Benproperine (phosphate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.108592
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.104861
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0974567
SLC35F3 solute carrier family 35, member F3 0.0946348
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0797856
RASAL2 RAS protein activator like 2 0.0719948
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0659879
PDLIM5 PDZ and LIM domain 5 0.0638335
DPYD dihydropyrimidine dehydrogenase 0.0583138
LMO7 LIM domain 7 0.0535439
PDE4D phosphodiesterase 4D, cAMP-specific 0.0490087
BCAR3 breast cancer anti-estrogen resistance 3 0.0462943
ANO1 anoctamin 1, calcium activated chloride channel 0.0456596
PODXL podocalyxin-like 0.0446631
GRB10 growth factor receptor-bound protein 10 0.043265
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0428138
INTS6 integrator complex subunit 6 0.0425509
ALCAM activated leukocyte cell adhesion molecule 0.0403961
HDAC9 histone deacetylase 9 0.0396784
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0393946
PLS3 plastin 3 0.039345
PICALM phosphatidylinositol binding clathrin assembly protein 0.0374521
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.036903
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0351097
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0347265
PSD3 pleckstrin and Sec7 domain containing 3 0.0332031
VCL vinculin 0.0329155
EXT1 exostosin glycosyltransferase 1 0.0325396
RCOR1 REST corepressor 1 0.0323878
HMGA2 high mobility group AT-hook 2 0.0320248
RABGAP1L RAB GTPase activating protein 1-like 0.0317651
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.030476
JMJD1C jumonji domain containing 1C 0.0292916
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0288734
LAMC2 laminin, gamma 2 0.0282966
MYO10 myosin X 0.0279423
ZSWIM6 zinc finger, SWIM-type containing 6 0.0274812
CDK6 cyclin-dependent kinase 6 0.0267198
MACF1 microtubule-actin crosslinking factor 1 0.0258388
AKAP13 A kinase (PRKA) anchor protein 13 0.0256499
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0256046
PTK2 protein tyrosine kinase 2 0.0241784
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0241572
NEK7 NIMA-related kinase 7 0.0241543
ANKRD11 ankyrin repeat domain 11 0.0240739
SAMD9 sterile alpha motif domain containing 9 0.0237879
UTRN utrophin 0.0237806
NAV2 neuron navigator 2 0.0237762
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0234786
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0232717
CALB1 calbindin 1, 28kDa 0.02323
SULF2 sulfatase 2 0.0228133
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0225391
SOX5 SRY (sex determining region Y)-box 5 0.0225171
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0225028
LRP1B low density lipoprotein receptor-related protein 1B 0.0224854
ABI3BP ABI family, member 3 (NESH) binding protein 0.0224564
KDM4C lysine (K)-specific demethylase 4C 0.0221065
DGKH diacylglycerol kinase, eta 0.0220447
MSN moesin 0.0219438
CSMD2 CUB and Sushi multiple domains 2 0.0219237
LUZP1 leucine zipper protein 1 0.0216146
SMYD3 SET and MYND domain containing 3 0.0211444
TSC22D1 TSC22 domain family, member 1 0.020842
SLK STE20-like kinase 0.0207383
MTSS1 metastasis suppressor 1 0.020669
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0200142
RAD51B RAD51 paralog B 0.0195504
RAB7A RAB7A, member RAS oncogene family 0.0194139
RAI14 retinoic acid induced 14 0.0192342
CLIC4 chloride intracellular channel 4 0.0190603
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0189886
MTAP methylthioadenosine phosphorylase 0.0187959
HSPH1 heat shock 105kDa/110kDa protein 1 0.0186387
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0183712
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0182871
THSD4 thrombospondin, type I, domain containing 4 0.0181984
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0181719
PALLD palladin, cytoskeletal associated protein 0.0181714
NRIP1 nuclear receptor interacting protein 1 0.0181577
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0179673
TTC28 tetratricopeptide repeat domain 28 0.0177818
SIK3 SIK family kinase 3 0.0176603
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0173397
PRSS23 protease, serine, 23 0.0170745
SEPTIN9 septin 9 0.0167282
FRMD5 FERM domain containing 5 0.016652
SETX senataxin 0.0166263
MECOM MDS1 and EVI1 complex locus 0.0166207
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0164446
WARS1 tryptophanyl-tRNA synthetase 1 0.0164024
EGFR epidermal growth factor receptor 0.0163763
RNF217 ring finger protein 217 0.0162701
TBC1D5 TBC1 domain family, member 5 0.0161802
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0161716
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.016055
