Benproperine (phosphate)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.16239
CXCL8 chemokine (C-X-C motif) ligand 8 0.125813
NALF1 NALCN channel auxiliary factor 1 0.0728117
TRIO trio Rho guanine nucleotide exchange factor 0.0689938
ATP13A3 ATPase type 13A3 0.0655862
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0544631
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.051759
COL6A3 collagen, type VI, alpha 3 0.0508718
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0457487
CADM1 cell adhesion molecule 1 0.0406546
PDE10A phosphodiesterase 10A 0.0405616
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0354913
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.033678
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0313528
ADAM9 ADAM metallopeptidase domain 9 0.0311052
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0306147
BBX bobby sox homolog (Drosophila) 0.0291242
GSK3B glycogen synthase kinase 3 beta 0.0281725
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0274942
F3 coagulation factor III (thromboplastin, tissue factor) 0.0238887
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0233453
FNDC3B fibronectin type III domain containing 3B 0.0224959
MBNL1 muscleblind-like splicing regulator 1 0.0222777
PRR16 proline rich 16 0.0222593
SMYD3 SET and MYND domain containing 3 0.0214075
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0212983
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0211044
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0205863
TENT5A terminal nucleotidyltransferase 5A 0.0204294
LPP LIM domain containing preferred translocation partner in lipoma 0.0202096
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0200433
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0194952
BNC2 basonuclin 2 0.0193928
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.019175
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.018719
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0186395
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0185615
NECTIN3 nectin cell adhesion molecule 3 0.0184152
JARID2 jumonji, AT rich interactive domain 2 0.0183838
CDK6 cyclin-dependent kinase 6 0.0183815
PIAS2 protein inhibitor of activated STAT, 2 0.0182294
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0179779
SOD2 superoxide dismutase 2, mitochondrial 0.0179115
ELL2 elongation factor, RNA polymerase II, 2 0.0178255
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0177897
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0176768
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0175556
POSTN periostin, osteoblast specific factor 0.0174553
TRPS1 trichorhinophalangeal syndrome I 0.0170327
VEGFC vascular endothelial growth factor C 0.017028
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0170213
HMCN1 hemicentin 1 0.016971
MSI2 musashi RNA-binding protein 2 0.0168812
RICTOR RPTOR independent companion of MTOR, complex 2 0.0168445
EXOC4 exocyst complex component 4 0.0165053
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0164065
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0161787
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0161762
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0160947
FTH1 ferritin, heavy polypeptide 1 0.0160772
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0157976
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0156763
MAML2 mastermind-like 2 (Drosophila) 0.0151804
TM9SF3 transmembrane 9 superfamily member 3 0.0146216
TIMP3 TIMP metallopeptidase inhibitor 3 0.0144987
ZFPM2 zinc finger protein, FOG family member 2 0.0144365
FOXP1 forkhead box P1 0.0144233
DLG1 discs, large homolog 1 (Drosophila) 0.0143554
BIRC6 baculoviral IAP repeat containing 6 0.0142643
ZFAND3 zinc finger, AN1-type domain 3 0.0142275
TENM3 teneurin transmembrane protein 3 0.0141922
KLF6 Kruppel-like factor 6 0.0140956
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0140618
DLC1 DLC1 Rho GTPase activating protein 0.0140031
COG5 component of oligomeric golgi complex 5 0.0135965
PAWR PRKC, apoptosis, WT1, regulator 0.0135197
GJA1 gap junction protein, alpha 1, 43kDa 0.0134893
ZNF148 zinc finger protein 148 0.0133079
PTPRG protein tyrosine phosphatase, receptor type, G 0.0133048
EPS15 epidermal growth factor receptor pathway substrate 15 0.0132607
ABI3BP ABI family, member 3 (NESH) binding protein 0.0131698
SNX9 sorting nexin 9 0.0131507
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.013144
ZNF644 zinc finger protein 644 0.0130658
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0128831
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0127918
FAT1 FAT atypical cadherin 1 0.0127834
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0126829
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0126021
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0125794
GCLM glutamate-cysteine ligase, modifier subunit 0.0125347
DPYD dihydropyrimidine dehydrogenase 0.0124091
MYO10 myosin X 0.0123508
TES testin LIM domain protein 0.0122162
