Benproperine (phosphate)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
THSD4 thrombospondin, type I, domain containing 4 0.0706729
TRIO trio Rho guanine nucleotide exchange factor 0.0655541
AHNAK AHNAK nucleoprotein 0.0504778
SLC35F3 solute carrier family 35, member F3 0.0485414
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0474809
ATP13A3 ATPase type 13A3 0.0452201
FMNL2 formin-like 2 0.0391887
NAV2 neuron navigator 2 0.0381634
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0348583
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0345657
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0275846
QKI QKI, KH domain containing, RNA binding 0.0257156
RAP1B RAP1B, member of RAS oncogene family 0.0251202
ZFAND3 zinc finger, AN1-type domain 3 0.0241312
MYO10 myosin X 0.024016
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0236561
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0230818
PTK2 protein tyrosine kinase 2 0.0229075
PDE10A phosphodiesterase 10A 0.0228713
HMGA2 high mobility group AT-hook 2 0.0227465
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0219986
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0218425
CD109 CD109 molecule 0.0213498
USP3 ubiquitin specific peptidase 3 0.0208672
DIAPH2 diaphanous-related formin 2 0.0207411
EGFR epidermal growth factor receptor 0.0198167
ANKRD11 ankyrin repeat domain 11 0.0196467
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0183954
TFG TRK-fused gene 0.0183787
PICALM phosphatidylinositol binding clathrin assembly protein 0.0178785
ZEB1 zinc finger E-box binding homeobox 1 0.0177771
ADAM17 ADAM metallopeptidase domain 17 0.017575
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0171728
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.016834
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0163133
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0161046
ELL2 elongation factor, RNA polymerase II, 2 0.0160548
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0156115
NHSL1 NHS-like 1 0.0154923
UBASH3B ubiquitin associated and SH3 domain containing B 0.0145892
PTPRJ protein tyrosine phosphatase, receptor type, J 0.014114
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.013757
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0134661
UGCG UDP-glucose ceramide glucosyltransferase 0.0132532
BZW1 basic leucine zipper and W2 domains 1 0.0130187
CMIP c-Maf inducing protein 0.012624
MED13L mediator complex subunit 13-like 0.0125831
ITGA6 integrin, alpha 6 0.0124508
FOXJ3 forkhead box J3 0.0123913
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0123255
GRB10 growth factor receptor-bound protein 10 0.0122861
SH3KBP1 SH3-domain kinase binding protein 1 0.0120988
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0119167
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0118627
RNF220 ring finger protein 220 0.0117304
ECT2 epithelial cell transforming 2 0.0116736
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0115874
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0114857
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0114568
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0113533
CRY1 cryptochrome circadian clock 1 0.0112896
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0112561
BIRC3 baculoviral IAP repeat containing 3 0.0110296
PUM2 pumilio RNA-binding family member 2 0.0110233
MEF2A myocyte enhancer factor 2A 0.0109854
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0108447
KRT8 keratin 8, type II 0.01071
MARCHF6 membrane associated ring-CH-type finger 6 0.0106451
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0106171
HIPK2 homeodomain interacting protein kinase 2 0.0104647
RAD23B RAD23 homolog B (S. cerevisiae) 0.010386
SDK1 sidekick cell adhesion molecule 1 0.0102648
SPAG9 sperm associated antigen 9 0.0101894
CAMTA1 calmodulin binding transcription activator 1 0.0101656
RYK receptor-like tyrosine kinase 0.0100361
TM9SF3 transmembrane 9 superfamily member 3 0.00982766
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.00981932
LRPPRC leucine-rich pentatricopeptide repeat containing 0.00976557
WAC WW domain containing adaptor with coiled-coil 0.0097599
LPP LIM domain containing preferred translocation partner in lipoma 0.00975909
OLA1 Obg-like ATPase 1 0.00974473
BIRC6 baculoviral IAP repeat containing 6 0.00969015
FAR1 fatty acyl CoA reductase 1 0.0096747
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.00963137
ADGRG6 adhesion G protein-coupled receptor G6 0.00961578
EXOC4 exocyst complex component 4 0.00956101
SNX9 sorting nexin 9 0.00954227
ATG7 autophagy related 7 0.0094844
HSPG2 heparan sulfate proteoglycan 2 0.00945596
CTBP2 C-terminal binding protein 2 0.00940954
WWC2 WW and C2 domain containing 2 0.00936316
LRRC49 leucine rich repeat containing 49 0.00933867
NPAS2 neuronal PAS domain protein 2 0.00932095
TMEM123 transmembrane protein 123 0.00911033
ADAM9 ADAM metallopeptidase domain 9 0.00900961
