Benproperine (phosphate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.0399642
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0272079
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0230757
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0216891
CENPF centromere protein F, 350/400kDa 0.0215807
PSD3 pleckstrin and Sec7 domain containing 3 0.0207803
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0189752
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0187916
TSC22D1 TSC22 domain family, member 1 0.0187507
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0166899
PCBP2 poly(rC) binding protein 2 0.0161319
RAD51B RAD51 paralog B 0.0160077
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0157056
TTC28 tetratricopeptide repeat domain 28 0.0155063
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0151021
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0149452
RAB27B RAB27B, member RAS oncogene family 0.0149036
PRELID2 PRELI domain containing 2 0.014581
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0143344
LPP LIM domain containing preferred translocation partner in lipoma 0.0138065
SOD2 superoxide dismutase 2, mitochondrial 0.0136853
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0134086
FNIP1 folliculin interacting protein 1 0.0132019
EXOC4 exocyst complex component 4 0.0127755
CADM2 cell adhesion molecule 2 0.0127125
MKI67 marker of proliferation Ki-67 0.0116677
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0116058
PIAS2 protein inhibitor of activated STAT, 2 0.0113728
SMYD3 SET and MYND domain containing 3 0.0112657
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0111459
DOCK11 dedicator of cytokinesis 11 0.0109778
PDE10A phosphodiesterase 10A 0.010939
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0109388
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0108129
CFAP299 cilia and flagella associated protein 299 0.0106583
TP63 tumor protein p63 0.0103633
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0103629
SLK STE20-like kinase 0.0102654
ETNK1 ethanolamine kinase 1 0.0101526
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.00992643
ASPH aspartate beta-hydroxylase 0.00962955
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00940482
DPYD dihydropyrimidine dehydrogenase 0.00906711
TRIP12 thyroid hormone receptor interactor 12 0.00897963
PARP14 poly (ADP-ribose) polymerase family, member 14 0.00896665
FNDC3B fibronectin type III domain containing 3B 0.00893258
MSN moesin 0.00879622
ECPAS Ecm29 proteasome adaptor and scaffold 0.00871635
EFNA5 ephrin-A5 0.00867623
GPAT3 glycerol-3-phosphate acyltransferase 3 0.00867538
ATP13A3 ATPase type 13A3 0.00864782
SFPQ splicing factor proline/glutamine-rich 0.00855888
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.00850046
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.008336
PTK2 protein tyrosine kinase 2 0.00829264
SDK1 sidekick cell adhesion molecule 1 0.00829183
FAR1 fatty acyl CoA reductase 1 0.00827044
CCNL1 cyclin L1 0.00820007
DNER delta/notch-like EGF repeat containing 0.00811607
DIAPH3 diaphanous-related formin 3 0.00807284
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.00806728
ANKRD36 ankyrin repeat domain 36 0.00803802
COL5A2 collagen, type V, alpha 2 0.00798379
EIF5 eukaryotic translation initiation factor 5 0.00787604
ZNF148 zinc finger protein 148 0.00783656
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.00778082
CDK19 cyclin-dependent kinase 19 0.00777016
PLSCR1 phospholipid scramblase 1 0.00773101
CAPRIN2 caprin family member 2 0.00763595
SOCS6 suppressor of cytokine signaling 6 0.00747604
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0074601
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00728418
PANK3 pantothenate kinase 3 0.00727841
SMC4 structural maintenance of chromosomes 4 0.00718741
FXR1 fragile X mental retardation, autosomal homolog 1 0.00718076
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.00706667
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0070617
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.00704032
MAT2A methionine adenosyltransferase II, alpha 0.0069291
RTTN rotatin 0.00691382
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.00677843
ADAM17 ADAM metallopeptidase domain 17 0.00675209
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.00672783
RIGI RNA sensor RIG-I 0.00669424
TPM3 tropomyosin 3 0.00667296
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00662209
ADAM10 ADAM metallopeptidase domain 10 0.00661885
BCLAF1 BCL2-associated transcription factor 1 0.00660218
FUBP1 far upstream element (FUSE) binding protein 1 0.00656659
RNF145 ring finger protein 145 0.00655376
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.00654856
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.00653903
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0065318
