Benproperine (phosphate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0464598
THSD4 thrombospondin, type I, domain containing 4 0.0408498
ERRFI1 ERBB receptor feedback inhibitor 1 0.0382817
FMNL2 formin-like 2 0.0318
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0315519
MACF1 microtubule-actin crosslinking factor 1 0.0296848
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0252354
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0245873
PRELID2 PRELI domain containing 2 0.0245534
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0243181
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0238575
ZFAND3 zinc finger, AN1-type domain 3 0.0226284
EXOC4 exocyst complex component 4 0.0220521
HMGA2 high mobility group AT-hook 2 0.0218298
DOCK5 dedicator of cytokinesis 5 0.0215782
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0207395
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0199268
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0198892
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0191671
RAD51B RAD51 paralog B 0.018482
SMYD3 SET and MYND domain containing 3 0.0183548
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0179373
EXT1 exostosin glycosyltransferase 1 0.0174173
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0173705
AFF3 AF4/FMR2 family, member 3 0.0167136
CDK17 cyclin-dependent kinase 17 0.016704
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0153116
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0153013
WDPCP WD repeat containing planar cell polarity effector 0.0152968
YAP1 Yes-associated protein 1 0.0146479
ETNK1 ethanolamine kinase 1 0.0145804
WWOX WW domain containing oxidoreductase 0.0145404
SAMD4A sterile alpha motif domain containing 4A 0.0144644
ZNF407 zinc finger protein 407 0.0142709
ATXN1 ataxin 1 0.0142102
SLC38A2 solute carrier family 38, member 2 0.014203
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0140472
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0140127
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0139921
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0138813
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.013615
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0133509
PDE4D phosphodiesterase 4D, cAMP-specific 0.0125087
ATP13A3 ATPase type 13A3 0.0124755
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0124419
MED13L mediator complex subunit 13-like 0.0124377
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.012397
PTBP3 polypyrimidine tract binding protein 3 0.0123686
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0122818
MARCHF4 membrane associated ring-CH-type finger 4 0.0122575
MAPK8 mitogen-activated protein kinase 8 0.0121543
PDLIM5 PDZ and LIM domain 5 0.0120695
EFNA5 ephrin-A5 0.0120094
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0119109
PUM2 pumilio RNA-binding family member 2 0.0117922
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.011779
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.011773
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0116345
CEP192 centrosomal protein 192kDa 0.0116149
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0114986
RYR3 ryanodine receptor 3 0.011338
ZEB1 zinc finger E-box binding homeobox 1 0.0112034
SFPQ splicing factor proline/glutamine-rich 0.0111286
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.011081
PTK2 protein tyrosine kinase 2 0.0109865
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0108844
CDCP1 CUB domain containing protein 1 0.010834
RIMS2 regulating synaptic membrane exocytosis 2 0.0108305
RNF145 ring finger protein 145 0.0105705
AKAP12 A kinase (PRKA) anchor protein 12 0.0105676
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.010284
RABGAP1L RAB GTPase activating protein 1-like 0.0102612
DST dystonin 0.0102463
AFG2A AFG2 AAA ATPase homolog A 0.0101949
MEMO1 mediator of cell motility 1 0.010144
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0101231
PLCB4 phospholipase C, beta 4 0.0100983
AHCTF1 AT hook containing transcription factor 1 0.0100448
CARD16 caspase recruitment domain family, member 16 0.00999489
SP3 Sp3 transcription factor 0.00994155
GSK3B glycogen synthase kinase 3 beta 0.00990156
CAMTA1 calmodulin binding transcription activator 1 0.00988591
TM4SF1 transmembrane 4 L six family member 1 0.00988178
CLDN1 claudin 1 0.00981787
FNDC3B fibronectin type III domain containing 3B 0.00973234
TRIP12 thyroid hormone receptor interactor 12 0.00964169
OSMR oncostatin M receptor 0.00956091
CDYL chromodomain protein, Y-like 0.00953885
MTMR3 myotubularin related protein 3 0.00937128
LOXL2 lysyl oxidase-like 2 0.00929263
RERE arginine-glutamic acid dipeptide (RE) repeats 0.009291
SPIRE1 spire-type actin nucleation factor 1 0.00917383
CPNE8 copine VIII 0.00914125
LUZP1 leucine zipper protein 1 0.00910123
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.00909418
