Benproperine (phosphate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0326598
FOS FBJ murine osteosarcoma viral oncogene homolog 0.03109
MCL1 myeloid cell leukemia 1 0.0284907
EGR1 early growth response 1 0.0265921
MED13L mediator complex subunit 13-like 0.0246135
NUP58 nucleoporin 58 0.0233907
GRB10 growth factor receptor-bound protein 10 0.0232735
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0226788
TPD52 tumor protein D52 0.0215262
ERRFI1 ERBB receptor feedback inhibitor 1 0.0206174
VEGFA vascular endothelial growth factor A 0.0194503
FNDC3B fibronectin type III domain containing 3B 0.0189841
APLP2 amyloid beta (A4) precursor-like protein 2 0.0187842
KMT2E lysine (K)-specific methyltransferase 2E 0.0183525
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0181329
KTN1 kinectin 1 (kinesin receptor) 0.018114
ZNF292 zinc finger protein 292 0.0176283
JAM3 junctional adhesion molecule 3 0.017618
CA8 carbonic anhydrase VIII 0.017545
ADAM17 ADAM metallopeptidase domain 17 0.0166074
TPM3 tropomyosin 3 0.0165747
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0165745
CCNL1 cyclin L1 0.0163102
TPM4 tropomyosin 4 0.0160804
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0160606
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0149172
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0148051
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0146538
MIDEAS mitotic deacetylase associated SANT domain protein 0.0146391
MYH9 myosin, heavy chain 9, non-muscle 0.0143485
PCBP2 poly(rC) binding protein 2 0.0141673
PUM2 pumilio RNA-binding family member 2 0.0138793
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0134226
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0134044
SLF1 SMC5-SMC6 complex localization factor 1 0.0133543
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0133131
MBNL2 muscleblind-like splicing regulator 2 0.013249
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0130172
FAM13A family with sequence similarity 13, member A 0.0129696
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0129601
NUF2 NUF2, NDC80 kinetochore complex component 0.0129484
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0128661
ASPH aspartate beta-hydroxylase 0.0128412
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0128068
PIAS2 protein inhibitor of activated STAT, 2 0.0127697
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0124007
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0123806
RNF145 ring finger protein 145 0.0122865
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0122192
RREB1 ras responsive element binding protein 1 0.0120158
XPO1 exportin 1 0.0119059
CHGB chromogranin B 0.0116948
WDR45B WD repeat domain 45B 0.0116711
UBA6 ubiquitin-like modifier activating enzyme 6 0.0116114
PICALM phosphatidylinositol binding clathrin assembly protein 0.011541
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.011508
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.011479
CD24 CD24 molecule 0.0113757
JUN jun proto-oncogene 0.0111092
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0110604
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0110171
RNPS1 RNA binding protein S1, serine-rich domain 0.0109995
TENT5A terminal nucleotidyltransferase 5A 0.0109829
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0109395
VMP1 vacuole membrane protein 1 0.0108694
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0108644
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0108549
SREBF2 sterol regulatory element binding transcription factor 2 0.0108517
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0108495
RTN4 reticulon 4 0.0108436
KDM6A lysine (K)-specific demethylase 6A 0.0108286
PKM pyruvate kinase, muscle 0.0108132
NAMPT nicotinamide phosphoribosyltransferase 0.0107899
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0107763
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0107252
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0106566
FAM162A family with sequence similarity 162, member A 0.0103449
AZIN1 antizyme inhibitor 1 0.0102851
HP1BP3 heterochromatin protein 1, binding protein 3 0.0102494
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0102385
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00997592
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.00997226
YTHDC1 YTH domain containing 1 0.00993091
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.00972195
EIF5 eukaryotic translation initiation factor 5 0.00970383
RCOR1 REST corepressor 1 0.00969441
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.00966529
RHOA ras homolog family member A 0.009611
ACSL3 acyl-CoA synthetase long-chain family member 3 0.00960737
ARHGAP29 Rho GTPase activating protein 29 0.00956506
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.00951216
AHR aryl hydrocarbon receptor 0.00951144
WDFY2 WD repeat and FYVE domain containing 2 0.00950916
CDK8 cyclin-dependent kinase 8 0.0094768
PGAP1 post-GPI attachment to proteins 1 0.00938232
ATAD2 ATPase family, AAA domain containing 2 0.00938184
EGLN3 egl-9 family hypoxia-inducible factor 3 0.00937958