ARF6 ADP-ribosylation factor 6 0.00649334
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.00646702
TPX2 TPX2, microtubule-associated 0.00644859
DPH6 diphthamine biosynthesis 6 0.0064278
MYH9 myosin, heavy chain 9, non-muscle 0.00642739
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.00636511
RAD23B RAD23 homolog B (S. cerevisiae) 0.00633134

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.291648
VIM vimentin -0.16246
TMSB10 thymosin beta 10 -0.0958071
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0855086
MT2A metallothionein 2A -0.0786482
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0751136
PTMA prothymosin, alpha -0.0687104
FTL ferritin, light polypeptide -0.0581233
TM4SF1 transmembrane 4 L six family member 1 -0.0425632
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0402103
ACTG1 actin gamma 1 -0.0397118
RPL35A ribosomal protein L35a -0.0371879
TXNRD1 thioredoxin reductase 1 -0.0363722
LOC112694756 uncharaterized LOC112694756 -0.0339814
TPT1 tumor protein, translationally-controlled 1 -0.0334955
RPS8 ribosomal protein S8 -0.030564
TMSB4X thymosin beta 4, X-linked -0.02997
EIF1 eukaryotic translation initiation factor 1 -0.0298358
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0296023
MT1X metallothionein 1X -0.0287968
RAB7A RAB7A, member RAS oncogene family -0.0274343
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0273392
RPLP1 ribosomal protein, large, P1 -0.0262019
RPL12 ribosomal protein L12 -0.0256167
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0248144
RPS19 ribosomal protein S19 -0.0241996
RACK1 receptor for activated C kinase 1 -0.0240199
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0237027
EZR ezrin -0.0219727
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0212254
RPS6 ribosomal protein S6 -0.0208515
EIF4A1 eukaryotic translation initiation factor 4A1 -0.020708
PTPRF protein tyrosine phosphatase, receptor type, F -0.020434
RPL19 ribosomal protein L19 -0.0201994
CANX calnexin -0.0201784
GNAS GNAS complex locus -0.0193289
MT1E metallothionein 1E -0.0192513
RPS3 ribosomal protein S3 -0.0187952
EGR1 early growth response 1 -0.0187166
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0186766
KLF6 Kruppel-like factor 6 -0.0185569
JUN jun proto-oncogene -0.0184408
RPL31 ribosomal protein L31 -0.0184222
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0183774
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0183769
RPS27A ribosomal protein S27a -0.0180664
RPL8 ribosomal protein L8 -0.0180464
RPLP2 ribosomal protein, large, P2 -0.0173921
SQSTM1 sequestosome 1 -0.0172484
CALR calreticulin -0.017235
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0170546
RPL36 ribosomal protein L36 -0.0170383
RPL5 ribosomal protein L5 -0.0170253
S100A10 S100 calcium binding protein A10 -0.0167124
FTH1 ferritin, heavy polypeptide 1 -0.01666
TFRC transferrin receptor -0.0163977
SRGN serglycin -0.016119
EEF2 eukaryotic translation elongation factor 2 -0.0160164
RPL7A ribosomal protein L7a -0.0159892
RPL26 ribosomal protein L26 -0.0155362
CAVIN1 caveolae associated protein 1 -0.0153134
S100A9 S100 calcium binding protein A9 -0.01529
MYOF myoferlin -0.0152877
HMGA1 high mobility group AT-hook 1 -0.0151204
KDM3A lysine (K)-specific demethylase 3A -0.0151023
S100A6 S100 calcium binding protein A6 -0.0150861
IARS1 isoleucyl-tRNA synthetase 1 -0.015058
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0148436
JMJD1C jumonji domain containing 1C -0.0148203
LOXL2 lysyl oxidase-like 2 -0.0147031
CLIP2 CAP-GLY domain containing linker protein 2 -0.0144842
RPL37 ribosomal protein L37 -0.0144446
ANXA2 annexin A2 -0.0144306
UBC ubiquitin C -0.0143698
KPNB1 karyopherin (importin) beta 1 -0.0143143
RPS29 ribosomal protein S29 -0.0143002
WDR45B WD repeat domain 45B -0.0142212
LDHA lactate dehydrogenase A -0.0138706
RPS24 ribosomal protein S24 -0.01364
RPL37A ribosomal protein L37a -0.0136102
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.013376
GCLM glutamate-cysteine ligase, modifier subunit -0.0132291
RPS13 ribosomal protein S13 -0.0131143
RPL18 ribosomal protein L18 -0.0128465
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0127008
RPL38 ribosomal protein L38 -0.0126981
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0126939
APP amyloid beta (A4) precursor protein -0.0126452
RPL36A ribosomal protein L36a -0.0126367
RPL28 ribosomal protein L28 -0.012563
RUNX1 runt-related transcription factor 1 -0.0124642
NPR2 natriuretic peptide receptor 2 -0.0124446
SEPTIN7 septin 7 -0.0124238
RPS25 ribosomal protein S25 -0.0123719
PKM pyruvate kinase, muscle -0.0123717
RPS14 ribosomal protein S14 -0.0123299
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.012275
POTEF POTE ankyrin domain family, member F -0.0121292
HLA-B major histocompatibility complex, class I, B -0.0121292
RPS16 ribosomal protein S16 -0.0120495