Benproperine (phosphate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0511661
EREG epiregulin 0.039581
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0365594
LMO7 LIM domain 7 0.0340804
GCLC glutamate-cysteine ligase, catalytic subunit 0.0335063
PDE4B phosphodiesterase 4B, cAMP-specific 0.0313703
TOP1 topoisomerase (DNA) I 0.0304937
ITPRID2 ITPR interacting domain containing 2 0.0300492
GARS1 glycyl-tRNA synthetase 1 0.0291488
MYO5B myosin VB 0.026959
DSCAM Down syndrome cell adhesion molecule 0.0261029
FOXO1 forkhead box O1 0.0246409
RBM39 RNA binding motif protein 39 0.0237443
TXNRD1 thioredoxin reductase 1 0.0237261
TSC22D2 TSC22 domain family, member 2 0.0236114
USP3 ubiquitin specific peptidase 3 0.0235375
RNF43 ring finger protein 43 0.0219448
COG5 component of oligomeric golgi complex 5 0.0217096
NUP58 nucleoporin 58 0.0208968
NBAS neuroblastoma amplified sequence 0.020254
KDM6A lysine (K)-specific demethylase 6A 0.0201154
FAR1 fatty acyl CoA reductase 1 0.020095
KLF5 Kruppel-like factor 5 (intestinal) 0.0197156
ESYT2 extended synaptotagmin-like protein 2 0.0190913
USP6NL USP6 N-terminal like 0.0180983
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0179159
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0170385
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0169378
RAB6A RAB6A, member RAS oncogene family 0.0167165
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0165406
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0161425
NDRG1 N-myc downstream regulated 1 0.0160606
GOLGA4 golgin A4 0.0159768
UBA6 ubiquitin-like modifier activating enzyme 6 0.0153858
BBX bobby sox homolog (Drosophila) 0.0150649
INSIG2 insulin induced gene 2 0.0150639
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0149643
RANBP9 RAN binding protein 9 0.0149348
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0148766
TFG TRK-fused gene 0.0147718
SNX9 sorting nexin 9 0.01469
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.014398
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0142847
ADAM9 ADAM metallopeptidase domain 9 0.0141958
CHD1 chromodomain helicase DNA binding protein 1 0.0140248
NAMPT nicotinamide phosphoribosyltransferase 0.0140179
ZFAND3 zinc finger, AN1-type domain 3 0.0138505
DIAPH1 diaphanous-related formin 1 0.013834
SLMAP sarcolemma associated protein 0.0135539
PPME1 protein phosphatase methylesterase 1 0.0135222
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0131986
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0131966
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0131906
ESRP1 epithelial splicing regulatory protein 1 0.013099
ANKRD10 ankyrin repeat domain 10 0.0130265
ARHGAP42 Rho GTPase activating protein 42 0.0126092
KMT2C lysine (K)-specific methyltransferase 2C 0.0125507
TRA2A transformer 2 alpha homolog (Drosophila) 0.0124642
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0123064
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0122656
MTF2 metal response element binding transcription factor 2 0.0121639
RUNX2 runt-related transcription factor 2 0.0121374
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0120585
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0120375
NCKAP1 NCK-associated protein 1 0.0120248
CD2AP CD2-associated protein 0.011924
RAB1A RAB1A, member RAS oncogene family 0.0119031
PRDM1 PR domain containing 1, with ZNF domain 0.0117481
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0115537
SPAG9 sperm associated antigen 9 0.01144
FAT1 FAT atypical cadherin 1 0.0113871
FAM162A family with sequence similarity 162, member A 0.0113452
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0112978
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0112014
SEPTIN7 septin 7 0.0111631
SEC24D SEC24 family member D 0.0110374
RNF145 ring finger protein 145 0.0110287
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.011016
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0109713
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0108812
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0108613
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0108501
SCARB2 scavenger receptor class B, member 2 0.0108369
YAP1 Yes-associated protein 1 0.0108249
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0107931
ECT2 epithelial cell transforming 2 0.0107728
CDC73 cell division cycle 73 0.0107614
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0107209
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0106312
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0106092
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0105577
GLS2 glutaminase 2 (liver, mitochondrial) 0.0105305
FNBP1L formin binding protein 1-like 0.0104396
