Benproperine (phosphate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Benproperine (phosphate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZBTB20 zinc finger and BTB domain containing 20 0.0780005
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0612882
MT2A metallothionein 2A 0.0478926
ZFAND3 zinc finger, AN1-type domain 3 0.0473305
DLC1 DLC1 Rho GTPase activating protein 0.0464403
RAD51B RAD51 paralog B 0.0454434
LIMCH1 LIM and calponin homology domains 1 0.0423259
N4BP2L2 NEDD4 binding protein 2-like 2 0.0417667
HMGA2 high mobility group AT-hook 2 0.0369383
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0349778
CBX3 chromobox homolog 3 0.0339005
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0329871
THSD4 thrombospondin, type I, domain containing 4 0.0319698
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0318771
MKI67 marker of proliferation Ki-67 0.0312551
PSD3 pleckstrin and Sec7 domain containing 3 0.0304304
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0293265
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0292943
LPP LIM domain containing preferred translocation partner in lipoma 0.0288072
POTEF POTE ankyrin domain family, member F 0.0275763
EGFR epidermal growth factor receptor 0.0273157
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0271889
ERBIN erbb2 interacting protein 0.0268014
FHIT fragile histidine triad 0.0262662
NSRP1 nuclear speckle splicing regulatory protein 1 0.0262659
TAOK1 TAO kinase 1 0.0260038
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0254775
DCAF7 DDB1 and CUL4 associated factor 7 0.0250911
SPDYA speedy/RINGO cell cycle regulator family member A 0.025023
RHEX regulator of hemoglobinization and erythroid cell expansion 0.0250007
SMYD3 SET and MYND domain containing 3 0.0249155
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0243472
DEK DEK proto-oncogene 0.0241667
CDK13 cyclin-dependent kinase 13 0.0241536
ENO1 enolase 1, (alpha) 0.0232075
LAMA4 laminin, alpha 4 0.0228325
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0225074
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0224354
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0223008
MAML2 mastermind-like 2 (Drosophila) 0.022229
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0218829
EHBP1 EH domain binding protein 1 0.0217252
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.021259
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.0209964
PTEN phosphatase and tensin homolog 0.0207913
FNIP1 folliculin interacting protein 1 0.0207289
CDK12 cyclin-dependent kinase 12 0.0206682
CTNND1 catenin (cadherin-associated protein), delta 1 0.0206571
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.0204721
RANBP17 RAN binding protein 17 0.0203372
WWOX WW domain containing oxidoreductase 0.0201909
EXOC4 exocyst complex component 4 0.0200467
BICD1 bicaudal D homolog 1 (Drosophila) 0.0198764
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0198565
HDAC9 histone deacetylase 9 0.0197146
AIG1 androgen-induced 1 0.0195352
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.019524
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0192917
DIAPH3 diaphanous-related formin 3 0.0190846
DIAPH2 diaphanous-related formin 2 0.0188959
DOCK3 dedicator of cytokinesis 3 0.0187197
ZRANB3 zinc finger, RAN-binding domain containing 3 0.0187072
TMEM14B transmembrane protein 14B 0.0185576
SETD5 SET domain containing 5 0.0184518
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0183619
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0183316
LINGO2 leucine rich repeat and Ig domain containing 2 0.0183261
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0182864
SERBP1 SERPINE1 mRNA binding protein 1 0.0182241
ZFP36L1 ZFP36 ring finger protein-like 1 0.0181156
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.0180103
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0177813
RNF13 ring finger protein 13 0.0176037
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0175824
R3HDM1 R3H domain containing 1 0.0175583
SRRM1 serine/arginine repetitive matrix 1 0.0174733
NF1 neurofibromin 1 0.0173363
SH3KBP1 SH3-domain kinase binding protein 1 0.0172421
PURB purine-rich element binding protein B 0.0171909
GPR75-ASB3 GPR75-ASB3 readthrough 0.0170626
PDE4D phosphodiesterase 4D, cAMP-specific 0.0170563
DOCK4 dedicator of cytokinesis 4 0.0170326
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0170213
ITGA6 integrin, alpha 6 0.0170168
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0169222
CD2AP CD2-associated protein 0.0169152
THSD7A thrombospondin, type I, domain containing 7A 0.0169147
MYO10 myosin X 0.0168359
PA2G4 proliferation-associated 2G4, 38kDa 0.0167829
CCDC88A coiled-coil domain containing 88A 0.0165652
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.016535
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0163677
TMCC1 transmembrane and coiled-coil domain family 1 0.0163261
FOXJ3 forkhead box J3 0.0162176
SLC35F3 solute carrier family 35, member F3 0.0161991
