Benproperine (phosphate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in SW 900 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Benproperine (phosphate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.05259
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0322494
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.026238
CENPF centromere protein F, 350/400kDa 0.0234771
ZNF292 zinc finger protein 292 0.0228959
ITGA1 integrin, alpha 1 0.0219819
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0205028
SOD2 superoxide dismutase 2, mitochondrial 0.0198079
SPAG9 sperm associated antigen 9 0.0181142
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0180725
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0180064
PRELID2 PRELI domain containing 2 0.0170484
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0169038
PARD3 par-3 family cell polarity regulator 0.0161142
ABI1 abl-interactor 1 0.0154068
NAMPT nicotinamide phosphoribosyltransferase 0.0152678
MIS18BP1 MIS18 binding protein 1 0.0150233
CADM1 cell adhesion molecule 1 0.0149689
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0144463
MYO1B myosin IB 0.0143268
PDE4D phosphodiesterase 4D, cAMP-specific 0.0142309
PELO pelota homolog (Drosophila) 0.0140451
FXR1 fragile X mental retardation, autosomal homolog 1 0.0140066
MARCHF6 membrane associated ring-CH-type finger 6 0.0135917
FNDC3B fibronectin type III domain containing 3B 0.0132093
SDK1 sidekick cell adhesion molecule 1 0.0130656
NALF1 NALCN channel auxiliary factor 1 0.0128211
DIAPH3 diaphanous-related formin 3 0.0128158
KDM6A lysine (K)-specific demethylase 6A 0.0126966
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0125498
MAML2 mastermind-like 2 (Drosophila) 0.0123236
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0122051
NUMB numb homolog (Drosophila) 0.0117619
ARHGAP12 Rho GTPase activating protein 12 0.0116252
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0115648
RAB8B RAB8B, member RAS oncogene family 0.0115428
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0114441
ETNK1 ethanolamine kinase 1 0.0111049
NRIP1 nuclear receptor interacting protein 1 0.0109604
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0107863
AFDN afadin, adherens junction formation factor 0.0106101
USP9X ubiquitin specific peptidase 9, X-linked 0.0105803
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0105735
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0105641
NAV2 neuron navigator 2 0.0104587
SLMAP sarcolemma associated protein 0.0102141
MYH9 myosin, heavy chain 9, non-muscle 0.010145
MBNL2 muscleblind-like splicing regulator 2 0.0101029
PIAS2 protein inhibitor of activated STAT, 2 0.0101013
SAMD8 sterile alpha motif domain containing 8 0.0100882
RB1CC1 RB1-inducible coiled-coil 1 0.00994455
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00990831
SEPTIN10 septin 10 0.00961148
RUNX2 runt-related transcription factor 2 0.00958335
RAB18 RAB18, member RAS oncogene family 0.00941505
UGCG UDP-glucose ceramide glucosyltransferase 0.00938611
CCDC88A coiled-coil domain containing 88A 0.00935172
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.00934878
SEC63 SEC63 homolog (S. cerevisiae) 0.00923397
CDK19 cyclin-dependent kinase 19 0.00906837
ZBTB1 zinc finger and BTB domain containing 1 0.0090642
FHIT fragile histidine triad 0.0090069
ZFR zinc finger RNA binding protein 0.0089641
WWC2 WW and C2 domain containing 2 0.00895091
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0088623
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.00884483
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.00864987
SEC11A SEC11 homolog A (S. cerevisiae) 0.00863738
PICALM phosphatidylinositol binding clathrin assembly protein 0.0086313
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.00860927
UBQLN1 ubiquilin 1 0.00859952
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.00858006
TCERG1 transcription elongation regulator 1 0.00854672
PDE10A phosphodiesterase 10A 0.00852008
KIF11 kinesin family member 11 0.00850152
TNPO1 transportin 1 0.00846826
FAM13A family with sequence similarity 13, member A 0.00843465
TTC28 tetratricopeptide repeat domain 28 0.00841991
TAS2R14 taste receptor, type 2, member 14 0.00838261
AAK1 AP2 associated kinase 1 0.00826971
CEP95 centrosomal protein 95kDa 0.00823914
PHF21A PHD finger protein 21A 0.00817731
SS18 synovial sarcoma translocation, chromosome 18 0.00815449
AGFG1 ArfGAP with FG repeats 1 0.00811248
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.00810809
EYA1 EYA transcriptional coactivator and phosphatase 1 0.00799448
RUFY1 RUN and FYVE domain containing 1 0.00794716
CKAP2L cytoskeleton associated protein 2-like 0.00794341
TMEM39A transmembrane protein 39A 0.00792928
SIN3A SIN3 transcription regulator family member A 0.00791034
PTEN phosphatase and tensin homolog 0.00790559
DGKD diacylglycerol kinase, delta 130kDa 0.00790214
TM9SF3 transmembrane 9 superfamily member 3 0.00787988
