Benproperine (phosphate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.174712
CXCL8 chemokine (C-X-C motif) ligand 8 0.150354
RTN4 reticulon 4 0.0962087
NAMPT nicotinamide phosphoribosyltransferase 0.0834192
COL6A3 collagen, type VI, alpha 3 0.0761666
CADM1 cell adhesion molecule 1 0.0610164
DGKD diacylglycerol kinase, delta 130kDa 0.0608131
GARS1 glycyl-tRNA synthetase 1 0.059455
TXNRD1 thioredoxin reductase 1 0.0591919
EGFR epidermal growth factor receptor 0.0584109
ZFAND3 zinc finger, AN1-type domain 3 0.0576045
LRRC49 leucine rich repeat containing 49 0.0503434
TRIO trio Rho guanine nucleotide exchange factor 0.0482286
ATXN1 ataxin 1 0.0478118
AHNAK AHNAK nucleoprotein 0.0468013
ATP13A3 ATPase type 13A3 0.0467351
IL6ST interleukin 6 signal transducer 0.0460005
ANKRD11 ankyrin repeat domain 11 0.0449313
CD44 CD44 molecule (Indian blood group) 0.0444519
MAP1B microtubule-associated protein 1B 0.0436206
USP47 ubiquitin specific peptidase 47 0.0427119
SBF2 SET binding factor 2 0.0423087
ANKRD17 ankyrin repeat domain 17 0.0420464
GLIS3 GLIS family zinc finger 3 0.0418653
TNS3 tensin 3 0.0406189
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0399627
MSN moesin 0.0396349
EXT1 exostosin glycosyltransferase 1 0.0389225
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0385207
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0384328
SMAD3 SMAD family member 3 0.0377358
TPM4 tropomyosin 4 0.0374245
COG5 component of oligomeric golgi complex 5 0.0372228
ERRFI1 ERBB receptor feedback inhibitor 1 0.0361062
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.035977
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0352229
LPP LIM domain containing preferred translocation partner in lipoma 0.0347493
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0341361
ELL2 elongation factor, RNA polymerase II, 2 0.0326694
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0317633
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0317617
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.031491
PALM2AKAP2 PALM2 and AKAP2 fusion 0.031486
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0312733
MED13L mediator complex subunit 13-like 0.031175
NIPBL Nipped-B homolog (Drosophila) 0.0309894
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0300826
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0296325
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.028248
SOD2 superoxide dismutase 2, mitochondrial 0.0281838
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0279539
AKAP12 A kinase (PRKA) anchor protein 12 0.0279295
MAP4 microtubule-associated protein 4 0.0273994
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0271764
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0270549
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0268661
TOP1 topoisomerase (DNA) I 0.0266411
HIPK2 homeodomain interacting protein kinase 2 0.0266357
BIRC6 baculoviral IAP repeat containing 6 0.0265916
TNPO1 transportin 1 0.0264546
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0264193
MYH9 myosin, heavy chain 9, non-muscle 0.0263987
CALD1 caldesmon 1 0.0263557
MYO10 myosin X 0.0260893
MEF2A myocyte enhancer factor 2A 0.0259963
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0259834
JMJD1C jumonji domain containing 1C 0.0259797
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0258526
WWTR1 WW domain containing transcription regulator 1 0.0257902
ADAM9 ADAM metallopeptidase domain 9 0.0257401
NFE2L2 nuclear factor, erythroid 2-like 2 0.0256222
AHR aryl hydrocarbon receptor 0.0255806
BPTF bromodomain PHD finger transcription factor 0.0253747
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0250754
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0249229
TJP1 tight junction protein 1 0.0248528
PARVA parvin, alpha 0.0248267
LCOR ligand dependent nuclear receptor corepressor 0.0247887
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0246776
NKTR natural killer cell triggering receptor 0.0243286
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0238916
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0238868
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0238355
TPM3 tropomyosin 3 0.023737
SPRED2 sprouty-related, EVH1 domain containing 2 0.0236703
ADAM17 ADAM metallopeptidase domain 17 0.0235087
INHBA inhibin, beta A 0.0233827
MAML2 mastermind-like 2 (Drosophila) 0.0227171
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0226723
SLC38A2 solute carrier family 38, member 2 0.0225375
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.022323
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0222996
USP15 ubiquitin specific peptidase 15 0.0220354
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0220128
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0217322
TRIP12 thyroid hormone receptor interactor 12 0.0217165
MED13 mediator complex subunit 13 0.0217155
BRD4 bromodomain containing 4 0.0216725
