Benproperine (phosphate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.127416
NUP58 nucleoporin 58 0.0775397
TMSB10 thymosin beta 10 0.0723406
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0697461
PTMA prothymosin, alpha 0.0634882
TOP2A topoisomerase (DNA) II alpha 170kDa 0.049971
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0478122
GOLGA4 golgin A4 0.0440904
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.043924
GARS1 glycyl-tRNA synthetase 1 0.0410903
ERRFI1 ERBB receptor feedback inhibitor 1 0.0407033
RUNX1 runt-related transcription factor 1 0.0383845
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0379953
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0370999
USP3 ubiquitin specific peptidase 3 0.0365653
RNMT RNA (guanine-7-) methyltransferase 0.0365034
UBA6 ubiquitin-like modifier activating enzyme 6 0.0364381
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0330267
RAB6A RAB6A, member RAS oncogene family 0.0329891
SPAG9 sperm associated antigen 9 0.0316816
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0309243
FAM117B family with sequence similarity 117, member B 0.029681
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0293177
TSC22D2 TSC22 domain family, member 2 0.0287491
RLF rearranged L-myc fusion 0.0287482
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0284685
TRIO trio Rho guanine nucleotide exchange factor 0.0284188
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0270878
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0267146
ESYT2 extended synaptotagmin-like protein 2 0.0265255
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0262474
ELL2 elongation factor, RNA polymerase II, 2 0.0247274
DLG1 discs, large homolog 1 (Drosophila) 0.024399
WSB1 WD repeat and SOCS box containing 1 0.0243704
FOXO3 forkhead box O3 0.0243157
UBA2 ubiquitin-like modifier activating enzyme 2 0.0240897
RCOR1 REST corepressor 1 0.0236304
ZFC3H1 zinc finger, C3H1-type containing 0.0235551
NOP58 NOP58 ribonucleoprotein 0.0226517
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0225775
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.022317
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0223084
BLZF1 basic leucine zipper nuclear factor 1 0.022294
LMAN1 lectin, mannose-binding, 1 0.0221239
TRIM33 tripartite motif containing 33 0.0216094
RIOK3 RIO kinase 3 0.0206951
TPT1 tumor protein, translationally-controlled 1 0.0200197
SUCO SUN domain containing ossification factor 0.0196613
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0190245
PRRC2C proline-rich coiled-coil 2C 0.0190174
S100A10 S100 calcium binding protein A10 0.0188706
CDCP1 CUB domain containing protein 1 0.0186528
KDM7A lysine (K)-specific demethylase 7A 0.0185932
SGO2 shugoshin 2 0.0184372
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0181715
UGCG UDP-glucose ceramide glucosyltransferase 0.0179212
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0178564
ANKRD11 ankyrin repeat domain 11 0.0178137
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0176558
FAM193A family with sequence similarity 193, member A 0.0174621
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0173667
IPO7 importin 7 0.0173096
FAM107B family with sequence similarity 107, member B 0.0171988
WDR45B WD repeat domain 45B 0.0171572
MAP2K1 mitogen-activated protein kinase kinase 1 0.0171271
TENT2 terminal nucleotidyltransferase 2 0.0170389
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0170228
HJURP Holliday junction recognition protein 0.0169606
ZSWIM6 zinc finger, SWIM-type containing 6 0.016792
USP37 ubiquitin specific peptidase 37 0.016732
EGFR epidermal growth factor receptor 0.0166223
FTL ferritin, light polypeptide 0.0165139
TRAM1 translocation associated membrane protein 1 0.016454
FBL fibrillarin 0.0163757
AGO3 argonaute RISC catalytic component 3 0.016253
CLINT1 clathrin interactor 1 0.0161581
SRP54 signal recognition particle 54kDa 0.0161109
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0161015
ANLN anillin, actin binding protein 0.0159392
ATP13A3 ATPase type 13A3 0.0158622
DIAPH3 diaphanous-related formin 3 0.0156806
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0156443
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0156124
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0155881
ERBIN erbb2 interacting protein 0.0153596
PROSER2 proline and serine rich 2 0.0152337
SLK STE20-like kinase 0.0150726
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0150548
MIMS1 mitochondrial inner membrane scaffold 1 0.0150321
SH3GL1 SH3-domain GRB2-like 1 0.0149936
BZW1 basic leucine zipper and W2 domains 1 0.0149467
MT2A metallothionein 2A 0.0149346
PSD3 pleckstrin and Sec7 domain containing 3 0.0148136
UBAP1 ubiquitin associated protein 1 0.0148011
USP36 ubiquitin specific peptidase 36 0.0146732
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0146581
