| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benproperine (phosphate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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194 genes differentially expressed following the Benproperine (phosphate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.125453 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.10471 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.104331 |
| EGFR | epidermal growth factor receptor | 0.10349 |
| VIM | vimentin | 0.100935 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0858077 |
| TXNRD1 | thioredoxin reductase 1 | 0.0830843 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0828297 |
| TMSB10 | thymosin beta 10 | 0.0799114 |
| FTL | ferritin, light polypeptide | 0.0771743 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0759009 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0701853 |
| GPC6 | glypican 6 | 0.0691123 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0686602 |
| FMNL2 | formin-like 2 | 0.068597 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0648312 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0646522 |
| MYOF | myoferlin | 0.0639559 |
| PTMA | prothymosin, alpha | 0.0588578 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0583134 |
| B2M | beta-2-microglobulin | 0.0575063 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0572801 |
| RPLP1 | ribosomal protein, large, P1 | 0.0552684 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0547232 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0545304 |
| FN1 | fibronectin 1 | 0.05224 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0512088 |
| FLNB | filamin B, beta | 0.0495139 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0493176 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0478875 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.046875 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0463763 |
| GOLGA4 | golgin A4 | 0.0462213 |
| RPL11 | ribosomal protein L11 | 0.0459968 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0424953 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0413628 |
| MEF2A | myocyte enhancer factor 2A | 0.0410677 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0382102 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0380767 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0365902 |
| SMAD3 | SMAD family member 3 | 0.0363803 |
| POTEF | POTE ankyrin domain family, member F | 0.0363093 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0350269 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0346375 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0344122 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.034372 |
| PTK2 | protein tyrosine kinase 2 | 0.0328752 |
| RPS16 | ribosomal protein S16 | 0.0323585 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0321337 |
| PHF21A | PHD finger protein 21A | 0.0298781 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0295625 |
| GOLGB1 | golgin B1 | 0.0294412 |
| PCBP2 | poly(rC) binding protein 2 | 0.0294024 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0277037 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0265686 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0264735 |
| NF1 | neurofibromin 1 | 0.0261624 |
| FBXO11 | F-box protein 11 | 0.0249923 |
| RPS12 | ribosomal protein S12 | 0.0249376 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0247327 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0246821 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0239006 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0233283 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0229169 |
| LOXL2 | lysyl oxidase-like 2 | 0.0222015 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0217636 |
| NAV2 | neuron navigator 2 | 0.0213347 |
| KLF6 | Kruppel-like factor 6 | 0.0212854 |
| SNX9 | sorting nexin 9 | 0.0205452 |
| SETD5 | SET domain containing 5 | 0.0200574 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0197781 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0191868 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0187571 |
| PDE10A | phosphodiesterase 10A | 0.0175372 |
| DIAPH1 | diaphanous-related formin 1 | 0.016765 |
| RAB10 | RAB10, member RAS oncogene family | 0.0164103 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0149436 |
| ENO1 | enolase 1, (alpha) | 0.0146109 |
| ERBIN | erbb2 interacting protein | 0.0140451 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0136617 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.012773 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0125776 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0117272 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0100396 |
| PGK1 | phosphoglycerate kinase 1 | 0.00998952 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.00996947 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.00875492 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0087453 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.00793812 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0078299 |
| SBF2 | SET binding factor 2 | 0.00772165 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.006984 |
| RIOK3 | RIO kinase 3 | 0.00683133 |
| GRB10 | growth factor receptor-bound protein 10 | 0.00660804 |
| RBM39 | RNA binding motif protein 39 | 0.00585465 |
| ASPH | aspartate beta-hydroxylase | 0.0049126 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.00287319 |
| EFNA5 | ephrin-A5 | 0.00228609 |
| RNF213 | ring finger protein 213 | 0.00169752 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0014566 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.257086 |
| MYO1E | myosin IE | -0.15151 |
| LAMB3 | laminin, beta 3 | -0.147722 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.138877 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.129532 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.107932 |
| KYNU | kynureninase | -0.0919942 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0904729 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0902312 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0892899 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0890979 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0872994 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0849134 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0823698 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0802685 |
| SPAG9 | sperm associated antigen 9 | -0.0778602 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0777368 |
| NDRG1 | N-myc downstream regulated 1 | -0.0741294 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0618793 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0587924 |
| RUNX1 | runt-related transcription factor 1 | -0.0569808 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0555013 |
| KIF5B | kinesin family member 5B | -0.0533955 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0525928 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0522174 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0497644 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0488589 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.045448 |
| ZNF292 | zinc finger protein 292 | -0.0439803 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0431194 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0393741 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0385516 |
| MAP4 | microtubule-associated protein 4 | -0.0368824 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0360789 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0359534 |
| USP33 | ubiquitin specific peptidase 33 | -0.033728 |
| RNF145 | ring finger protein 145 | -0.0334522 |
| CANX | calnexin | -0.0331776 |
| RLF | rearranged L-myc fusion | -0.0322488 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.0316463 |
| RPS6 | ribosomal protein S6 | -0.0313875 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0311003 |
| SMYD3 | SET and MYND domain containing 3 | -0.0293726 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0292011 |
| OGA | O-GlcNAcase | -0.0291725 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0289455 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0289237 |
| HELZ | helicase with zinc finger | -0.0285953 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0278044 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0270675 |
| LMO7 | LIM domain 7 | -0.0270314 |
| ATXN1 | ataxin 1 | -0.026807 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0264615 |
| LDHA | lactate dehydrogenase A | -0.024579 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.022227 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0218829 |
| RPL8 | ribosomal protein L8 | -0.0214308 |
| INSIG1 | insulin induced gene 1 | -0.0209231 |
| SRPK2 | SRSF protein kinase 2 | -0.0208189 |
| DST | dystonin | -0.0195717 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0190662 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0189156 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0189022 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0187929 |
| ZNF638 | zinc finger protein 638 | -0.0162405 |
| IGF2 | insulin-like growth factor 2 | -0.016066 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0153277 |
| RBM25 | RNA binding motif protein 25 | -0.0129462 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0121982 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0119764 |
| ANXA2 | annexin A2 | -0.0117972 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0116607 |
| JMJD1C | jumonji domain containing 1C | -0.0112164 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0111719 |
| RTN4 | reticulon 4 | -0.0110692 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0104755 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.00997696 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.00933259 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.00894623 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.00825816 |
| PARD3 | par-3 family cell polarity regulator | -0.00815488 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.00679698 |
| CD44 | CD44 molecule (Indian blood group) | -0.00611496 |
| STC1 | stanniocalcin 1 | -0.00567536 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0044496 |
| IER3 | immediate early response 3 | -0.00416504 |
| INHBA | inhibin, beta A | -0.00342876 |
| SEPTIN7 | septin 7 | -0.0033616 |
| PKM | pyruvate kinase, muscle | -0.00293891 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0018121 |
| RPS19 | ribosomal protein S19 | -8.87288E-4 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -6.24004E-4 |
| LMAN1 | lectin, mannose-binding, 1 | -1.66386E-4 |
| DDIT4 | DNA-damage-inducible transcript 4 | -1.03341E-4 |