FMNL2 formin-like 2 0.0121762
PDIA3 protein disulfide isomerase family A, member 3 0.0121588
CCN2 cellular communication network factor 2 0.0121267
NAV3 neuron navigator 3 0.0120668
CCDC91 coiled-coil domain containing 91 0.0120163
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0119969

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.215901
VIM vimentin -0.196741
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.189467
NDRG1 N-myc downstream regulated 1 -0.181802
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108387
VEGFA vascular endothelial growth factor A -0.0908561
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0866233
TGFBI transforming growth factor, beta-induced, 68kDa -0.0863652
CD44 CD44 molecule (Indian blood group) -0.0818266
RPS8 ribosomal protein S8 -0.0817558
PTMA prothymosin, alpha -0.0658819
FN1 fibronectin 1 -0.065625
MYH9 myosin, heavy chain 9, non-muscle -0.0622759
RPS6 ribosomal protein S6 -0.0622097
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.062068
WWTR1 WW domain containing transcription regulator 1 -0.0619406
EIF1 eukaryotic translation initiation factor 1 -0.0594287
TPM4 tropomyosin 4 -0.0572357
LOXL2 lysyl oxidase-like 2 -0.0545907
STC1 stanniocalcin 1 -0.0519298
TMSB10 thymosin beta 10 -0.0514667
RRBP1 ribosome binding protein 1 -0.0509122
ACTG1 actin gamma 1 -0.0503703
RPL7 ribosomal protein L7 -0.0494469
CALR calreticulin -0.0486671
CANX calnexin -0.0486076
RPS2 ribosomal protein S2 -0.0473172
LDHA lactate dehydrogenase A -0.047082
RPL11 ribosomal protein L11 -0.0456989
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.045578
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0451513
S100A9 S100 calcium binding protein A9 -0.0446949
FTL ferritin, light polypeptide -0.0446398
B2M beta-2-microglobulin -0.043856
RAB2A RAB2A, member RAS oncogene family -0.0437185
ENO1 enolase 1, (alpha) -0.0415687
ZBTB38 zinc finger and BTB domain containing 38 -0.0408141
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0385931
IGFBP7 insulin-like growth factor binding protein 7 -0.0381418
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0377636
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0377317
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0370965
RPL37A ribosomal protein L37a -0.0369749
HLA-B major histocompatibility complex, class I, B -0.036689
MTDH metadherin -0.0362432
SMAD3 SMAD family member 3 -0.0355375
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0354105
MT1X metallothionein 1X -0.0353706
GOLGB1 golgin B1 -0.035142
RPL26 ribosomal protein L26 -0.03513
RPL30 ribosomal protein L30 -0.0350926
RPLP2 ribosomal protein, large, P2 -0.0344036
RPL35A ribosomal protein L35a -0.0342452
TPT1 tumor protein, translationally-controlled 1 -0.0339249
RPS19 ribosomal protein S19 -0.0338628
RPL19 ribosomal protein L19 -0.0338561
RPS3 ribosomal protein S3 -0.0338408
RPS13 ribosomal protein S13 -0.0335975
MYO9B myosin IXB -0.0333616
RPL8 ribosomal protein L8 -0.0332125
CSNK1A1 casein kinase 1, alpha 1 -0.0330284
RACK1 receptor for activated C kinase 1 -0.0325429
EEF2 eukaryotic translation elongation factor 2 -0.0320962
RPL5 ribosomal protein L5 -0.0320533
IFI6 interferon, alpha-inducible protein 6 -0.032013
RPS12 ribosomal protein S12 -0.0316446
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0314235
ANXA2 annexin A2 -0.0309775
RPL12 ribosomal protein L12 -0.0308396
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0303569
RPS27A ribosomal protein S27a -0.0300235
KMT2E lysine (K)-specific methyltransferase 2E -0.0299111
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0295078
IER3 immediate early response 3 -0.0293545
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0293186
ECE1 endothelin converting enzyme 1 -0.0290044
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0288027
TTC3 tetratricopeptide repeat domain 3 -0.0287692
CAVIN1 caveolae associated protein 1 -0.0287582
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.028578
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0282326
NAP1L1 nucleosome assembly protein 1-like 1 -0.0280502
SEPTIN7 septin 7 -0.0279822
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0277996
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0276127
RPL32 ribosomal protein L32 -0.0273623
LTBP1 latent transforming growth factor beta binding protein 1 -0.0273492
NAMPT nicotinamide phosphoribosyltransferase -0.0273245
RPL9 ribosomal protein L9 -0.0271904
COL1A1 collagen, type I, alpha 1 -0.0270424
PLEC plectin -0.0269187
DSTN destrin (actin depolymerizing factor) -0.026858
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0268353
RIGI RNA sensor RIG-I -0.0267885
PDIA5 protein disulfide isomerase family A, member 5 -0.0266667
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0265522
RAB1A RAB1A, member RAS oncogene family -0.0263829
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0263643
LMNA lamin A/C -0.02615
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.025822