Benproperine (phosphate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.17874
POTEF POTE ankyrin domain family, member F 0.167678
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.149263
KRT7 keratin 7, type II 0.123933
ACTG1 actin gamma 1 0.113591
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0943684
CCND1 cyclin D1 0.0906214
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.075061
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.067275
EEF2 eukaryotic translation elongation factor 2 0.0655103
BHLHE40 basic helix-loop-helix family, member e40 0.0634503
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0622823
RACK1 receptor for activated C kinase 1 0.055988
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0558218
ASPH aspartate beta-hydroxylase 0.0554962
ZFP36L1 ZFP36 ring finger protein-like 1 0.0552118
TRIO trio Rho guanine nucleotide exchange factor 0.0547395
SAMD4A sterile alpha motif domain containing 4A 0.0527013
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0521761
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0512923
TM4SF1 transmembrane 4 L six family member 1 0.0492964
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0484382
USP3 ubiquitin specific peptidase 3 0.0471501
ALCAM activated leukocyte cell adhesion molecule 0.0456768
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0455591
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0451766
FXR1 fragile X mental retardation, autosomal homolog 1 0.0424068
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0418452
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.040659
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0397782
ANXA2 annexin A2 0.0394014
ZSWIM6 zinc finger, SWIM-type containing 6 0.0393723
PLAU plasminogen activator, urokinase 0.0392212
PGK1 phosphoglycerate kinase 1 0.0387678
PCBP2 poly(rC) binding protein 2 0.0372852
DST dystonin 0.0369594
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0366661
ADAM9 ADAM metallopeptidase domain 9 0.0365061
RPL34 ribosomal protein L34 0.03553
PAPOLA poly(A) polymerase alpha 0.0353527
SVIL supervillin 0.0353506
S100A6 S100 calcium binding protein A6 0.0351556
EEF1G eukaryotic translation elongation factor 1 gamma 0.0344191
AREG amphiregulin 0.0343022
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0342705
PLEC plectin 0.0341487
SCEL sciellin 0.0337959
SDC4 syndecan 4 0.0337202
CAV1 caveolin 1, caveolae protein, 22kDa 0.0332452
CXCL8 chemokine (C-X-C motif) ligand 8 0.0331937
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0326607
SLC38A1 solute carrier family 38, member 1 0.0323118
SGMS2 sphingomyelin synthase 2 0.0319267
AHNAK AHNAK nucleoprotein 0.0316645
CSDE1 cold shock domain containing E1, RNA-binding 0.0314965
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0314892
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0314052
NUP58 nucleoporin 58 0.0313881
CDC73 cell division cycle 73 0.0313341
CTSB cathepsin B 0.0312143
MYH9 myosin, heavy chain 9, non-muscle 0.0310604
MBNL1 muscleblind-like splicing regulator 1 0.0306361
ZFAND3 zinc finger, AN1-type domain 3 0.0304786
MSN moesin 0.0303311
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.030303
HSPA8 heat shock 70kDa protein 8 0.0294032
LMO7 LIM domain 7 0.0293443
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0292913
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0290815
EGR1 early growth response 1 0.0290467
S100A10 S100 calcium binding protein A10 0.0286159
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0285138
APP amyloid beta (A4) precursor protein 0.0283217
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0281549
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0281011
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0280809
DEK DEK proto-oncogene 0.0277693
CELF2 CUGBP, Elav-like family member 2 0.0277345
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.027388
DENND4A DENN/MADD domain containing 4A 0.027385
HMGA1 high mobility group AT-hook 1 0.0271173
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0268805
APLP2 amyloid beta (A4) precursor-like protein 2 0.0268307
ZBTB20 zinc finger and BTB domain containing 20 0.0264211
FTH1 ferritin, heavy polypeptide 1 0.026167
CRABP2 cellular retinoic acid binding protein 2 0.0253235
KPNB1 karyopherin (importin) beta 1 0.0249356
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0248867
RPS2 ribosomal protein S2 0.0248607
RPL27A ribosomal protein L27a 0.024856
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.024772
RPS20 ribosomal protein S20 0.0246357
BTBD7 BTB (POZ) domain containing 7 0.02442
RPL14 ribosomal protein L14 0.0243623
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0243296
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0242229
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0241904
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0241697
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0240471
ACTN4 actinin, alpha 4 0.0239851

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.205499
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.177161
FAM13A family with sequence similarity 13, member A -0.106138
