Benproperine (phosphate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0318168
NUP58 nucleoporin 58 0.0257257
UGCG UDP-glucose ceramide glucosyltransferase 0.0230667
RAD23B RAD23 homolog B (S. cerevisiae) 0.0157941
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.015356
SOD2 superoxide dismutase 2, mitochondrial 0.0143218
ZFAND3 zinc finger, AN1-type domain 3 0.0141444
CD109 CD109 molecule 0.0140632
ERBIN erbb2 interacting protein 0.0132404
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0129997
TFG TRK-fused gene 0.0128375
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0125458
ABI1 abl-interactor 1 0.0121547
TMEM123 transmembrane protein 123 0.0118747
UBQLN1 ubiquilin 1 0.0118279
SMAD3 SMAD family member 3 0.0112637
PLK2 polo-like kinase 2 0.0111194
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.01105
MYO6 myosin VI 0.0110198
MCTP1 multiple C2 domains, transmembrane 1 0.0109108
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0106113
KLF6 Kruppel-like factor 6 0.0105749
ATP13A3 ATPase type 13A3 0.0105334
CASC3 cancer susceptibility candidate 3 0.0105181
TRA2A transformer 2 alpha homolog (Drosophila) 0.0104694
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0100936
PAPOLA poly(A) polymerase alpha 0.0100531
TSC22D2 TSC22 domain family, member 2 0.00983666
TOP2B topoisomerase (DNA) II beta 180kDa 0.00967979
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.00941448
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.00936823
WDR43 WD repeat domain 43 0.00928694
WAC WW domain containing adaptor with coiled-coil 0.0091523
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00913045
USP12 ubiquitin specific peptidase 12 0.00910289
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0090056
YME1L1 YME1-like 1 ATPase 0.00894456
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.00893726
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.00887041
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.00886569
HDIP1 HDAC and MIER1 interacting protein 1 0.00883317
RNF145 ring finger protein 145 0.00862584
POU2F1 POU class 2 homeobox 1 0.00851332
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.00840286
EPS8 epidermal growth factor receptor pathway substrate 8 0.00840255
BBX bobby sox homolog (Drosophila) 0.00836975
HBP1 HMG-box transcription factor 1 0.00818894
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.00814453
SERINC3 serine incorporator 3 0.00809987
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 0.00804427
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.00802604
PAWR PRKC, apoptosis, WT1, regulator 0.00801637
RO60 Ro60, Y RNA binding protein 0.00795382
SQSTM1 sequestosome 1 0.00789774
EREG epiregulin 0.00787188
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.00777335
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.00773828
BDNF brain-derived neurotrophic factor 0.00772766
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.00765884
FXR1 fragile X mental retardation, autosomal homolog 1 0.00759335
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.00757905
SUCO SUN domain containing ossification factor 0.00756689
SMG7 SMG7 nonsense mediated mRNA decay factor 0.00754475
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 0.00738725
TNPO1 transportin 1 0.0073235
SAMD9 sterile alpha motif domain containing 9 0.00732087
HDAC2 histone deacetylase 2 0.00726758
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.00725288
EED embryonic ectoderm development 0.00722795
TXNRD1 thioredoxin reductase 1 0.00721578
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.00720741
TNRC6A trinucleotide repeat containing 6A 0.00720381
LARP4 La ribonucleoprotein domain family, member 4 0.00717988
HDAC3 histone deacetylase 3 0.0071528
RBM7 RNA binding motif protein 7 0.00713338
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.00713329
CD164 CD164 molecule, sialomucin 0.00712254
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.00708123
COLEC11 collectin sub-family member 11 0.00705735
CUL3 cullin 3 0.00703672
CEP83 centrosomal protein 83kDa 0.00698285
MED13L mediator complex subunit 13-like 0.00698162
NDC1 NDC1 transmembrane nucleoporin 0.00698047
ETV5 ets variant 5 0.00696237
BHLHE40 basic helix-loop-helix family, member e40 0.00693487
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.00687441
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.00687138
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.00687084
PTEN phosphatase and tensin homolog 0.00685189
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.00684493
BCAR3 breast cancer anti-estrogen resistance 3 0.00681137
SERINC1 serine incorporator 1 0.00680068
SRFBP1 serum response factor binding protein 1 0.00679321
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.00677052
CRY1 cryptochrome circadian clock 1 0.00667951
SCAF4 SR-related CTD-associated factor 4 0.00666389
INSIG1 insulin induced gene 1 0.00663922
