Benproperine (phosphate)_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MAML2 mastermind-like 2 (Drosophila) 0.0837907
ATXN1 ataxin 1 0.0529265
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0483954
MBNL2 muscleblind-like splicing regulator 2 0.0483371
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0391011
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0351517
PCBP2 poly(rC) binding protein 2 0.0346516
KLHL29 kelch-like family member 29 0.0318502
FNDC3B fibronectin type III domain containing 3B 0.0296555
GRB10 growth factor receptor-bound protein 10 0.0267236
NPSR1 neuropeptide S receptor 1 0.0265783
INTS6 integrator complex subunit 6 0.0258159
APLP2 amyloid beta (A4) precursor-like protein 2 0.0254822
VEGFA vascular endothelial growth factor A 0.0251471
EHBP1 EH domain binding protein 1 0.0245877
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0237802
CCNY cyclin Y 0.0227055
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0225485
ESYT2 extended synaptotagmin-like protein 2 0.0217068
ZSWIM6 zinc finger, SWIM-type containing 6 0.0213701
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0209638
KDM6A lysine (K)-specific demethylase 6A 0.0195475
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0194658
KIF16B kinesin family member 16B 0.0190167
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0187538
ARHGAP29 Rho GTPase activating protein 29 0.0183931
AUTS2 autism susceptibility candidate 2 0.0182874
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0181959
SND1 staphylococcal nuclease and tudor domain containing 1 0.0175814
ZNF292 zinc finger protein 292 0.0175177
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0175054
ERRFI1 ERBB receptor feedback inhibitor 1 0.0174008
TNIK TRAF2 and NCK interacting kinase 0.0172214
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.016789
PTEN phosphatase and tensin homolog 0.0166997
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0165762
ZCCHC7 zinc finger, CCHC domain containing 7 0.0161097
HKDC1 hexokinase domain containing 1 0.016031
C6ORF62 chromosome 6 open reading frame 62 0.0158026
FAM13A family with sequence similarity 13, member A 0.0155385
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0155153
CEMIP2 cell migration inducing hyaluronidase 2 0.0153916
EXOC4 exocyst complex component 4 0.015341
RPS12 ribosomal protein S12 0.015332
KDM4C lysine (K)-specific demethylase 4C 0.0152591
PDLIM5 PDZ and LIM domain 5 0.0148308
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0148026
RAD51B RAD51 paralog B 0.0146219
FNIP1 folliculin interacting protein 1 0.014566
ANO1 anoctamin 1, calcium activated chloride channel 0.0138561
ARF4 ADP-ribosylation factor 4 0.0135905
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0133226
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0132995
FOXO3 forkhead box O3 0.0131552
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0129807
YEATS2 YEATS domain containing 2 0.0129542
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.0129118
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0128661
TRA2A transformer 2 alpha homolog (Drosophila) 0.0127955
IFRD1 interferon-related developmental regulator 1 0.0127766
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0125929
ZFAND3 zinc finger, AN1-type domain 3 0.0125874
GTPBP2 GTP binding protein 2 0.0125689
TMCC1 transmembrane and coiled-coil domain family 1 0.0125652
FLNB filamin B, beta 0.0123229
PPARG peroxisome proliferator-activated receptor gamma 0.0122735
EGFR epidermal growth factor receptor 0.012265
SNX13 sorting nexin 13 0.0122184
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0121135
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0120067
EIF5 eukaryotic translation initiation factor 5 0.0119645
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0116859
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0116837
MED13L mediator complex subunit 13-like 0.0116566
TRPS1 trichorhinophalangeal syndrome I 0.0115016
ARHGAP32 Rho GTPase activating protein 32 0.0114468
NDRG1 N-myc downstream regulated 1 0.0114443
DLC1 DLC1 Rho GTPase activating protein 0.0114175
MCL1 myeloid cell leukemia 1 0.0113808
GLS2 glutaminase 2 (liver, mitochondrial) 0.0112723
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0112191
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0111774
RYK receptor-like tyrosine kinase 0.0111608
ADAM9 ADAM metallopeptidase domain 9 0.0109362
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.010768
XYLT1 xylosyltransferase I 0.0107521
PRELID2 PRELI domain containing 2 0.0107312
NABP1 nucleic acid binding protein 1 0.0106744
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.010626
COG5 component of oligomeric golgi complex 5 0.0106233
BTBD9 BTB (POZ) domain containing 9 0.0105233
STK17A serine/threonine kinase 17a 0.0104654
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0104578
ANXA1 annexin A1 0.0103804
DOCK5 dedicator of cytokinesis 5 0.0103726
PGM3 phosphoglucomutase 3 0.0102581
NIBAN1 niban apoptosis regulator 1 0.0102527