STRN3 striatin, calmodulin binding protein 3 0.00907627
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00906889
PALM2AKAP2 PALM2 and AKAP2 fusion 0.00897438
ANO6 anoctamin 6 0.00897403
TTC28 tetratricopeptide repeat domain 28 0.0089605

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.392934
VIM vimentin -0.116403
TMSB10 thymosin beta 10 -0.0941093
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0931377
PTMA prothymosin, alpha -0.0914854
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0869457
TPI1 triosephosphate isomerase 1 -0.0765313
RPS8 ribosomal protein S8 -0.0713735
EEF2 eukaryotic translation elongation factor 2 -0.0655869
RPS3 ribosomal protein S3 -0.062822
ACTG1 actin gamma 1 -0.0617086
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0579928
RPLP1 ribosomal protein, large, P1 -0.0575796
YBX3 Y box binding protein 3 -0.0566755
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0554255
RPL37A ribosomal protein L37a -0.0545413
RPL37 ribosomal protein L37 -0.0544625
EIF1 eukaryotic translation initiation factor 1 -0.0517772
MYL12B myosin, light chain 12B, regulatory -0.0471088
EGR1 early growth response 1 -0.0470525
RPS21 ribosomal protein S21 -0.0466639
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0463156
RPL23 ribosomal protein L23 -0.0457788
RPL26 ribosomal protein L26 -0.0456219
RPL12 ribosomal protein L12 -0.0456072
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0451361
FTL ferritin, light polypeptide -0.0447418
RPLP0 ribosomal protein, large, P0 -0.0439557
RPL35A ribosomal protein L35a -0.0435003
PFN1 profilin 1 -0.0406771
RPS19 ribosomal protein S19 -0.0402293
TFPI2 tissue factor pathway inhibitor 2 -0.0395211
RPS27 ribosomal protein S27 -0.0393169
RPL19 ribosomal protein L19 -0.0391097
TPT1 tumor protein, translationally-controlled 1 -0.0379901
GNAS GNAS complex locus -0.0374609
ENO1 enolase 1, (alpha) -0.0362305
MORF4L2 mortality factor 4 like 2 -0.0358441
RPS29 ribosomal protein S29 -0.0356771
RPS12 ribosomal protein S12 -0.0352269
RPL11 ribosomal protein L11 -0.0345939
CSDE1 cold shock domain containing E1, RNA-binding -0.0345247
RACK1 receptor for activated C kinase 1 -0.0340909
RPL32 ribosomal protein L32 -0.0331711
RPS15 ribosomal protein S15 -0.0331581
RPL5 ribosomal protein L5 -0.0328933
MT2A metallothionein 2A -0.032751
RPL8 ribosomal protein L8 -0.0327271
RPL31 ribosomal protein L31 -0.0324042
RPS27A ribosomal protein S27a -0.0320768
YBX1 Y box binding protein 1 -0.0310239
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0307742
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.030568
KTN1 kinectin 1 (kinesin receptor) -0.030286
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0301881
RPL36 ribosomal protein L36 -0.0296086
UBC ubiquitin C -0.0294596
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0290386
LMAN1 lectin, mannose-binding, 1 -0.0280593
RPL34 ribosomal protein L34 -0.0279952
H1-0 H1.0 linker histone -0.027906
TPM2 tropomyosin 2 (beta) -0.0278118
RPS10 ribosomal protein S10 -0.0278026
NACA nascent polypeptide-associated complex alpha subunit -0.0272908
KDM2A lysine (K)-specific demethylase 2A -0.0271865
RPS6 ribosomal protein S6 -0.0271349
LDHB lactate dehydrogenase B -0.0269243
RPLP2 ribosomal protein, large, P2 -0.0265355
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0264065
RPL38 ribosomal protein L38 -0.0262779
BRD2 bromodomain containing 2 -0.0262388
LOC112694756 uncharaterized LOC112694756 -0.0262181
CANX calnexin -0.0261667
S100A6 S100 calcium binding protein A6 -0.0261023
RPL7A ribosomal protein L7a -0.0260247
NAP1L1 nucleosome assembly protein 1-like 1 -0.0257448
TXNRD1 thioredoxin reductase 1 -0.0254864
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0247795
WSB1 WD repeat and SOCS box containing 1 -0.0247683
RPS4X ribosomal protein S4, X-linked -0.0247626
LRRC23 leucine rich repeat containing 23 -0.0246079
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0241688
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0239896
SRP72 signal recognition particle 72kDa -0.023988
UBB ubiquitin B -0.0238142
KMT2A lysine (K)-specific methyltransferase 2A -0.023722
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0236461
CALR calreticulin -0.0236048
PGK1 phosphoglycerate kinase 1 -0.0234924
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0233262
HLA-B major histocompatibility complex, class I, B -0.0231805
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.023073
EIF5B eukaryotic translation initiation factor 5B -0.0229415
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0229315
RPL36A ribosomal protein L36a -0.0229154
RPL35 ribosomal protein L35 -0.022754
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.022734
RPS25 ribosomal protein S25 -0.0224692
VDAC1 voltage-dependent anion channel 1 -0.0223518
CAVIN1 caveolae associated protein 1 -0.022295