Benproperine (phosphate)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in HOP62 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Benproperine (phosphate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.121655
TRIO trio Rho guanine nucleotide exchange factor 0.113072
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.108791
CXCL8 chemokine (C-X-C motif) ligand 8 0.0962003
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0896116
FAM13A family with sequence similarity 13, member A 0.0800355
ANKRD12 ankyrin repeat domain 12 0.0780469
ERRFI1 ERBB receptor feedback inhibitor 1 0.0658614
FNDC3B fibronectin type III domain containing 3B 0.0641214
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.06109
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0584904
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0557457
ASPH aspartate beta-hydroxylase 0.0548684
CD44 CD44 molecule (Indian blood group) 0.0538092
AHNAK AHNAK nucleoprotein 0.0533318
NGLY1 N-glycanase 1 0.0519317
TAS2R14 taste receptor, type 2, member 14 0.0486543
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0475027
CD109 CD109 molecule 0.0456745
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0448127
MATR3 matrin 3 0.0447064
SPAG9 sperm associated antigen 9 0.0443556
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0431531
MYOF myoferlin 0.042391
JARID2 jumonji, AT rich interactive domain 2 0.0418625
AKAP12 A kinase (PRKA) anchor protein 12 0.041344
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0406732
ELL2 elongation factor, RNA polymerase II, 2 0.0406623
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0405864
CEP350 centrosomal protein 350kDa 0.040181
OGA O-GlcNAcase 0.0397559
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0388819
TTC3 tetratricopeptide repeat domain 3 0.0381483
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0373967
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0373589
PCBP3 poly(rC) binding protein 3 0.0371792
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0367263
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0364001
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0363213
GLIS3 GLIS family zinc finger 3 0.036057
UBA6 ubiquitin-like modifier activating enzyme 6 0.0360141
TM9SF3 transmembrane 9 superfamily member 3 0.0357213
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.035293
PTPRM protein tyrosine phosphatase, receptor type, M 0.0351158
NAV2 neuron navigator 2 0.0349786
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0349596
MYO10 myosin X 0.0346909
CALU calumenin 0.0346539
GOLGA4 golgin A4 0.0344948
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0342045
CDH13 cadherin 13 0.0339862
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0339563
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0338694
LDHA lactate dehydrogenase A 0.0337385
SUCO SUN domain containing ossification factor 0.0334973
PRELID2 PRELI domain containing 2 0.0326887
PTK2 protein tyrosine kinase 2 0.0325182
CANX calnexin 0.032424
GRB10 growth factor receptor-bound protein 10 0.0323233
COPB1 coatomer protein complex, subunit beta 1 0.03228
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0321413
FNIP1 folliculin interacting protein 1 0.0316477
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0314789
NBAS neuroblastoma amplified sequence 0.0310993
TNIP1 TNFAIP3 interacting protein 1 0.0307943
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0306863
CLTC clathrin, heavy chain (Hc) 0.0306705
MORF4L2 mortality factor 4 like 2 0.0306668
PDIA3 protein disulfide isomerase family A, member 3 0.0305947
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0305289
SETD5 SET domain containing 5 0.0304808
PRRC2C proline-rich coiled-coil 2C 0.0303018
RRM2 ribonucleotide reductase M2 0.0301431
ACBD3 acyl-CoA binding domain containing 3 0.0300253
SEPTIN2 septin 2 0.029806
HELZ helicase with zinc finger 0.0292339
SBF2 SET binding factor 2 0.0291358
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0291141
KDM2A lysine (K)-specific demethylase 2A 0.0289937
RBM39 RNA binding motif protein 39 0.0286869
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0286655
ZNF292 zinc finger protein 292 0.0283871
RB1CC1 RB1-inducible coiled-coil 1 0.0283644
NAMPT nicotinamide phosphoribosyltransferase 0.0278918
INHBA inhibin, beta A 0.027605
SYAP1 synapse associated protein 1 0.0274812
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0274153
ZFC3H1 zinc finger, C3H1-type containing 0.0269318
BRWD1 bromodomain and WD repeat domain containing 1 0.0268121
CLEC1B C-type lectin domain family 1, member B 0.0264722
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0262391
COL6A3 collagen, type VI, alpha 3 0.0262176
HDLBP high density lipoprotein binding protein 0.0261515
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0261362
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0260402