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.00896542
PTBP3 polypyrimidine tract binding protein 3 0.00895173
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.00885067
MSN moesin 0.00884252
PLAU plasminogen activator, urokinase 0.00876602

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.252248
VIM vimentin -0.156872
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.141607
SAMD4B sterile alpha motif domain containing 4B -0.0961793
AKAP12 A kinase (PRKA) anchor protein 12 -0.0758683
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.070377
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0695887
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0653988
PTMA prothymosin, alpha -0.0630021
TXNRD1 thioredoxin reductase 1 -0.0597995
RPLP2 ribosomal protein, large, P2 -0.0568087
FBL fibrillarin -0.0564376
RPS2 ribosomal protein S2 -0.0550444
KTN1 kinectin 1 (kinesin receptor) -0.0532697
SFTPA2 surfactant protein A2 -0.052126
SMAD3 SMAD family member 3 -0.0516516
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0506272
FTL ferritin, light polypeptide -0.0475978
RPLP1 ribosomal protein, large, P1 -0.0475114
WWTR1 WW domain containing transcription regulator 1 -0.0474445
RPS8 ribosomal protein S8 -0.0468378
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0467255
ACTN4 actinin, alpha 4 -0.0436096
EIF1 eukaryotic translation initiation factor 1 -0.0430081
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0405857
VMP1 vacuole membrane protein 1 -0.040578
RPS12 ribosomal protein S12 -0.0395424
SQSTM1 sequestosome 1 -0.0394593
JMJD1C jumonji domain containing 1C -0.0382804
RPS3 ribosomal protein S3 -0.0381208
BRD2 bromodomain containing 2 -0.0375682
ANXA2 annexin A2 -0.0374519
ARRDC3 arrestin domain containing 3 -0.036173
CSNK1A1 casein kinase 1, alpha 1 -0.0358323
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0350289
ACTG1 actin gamma 1 -0.0347639
MYH9 myosin, heavy chain 9, non-muscle -0.0346016
B2M beta-2-microglobulin -0.0340501
RPL37A ribosomal protein L37a -0.0340043
CDK19 cyclin-dependent kinase 19 -0.0335675
S100A6 S100 calcium binding protein A6 -0.0331488
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0327569
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.032636
CENPF centromere protein F, 350/400kDa -0.0323011
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0321865
MED29 mediator complex subunit 29 -0.0319017
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0318133
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0315592
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0312359
RPS13 ribosomal protein S13 -0.0309791
LMNA lamin A/C -0.0301645
ZFP36 ZFP36 ring finger protein -0.0300716
DSCAM Down syndrome cell adhesion molecule -0.0300365
CARS1 cysteinyl-tRNA synthetase 1 -0.0299322
RPL28 ribosomal protein L28 -0.0287168
RPL7 ribosomal protein L7 -0.0284727
ATXN1 ataxin 1 -0.028402
SEPTIN9 septin 9 -0.0281117
NAP1L1 nucleosome assembly protein 1-like 1 -0.0278784
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0277753
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0274305
KDM2A lysine (K)-specific demethylase 2A -0.0274203
MYOF myoferlin -0.0271089
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0268774
MORF4L2 mortality factor 4 like 2 -0.0267528
GOLGB1 golgin B1 -0.0266909
RPS6 ribosomal protein S6 -0.0266625
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -0.0265884
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0262417
NUP98 nucleoporin 98kDa -0.026132
FBXO17 F-box protein 17 -0.0259363
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0259004
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0258337
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0257119
RPL12 ribosomal protein L12 -0.025666
SET SET nuclear proto-oncogene -0.0255941
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0253331
RPLP0 ribosomal protein, large, P0 -0.0253146
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0251505
RPL36A ribosomal protein L36a -0.0248221
RPL26 ribosomal protein L26 -0.0243844
THOC2 THO complex 2 -0.024253
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0242255
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0240196
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0237484
RACK1 receptor for activated C kinase 1 -0.0237457
SMYD3 SET and MYND domain containing 3 -0.0236713
MAP3K10 mitogen-activated protein kinase kinase kinase 10 -0.0236243
ANGPTL4 angiopoietin-like 4 -0.0235876
WNK1 WNK lysine deficient protein kinase 1 -0.0235857
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.0235288
CANX calnexin -0.0234635
MKI67 marker of proliferation Ki-67 -0.0233703
UBC ubiquitin C -0.0233605
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0232736
RPL38 ribosomal protein L38 -0.0231868
AKAP9 A kinase (PRKA) anchor protein 9 -0.0231719
RPL11 ribosomal protein L11 -0.0230602
PRRC2C proline-rich coiled-coil 2C -0.0229049
ASPH aspartate beta-hydroxylase -0.022686