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0102422
HELZ helicase with zinc finger 0.0102267
TBC1D22A TBC1 domain family, member 22A 0.0102233

decreased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 -0.272068
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.170385
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.163601
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120217
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.101457
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0975393
TMC5 transmembrane channel-like 5 -0.0826563
TPT1 tumor protein, translationally-controlled 1 -0.0820516
H1-0 H1.0 linker histone -0.0655103
AGR2 anterior gradient 2 -0.0647888
ANXA2 annexin A2 -0.0618487
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0563902
TMSB10 thymosin beta 10 -0.0562164
S100A10 S100 calcium binding protein A10 -0.0550941
LMO7 LIM domain 7 -0.0518953
EPCAM epithelial cell adhesion molecule -0.0506204
RRBP1 ribosome binding protein 1 -0.0498887
CALR calreticulin -0.0493304
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0493174
PTMA prothymosin, alpha -0.0491939
EIF1 eukaryotic translation initiation factor 1 -0.0466939
B2M beta-2-microglobulin -0.0455465
HLA-E major histocompatibility complex, class I, E -0.0443457
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0422973
ACTN4 actinin, alpha 4 -0.0405842
KRT18 keratin 18, type I -0.0402368
CD2AP CD2-associated protein -0.0399411
S100A6 S100 calcium binding protein A6 -0.0395764
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0382435
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0379678
TM4SF1 transmembrane 4 L six family member 1 -0.0365331
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0364614
MUC17 mucin 17, cell surface associated -0.0362995
LOC102724023 ES1 protein homolog, mitochondrial -0.0355927
TMEM123 transmembrane protein 123 -0.0354797
IFI27 interferon, alpha-inducible protein 27 -0.0353244
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0351437
EMP1 epithelial membrane protein 1 -0.0340705
ACTG1 actin gamma 1 -0.0338973
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0336365
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0334393
PDIA4 protein disulfide isomerase family A, member 4 -0.0332793
HLA-C major histocompatibility complex, class I, C -0.0321292
RPL35A ribosomal protein L35a -0.0316157
IFI6 interferon, alpha-inducible protein 6 -0.0314111
TMEM45B transmembrane protein 45B -0.0311843
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0309607
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0309336
LOC112694756 uncharaterized LOC112694756 -0.0307984
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.030784
RAB7A RAB7A, member RAS oncogene family -0.030647
MCU mitochondrial calcium uniporter -0.0306413
FTH1 ferritin, heavy polypeptide 1 -0.0288985
PRSS3 protease, serine, 3 -0.0286928
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0280851
SEPTIN9 septin 9 -0.0277422
RPL19 ribosomal protein L19 -0.0276725
KPNB1 karyopherin (importin) beta 1 -0.0262469
RNF213 ring finger protein 213 -0.0261938
DSG2 desmoglein 2 -0.0258243
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0254879
SLC38A1 solute carrier family 38, member 1 -0.0254116
HLA-A major histocompatibility complex, class I, A -0.0253468
CANX calnexin -0.0253299
FTL ferritin, light polypeptide -0.025117
RPL8 ribosomal protein L8 -0.0251099
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0251097
GPX2 glutathione peroxidase 2 -0.0245293
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0244824
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0244744
MUC13 mucin 13, cell surface associated -0.0242606
XAF1 XIAP associated factor 1 -0.0242296
PDIA3 protein disulfide isomerase family A, member 3 -0.0240172
H3-3B H3.3 histone B -0.0239171
MYO1E myosin IE -0.0237948
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0235653
RPL34 ribosomal protein L34 -0.0234666
MKI67 marker of proliferation Ki-67 -0.0231825
PLSCR1 phospholipid scramblase 1 -0.0231771
TMSB4X thymosin beta 4, X-linked -0.0226724
INSIG1 insulin induced gene 1 -0.0225666
RAB1A RAB1A, member RAS oncogene family -0.0225654
SHROOM3 shroom family member 3 -0.0225136
HMGB1 high mobility group box 1 -0.0223056
WDR45B WD repeat domain 45B -0.0221382
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0221172
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0214362
RSL1D1 ribosomal L1 domain containing 1 -0.0212416
AOPEP aminopeptidase O (putative) -0.0210708
RPLP1 ribosomal protein, large, P1 -0.0210548
S100A9 S100 calcium binding protein A9 -0.0207084
RPL23 ribosomal protein L23 -0.0205441
ARF1 ADP-ribosylation factor 1 -0.0204177
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0203406
RPS25 ribosomal protein S25 -0.0200857
S100A11 S100 calcium binding protein A11 -0.0200027
TPM4 tropomyosin 4 -0.0199447
MGAM2 maltase-glucoamylase 2 (putative) -0.0199434
MTUS1 microtubule associated tumor suppressor 1 -0.019736
HDLBP high density lipoprotein binding protein -0.0195929