Benproperine (phosphate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DOCK4 dedicator of cytokinesis 4 0.0295338
NRCAM neuronal cell adhesion molecule 0.029199
FNDC3B fibronectin type III domain containing 3B 0.0239639
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0223521
TNPO1 transportin 1 0.0219814
ASPH aspartate beta-hydroxylase 0.0218749
PM20D1 peptidase M20 domain containing 1 0.0213992
LSAMP limbic system-associated membrane protein 0.0205066
P3H2 prolyl 3-hydroxylase 2 0.0203693
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0193464
NRG1 neuregulin 1 0.0192339
PTEN phosphatase and tensin homolog 0.0179155
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0177318
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0162479
BDNF brain-derived neurotrophic factor 0.0159843
COL5A2 collagen, type V, alpha 2 0.0153997
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0153929
NEK7 NIMA-related kinase 7 0.0143107
GPC6 glypican 6 0.0140879
BCAR3 breast cancer anti-estrogen resistance 3 0.0137706
AGFG1 ArfGAP with FG repeats 1 0.0131617
CENPF centromere protein F, 350/400kDa 0.0130405
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0129518
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0122781
SLC38A2 solute carrier family 38, member 2 0.0122068
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0116626
EXT1 exostosin glycosyltransferase 1 0.0114742
ARHGAP29 Rho GTPase activating protein 29 0.0113226
PTBP2 polypyrimidine tract binding protein 2 0.0112579
MED13L mediator complex subunit 13-like 0.0111717
RTN4 reticulon 4 0.0110701
CHD1 chromodomain helicase DNA binding protein 1 0.0110572
SDK1 sidekick cell adhesion molecule 1 0.0108188
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0105921
TENT4A terminal nucleotidyltransferase 4A 0.010503
RBM25 RNA binding motif protein 25 0.0104741
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0103754
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0102938
SMOC1 SPARC related modular calcium binding 1 0.0102292
UGCG UDP-glucose ceramide glucosyltransferase 0.0102041
TRIO trio Rho guanine nucleotide exchange factor 0.0100879
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0100649
GPAT3 glycerol-3-phosphate acyltransferase 3 0.00992563
AKAP13 A kinase (PRKA) anchor protein 13 0.00982295
CLINT1 clathrin interactor 1 0.00981036
DIAPH3 diaphanous-related formin 3 0.00979793
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.00979417
GPRIN3 GPRIN family member 3 0.00976065
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.00969804
CUL3 cullin 3 0.00967977
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.00962288
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.00955446
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.00948129
RAD51B RAD51 paralog B 0.00933746
BTBD10 BTB (POZ) domain containing 10 0.0093129
SRSF4 serine/arginine-rich splicing factor 4 0.00930157
CAMTA1 calmodulin binding transcription activator 1 0.00929413
SNX13 sorting nexin 13 0.00923028
ANLN anillin, actin binding protein 0.00919287
NUP58 nucleoporin 58 0.00914581
SMG7 SMG7 nonsense mediated mRNA decay factor 0.00912236
PCBP3 poly(rC) binding protein 3 0.009097
ZNF292 zinc finger protein 292 0.00908249
ADAM9 ADAM metallopeptidase domain 9 0.00902891
ATP13A3 ATPase type 13A3 0.00898128
KDM6A lysine (K)-specific demethylase 6A 0.00897229
SFPQ splicing factor proline/glutamine-rich 0.00885923
CDK6 cyclin-dependent kinase 6 0.00885152
MYO10 myosin X 0.00883357
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.00881702
LIN7A lin-7 homolog A (C. elegans) 0.00881219
FBXL5 F-box and leucine-rich repeat protein 5 0.00872924
ARHGAP26 Rho GTPase activating protein 26 0.0087176
WWOX WW domain containing oxidoreductase 0.00869114
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0086877
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0086645
ENAH enabled homolog (Drosophila) 0.00863424
DIDO1 death inducer-obliterator 1 0.00863122
WWTR1 WW domain containing transcription regulator 1 0.00861241
ETNK1 ethanolamine kinase 1 0.00852519
FAM3C family with sequence similarity 3, member C 0.00850819
RASA2 RAS p21 protein activator 2 0.00844057
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.00841132
AGTPBP1 ATP/GTP binding protein 1 0.00833396
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.00823569
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.00821138
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 0.00821016
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.00817663
ANKRD11 ankyrin repeat domain 11 0.00815234
STAT1 signal transducer and activator of transcription 1, 91kDa 0.00813135
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.00812067
TAS2R14 taste receptor, type 2, member 14 0.00803452
PDE8A phosphodiesterase 8A 0.00801515
PSME4 proteasome (prosome, macropain) activator subunit 4 0.00800235
PTBP3 polypyrimidine tract binding protein 3 0.00798171
RBM33 RNA binding motif protein 33 0.00794743