GSK3B glycogen synthase kinase 3 beta 0.00784129
ECT2 epithelial cell transforming 2 0.00781401
STK38L serine/threonine kinase 38 like 0.00780705
UBE2O ubiquitin-conjugating enzyme E2O 0.00770163
ZEB1 zinc finger E-box binding homeobox 1 0.00769851
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.00768858
CD109 CD109 molecule 0.00766834

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.390439
MT2A metallothionein 2A -0.107116
FTL ferritin, light polypeptide -0.0951791
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.091195
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0869071
FN1 fibronectin 1 -0.0787532
PTMA prothymosin, alpha -0.0706657
TMSB10 thymosin beta 10 -0.0694938
VIM vimentin -0.0679599
HLA-B major histocompatibility complex, class I, B -0.0666868
EXT1 exostosin glycosyltransferase 1 -0.0638311
SQSTM1 sequestosome 1 -0.0627823
CANX calnexin -0.0563397
RACK1 receptor for activated C kinase 1 -0.0559989
S100A6 S100 calcium binding protein A6 -0.0551786
IFI27 interferon, alpha-inducible protein 27 -0.0549265
RPLP1 ribosomal protein, large, P1 -0.0515946
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0513344
NRG1 neuregulin 1 -0.0508594
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0503396
B2M beta-2-microglobulin -0.0478741
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0467421
SFTPA2 surfactant protein A2 -0.0436145
RPS19 ribosomal protein S19 -0.0421033
FTH1 ferritin, heavy polypeptide 1 -0.0418989
NDRG1 N-myc downstream regulated 1 -0.0405768
RPL37A ribosomal protein L37a -0.0392582
TPT1 tumor protein, translationally-controlled 1 -0.0391972
ENO1 enolase 1, (alpha) -0.0385686
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0383323
TXNIP thioredoxin interacting protein -0.0382139
RPS20 ribosomal protein S20 -0.0375735
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0371889
RPL12 ribosomal protein L12 -0.0369673
RPL35A ribosomal protein L35a -0.036417
RPS6 ribosomal protein S6 -0.0354179
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0349087
RPS3 ribosomal protein S3 -0.034907
RPL26 ribosomal protein L26 -0.0346687
RPS12 ribosomal protein S12 -0.0344713
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0344141
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0341864
PKM pyruvate kinase, muscle -0.0341524
RPS8 ribosomal protein S8 -0.0341059
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0337937
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0334268
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0333512
TPI1 triosephosphate isomerase 1 -0.0324513
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0322219
RPL34 ribosomal protein L34 -0.0318379
AKAP12 A kinase (PRKA) anchor protein 12 -0.0317297
GNAS GNAS complex locus -0.0310179
RPS27A ribosomal protein S27a -0.0309947
RPL30 ribosomal protein L30 -0.0307618
RPS29 ribosomal protein S29 -0.0303981
RPS25 ribosomal protein S25 -0.0303624
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0303444
RPL37 ribosomal protein L37 -0.0299973
CALR calreticulin -0.0297132
RPL28 ribosomal protein L28 -0.0295831
RPL9 ribosomal protein L9 -0.0287872
SYT1 synaptotagmin I -0.0286941
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.028677
HLA-A major histocompatibility complex, class I, A -0.0285812
VCL vinculin -0.0285032
UBC ubiquitin C -0.0280946
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0277053
LMNA lamin A/C -0.0275713
EIF1 eukaryotic translation initiation factor 1 -0.0272434
RPS27 ribosomal protein S27 -0.0265123
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0265056
S100A10 S100 calcium binding protein A10 -0.0260922
ARID4B AT rich interactive domain 4B (RBP1-like) -0.025969
RRBP1 ribosome binding protein 1 -0.0257673
LDHA lactate dehydrogenase A -0.0257097
KMT2C lysine (K)-specific methyltransferase 2C -0.0256504
IFI6 interferon, alpha-inducible protein 6 -0.0254637
RPL19 ribosomal protein L19 -0.0253006
LOC102724023 ES1 protein homolog, mitochondrial -0.0248416
RPS5 ribosomal protein S5 -0.0246553
NAP1L1 nucleosome assembly protein 1-like 1 -0.0242108
CALU calumenin -0.0238386
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0235973
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0234032
ENO2 enolase 2 (gamma, neuronal) -0.023397
PRRC2C proline-rich coiled-coil 2C -0.0233507
BASP1 brain abundant, membrane attached signal protein 1 -0.0233405
NTN4 netrin 4 -0.0233296
RPS21 ribosomal protein S21 -0.0231949
RPL7 ribosomal protein L7 -0.0229285
DSTN destrin (actin depolymerizing factor) -0.0229199
RPLP0 ribosomal protein, large, P0 -0.022734
ACTG1 actin gamma 1 -0.0226801
RPL11 ribosomal protein L11 -0.0226685
RPS17 ribosomal protein S17 -0.0223567
TPR translocated promoter region, nuclear basket protein -0.0221196
SMAD3 SMAD family member 3 -0.0220978
KTN1 kinectin 1 (kinesin receptor) -0.0217683
RPL23 ribosomal protein L23 -0.021433
BICD1 bicaudal D homolog 1 (Drosophila) -0.0212546