SRP54 signal recognition particle 54kDa 0.0104242
TCEA1 transcription elongation factor A (SII), 1 0.0103877
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.0103722
RBM26 RNA binding motif protein 26 0.0103274
MARCHF6 membrane associated ring-CH-type finger 6 0.0102747
ZNF292 zinc finger protein 292 0.0102654
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0102283

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.139758
ACTG1 actin gamma 1 -0.110214
HMGA2 high mobility group AT-hook 2 -0.101215
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0835666
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0822745
RPL35A ribosomal protein L35a -0.0716152
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0664982
RPS6 ribosomal protein S6 -0.0635321
EGR1 early growth response 1 -0.058337
RPS8 ribosomal protein S8 -0.0580169
CD36 CD36 molecule (thrombospondin receptor) -0.0545236
TMSB10 thymosin beta 10 -0.0488407
TPT1 tumor protein, translationally-controlled 1 -0.0487036
RAD51B RAD51 paralog B -0.0480198
RPS19 ribosomal protein S19 -0.0466616
FHIT fragile histidine triad -0.0455467
RPLP1 ribosomal protein, large, P1 -0.0448125
IER3 immediate early response 3 -0.0441618
RPL12 ribosomal protein L12 -0.0435149
LOC102724023 ES1 protein homolog, mitochondrial -0.0405231
RPS3 ribosomal protein S3 -0.04008
VCL vinculin -0.0397537
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0391555
LAMA4 laminin, alpha 4 -0.0382213
ENO1 enolase 1, (alpha) -0.0371081
EGFR epidermal growth factor receptor -0.0368482
RPS29 ribosomal protein S29 -0.036455
RPL34 ribosomal protein L34 -0.0363869
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0353274
S100A6 S100 calcium binding protein A6 -0.0352304
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0346542
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0345765
RPL9 ribosomal protein L9 -0.0341664
EEF2 eukaryotic translation elongation factor 2 -0.0337483
RPS25 ribosomal protein S25 -0.0337026
RPLP2 ribosomal protein, large, P2 -0.0332487
RPS12 ribosomal protein S12 -0.03323
LDHA lactate dehydrogenase A -0.0331117
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0328452
RCOR1 REST corepressor 1 -0.0324114
RPL8 ribosomal protein L8 -0.0321455
RPS14 ribosomal protein S14 -0.0309141
EHBP1 EH domain binding protein 1 -0.0309004
RPL31 ribosomal protein L31 -0.0308665
RPS13 ribosomal protein S13 -0.0306155
RPS17 ribosomal protein S17 -0.0304985
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0299324
LAMB3 laminin, beta 3 -0.0287424
RPL19 ribosomal protein L19 -0.0281155
RPL11 ribosomal protein L11 -0.0279048
RPL5 ribosomal protein L5 -0.0278375
AKAP12 A kinase (PRKA) anchor protein 12 -0.0277934
TPM4 tropomyosin 4 -0.0277447
RPL7A ribosomal protein L7a -0.0277299
RPL37A ribosomal protein L37a -0.0277069
MTAP methylthioadenosine phosphorylase -0.0275758
CD9 CD9 molecule -0.0273863
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0268846
RPS5 ribosomal protein S5 -0.0260626
PHF14 PHD finger protein 14 -0.0256898
BMP4 bone morphogenetic protein 4 -0.0255659
MT2A metallothionein 2A -0.0255338
RPS16 ribosomal protein S16 -0.0255003
RPS23 ribosomal protein S23 -0.0253687
RPL26 ribosomal protein L26 -0.0253113
RPS27A ribosomal protein S27a -0.0252778
ANXA2 annexin A2 -0.0249358
FTL ferritin, light polypeptide -0.0247488
SQSTM1 sequestosome 1 -0.0240748
RPL32 ribosomal protein L32 -0.0237174
RPS21 ribosomal protein S21 -0.0236294
FERMT1 fermitin family member 1 -0.0229174
RPS4X ribosomal protein S4, X-linked -0.022752
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0226187
SMYD3 SET and MYND domain containing 3 -0.0220995
RPL23 ribosomal protein L23 -0.0217878
RPL15 ribosomal protein L15 -0.0217674
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0214787
CUX1 cut-like homeobox 1 -0.0213199
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0212939
RPS24 ribosomal protein S24 -0.0212254
MKI67 marker of proliferation Ki-67 -0.0210501
HDAC2 histone deacetylase 2 -0.0207008
EXOC4 exocyst complex component 4 -0.0206577
RPL36A ribosomal protein L36a -0.0206413
RPL7 ribosomal protein L7 -0.0205949
AHNAK AHNAK nucleoprotein -0.0202435
EZR ezrin -0.0200705
RPS10 ribosomal protein S10 -0.0197489
ACTN4 actinin, alpha 4 -0.0196891
FOSL1 FOS-like antigen 1 -0.0196116
HLA-B major histocompatibility complex, class I, B -0.019077
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0190559
RPL37 ribosomal protein L37 -0.0190098
SEPTIN9 septin 9 -0.0188914
RPL30 ribosomal protein L30 -0.0188161
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0187528
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0186549
ITGB4 integrin, beta 4 -0.0185359
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0184307