Benproperine (phosphate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benproperine (phosphate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benproperine (phosphate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.173439
NALF1 NALCN channel auxiliary factor 1 0.172088
INHBA inhibin, beta A 0.13025
COL1A1 collagen, type I, alpha 1 0.102023
AKAP12 A kinase (PRKA) anchor protein 12 0.0916159
PRKG1 protein kinase, cGMP-dependent, type I 0.0891816
HMGA2 high mobility group AT-hook 2 0.0594065
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0592861
MYO10 myosin X 0.0590907
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0569401
COL1A2 collagen, type I, alpha 2 0.0564133
JARID2 jumonji, AT rich interactive domain 2 0.0473418
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.0463251
ABI3BP ABI family, member 3 (NESH) binding protein 0.0435834
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0424506
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0417048
CDH13 cadherin 13 0.0415814
AHNAK AHNAK nucleoprotein 0.0411438
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.041042
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.040952
ASPH aspartate beta-hydroxylase 0.0408676
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0383325
NAV1 neuron navigator 1 0.0372235
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0371003
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0369332
EXT1 exostosin glycosyltransferase 1 0.0362005
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0347977
FN1 fibronectin 1 0.0347027
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0327941
CALD1 caldesmon 1 0.0317831
RAD51B RAD51 paralog B 0.0316456
GLIS3 GLIS family zinc finger 3 0.0314231
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0313485
CXCL8 chemokine (C-X-C motif) ligand 8 0.0301682
WNT5A wingless-type MMTV integration site family, member 5A 0.0294753
PRSS23 protease, serine, 23 0.0290164
DIAPH2 diaphanous-related formin 2 0.028378
OXR1 oxidation resistance 1 0.0270838
KIAA1549L KIAA1549-like 0.0255704
RAI14 retinoic acid induced 14 0.0247932
MED13L mediator complex subunit 13-like 0.0247728
COL6A2 collagen, type VI, alpha 2 0.0241837
VCL vinculin 0.0239982
PRR16 proline rich 16 0.0239088
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.02389
PDE4D phosphodiesterase 4D, cAMP-specific 0.0234819
COL3A1 collagen, type III, alpha 1 0.0229135
CDK6 cyclin-dependent kinase 6 0.0228378
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0224759
ATP13A3 ATPase type 13A3 0.0220868
GREM1 gremlin 1, DAN family BMP antagonist 0.0218978
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0213631
PTK2 protein tyrosine kinase 2 0.0209241
PSD3 pleckstrin and Sec7 domain containing 3 0.0206405
EGFR epidermal growth factor receptor 0.020546
ANKRD12 ankyrin repeat domain 12 0.0202527
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0201829
COL6A1 collagen, type VI, alpha 1 0.020117
FNDC3B fibronectin type III domain containing 3B 0.0198698
TRIO trio Rho guanine nucleotide exchange factor 0.0192007
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0191089
POTEF POTE ankyrin domain family, member F 0.0188262
HIPK2 homeodomain interacting protein kinase 2 0.0187393
LPP LIM domain containing preferred translocation partner in lipoma 0.0184956
MMP1 matrix metallopeptidase 1 0.0184911
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0183964
FRMD6 FERM domain containing 6 0.0183928
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.018338
PRELID2 PRELI domain containing 2 0.0181173
ADGRB3 adhesion G protein-coupled receptor B3 0.0177931
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.017727
NCKAP5 NCK-associated protein 5 0.0176052
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0175594
SEPTIN11 septin 11 0.0175502
DSPP dentin sialophosphoprotein 0.0174924
SAMD3 sterile alpha motif domain containing 3 0.0168608
RASAL2 RAS protein activator like 2 0.0164227
MMP12 matrix metallopeptidase 12 0.01636
PDLIM5 PDZ and LIM domain 5 0.0163543
ARHGAP22 Rho GTPase activating protein 22 0.0161465
ANO6 anoctamin 6 0.016069
FBN1 fibrillin 1 0.0160574
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0159966
CAV1 caveolin 1, caveolae protein, 22kDa 0.0156191
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0152701
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0151294