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.00787428
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.00786341
DPY19L1 dpy-19-like 1 (C. elegans) 0.00782585
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.00782185

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.216274
FN1 fibronectin 1 -0.174587
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.151762
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.110002
VIM vimentin -0.105944
TMSB10 thymosin beta 10 -0.0941071
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.085609
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0831548
IGFBP3 insulin-like growth factor binding protein 3 -0.0714943
CANX calnexin -0.0693213
PTMA prothymosin, alpha -0.0656721
FTL ferritin, light polypeptide -0.0640019
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0598663
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0564101
PGK1 phosphoglycerate kinase 1 -0.0552506
RPLP1 ribosomal protein, large, P1 -0.053978
EFNA5 ephrin-A5 -0.0512526
B2M beta-2-microglobulin -0.0511661
S100A6 S100 calcium binding protein A6 -0.0507948
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0494199
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0488904
DDIT4 DNA-damage-inducible transcript 4 -0.0465869
MT2A metallothionein 2A -0.0449702
RPL12 ribosomal protein L12 -0.0447509
EIF1 eukaryotic translation initiation factor 1 -0.0440094
LDHA lactate dehydrogenase A -0.0426012
NAMPT nicotinamide phosphoribosyltransferase -0.0415441
MAML3 mastermind-like 3 (Drosophila) -0.0408591
RPL19 ribosomal protein L19 -0.0405401
ENO1 enolase 1, (alpha) -0.0393188
RPS6 ribosomal protein S6 -0.0388198
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0384413
MYOF myoferlin -0.0380548
RPL7A ribosomal protein L7a -0.0380049
TFPI2 tissue factor pathway inhibitor 2 -0.0378779
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0376824
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0374351
RPL31 ribosomal protein L31 -0.0370166
S100A10 S100 calcium binding protein A10 -0.0368029
NAP1L1 nucleosome assembly protein 1-like 1 -0.0364307
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.035313
TPT1 tumor protein, translationally-controlled 1 -0.0352662
EEF2 eukaryotic translation elongation factor 2 -0.0352168
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0349368
RPS12 ribosomal protein S12 -0.0346649
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0343074
RPLP0 ribosomal protein, large, P0 -0.0343071
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0335188
RPS23 ribosomal protein S23 -0.033475
RPS19 ribosomal protein S19 -0.0333513
TM4SF1 transmembrane 4 L six family member 1 -0.0331764
RPS16 ribosomal protein S16 -0.0327383
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0319441
PDIA3 protein disulfide isomerase family A, member 3 -0.0316705
RPS3 ribosomal protein S3 -0.0315677
PYGL phosphorylase, glycogen, liver -0.0315149
HLA-B major histocompatibility complex, class I, B -0.0310269
LIMCH1 LIM and calponin homology domains 1 -0.0307528
TGFBI transforming growth factor, beta-induced, 68kDa -0.030594
DGKD diacylglycerol kinase, delta 130kDa -0.030213
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0300649
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0296334
SPAG9 sperm associated antigen 9 -0.0296168
BZW1 basic leucine zipper and W2 domains 1 -0.029604
RPS8 ribosomal protein S8 -0.0291677
MXI1 MAX interactor 1, dimerization protein -0.0289704
ELL2 elongation factor, RNA polymerase II, 2 -0.0287091
RPL13A ribosomal protein L13a -0.0280572
ANXA2 annexin A2 -0.0277928
ACTG1 actin gamma 1 -0.0276536
HLA-A major histocompatibility complex, class I, A -0.0275026
RPS29 ribosomal protein S29 -0.0274865
CTSL cathepsin L -0.0272699
RPL37A ribosomal protein L37a -0.0269699
WSB1 WD repeat and SOCS box containing 1 -0.0269543
PDGFA platelet-derived growth factor alpha polypeptide -0.026833
PDE4D phosphodiesterase 4D, cAMP-specific -0.0265063
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0263946
RPL35A ribosomal protein L35a -0.0263525
GNAS GNAS complex locus -0.0263315
FAM13A family with sequence similarity 13, member A -0.0261698
RPL37 ribosomal protein L37 -0.0259062
SQSTM1 sequestosome 1 -0.0258653
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0257623
PDE10A phosphodiesterase 10A -0.0252578
RACK1 receptor for activated C kinase 1 -0.0249597
SFTPA2 surfactant protein A2 -0.0249205
PRRC2C proline-rich coiled-coil 2C -0.0249086
RPL27A ribosomal protein L27a -0.0246828
RGS2 regulator of G-protein signaling 2 -0.0246391
YBX3 Y box binding protein 3 -0.0244302
TBXT T-box transcription factor T -0.0243472
PKM pyruvate kinase, muscle -0.0238508
STC1 stanniocalcin 1 -0.0237056
SMYD3 SET and MYND domain containing 3 -0.0235177
RPS14 ribosomal protein S14 -0.0234376
TPI1 triosephosphate isomerase 1 -0.0234108
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0232619
ESYT2 extended synaptotagmin-like protein 2 -0.0230118
RPL34 ribosomal protein L34 -0.0226495