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0145884
FN1 fibronectin 1 0.0144177
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0143857
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0143043

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.120625
PRELID2 PRELI domain containing 2 -0.0987246
FAT1 FAT atypical cadherin 1 -0.0985862
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.078607
RAD51B RAD51 paralog B -0.0780226
FHIT fragile histidine triad -0.075603
MBD5 methyl-CpG binding domain protein 5 -0.0673738
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0667294
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0603038
KDM4C lysine (K)-specific demethylase 4C -0.0570057
VCL vinculin -0.0512429
PATJ PATJ crumbs cell polarity complex component -0.05042
ZBTB20 zinc finger and BTB domain containing 20 -0.0474907
TXNRD1 thioredoxin reductase 1 -0.0472565
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0462572
EXOC4 exocyst complex component 4 -0.0459753
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0457364
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0437226
CANX calnexin -0.043492
ARF4 ADP-ribosylation factor 4 -0.0422316
TENM3 teneurin transmembrane protein 3 -0.0384826
SQSTM1 sequestosome 1 -0.037829
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0375145
GOLGB1 golgin B1 -0.0369428
SUMF1 sulfatase modifying factor 1 -0.0363488
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.036238
MYO9A myosin IXA -0.0359558
METTL15 methyltransferase like 15 -0.0358664
LSR lipolysis stimulated lipoprotein receptor -0.0350423
EEF2 eukaryotic translation elongation factor 2 -0.0334375
BBS9 Bardet-Biedl syndrome 9 -0.0330242
SPIDR scaffolding protein involved in DNA repair -0.0329316
PKP2 plakophilin 2 -0.0323298
RRBP1 ribosome binding protein 1 -0.0321364
EGR1 early growth response 1 -0.0320061
ANKRD12 ankyrin repeat domain 12 -0.0317049
NF1 neurofibromin 1 -0.0316545
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0314417
TPM4 tropomyosin 4 -0.0312016
ZNF638 zinc finger protein 638 -0.0306109
BBX bobby sox homolog (Drosophila) -0.0301708
LPP LIM domain containing preferred translocation partner in lipoma -0.0297168
TBC1D5 TBC1 domain family, member 5 -0.0288532
TAS2R14 taste receptor, type 2, member 14 -0.0286257
ZC3H12B zinc finger CCCH-type containing 12B -0.0284414
FUS FUS RNA binding protein -0.02739
MED13L mediator complex subunit 13-like -0.0273799
TCF12 transcription factor 12 -0.0268456
RPL26 ribosomal protein L26 -0.0268059
BPTF bromodomain PHD finger transcription factor -0.0267777
PDZD8 PDZ domain containing 8 -0.0266218
RPL4 ribosomal protein L4 -0.0264833
ARB2A ARB2 cotranscriptional regulator A -0.0257774
HDAC8 histone deacetylase 8 -0.0256201
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0256082
UBXN4 UBX domain protein 4 -0.0254263
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0253311
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0252957
BCAS3 breast carcinoma amplified sequence 3 -0.0251063
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0249766
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0247682
KIAA1217 KIAA1217 -0.0247182
RBBP6 retinoblastoma binding protein 6 -0.024711
LDLR low density lipoprotein receptor -0.0243668
TBC1D4 TBC1 domain family, member 4 -0.0242995
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0241757
SON SON DNA binding protein -0.0241514
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0240525
BABAM2 BRISC and BRCA1 A complex member 2 -0.0240389
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0238984
EXOC6B exocyst complex component 6B -0.0238926
WWOX WW domain containing oxidoreductase -0.0238013
PHF3 PHD finger protein 3 -0.0236872
GPHN gephyrin -0.0234201
NEBL nebulette -0.0231847
YAP1 Yes-associated protein 1 -0.0231841
UTRN utrophin -0.0231711
FOXP1 forkhead box P1 -0.0230883
FBXL17 F-box and leucine-rich repeat protein 17 -0.0230554
SHROOM3 shroom family member 3 -0.0229319
JMJD1C jumonji domain containing 1C -0.0228354
EPB41 erythrocyte membrane protein band 4.1 -0.0226301
WWC2 WW and C2 domain containing 2 -0.0226275
RNF213 ring finger protein 213 -0.0225449
AEBP2 AE binding protein 2 -0.0224788
GPBP1L1 GC-rich promoter binding protein 1-like 1 -0.0224332
LOC112694756 uncharaterized LOC112694756 -0.0223351
UGDH UDP-glucose 6-dehydrogenase -0.022258
DENND4C DENN/MADD domain containing 4C -0.0221986
ATXN1 ataxin 1 -0.022176
HOXB3 homeobox B3 -0.0220288
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0218693
CD2AP CD2-associated protein -0.0217928
AKAP9 A kinase (PRKA) anchor protein 9 -0.0217628
SEC31A SEC31 homolog A (S. cerevisiae) -0.0216895
FER fer (fps/fes related) tyrosine kinase -0.0214973
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0214225
RBM39 RNA binding motif protein 39 -0.0213946
NFIA nuclear factor I/A -0.0213546
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0213257