Benproperine (phosphate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EPS8 epidermal growth factor receptor pathway substrate 8 0.124991
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0809791
FAT1 FAT atypical cadherin 1 0.0760998
TXNRD1 thioredoxin reductase 1 0.0396526
ITGA6 integrin, alpha 6 0.0389715
SHROOM3 shroom family member 3 0.0388301
GOLGA4 golgin A4 0.0377427
FOXO1 forkhead box O1 0.0369371
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0366537
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.035829
PRELID2 PRELI domain containing 2 0.0353793
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.033448
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0321653
MYOF myoferlin 0.0321181
AKAP13 A kinase (PRKA) anchor protein 13 0.0318061
PDE4D phosphodiesterase 4D, cAMP-specific 0.031133
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.030972
MON2 MON2 homolog (S. cerevisiae) 0.030207
PKP2 plakophilin 2 0.0298375
FLNB filamin B, beta 0.0294394
RNF145 ring finger protein 145 0.0293079
PTPRR protein tyrosine phosphatase, receptor type, R 0.0291532
PCDHB16 protocadherin beta 16 0.029129
GARS1 glycyl-tRNA synthetase 1 0.0289535
PPARG peroxisome proliferator-activated receptor gamma 0.0288892
TRIM2 tripartite motif containing 2 0.0286878
KMT2C lysine (K)-specific methyltransferase 2C 0.0280007
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0279783
RAD51B RAD51 paralog B 0.02708
MED13L mediator complex subunit 13-like 0.0267603
COG5 component of oligomeric golgi complex 5 0.0259476
DSCAM Down syndrome cell adhesion molecule 0.0250825
NF1 neurofibromin 1 0.0250709
TCF12 transcription factor 12 0.0248927
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0248407
ZFAND3 zinc finger, AN1-type domain 3 0.0243709
PTPRK protein tyrosine phosphatase, receptor type, K 0.0242888
PRSS3 protease, serine, 3 0.0238417
MYO6 myosin VI 0.0237701
PLAC8 placenta-specific 8 0.0232106
PTPRG protein tyrosine phosphatase, receptor type, G 0.0229882
RTN4 reticulon 4 0.022828
PTEN phosphatase and tensin homolog 0.0223855
ETNK1 ethanolamine kinase 1 0.0221494
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0220195
LMO7 LIM domain 7 0.0219454
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0217625
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0216665
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0215246
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0213996
THSD4 thrombospondin, type I, domain containing 4 0.0211073
COPA coatomer protein complex, subunit alpha 0.0209366
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0205242
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0205085
ANKRD17 ankyrin repeat domain 17 0.0204588
USP3 ubiquitin specific peptidase 3 0.0204451
JMJD1C jumonji domain containing 1C 0.0203258
UBE2H ubiquitin-conjugating enzyme E2H 0.0201089
RAP1B RAP1B, member of RAS oncogene family 0.0200623
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0196892
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.019565
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0194856
PDE8A phosphodiesterase 8A 0.0193868
ZFC3H1 zinc finger, C3H1-type containing 0.0193597
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0192747
ANKRD11 ankyrin repeat domain 11 0.0192659
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0191713
CDC42SE2 CDC42 small effector 2 0.0191476
ABHD17C abhydrolase domain containing 17C 0.0191178
FGD4 FYVE, RhoGEF and PH domain containing 4 0.019095
BTBD9 BTB (POZ) domain containing 9 0.019086
ANO6 anoctamin 6 0.0190335
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0187726
SH3RF1 SH3 domain containing ring finger 1 0.018709
PTBP3 polypyrimidine tract binding protein 3 0.0186985
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0185532
ARHGAP29 Rho GTPase activating protein 29 0.0183955
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0183454
UBA6 ubiquitin-like modifier activating enzyme 6 0.018245
CTNND1 catenin (cadherin-associated protein), delta 1 0.0182281
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0181808
BIRC6 baculoviral IAP repeat containing 6 0.0179846
CDK19 cyclin-dependent kinase 19 0.0179106
ZNF292 zinc finger protein 292 0.0177013
NIPBL Nipped-B homolog (Drosophila) 0.0176476
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0176168
ZFAND6 zinc finger, AN1-type domain 6 0.017586
FOXP1 forkhead box P1 0.0175816
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0175301
SBF2 SET binding factor 2 0.0173089
SNX13 sorting nexin 13 0.0170418
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0169801
LRRC1 leucine rich repeat containing 1 0.0167996
EREG epiregulin 0.0167464
EIF4B eukaryotic translation initiation factor 4B 0.0166971