FTL ferritin, light polypeptide -0.0966044
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0855646
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.08512
GOLGA4 golgin A4 -0.0846534
PTMA prothymosin, alpha -0.0844488
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0661749
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0643357
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0626335
FBXO32 F-box protein 32 -0.0575287
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0565607
ACBD3 acyl-CoA binding domain containing 3 -0.0525835
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0525776
NPEPPS aminopeptidase puromycin sensitive -0.0524061
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0519067
IGFBP3 insulin-like growth factor binding protein 3 -0.0509323
RSRC2 arginine/serine-rich coiled-coil 2 -0.049319
SEC31A SEC31 homolog A (S. cerevisiae) -0.0490625
IFI16 interferon, gamma-inducible protein 16 -0.0487374
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0478188
DTNA dystrobrevin, alpha -0.0450816
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0434743
IFI27 interferon, alpha-inducible protein 27 -0.0429479
RBM25 RNA binding motif protein 25 -0.0425999
FNDC3B fibronectin type III domain containing 3B -0.0419747
BASP1 brain abundant, membrane attached signal protein 1 -0.0419667
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0402538
OSBPL3 oxysterol binding protein-like 3 -0.0374358
SEC23A Sec23 homolog A (S. cerevisiae) -0.0374049
OGA O-GlcNAcase -0.0361069
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0357896
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0351944
PLAUR plasminogen activator, urokinase receptor -0.0349391
BIRC6 baculoviral IAP repeat containing 6 -0.0340382
ARRDC3 arrestin domain containing 3 -0.0339534
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0338955
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0336954
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0335228
TPT1 tumor protein, translationally-controlled 1 -0.0332575
DSCAM Down syndrome cell adhesion molecule -0.0330483
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0326406
UPP1 uridine phosphorylase 1 -0.0326043
SLMAP sarcolemma associated protein -0.032479
WSB1 WD repeat and SOCS box containing 1 -0.0323355
NKTR natural killer cell triggering receptor -0.0320764
FAM3C family with sequence similarity 3, member C -0.0318571
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0317317
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0317119
FAM162A family with sequence similarity 162, member A -0.0316538
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0315995
VEZT vezatin, adherens junctions transmembrane protein -0.0315768
KMT2C lysine (K)-specific methyltransferase 2C -0.0314137
LIMCH1 LIM and calponin homology domains 1 -0.0310731
BBX bobby sox homolog (Drosophila) -0.0308448
MRPS6 mitochondrial ribosomal protein S6 -0.0307512
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0306678
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0305708
NAV2 neuron navigator 2 -0.0305493
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0305054
COPA coatomer protein complex, subunit alpha -0.0304356
ATP11B ATPase, class VI, type 11B -0.0300083
KDM3A lysine (K)-specific demethylase 3A -0.030005
TMEM263 transmembrane protein 263 -0.029912
RPLP2 ribosomal protein, large, P2 -0.0294589
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0293576
ITCH itchy E3 ubiquitin protein ligase -0.02916
C15ORF48 chromosome 15 open reading frame 48 -0.0289201
NEMF nuclear export mediator factor -0.0287731
IFIH1 interferon induced with helicase C domain 1 -0.0281048
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0280752
CCNY cyclin Y -0.0277353
MYO1E myosin IE -0.0276818
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0267517
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0265907
TMF1 TATA element modulatory factor 1 -0.026536
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0265255
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0264871
RPS19 ribosomal protein S19 -0.0264349
DLG1 discs, large homolog 1 (Drosophila) -0.02623
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.0258123
KLHL24 kelch-like family member 24 -0.025705
ZMYM2 zinc finger, MYM-type 2 -0.0253826
NDFIP1 Nedd4 family interacting protein 1 -0.0252535
SRPK2 SRSF protein kinase 2 -0.0251322
KDM5B lysine (K)-specific demethylase 5B -0.0249753
BRWD1 bromodomain and WD repeat domain containing 1 -0.0248893
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0247165
AFDN afadin, adherens junction formation factor -0.0243039
TM9SF3 transmembrane 9 superfamily member 3 -0.0242932
TMEM41B transmembrane protein 41B -0.0242125
CTNND1 catenin (cadherin-associated protein), delta 1 -0.024025
RPL9 ribosomal protein L9 -0.023918
FBXO34 F-box protein 34 -0.0238472
BRWD3 bromodomain and WD repeat domain containing 3 -0.0237258
HLA-B major histocompatibility complex, class I, B -0.0236199
NRIP1 nuclear receptor interacting protein 1 -0.0235354
CD109 CD109 molecule -0.0234973
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0234894