Benproperine (phosphate)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0377109
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0346809
WAC WW domain containing adaptor with coiled-coil 0.0295894
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.022742
WWOX WW domain containing oxidoreductase 0.0219378
TRIO trio Rho guanine nucleotide exchange factor 0.0209716
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0200827
NCKAP1 NCK-associated protein 1 0.0188137
BIRC3 baculoviral IAP repeat containing 3 0.0186294
ALCAM activated leukocyte cell adhesion molecule 0.0185845
KTN1 kinectin 1 (kinesin receptor) 0.0179036
NDRG1 N-myc downstream regulated 1 0.0177862
SOD2 superoxide dismutase 2, mitochondrial 0.0177613
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0172157
TNPO1 transportin 1 0.0166613
ZEB1 zinc finger E-box binding homeobox 1 0.0159139
MARCHF6 membrane associated ring-CH-type finger 6 0.0157959
XPO1 exportin 1 0.0154756
UBA6 ubiquitin-like modifier activating enzyme 6 0.0150795
FLNB filamin B, beta 0.0149432
SLMAP sarcolemma associated protein 0.014582
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0144305
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0143658
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0143283
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0142084
AHNAK AHNAK nucleoprotein 0.0138717
SMAD3 SMAD family member 3 0.0136218
UHMK1 U2AF homology motif (UHM) kinase 1 0.0135951
PUM2 pumilio RNA-binding family member 2 0.0134007
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0132478
PRELID2 PRELI domain containing 2 0.0128919
RNF145 ring finger protein 145 0.012848
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0127986
YAP1 Yes-associated protein 1 0.0124014
PCBP2 poly(rC) binding protein 2 0.0121984
PAWR PRKC, apoptosis, WT1, regulator 0.0121211
KDM3A lysine (K)-specific demethylase 3A 0.0120339
RBM5 RNA binding motif protein 5 0.0119722
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0118472
APP amyloid beta (A4) precursor protein 0.0118208
ITSN2 intersectin 2 0.0117763
UGCG UDP-glucose ceramide glucosyltransferase 0.011749
ANKRD11 ankyrin repeat domain 11 0.0116152
ADAM17 ADAM metallopeptidase domain 17 0.0114182
ATP13A3 ATPase type 13A3 0.0113887
OGA O-GlcNAcase 0.0113543
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0112988
ZNF451 zinc finger protein 451 0.0112787
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0112567
CEP350 centrosomal protein 350kDa 0.0111323
KMT2C lysine (K)-specific methyltransferase 2C 0.0110393
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0109784
FRMD6 FERM domain containing 6 0.0109501
COG5 component of oligomeric golgi complex 5 0.0107903
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0106997
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0106214
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0105971
RAB2A RAB2A, member RAS oncogene family 0.0105932
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0105274
SEC23A Sec23 homolog A (S. cerevisiae) 0.0103449
RB1CC1 RB1-inducible coiled-coil 1 0.0102949
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0102891
TP53BP1 tumor protein p53 binding protein 1 0.010227
EPS8 epidermal growth factor receptor pathway substrate 8 0.0102052
HDAC2 histone deacetylase 2 0.010192
NEK7 NIMA-related kinase 7 0.0100049
LMO7 LIM domain 7 0.00999586
AKAP13 A kinase (PRKA) anchor protein 13 0.00991575
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00981595
SAMD4A sterile alpha motif domain containing 4A 0.00977568
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.00975882
NEMF nuclear export mediator factor 0.0095946
MYH9 myosin, heavy chain 9, non-muscle 0.00952558
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0094721
DIDO1 death inducer-obliterator 1 0.00946919
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.00940686
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.00927231
CDC73 cell division cycle 73 0.00924903
NIPBL Nipped-B homolog (Drosophila) 0.00917574
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.00915493
ZMYM2 zinc finger, MYM-type 2 0.0091337
MARCHF7 membrane associated ring-CH-type finger 7 0.00901099
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.00899637
TM9SF3 transmembrane 9 superfamily member 3 0.00898099
EIF3E eukaryotic translation initiation factor 3, subunit E 0.00887146
RASA2 RAS p21 protein activator 2 0.00886894
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.00886208
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.00884255
CLIP1 CAP-GLY domain containing linker protein 1 0.00881369
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00881066
SBF2 SET binding factor 2 0.00876294
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.00875582
CXCL2 chemokine (C-X-C motif) ligand 2 0.0087335
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.00872223
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.00866335