ARL5B ADP-ribosylation factor-like 5B 0.00662412
RPS7 ribosomal protein S7 0.00659169
FBL fibrillarin 0.00657123

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.176725
DTNA dystrobrevin, alpha -0.175079
EFNA5 ephrin-A5 -0.164529
EXT1 exostosin glycosyltransferase 1 -0.124085
AKAP12 A kinase (PRKA) anchor protein 12 -0.114168
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0997861
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0906952
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0755867
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0724389
RPS6 ribosomal protein S6 -0.0706256
SAMD3 sterile alpha motif domain containing 3 -0.0705994
TMSB10 thymosin beta 10 -0.0691159
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0612104
NDRG1 N-myc downstream regulated 1 -0.0597961
ASPH aspartate beta-hydroxylase -0.0594753
RUNX1 runt-related transcription factor 1 -0.0565619
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.05653
PRKG1 protein kinase, cGMP-dependent, type I -0.056145
KIAA1549L KIAA1549-like -0.0559567
LIMCH1 LIM and calponin homology domains 1 -0.0541196
TRIO trio Rho guanine nucleotide exchange factor -0.0533692
CALD1 caldesmon 1 -0.0525955
PHACTR1 phosphatase and actin regulator 1 -0.0517798
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0513258
KIAA1217 KIAA1217 -0.0507728
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0506686
CDH13 cadherin 13 -0.0490769
NAV1 neuron navigator 1 -0.0489705
PTMA prothymosin, alpha -0.0470525
PRKCE protein kinase C, epsilon -0.0469349
NALF1 NALCN channel auxiliary factor 1 -0.0469166
PTPRD protein tyrosine phosphatase, receptor type, D -0.0451982
NABP1 nucleic acid binding protein 1 -0.0449128
MMP12 matrix metallopeptidase 12 -0.0420417
TPT1 tumor protein, translationally-controlled 1 -0.0419131
JMJD1C jumonji domain containing 1C -0.0406937
GPC6 glypican 6 -0.0402624
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0391831
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.039018
PBX3 pre-B-cell leukemia homeobox 3 -0.038767
HMGA2 high mobility group AT-hook 2 -0.0386106
ENKUR enkurin, TRPC channel interacting protein -0.0381723
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0380225
USP34 ubiquitin specific peptidase 34 -0.0380218
ACTG1 actin gamma 1 -0.0378239
LSAMP limbic system-associated membrane protein -0.0367339
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0365856
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0364698
RPL37A ribosomal protein L37a -0.036469
RPS19 ribosomal protein S19 -0.0355201
MYO10 myosin X -0.0345453
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0345152
MT2A metallothionein 2A -0.0337306
KDM4C lysine (K)-specific demethylase 4C -0.033585
NAP1L1 nucleosome assembly protein 1-like 1 -0.0335172
HDAC9 histone deacetylase 9 -0.0335038
SDCCAG8 serologically defined colon cancer antigen 8 -0.0327674
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0323788
RPS8 ribosomal protein S8 -0.0323474
DSCAM Down syndrome cell adhesion molecule -0.0319322
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0318859
RPL23 ribosomal protein L23 -0.0314026
FMNL2 formin-like 2 -0.0308138
PTPRG protein tyrosine phosphatase, receptor type, G -0.0297202
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0293393
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0291391
C2CD2 C2 calcium-dependent domain containing 2 -0.0290759
SAMD4A sterile alpha motif domain containing 4A -0.0290255
DST dystonin -0.0289757
RPS12 ribosomal protein S12 -0.0288032
RPL26 ribosomal protein L26 -0.028621
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0284501
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0282981
NF1 neurofibromin 1 -0.0282433
PRELID2 PRELI domain containing 2 -0.0281042
ZNF804A zinc finger protein 804A -0.0280667
NTM neurotrimin -0.0277856
MARCHF4 membrane associated ring-CH-type finger 4 -0.0273503
PKM pyruvate kinase, muscle -0.0272095
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0270957
SBF2 SET binding factor 2 -0.0268587
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0267817
SSH2 slingshot protein phosphatase 2 -0.0265983
SP100 SP100 nuclear antigen -0.0265141
PTK2 protein tyrosine kinase 2 -0.0265051
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0265034
TRPS1 trichorhinophalangeal syndrome I -0.0262899
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0262137
LDHA lactate dehydrogenase A -0.0257903
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0256434
SASH1 SAM and SH3 domain containing 1 -0.0255227
KTN1 kinectin 1 (kinesin receptor) -0.0254896
RPL5 ribosomal protein L5 -0.0254425
ARHGAP18 Rho GTPase activating protein 18 -0.0252396
RPS3 ribosomal protein S3 -0.0251797
GLS2 glutaminase 2 (liver, mitochondrial) -0.0246783
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0245141
YEATS2 YEATS domain containing 2 -0.0243819
DOCK4 dedicator of cytokinesis 4 -0.0243768
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0243011