Benproperine (phosphate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.0946049
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0874722
NAMPT nicotinamide phosphoribosyltransferase 0.0592761
CENPF centromere protein F, 350/400kDa 0.058629
FNDC3B fibronectin type III domain containing 3B 0.0561544
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0517524
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0457737
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0454128
ELL2 elongation factor, RNA polymerase II, 2 0.0419786
ZNF292 zinc finger protein 292 0.0416348
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0411463
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0394195
GOLGA4 golgin A4 0.0367193
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0360361
CKAP5 cytoskeleton associated protein 5 0.0342366
MSN moesin 0.0327844
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0327729
B2M beta-2-microglobulin 0.0320139
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0300858
KIF4A kinesin family member 4A 0.0299875
GARS1 glycyl-tRNA synthetase 1 0.0299588
MATR3 matrin 3 0.029504
TENT5A terminal nucleotidyltransferase 5A 0.0288389
PARP14 poly (ADP-ribose) polymerase family, member 14 0.028472
DSTN destrin (actin depolymerizing factor) 0.0274711
EZR ezrin 0.0274483
ARRDC3 arrestin domain containing 3 0.0268443
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0268306
BCLAF1 BCL2-associated transcription factor 1 0.0266939
SMAD3 SMAD family member 3 0.0265702
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0264649
ANXA1 annexin A1 0.0262375
TNIP1 TNFAIP3 interacting protein 1 0.0259463
COL1A2 collagen, type I, alpha 2 0.0254352
MKI67 marker of proliferation Ki-67 0.0251361
RSRC2 arginine/serine-rich coiled-coil 2 0.0251054
MYH9 myosin, heavy chain 9, non-muscle 0.0249053
XPO1 exportin 1 0.0247819
UBA6 ubiquitin-like modifier activating enzyme 6 0.0242794
CDCP1 CUB domain containing protein 1 0.0242038
NUP58 nucleoporin 58 0.0241166
YME1L1 YME1-like 1 ATPase 0.023714
SPAG9 sperm associated antigen 9 0.0235291
AHR aryl hydrocarbon receptor 0.023491
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0233843
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0232709
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0232121
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0228421
CENPE centromere protein E, 312kDa 0.0227768
RLIM ring finger protein, LIM domain interacting 0.0224912
RB1CC1 RB1-inducible coiled-coil 1 0.0223191
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0221978
RTN4 reticulon 4 0.0221835
TPM3 tropomyosin 3 0.0220965
RAI1 retinoic acid induced 1 0.0220622
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0219676
CIRSR corepressor of RBPJ and splicing regulator 0.0213674
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0210499
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0210404
CLTC clathrin, heavy chain (Hc) 0.0210364
MYADM myeloid-associated differentiation marker 0.0206514
PTBP2 polypyrimidine tract binding protein 2 0.0202853
SETD5 SET domain containing 5 0.0202739
TPX2 TPX2, microtubule-associated 0.0198143
CSDE1 cold shock domain containing E1, RNA-binding 0.0196295
ATP13A3 ATPase type 13A3 0.0193549
PGM3 phosphoglucomutase 3 0.0193502
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0193033
EHBP1 EH domain binding protein 1 0.0192362
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0191706
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0189495
MED23 mediator complex subunit 23 0.0189324
ALCAM activated leukocyte cell adhesion molecule 0.018902
TENT2 terminal nucleotidyltransferase 2 0.018896
SETD2 SET domain containing 2 0.0187052
SBF2 SET binding factor 2 0.0185399
DIAPH3 diaphanous-related formin 3 0.0184802
PCBP2 poly(rC) binding protein 2 0.0184389
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0182395
FXR1 fragile X mental retardation, autosomal homolog 1 0.0180425
ZNF451 zinc finger protein 451 0.0180229
NKTR natural killer cell triggering receptor 0.0178569
TXNRD1 thioredoxin reductase 1 0.0178411
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0178088
BIRC3 baculoviral IAP repeat containing 3 0.0173893
ANLN anillin, actin binding protein 0.0173242
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0172578
MYOF myoferlin 0.017031
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0169729
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0169434
USP37 ubiquitin specific peptidase 37 0.0168646
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0168305
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0168195
THBS1 thrombospondin 1 0.0167698
KIF18A kinesin family member 18A 0.016635
IL6ST interleukin 6 signal transducer 0.0165179
CPNE8 copine VIII 0.0164387
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.016418