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0159763
EXOC4 exocyst complex component 4 0.0159609
FRMD4B FERM domain containing 4B 0.0159268
SVIL supervillin 0.0159179

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.174242
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.133502
TMSB10 thymosin beta 10 -0.103664
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0954547
STC1 stanniocalcin 1 -0.0894111
ENO1 enolase 1, (alpha) -0.0893643
CLU clusterin -0.0890955
FLNB filamin B, beta -0.0779797
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0775041
LMNA lamin A/C -0.0732516
GNAS GNAS complex locus -0.0708724
LOC112694756 uncharaterized LOC112694756 -0.0685877
ANXA1 annexin A1 -0.0676396
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0664034
PGK1 phosphoglycerate kinase 1 -0.0648964
PTMA prothymosin, alpha -0.0643549
CEMIP cell migration inducing protein, hyaluronan binding -0.0626991
EMP1 epithelial membrane protein 1 -0.0621015
ANXA2 annexin A2 -0.0591674
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0583224
EIF1 eukaryotic translation initiation factor 1 -0.0552596
NAMPT nicotinamide phosphoribosyltransferase -0.0524999
TRIO trio Rho guanine nucleotide exchange factor -0.050982
B2M beta-2-microglobulin -0.0508687
CANX calnexin -0.0490805
MT2A metallothionein 2A -0.0488418
IFITM3 interferon induced transmembrane protein 3 -0.0483201
S100A6 S100 calcium binding protein A6 -0.0476596
S100A10 S100 calcium binding protein A10 -0.0474658
RPLP1 ribosomal protein, large, P1 -0.0471241
LDHA lactate dehydrogenase A -0.0463708
TPT1 tumor protein, translationally-controlled 1 -0.0456191
CALU calumenin -0.0450542
SULF1 sulfatase 1 -0.0449054
S100A2 S100 calcium binding protein A2 -0.0440028
TMSB4X thymosin beta 4, X-linked -0.0433769
KRT17 keratin 17, type I -0.0433677
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0426558
RPLP2 ribosomal protein, large, P2 -0.0426058
EZR ezrin -0.0419407
RBM39 RNA binding motif protein 39 -0.041686
GOLGA4 golgin A4 -0.0415794
FSCN1 fascin actin-bundling protein 1 -0.040306
RPS6 ribosomal protein S6 -0.0401348
IFITM1 interferon induced transmembrane protein 1 -0.0400495
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.038987
LMAN1 lectin, mannose-binding, 1 -0.0386672
MORF4L2 mortality factor 4 like 2 -0.0382289
PKM pyruvate kinase, muscle -0.0377312
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0368374
KDM3A lysine (K)-specific demethylase 3A -0.0368299
OGA O-GlcNAcase -0.0367883
ITCH itchy E3 ubiquitin protein ligase -0.0367592
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0361412
RPS19 ribosomal protein S19 -0.0360678
SQLE squalene epoxidase -0.0355997
RPL11 ribosomal protein L11 -0.0353683
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0349381
RPL12 ribosomal protein L12 -0.0343012
BHLHE40 basic helix-loop-helix family, member e40 -0.03419
SEC31A SEC31 homolog A (S. cerevisiae) -0.033959
MEF2A myocyte enhancer factor 2A -0.0338613
MYOF myoferlin -0.0336316
RPL27A ribosomal protein L27a -0.0332459
CALR calreticulin -0.0330288
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0326913
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0326273
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0323494
YBX3 Y box binding protein 3 -0.0322856
RPL7A ribosomal protein L7a -0.0321428
ARRDC3 arrestin domain containing 3 -0.0320712
RPS21 ribosomal protein S21 -0.0316007
WASF2 WAS protein family, member 2 -0.0312031
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0308822
YBX1 Y box binding protein 1 -0.0305269
RPL37A ribosomal protein L37a -0.0303329
NAP1L1 nucleosome assembly protein 1-like 1 -0.030306
ANGPTL4 angiopoietin-like 4 -0.0301412
RPS13 ribosomal protein S13 -0.0298318
HDLBP high density lipoprotein binding protein -0.0298205
KIAA1217 KIAA1217 -0.0296318
AKAP9 A kinase (PRKA) anchor protein 9 -0.0296215
RPS12 ribosomal protein S12 -0.0295091
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0290016
CAV1 caveolin 1, caveolae protein, 22kDa -0.0289308
HM13 histocompatibility (minor) 13 -0.0287461
EEF2 eukaryotic translation elongation factor 2 -0.028744
RPL8 ribosomal protein L8 -0.0287049
ESYT2 extended synaptotagmin-like protein 2 -0.0285821
HLA-B major histocompatibility complex, class I, B -0.0285707
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0282894
DSTN destrin (actin depolymerizing factor) -0.0282882
RACK1 receptor for activated C kinase 1 -0.0282521
FLNA filamin A, alpha -0.0280513
PLAT plasminogen activator, tissue -0.0278655
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0277745
VDAC1 voltage-dependent anion channel 1 -0.0277583
COPB1 coatomer protein complex, subunit beta 1 -0.0275252
KRT6A keratin 6A, type II -0.0275166
SLC38A1 solute carrier family 38, member 1 -0.0274513