STC1 stanniocalcin 1 0.0259362
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0256964
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0255124
CAMTA1 calmodulin binding transcription activator 1 0.0253361
BACE2 beta-site APP-cleaving enzyme 2 0.0252784

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.433894
NDRG1 N-myc downstream regulated 1 -0.126884
EGR1 early growth response 1 -0.112399
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.101886
ACTG1 actin gamma 1 -0.0928116
IGF2 insulin-like growth factor 2 -0.0912966
COL6A1 collagen, type VI, alpha 1 -0.0757868
TMSB10 thymosin beta 10 -0.0732829
MT2A metallothionein 2A -0.0707661
TPT1 tumor protein, translationally-controlled 1 -0.0657454
HMGA2 high mobility group AT-hook 2 -0.0580676
FTL ferritin, light polypeptide -0.0546872
ENO2 enolase 2 (gamma, neuronal) -0.0457021
COL6A2 collagen, type VI, alpha 2 -0.0451941
RPL35A ribosomal protein L35a -0.0437682
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0411896
TGFBI transforming growth factor, beta-induced, 68kDa -0.0404273
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0390457
RPS16 ribosomal protein S16 -0.0386923
RPS29 ribosomal protein S29 -0.0337492
VEGFA vascular endothelial growth factor A -0.0333099
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.032089
FLNA filamin A, alpha -0.0318394
PLAUR plasminogen activator, urokinase receptor -0.0315011
RPLP1 ribosomal protein, large, P1 -0.0299618
ACTN4 actinin, alpha 4 -0.029846
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0296891
COL1A1 collagen, type I, alpha 1 -0.0293197
RPS3 ribosomal protein S3 -0.0286035
FOSL1 FOS-like antigen 1 -0.0274973
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0273577
PTPRG protein tyrosine phosphatase, receptor type, G -0.0272771
BICD1 bicaudal D homolog 1 (Drosophila) -0.0263686
MRC2 mannose receptor, C type 2 -0.0261565
POTEF POTE ankyrin domain family, member F -0.0258963
CCND1 cyclin D1 -0.025813
RPS13 ribosomal protein S13 -0.0257611
RPL34 ribosomal protein L34 -0.0257356
RPL19 ribosomal protein L19 -0.0257085
AGRN agrin -0.02557
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0255202
HLA-B major histocompatibility complex, class I, B -0.0251095
RPS14 ribosomal protein S14 -0.0249483
FTH1 ferritin, heavy polypeptide 1 -0.02479
RPS6 ribosomal protein S6 -0.0244161
RPL31 ribosomal protein L31 -0.0240877
RHOA ras homolog family member A -0.0240734
CTSB cathepsin B -0.0239423
NALF1 NALCN channel auxiliary factor 1 -0.0232053
IGFBP3 insulin-like growth factor binding protein 3 -0.0230396
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.022588
RPS10 ribosomal protein S10 -0.0225484
PLEC plectin -0.0225221
MCL1 myeloid cell leukemia 1 -0.0225015
ICAM1 intercellular adhesion molecule 1 -0.0221463
RPL7A ribosomal protein L7a -0.0219611
MPRIP myosin phosphatase Rho interacting protein -0.0214864
RPL15 ribosomal protein L15 -0.0211369
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.021094
RPS20 ribosomal protein S20 -0.0210611
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0209068
THBS1 thrombospondin 1 -0.0206887
S100A10 S100 calcium binding protein A10 -0.0206058
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0206017
RPL37A ribosomal protein L37a -0.0203377
CLIC4 chloride intracellular channel 4 -0.0201899
RYBP RING1 and YY1 binding protein -0.0197856
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0197853
TRA2B transformer 2 beta homolog (Drosophila) -0.019677
EEF2 eukaryotic translation elongation factor 2 -0.0196251
BSG basigin (Ok blood group) -0.0196164
YAP1 Yes-associated protein 1 -0.0193843
HMGA1 high mobility group AT-hook 1 -0.0193747
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0192757
RPL23 ribosomal protein L23 -0.0191945
RPS19 ribosomal protein S19 -0.0191808
VDAC1 voltage-dependent anion channel 1 -0.0190033
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0190004
MAP4 microtubule-associated protein 4 -0.018762
RPL9 ribosomal protein L9 -0.0186387
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0184077
RPLP2 ribosomal protein, large, P2 -0.0184054
RPS23 ribosomal protein S23 -0.0183164
RPS12 ribosomal protein S12 -0.0181732
TBCA tubulin folding cofactor A -0.0179854
MSN moesin -0.0177537
IER3 immediate early response 3 -0.0176012
SH2B3 SH2B adaptor protein 3 -0.0175507
INTS6 integrator complex subunit 6 -0.0175305
LPP LIM domain containing preferred translocation partner in lipoma -0.0174384
MBD5 methyl-CpG binding domain protein 5 -0.0173405
RPL38 ribosomal protein L38 -0.0172779
BRD4 bromodomain containing 4 -0.0170569
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0170367
PDE8A phosphodiesterase 8A -0.017005
LRRC23 leucine rich repeat containing 23 -0.0169271
ADM adrenomedullin -0.0166988
RAB7A RAB7A, member RAS oncogene family -0.0166597
RPS21 ribosomal protein S21 -0.0164228
DEPP1 DEPP autophagy regulator 1 -0.0163841