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00934898
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.00932421
TSPYL2 TSPY-like 2 0.00931304

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.191791
NALF1 NALCN channel auxiliary factor 1 -0.131163
RIMS2 regulating synaptic membrane exocytosis 2 -0.0884551
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0792265
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0750328
SNTG1 syntrophin, gamma 1 -0.0704293
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0690003
FGF14 fibroblast growth factor 14 -0.0678093
SMYD3 SET and MYND domain containing 3 -0.0676123
NRG1 neuregulin 1 -0.0666714
NCKAP5 NCK-associated protein 5 -0.0619574
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.05479
GPC6 glypican 6 -0.0531349
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0530482
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0513594
CNTNAP2 contactin associated protein-like 2 -0.0490552
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0476311
GPC5 glypican 5 -0.0469091
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0441986
ADGRL2 adhesion G protein-coupled receptor L2 -0.0418148
TENM1 teneurin transmembrane protein 1 -0.0405648
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.0404403
TSHZ2 teashirt zinc finger homeobox 2 -0.040191
ENO1 enolase 1, (alpha) -0.0396261
MT2A metallothionein 2A -0.0393988
FTL ferritin, light polypeptide -0.0390739
PDE4B phosphodiesterase 4B, cAMP-specific -0.0389431
IGF1R insulin-like growth factor 1 receptor -0.0388028
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.038519
SLC35F4 solute carrier family 35, member F4 -0.0383861
RPH3AL rabphilin 3A-like (without C2 domains) -0.0374021
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.036681
ZBTB20 zinc finger and BTB domain containing 20 -0.0361025
PHF14 PHD finger protein 14 -0.0345747
RPS21 ribosomal protein S21 -0.0344295
PTMA prothymosin, alpha -0.033761
CALCA calcitonin-related polypeptide alpha -0.0335849
GDAP1 ganglioside induced differentiation associated protein 1 -0.0328163
IFI6 interferon, alpha-inducible protein 6 -0.0326208
WWOX WW domain containing oxidoreductase -0.032255
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0321516
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0318995
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0315045
SYT1 synaptotagmin I -0.0313739
SASH1 SAM and SH3 domain containing 1 -0.0312668
PDE4D phosphodiesterase 4D, cAMP-specific -0.0310893
SCFD2 sec1 family domain containing 2 -0.0310592
CNKSR3 CNKSR family member 3 -0.0309695
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0304166
RNF213 ring finger protein 213 -0.0300049
RALYL RALY RNA binding protein-like -0.029757
LSAMP limbic system-associated membrane protein -0.0294833
NPAS3 neuronal PAS domain protein 3 -0.029274
KIAA0825 KIAA0825 -0.0290363
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -0.0289334
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0289089
PEX5L peroxisomal biogenesis factor 5-like -0.0279692
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0278238
VGF VGF nerve growth factor inducible -0.0275808
RPLP1 ribosomal protein, large, P1 -0.0275422
COL22A1 collagen, type XXII, alpha 1 -0.0266547
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -0.0263843
ZBTB7C zinc finger and BTB domain containing 7C -0.0257216
RGS7 regulator of G-protein signaling 7 -0.0256264
NBEA neurobeachin -0.0253272
ACTG1 actin gamma 1 -0.0243952
ARB2A ARB2 cotranscriptional regulator A -0.0240152
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0239727
RPS6 ribosomal protein S6 -0.0238786
RPL38 ribosomal protein L38 -0.0235454
RPS8 ribosomal protein S8 -0.0235036
PCSK2 proprotein convertase subtilisin/kexin type 2 -0.023389
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.0231633
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0228592
ASIC2 acid sensing (proton gated) ion channel 2 -0.0228058
MMP26 matrix metallopeptidase 26 -0.0227387
TMSB10 thymosin beta 10 -0.0226699
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0225749
RIGI RNA sensor RIG-I -0.0224838
SIK2 salt-inducible kinase 2 -0.0224591
FHIT fragile histidine triad -0.0224058
PCDH9 protocadherin 9 -0.0223406
UBB ubiquitin B -0.0221954
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 -0.0221868
FAAH2 fatty acid amide hydrolase 2 -0.0216401
DGKB diacylglycerol kinase, beta 90kDa -0.0215557
KCTD8 potassium channel tetramerization domain containing 8 -0.0214069
RPS27A ribosomal protein S27a -0.0213454
RPL26 ribosomal protein L26 -0.021309
RPL37A ribosomal protein L37a -0.0212995
ZNF804A zinc finger protein 804A -0.0212835
HMGB1 high mobility group box 1 -0.0212754
FNDC3A fibronectin type III domain containing 3A -0.0211408
RPL4 ribosomal protein L4 -0.0210343
NLGN1 neuroligin 1 -0.0210231
RPL11 ribosomal protein L11 -0.0207835
SPIDR scaffolding protein involved in DNA repair -0.0205616
STAU2 staufen double-stranded RNA binding protein 2 -0.0205045
GPHN gephyrin -0.0204522
RPS3 ribosomal protein S3 -0.0203893