TMOD3 tropomodulin 3 (ubiquitous) 0.00862418
XPOT exportin, tRNA 0.00862046
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.00850175
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.00847655
GLS2 glutaminase 2 (liver, mitochondrial) 0.0084697

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.142808
TMSB10 thymosin beta 10 -0.130942
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.127942
FTL ferritin, light polypeptide -0.122386
TFPI2 tissue factor pathway inhibitor 2 -0.0792239
PDE4D phosphodiesterase 4D, cAMP-specific -0.0756056
PM20D1 peptidase M20 domain containing 1 -0.0727674
VIM vimentin -0.0593096
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0515989
TXNRD1 thioredoxin reductase 1 -0.0501994
GRAMD1B GRAM domain containing 1B -0.0480168
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0461911
ACTG1 actin gamma 1 -0.0454235
EGR1 early growth response 1 -0.0449357
AKAP12 A kinase (PRKA) anchor protein 12 -0.0437694
RPLP1 ribosomal protein, large, P1 -0.0423499
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0417286
FGB fibrinogen beta chain -0.0385252
POTEF POTE ankyrin domain family, member F -0.0370995
PKM pyruvate kinase, muscle -0.0369389
RPL19 ribosomal protein L19 -0.0331706
RPS12 ribosomal protein S12 -0.0330953
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0326933
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0320608
RPLP0 ribosomal protein, large, P0 -0.0319219
SVIL supervillin -0.0318253
KYNU kynureninase -0.0303901
STC1 stanniocalcin 1 -0.0301782
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0295576
THSD4 thrombospondin, type I, domain containing 4 -0.0290725
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0288506
S100A6 S100 calcium binding protein A6 -0.0283024
HDAC9 histone deacetylase 9 -0.0281779
TPI1 triosephosphate isomerase 1 -0.0277697
PTMA prothymosin, alpha -0.027354
RPL30 ribosomal protein L30 -0.02628
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0251086
PDLIM5 PDZ and LIM domain 5 -0.0247831
IER3 immediate early response 3 -0.0245948
OSMR oncostatin M receptor -0.0244515
PFN1 profilin 1 -0.0243221
IGF2 insulin-like growth factor 2 -0.0242095
PRDX1 peroxiredoxin 1 -0.0240414
YBX1 Y box binding protein 1 -0.0234617
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0220752
LOC112694756 uncharaterized LOC112694756 -0.0220356
RACK1 receptor for activated C kinase 1 -0.0218068
RPL23 ribosomal protein L23 -0.0217089
FTH1 ferritin, heavy polypeptide 1 -0.0217055
MAML3 mastermind-like 3 (Drosophila) -0.0214433
RPS21 ribosomal protein S21 -0.0212174
MT2A metallothionein 2A -0.0211936
KLF6 Kruppel-like factor 6 -0.0208677
EFNA5 ephrin-A5 -0.0201568
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0197875
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0197831
NTN4 netrin 4 -0.0195294
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0193465
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0190829
DENND4A DENN/MADD domain containing 4A -0.0189948
DOCK5 dedicator of cytokinesis 5 -0.0186495
NAV3 neuron navigator 3 -0.0185921
LOC102724023 ES1 protein homolog, mitochondrial -0.0185406
RPS19 ribosomal protein S19 -0.0182943
RASAL2 RAS protein activator like 2 -0.0181666
S100A11 S100 calcium binding protein A11 -0.018037
RPL37A ribosomal protein L37a -0.0178272
HMGA1 high mobility group AT-hook 1 -0.0172827
PLS3 plastin 3 -0.0171788
SLC38A2 solute carrier family 38, member 2 -0.0171178
EEF2 eukaryotic translation elongation factor 2 -0.0170761
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0164202
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.015925
RPS16 ribosomal protein S16 -0.015738
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0155695
RAB7A RAB7A, member RAS oncogene family -0.0155271
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.015465
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0152348
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0150891
RTN4 reticulon 4 -0.0150656
MCL1 myeloid cell leukemia 1 -0.0148977
S100A9 S100 calcium binding protein A9 -0.0147441
RPL8 ribosomal protein L8 -0.014587
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0144934
MYOF myoferlin -0.0144826
BMP6 bone morphogenetic protein 6 -0.0144773
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0144149
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0144082
NRG1 neuregulin 1 -0.014274
TAGLN2 transgelin 2 -0.0142498
ANXA1 annexin A1 -0.0141244
RPS20 ribosomal protein S20 -0.0140689
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0140211
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0140116
SERF2 small EDRK-rich factor 2 -0.0139488
SMOC1 SPARC related modular calcium binding 1 -0.0137526
ATP5F1A ATP synthase F1 subunit alpha -0.0136873
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0136082
BMP5 bone morphogenetic protein 5 -0.0134441
RPL18 ribosomal protein L18 -0.0134272