BPTF bromodomain PHD finger transcription factor 0.0160978
PDHX pyruvate dehydrogenase complex, component X 0.0160492
RABGAP1L RAB GTPase activating protein 1-like 0.0160457
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0160329
PCBP2 poly(rC) binding protein 2 0.0159295

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.105882
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.1057
ANXA2 annexin A2 -0.0907446
APP amyloid beta (A4) precursor protein -0.0862644
SMAD3 SMAD family member 3 -0.0742878
RPS8 ribosomal protein S8 -0.0690969
NDRG1 N-myc downstream regulated 1 -0.0687461
LAMB3 laminin, beta 3 -0.0670111
ACTG1 actin gamma 1 -0.0650006
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0643755
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0630147
MYH9 myosin, heavy chain 9, non-muscle -0.0594718
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0592303
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0581002
SQSTM1 sequestosome 1 -0.0575995
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0551877
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.05303
KLF6 Kruppel-like factor 6 -0.0526063
RPLP1 ribosomal protein, large, P1 -0.0523999
RPL23 ribosomal protein L23 -0.0501925
RACK1 receptor for activated C kinase 1 -0.0501757
EEF2 eukaryotic translation elongation factor 2 -0.0489639
ACTN4 actinin, alpha 4 -0.0471321
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0468907
RPL26 ribosomal protein L26 -0.0466682
RPL31 ribosomal protein L31 -0.0454876
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.044856
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.0446915
RPL12 ribosomal protein L12 -0.0442134
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.043762
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0434693
RPL35A ribosomal protein L35a -0.0434204
SBF2 SET binding factor 2 -0.043299
RTN4 reticulon 4 -0.0427687
GNAS GNAS complex locus -0.0420053
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0416138
RPS2 ribosomal protein S2 -0.0408853
EIF1 eukaryotic translation initiation factor 1 -0.0403399
FTH1 ferritin, heavy polypeptide 1 -0.0402107
RPS5 ribosomal protein S5 -0.0398428
PKM pyruvate kinase, muscle -0.0389554
DDIT4 DNA-damage-inducible transcript 4 -0.0387824
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0387088
OGA O-GlcNAcase -0.0376424
RPS6 ribosomal protein S6 -0.0372236
HELZ helicase with zinc finger -0.0371988
MYO1D myosin ID -0.0370663
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0370586
SNX9 sorting nexin 9 -0.0368338
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0364573
S100A6 S100 calcium binding protein A6 -0.0363099
RPL5 ribosomal protein L5 -0.0362715
RPS12 ribosomal protein S12 -0.0358936
RPS25 ribosomal protein S25 -0.0356125
RPL37A ribosomal protein L37a -0.0353014
RPS16 ribosomal protein S16 -0.0350553
AFDN afadin, adherens junction formation factor -0.0348109
RPL9 ribosomal protein L9 -0.0343852
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0336774
NAP1L1 nucleosome assembly protein 1-like 1 -0.0335315
KDM3A lysine (K)-specific demethylase 3A -0.0334599
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0329116
CELF2 CUGBP, Elav-like family member 2 -0.0327066
RPS24 ribosomal protein S24 -0.0326173
BRWD3 bromodomain and WD repeat domain containing 3 -0.0325344
RPL13A ribosomal protein L13a -0.0324544
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0323169
RPL27A ribosomal protein L27a -0.0320545
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0319397
WDR45B WD repeat domain 45B -0.0315231
OLA1 Obg-like ATPase 1 -0.0312966
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0312784
DENND4C DENN/MADD domain containing 4C -0.0311256
SFXN1 sideroflexin 1 -0.0310159
HMGB1 high mobility group box 1 -0.030951
VCL vinculin -0.0307628
KRT7 keratin 7, type II -0.0304445
FBXL2 F-box and leucine-rich repeat protein 2 -0.0302691
PAX8 paired box 8 -0.0298372
TUBB tubulin, beta class I -0.0297804
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0297801
ARF1 ADP-ribosylation factor 1 -0.029687
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0296622
RPL34 ribosomal protein L34 -0.0296205
NCKAP1 NCK-associated protein 1 -0.0292014
ANKRD28 ankyrin repeat domain 28 -0.0290622
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0289687
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0287858
RPL7A ribosomal protein L7a -0.0287557
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0285653
MSI2 musashi RNA-binding protein 2 -0.0285032
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0283321
FLNA filamin A, alpha -0.0283122
MED13L mediator complex subunit 13-like -0.0282478
HLA-C major histocompatibility complex, class I, C -0.0280376
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0278777
CEP95 centrosomal protein 95kDa -0.0278456
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0278391
S100A10 S100 calcium binding protein A10 -0.0276085
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0275264