WWC1 WW and C2 domain containing 1 0.016693
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0166799
ARHGAP26 Rho GTPase activating protein 26 0.0165802
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0165219
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.01646

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.192812
RPLP1 ribosomal protein, large, P1 -0.136066
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.112189
RPS6 ribosomal protein S6 -0.105578
RPS12 ribosomal protein S12 -0.1007
RPS8 ribosomal protein S8 -0.0941473
RPS19 ribosomal protein S19 -0.0841982
RPL35A ribosomal protein L35a -0.082357
RPLP2 ribosomal protein, large, P2 -0.0770315
RPL37A ribosomal protein L37a -0.0768152
TMSB10 thymosin beta 10 -0.0748608
RPL34 ribosomal protein L34 -0.0729169
RPL31 ribosomal protein L31 -0.068863
RPS13 ribosomal protein S13 -0.0674025
PTMA prothymosin, alpha -0.0672579
RPS23 ribosomal protein S23 -0.0664483
RPS3 ribosomal protein S3 -0.0643352
RPL26 ribosomal protein L26 -0.0630006
RPS25 ribosomal protein S25 -0.0628307
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0599773
HLA-B major histocompatibility complex, class I, B -0.0599487
RPS27A ribosomal protein S27a -0.0574867
RPLP0 ribosomal protein, large, P0 -0.0573762
RPL12 ribosomal protein L12 -0.0572759
ACTG1 actin gamma 1 -0.055898
RPS29 ribosomal protein S29 -0.0513087
RPS17 ribosomal protein S17 -0.0503843
RACK1 receptor for activated C kinase 1 -0.0496218
RPL37 ribosomal protein L37 -0.0489347
RPL11 ribosomal protein L11 -0.0488865
IFI6 interferon, alpha-inducible protein 6 -0.0482777
RPL19 ribosomal protein L19 -0.0482577
RPS14 ribosomal protein S14 -0.0458754
RPL9 ribosomal protein L9 -0.0455151
RPL36 ribosomal protein L36 -0.0454421
RPS24 ribosomal protein S24 -0.0436237
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.043201
PKM pyruvate kinase, muscle -0.043103
RPL23 ribosomal protein L23 -0.042128
RPS11 ribosomal protein S11 -0.0410551
RPS16 ribosomal protein S16 -0.039107
RPL28 ribosomal protein L28 -0.0370174
RPL38 ribosomal protein L38 -0.0362902
RPL7A ribosomal protein L7a -0.0361398
RPS21 ribosomal protein S21 -0.0353725
RPL32 ribosomal protein L32 -0.0350997
RPS27 ribosomal protein S27 -0.0349966
RPL27A ribosomal protein L27a -0.0343132
RPL30 ribosomal protein L30 -0.0337853
KRT18 keratin 18, type I -0.0336428
RPL36A ribosomal protein L36a -0.0324982
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0321432
EIF1 eukaryotic translation initiation factor 1 -0.0314154
RPL8 ribosomal protein L8 -0.030175
RPS15 ribosomal protein S15 -0.0301475
S100P S100 calcium binding protein P -0.0300403
RPL13A ribosomal protein L13a -0.0295987
RPS5 ribosomal protein S5 -0.0291603
POTEF POTE ankyrin domain family, member F -0.0278006
RPS10 ribosomal protein S10 -0.0277777
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0273393
RPL5 ribosomal protein L5 -0.0268978
NAP1L1 nucleosome assembly protein 1-like 1 -0.0267879
IFI27 interferon, alpha-inducible protein 27 -0.0261276
MT2A metallothionein 2A -0.0257387
RPS20 ribosomal protein S20 -0.0254007
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0251443
LOC102724023 ES1 protein homolog, mitochondrial -0.0247773
RPL15 ribosomal protein L15 -0.0234129
FTL ferritin, light polypeptide -0.0233992
ISG15 ISG15 ubiquitin-like modifier -0.0232071
S100A6 S100 calcium binding protein A6 -0.0226492
MYO1E myosin IE -0.022638
RPL27 ribosomal protein L27 -0.0224728
IFITM3 interferon induced transmembrane protein 3 -0.0224168
RPL10A ribosomal protein L10a -0.0222096
RPL35 ribosomal protein L35 -0.021681
INTS6 integrator complex subunit 6 -0.0216246
RPL7 ribosomal protein L7 -0.0215817
ENO1 enolase 1, (alpha) -0.0209153
HLA-A major histocompatibility complex, class I, A -0.0208951
TPI1 triosephosphate isomerase 1 -0.0206718
IER3 immediate early response 3 -0.0205465
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0203074
CATSPERB catsper channel auxiliary subunit beta -0.0198695
LRRC23 leucine rich repeat containing 23 -0.019842
S100A11 S100 calcium binding protein A11 -0.0198018
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0195886
NACA nascent polypeptide-associated complex alpha subunit -0.0192433
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0190293
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0188974
CALR calreticulin -0.018524
S100A10 S100 calcium binding protein A10 -0.0185116
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0184802
FRMD5 FERM domain containing 5 -0.0179713
LOC112694756 uncharaterized LOC112694756 -0.0179208
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0174119
MYH14 myosin, heavy chain 14, non-muscle -0.0173546
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0163611
EGR1 early growth response 1 -0.0161538