| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benproperine (phosphate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benproperine (phosphate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.20355 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.122753 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.10087 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.081257 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0652859 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0615117 |
| RTN4 | reticulon 4 | 0.0514684 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0488696 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0485005 |
| PLIN2 | perilipin 2 | 0.0479765 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0454483 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0452734 |
| ITGAV | integrin, alpha V | 0.042515 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0421316 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0416609 |
| MRTFA | myocardin related transcription factor A | 0.0414416 |
| TXNRD1 | thioredoxin reductase 1 | 0.040297 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0384535 |
| RPS6 | ribosomal protein S6 | 0.0374317 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0369725 |
| SVIL | supervillin | 0.0369093 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0368097 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0367691 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0351131 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0348887 |
| CRY1 | cryptochrome circadian clock 1 | 0.0347063 |
| RPL3 | ribosomal protein L3 | 0.0338134 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0336901 |
| JMJD1C | jumonji domain containing 1C | 0.0335625 |
| BCL2L1 | BCL2-like 1 | 0.0335212 |
| WDR43 | WD repeat domain 43 | 0.0331456 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0321682 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0319995 |
| FAT1 | FAT atypical cadherin 1 | 0.0307767 |
| GOLGA4 | golgin A4 | 0.030547 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0303294 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0300635 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0299886 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0298335 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0293816 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0292487 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0289315 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0289207 |
| RNF24 | ring finger protein 24 | 0.0287479 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0283748 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0283059 |
| TRAM1 | translocation associated membrane protein 1 | 0.0277995 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0271898 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0267893 |
| USP3 | ubiquitin specific peptidase 3 | 0.0265932 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0265277 |
| AHSG | alpha-2-HS-glycoprotein | 0.0265038 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0264712 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0261519 |
| IFNGR1 | interferon gamma receptor 1 | 0.0256404 |
| CLINT1 | clathrin interactor 1 | 0.0255518 |
| LUZP1 | leucine zipper protein 1 | 0.025414 |
| MEF2A | myocyte enhancer factor 2A | 0.025401 |
| DIAPH1 | diaphanous-related formin 1 | 0.0251881 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0251562 |
| TFG | TRK-fused gene | 0.0249184 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.024538 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0239488 |
| GSPT1 | G1 to S phase transition 1 | 0.0237713 |
| PAPOLA | poly(A) polymerase alpha | 0.0234961 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0234868 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0234007 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0232895 |
| VEGFA | vascular endothelial growth factor A | 0.0231839 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0230285 |
| OPTN | optineurin | 0.0228042 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0225891 |
| B2M | beta-2-microglobulin | 0.022569 |
| TRAPPC10 | trafficking protein particle complex 10 | 0.0221877 |
| PTEN | phosphatase and tensin homolog | 0.0221787 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0221584 |
| SAMD8 | sterile alpha motif domain containing 8 | 0.0220219 |
| IL6ST | interleukin 6 signal transducer | 0.0219541 |
| RBM17 | RNA binding motif protein 17 | 0.0217818 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0217683 |
| MAGT1 | magnesium transporter 1 | 0.0217096 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0216938 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.021429 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0213419 |
| YTHDC1 | YTH domain containing 1 | 0.0212659 |
| RPL21 | ribosomal protein L21 | 0.0212175 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0211692 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0210827 |
| DTNA | dystrobrevin, alpha | 0.0209963 |
| NCKAP1 | NCK-associated protein 1 | 0.0209524 |
| NBAS | neuroblastoma amplified sequence | 0.0208254 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0207928 |
| POTEF | POTE ankyrin domain family, member F | 0.0207449 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0203452 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0203337 |
| CCNY | cyclin Y | 0.0201776 |
| CUL3 | cullin 3 | 0.020094 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0200615 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0199881 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0199646 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.147663 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.137833 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.131119 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.101202 |
| GPC6 | glypican 6 | -0.100004 |
| MT2A | metallothionein 2A | -0.0987334 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.098656 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.096861 |
| GPC3 | glypican 3 | -0.0925605 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0784936 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0689618 |
| EHBP1 | EH domain binding protein 1 | -0.0684604 |
| FRMD5 | FERM domain containing 5 | -0.0683537 |
| PEG3 | paternally expressed 3 | -0.0675954 |
| RNF213 | ring finger protein 213 | -0.0674843 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0640929 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0623376 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0621449 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0612577 |
| RUNX1 | runt-related transcription factor 1 | -0.0601851 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0577024 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0565079 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0563707 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0557886 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0549611 |
| DSPP | dentin sialophosphoprotein | -0.0538394 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0531698 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0529223 |
| AHNAK | AHNAK nucleoprotein | -0.0513407 |
| SMAD3 | SMAD family member 3 | -0.0510532 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0507186 |
| ATXN1 | ataxin 1 | -0.0506532 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.050499 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0501593 |
| INTS6 | integrator complex subunit 6 | -0.0500757 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0494097 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0484872 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0462745 |
| H1-0 | H1.0 linker histone | -0.04586 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0449604 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0446079 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0436027 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0425336 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0424914 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0423902 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0409433 |
| FMNL2 | formin-like 2 | -0.0402561 |
| NPAS2 | neuronal PAS domain protein 2 | -0.03984 |
| HDAC4 | histone deacetylase 4 | -0.0391451 |
| DST | dystonin | -0.0390133 |
| PTCHD4 | patched domain containing 4 | -0.0389914 |
| GNAS | GNAS complex locus | -0.0383524 |
| ATP10A | ATPase, class V, type 10A | -0.0376791 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0375779 |
| ASPH | aspartate beta-hydroxylase | -0.0354292 |
| RPS24 | ribosomal protein S24 | -0.0354076 |
| RPS27A | ribosomal protein S27a | -0.0353376 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0351431 |
| RPLP1 | ribosomal protein, large, P1 | -0.0346551 |
| PDLIM5 | PDZ and LIM domain 5 | -0.034355 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0340053 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0339694 |
| PRELID2 | PRELI domain containing 2 | -0.0334608 |
| SBF2 | SET binding factor 2 | -0.0324849 |
| MALT1 | MALT1 paracaspase | -0.0321979 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.0317165 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.031652 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0316098 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.031207 |
| ATP11A | ATPase, class VI, type 11A | -0.0311673 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0309169 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0308558 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -0.0304096 |
| NABP1 | nucleic acid binding protein 1 | -0.0299136 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0296703 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0294303 |
| ZNF638 | zinc finger protein 638 | -0.0293771 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0293392 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0287487 |
| APOA2 | apolipoprotein A-II | -0.02852 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0284313 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.02841 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0282311 |
| PRKCA | protein kinase C, alpha | -0.0281723 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0281516 |
| NDRG1 | N-myc downstream regulated 1 | -0.0278882 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0275855 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0272904 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0272787 |
| RAI14 | retinoic acid induced 14 | -0.0271398 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0271106 |
| OSMR | oncostatin M receptor | -0.0270988 |
| PHF3 | PHD finger protein 3 | -0.0269693 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0268826 |
| RPL12 | ribosomal protein L12 | -0.0267669 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0264057 |
| IGF2R | insulin-like growth factor 2 receptor | -0.026331 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0262544 |
| RIGI | RNA sensor RIG-I | -0.0261903 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0260184 |
