallopeptidase 1 0.00706048
HBP1 HMG-box transcription factor 1 0.00702604
LGALS8 lectin, galactoside-binding, soluble, 8 0.00699188
RLF rearranged L-myc fusion 0.00696134
STK39 serine threonine kinase 39 0.00687483
PPARD peroxisome proliferator-activated receptor delta 0.00684858
STARD4 StAR-related lipid transfer (START) domain containing 4 0.00683667
ADAM17 ADAM metallopeptidase domain 17 0.00681215
TMEM87B transmembrane protein 87B 0.00680494
AGR2 anterior gradient 2 0.0067986
CLOCK clock circadian regulator 0.00667523
ZNF460 zinc finger protein 460 0.00661631

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.130665
UBC ubiquitin C -0.117541
TPT1 tumor protein, translationally-controlled 1 -0.114202
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.112733
LCN2 lipocalin 2 -0.0897235
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0803939
IFI6 interferon, alpha-inducible protein 6 -0.0787036
RNF213 ring finger protein 213 -0.0764401
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0756793
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0680503
PKM pyruvate kinase, muscle -0.0645929
PTMA prothymosin, alpha -0.0638422
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0626813
HLA-B major histocompatibility complex, class I, B -0.0605777
ENO1 enolase 1, (alpha) -0.0593799
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0576186
STK24 serine/threonine kinase 24 -0.0561678
EPSTI1 epithelial stromal interaction 1 (breast) -0.0551574
RPL23 ribosomal protein L23 -0.0548562
RPS6 ribosomal protein S6 -0.0546944
PERP PERP, TP53 apoptosis effector -0.0542231
C6ORF132 chromosome 6 open reading frame 132 -0.0529161
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0523314
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0487473
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0486934
JUN jun proto-oncogene -0.0485149
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0483536
TSC22D1 TSC22 domain family, member 1 -0.0464932
TMSB10 thymosin beta 10 -0.0461825
RUNX1 runt-related transcription factor 1 -0.0458009
AHNAK AHNAK nucleoprotein -0.0428479
BTBD9 BTB (POZ) domain containing 9 -0.0421718
IFI27 interferon, alpha-inducible protein 27 -0.0413062
EIF1 eukaryotic translation initiation factor 1 -0.0409628
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0408249
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0408045
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0407476
RPLP1 ribosomal protein, large, P1 -0.0402825
MX1 MX dynamin-like GTPase 1 -0.0400373
EPCAM epithelial cell adhesion molecule -0.0399489
MYO1E myosin IE -0.0399144
ACTN4 actinin, alpha 4 -0.0389825
RNF43 ring finger protein 43 -0.0374092
MX2 MX dynamin-like GTPase 2 -0.0361842
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.036093
NCKAP5 NCK-associated protein 5 -0.0360836
RPS3 ribosomal protein S3 -0.0360213
FAT1 FAT atypical cadherin 1 -0.0355329
CALR calreticulin -0.0352178
FTL ferritin, light polypeptide -0.0349239
RRBP1 ribosome binding protein 1 -0.0347369
EEF2 eukaryotic translation elongation factor 2 -0.0347022
RPS8 ribosomal protein S8 -0.0340183
LDHA lactate dehydrogenase A -0.0339877
BPTF bromodomain PHD finger transcription factor -0.0337965
TXNIP thioredoxin interacting protein -0.0333843
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0332944
RPL19 ribosomal protein L19 -0.0329746
VMP1 vacuole membrane protein 1 -0.0324289
PRRC2C proline-rich coiled-coil 2C -0.0321264
SP100 SP100 nuclear antigen -0.031846
ZMYND8 zinc finger, MYND-type containing 8 -0.0316573
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0315276
RPL35A ribosomal protein L35a -0.0314092
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0310858
PDIA4 protein disulfide isomerase family A, member 4 -0.0309538
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0302025
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0299292
MT2A metallothionein 2A -0.029725
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0293839
MYH9 myosin, heavy chain 9, non-muscle -0.0292392
RHOBTB3 Rho-related BTB domain containing 3 -0.0289701
DSCAM Down syndrome cell adhesion molecule -0.0288754
LOC102724023 ES1 protein homolog, mitochondrial -0.0286751
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0285906
RPL12 ribosomal protein L12 -0.0276738
ACTG1 actin gamma 1 -0.027601
ADAR adenosine deaminase, RNA-specific -0.0275956
LOC112694756 uncharaterized LOC112694756 -0.0272466
LPP LIM domain containing preferred translocation partner in lipoma -0.0271872
ATXN1 ataxin 1 -0.0270385
TMC5 transmembrane channel-like 5 -0.0270045
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0269689
TRERF1 transcriptional regulating factor 1 -0.0268225
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0263522
RPS27 ribosomal protein S27 -0.0261983
PHF3 PHD finger protein 3 -0.0256204
S100A10 S100 calcium binding protein A10 -0.025495
TMEM62 transmembrane protein 62 -0.0252062
SFTPA2 surfactant protein A2 -0.025111
RPL37A ribosomal protein L37a -0.02493
NIPBL Nipped-B homolog (Drosophila) -0.024848
RPL7L1 ribosomal protein L7-like 1 -0.0247217
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0246907
TM9SF2 transmembrane 9 superfamily member 2 -0.0245259
IFNGR1 interferon gamma receptor 1 -0.0245187
RPS27A ribosomal protein S27a -0.0244187
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0243956
RPLP2 ribosomal protein, large, P2 -0.024303
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0242583