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0163512
ZFC3H1 zinc finger, C3H1-type containing 0.0161583

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.122817
HLA-B major histocompatibility complex, class I, B -0.0999677
FTL ferritin, light polypeptide -0.0921695
IER3 immediate early response 3 -0.089294
TPT1 tumor protein, translationally-controlled 1 -0.0856929
IGFBP3 insulin-like growth factor binding protein 3 -0.0850317
GLIS3 GLIS family zinc finger 3 -0.0815647
TMSB10 thymosin beta 10 -0.0719051
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0713592
MT2A metallothionein 2A -0.0689962
SOD2 superoxide dismutase 2, mitochondrial -0.0653676
EXT1 exostosin glycosyltransferase 1 -0.0562525
BICC1 BicC family RNA binding protein 1 -0.0560236
CDH13 cadherin 13 -0.0511135
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.050067
SQSTM1 sequestosome 1 -0.0481302
ADM adrenomedullin -0.0462493
TMEM132D transmembrane protein 132D -0.0450507
PTMA prothymosin, alpha -0.0449034
KYNU kynureninase -0.0445098
INTS6 integrator complex subunit 6 -0.0444077
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0423878
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0396714
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0396392
HMGA2 high mobility group AT-hook 2 -0.0392254
RAI14 retinoic acid induced 14 -0.0391132
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0379911
ZMYND8 zinc finger, MYND-type containing 8 -0.037599
DIAPH2 diaphanous-related formin 2 -0.0358025
EPAS1 endothelial PAS domain protein 1 -0.0357971
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0357326
RPS29 ribosomal protein S29 -0.0353636
EGFR epidermal growth factor receptor -0.0333354
RPS6 ribosomal protein S6 -0.0333103
RPLP2 ribosomal protein, large, P2 -0.0331042
SDK1 sidekick cell adhesion molecule 1 -0.0330479
VIM vimentin -0.0329475
SPDYA speedy/RINGO cell cycle regulator family member A -0.032385
RPLP1 ribosomal protein, large, P1 -0.0321309
EFNA5 ephrin-A5 -0.0317482
HLA-A major histocompatibility complex, class I, A -0.0317029
STC2 stanniocalcin 2 -0.0307781
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0307612
AHNAK AHNAK nucleoprotein -0.0306349
RPL37A ribosomal protein L37a -0.0305302
VCL vinculin -0.0301618
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0300315
ENO2 enolase 2 (gamma, neuronal) -0.0290649
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0288559
RPS16 ribosomal protein S16 -0.028802
HLA-E major histocompatibility complex, class I, E -0.028632
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.028305
RPS23 ribosomal protein S23 -0.0278888
RPS27A ribosomal protein S27a -0.0275994
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0270967
BASP1 brain abundant, membrane attached signal protein 1 -0.0270244
EIF1 eukaryotic translation initiation factor 1 -0.0269735
RPL9 ribosomal protein L9 -0.0264991
BTG1 B-cell translocation gene 1, anti-proliferative -0.0264439
AFF3 AF4/FMR2 family, member 3 -0.0262144
NALF1 NALCN channel auxiliary factor 1 -0.0260564
IGF1R insulin-like growth factor 1 receptor -0.0259972
RNF213 ring finger protein 213 -0.0258332
RPS24 ribosomal protein S24 -0.0257669
AKAP12 A kinase (PRKA) anchor protein 12 -0.0257573
WSB1 WD repeat and SOCS box containing 1 -0.0254154
ACTG1 actin gamma 1 -0.0253889
PTPRK protein tyrosine phosphatase, receptor type, K -0.0252804
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0250629
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0248732
TFPI2 tissue factor pathway inhibitor 2 -0.0246903
RPL12 ribosomal protein L12 -0.0246129
NABP1 nucleic acid binding protein 1 -0.0244737
RPL31 ribosomal protein L31 -0.0244276
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0240434
C3 complement component 3 -0.0238599
RPS3 ribosomal protein S3 -0.0235897
SFRP1 secreted frizzled-related protein 1 -0.0235163
RPL7A ribosomal protein L7a -0.0235161
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0232731
SDC4 syndecan 4 -0.02314
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0229371
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0228843
SOX5 SRY (sex determining region Y)-box 5 -0.0228584
RPL38 ribosomal protein L38 -0.0228267
RPS21 ribosomal protein S21 -0.0228134
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0228094
COL6A3 collagen, type VI, alpha 3 -0.0227185
FRMD5 FERM domain containing 5 -0.0227003
HILPDA hypoxia inducible lipid droplet-associated -0.0225002
FRMPD4 FERM and PDZ domain containing 4 -0.0223032
CCBE1 collagen and calcium binding EGF domains 1 -0.0220937
NDRG1 N-myc downstream regulated 1 -0.0218701
ANKRD10 ankyrin repeat domain 10 -0.0218629
JAK1 Janus kinase 1 -0.0217941
DDIT3 DNA-damage-inducible transcript 3 -0.0216977
RPS10 ribosomal protein S10 -0.0215415
RPL19 ribosomal protein L19 -0.0213858
SMAD2 SMAD family member 2 -0.0212846
DST dystonin -0.0212336