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0213727
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0209215

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.124691
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.120901
TMSB10 thymosin beta 10 -0.111353
IGFBP3 insulin-like growth factor binding protein 3 -0.105092
FTL ferritin, light polypeptide -0.0891421
NDRG1 N-myc downstream regulated 1 -0.0789111
MT2A metallothionein 2A -0.0743059
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0735843
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0585519
GRB10 growth factor receptor-bound protein 10 -0.0585101
RPS19 ribosomal protein S19 -0.0488081
HILPDA hypoxia inducible lipid droplet-associated -0.0470822
FN1 fibronectin 1 -0.0451515
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0403585
SQSTM1 sequestosome 1 -0.0394129
RPLP2 ribosomal protein, large, P2 -0.0383653
RPL35A ribosomal protein L35a -0.0379908
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0372298
RPL37A ribosomal protein L37a -0.0365605
RPLP1 ribosomal protein, large, P1 -0.0364733
FAM13A family with sequence similarity 13, member A -0.0351172
RPS8 ribosomal protein S8 -0.0343462
B2M beta-2-microglobulin -0.0342899
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0341274
NOP58 NOP58 ribonucleoprotein -0.0324856
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0319973
RPL27A ribosomal protein L27a -0.0318423
TGFBI transforming growth factor, beta-induced, 68kDa -0.0317202
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0311693
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0305868
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0301981
RPS13 ribosomal protein S13 -0.030114
LOC112694756 uncharaterized LOC112694756 -0.0297734
LDHA lactate dehydrogenase A -0.0294158
RPS12 ribosomal protein S12 -0.0287352
DST dystonin -0.0286636
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0278644
ZNF395 zinc finger protein 395 -0.0275913
LMNA lamin A/C -0.0269909
SEC61G Sec61 gamma subunit -0.0269222
PTPRD protein tyrosine phosphatase, receptor type, D -0.0268112
DTNA dystrobrevin, alpha -0.0266228
LRRC23 leucine rich repeat containing 23 -0.0265607
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0263951
PTMA prothymosin, alpha -0.0260199
RPL31 ribosomal protein L31 -0.0259619
RPL37 ribosomal protein L37 -0.0258135
RPL11 ribosomal protein L11 -0.0255383
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0248201
RPS16 ribosomal protein S16 -0.0246276
TPT1 tumor protein, translationally-controlled 1 -0.0244754
HLA-A major histocompatibility complex, class I, A -0.0244706
ASPH aspartate beta-hydroxylase -0.0244177
MMP12 matrix metallopeptidase 12 -0.0242312
RPS5 ribosomal protein S5 -0.0235633
BZW2 basic leucine zipper and W2 domains 2 -0.0229893
RIGI RNA sensor RIG-I -0.022893
RPS27A ribosomal protein S27a -0.022793
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0227907
IGFBP5 insulin-like growth factor binding protein 5 -0.0223059
RPL36 ribosomal protein L36 -0.0220085
PDE4D phosphodiesterase 4D, cAMP-specific -0.0219716
HLA-B major histocompatibility complex, class I, B -0.0218437
RPL7A ribosomal protein L7a -0.0217932
INTS6 integrator complex subunit 6 -0.0217841
INSIG2 insulin induced gene 2 -0.0217487
GLRX glutaredoxin (thioltransferase) -0.0217143
RPL28 ribosomal protein L28 -0.0217124
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0215334
RPL19 ribosomal protein L19 -0.0208611
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0207661
RPL7 ribosomal protein L7 -0.0207145
FAM162A family with sequence similarity 162, member A -0.0207034
RPL12 ribosomal protein L12 -0.0206987
LMAN1 lectin, mannose-binding, 1 -0.0205506
DDIT4 DNA-damage-inducible transcript 4 -0.020396
ZBTB20 zinc finger and BTB domain containing 20 -0.0202961
RPS23 ribosomal protein S23 -0.0199027
NABP1 nucleic acid binding protein 1 -0.0198921
OXR1 oxidation resistance 1 -0.0195472
TPI1 triosephosphate isomerase 1 -0.0194156
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0192172
RUNX1 runt-related transcription factor 1 -0.0191955
GLCCI1 glucocorticoid induced 1 -0.0190762
RPL9 ribosomal protein L9 -0.0187159
KDM3B lysine (K)-specific demethylase 3B -0.0186363
COPA coatomer protein complex, subunit alpha -0.0185805
SRP54 signal recognition particle 54kDa -0.0184623
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0184378
SFXN1 sideroflexin 1 -0.0183462
FUS FUS RNA binding protein -0.0183194
RPS6 ribosomal protein S6 -0.018269
UBAP2 ubiquitin associated protein 2 -0.0182281
RPLP0 ribosomal protein, large, P0 -0.0181655
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0180539
SMC4 structural maintenance of chromosomes 4 -0.0178908
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -0.0175751
BACE2 beta-site APP-cleaving enzyme 2 -0.0172647
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0172518
ZNF804A zinc finger protein 804A -0.0172436