ERRFI1 ERBB receptor feedback inhibitor 1 0.0146215
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0145966
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0145004
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0143964
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0143352
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0142138
EXOC4 exocyst complex component 4 0.0142088
SAMD4A sterile alpha motif domain containing 4A 0.0141441
MYO1E myosin IE 0.0140632
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0138006
NECTIN3 nectin cell adhesion molecule 3 0.0137326
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0136443
CCDC102B coiled-coil domain containing 102B 0.0134084
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0133058

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.164404
STC1 stanniocalcin 1 -0.119883
NDRG1 N-myc downstream regulated 1 -0.111848
VIM vimentin -0.0830437
ADM adrenomedullin -0.063022
MT2A metallothionein 2A -0.0623603
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0560889
SPAG9 sperm associated antigen 9 -0.0550511
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0542901
GOLGA4 golgin A4 -0.0512695
FTL ferritin, light polypeptide -0.0479759
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0433832
FAM13A family with sequence similarity 13, member A -0.0423599
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0413851
DSCAM Down syndrome cell adhesion molecule -0.0405232
B2M beta-2-microglobulin -0.0368675
MYH9 myosin, heavy chain 9, non-muscle -0.0356124
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0355824
TM4SF1 transmembrane 4 L six family member 1 -0.0350229
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0323327
EEF2 eukaryotic translation elongation factor 2 -0.0321979
EIF1 eukaryotic translation initiation factor 1 -0.0313258
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0311801
SRP54 signal recognition particle 54kDa -0.0306003
CALR calreticulin -0.0300256
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.029363
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.028693
CLTC clathrin, heavy chain (Hc) -0.0286709
RPS6 ribosomal protein S6 -0.0263417
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0260479
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0257589
MXI1 MAX interactor 1, dimerization protein -0.024864
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0243173
PTMA prothymosin, alpha -0.0242969
RUNX1 runt-related transcription factor 1 -0.023567
APOLD1 apolipoprotein L domain containing 1 -0.0232544
BRD2 bromodomain containing 2 -0.0223732
RPS2 ribosomal protein S2 -0.0222834
SRGN serglycin -0.0219429
ZNF292 zinc finger protein 292 -0.0219356
TXNIP thioredoxin interacting protein -0.0216826
OGA O-GlcNAcase -0.0213862
VEGFA vascular endothelial growth factor A -0.0203376
ARF4 ADP-ribosylation factor 4 -0.0203175
RPL19 ribosomal protein L19 -0.020273
AKAP9 A kinase (PRKA) anchor protein 9 -0.020006
LOX lysyl oxidase -0.0196326
GLG1 golgi glycoprotein 1 -0.0195921
ARHGAP21 Rho GTPase activating protein 21 -0.0195745
HLA-E major histocompatibility complex, class I, E -0.0194929
LOXL2 lysyl oxidase-like 2 -0.0193503
RPL26 ribosomal protein L26 -0.0193149
HILPDA hypoxia inducible lipid droplet-associated -0.019283
HLA-B major histocompatibility complex, class I, B -0.01905
BIRC6 baculoviral IAP repeat containing 6 -0.018839
GOLT1B golgi transport 1B -0.018729
COPA coatomer protein complex, subunit alpha -0.0183699
SOD2 superoxide dismutase 2, mitochondrial -0.0179122
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -0.0178658
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0176968
SETD5 SET domain containing 5 -0.0174842
RPL37A ribosomal protein L37a -0.0174401
UGCG UDP-glucose ceramide glucosyltransferase -0.0174382
TPT1 tumor protein, translationally-controlled 1 -0.0174146
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0171171
NUCB2 nucleobindin 2 -0.0170929
MORF4L2 mortality factor 4 like 2 -0.017056
RPL32 ribosomal protein L32 -0.0169941
ADAM9 ADAM metallopeptidase domain 9 -0.0169806
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0169572
SERF2 small EDRK-rich factor 2 -0.0169503
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.016931
CCDC88A coiled-coil domain containing 88A -0.0168075
USP37 ubiquitin specific peptidase 37 -0.0168
RPS3 ribosomal protein S3 -0.0167692
DDIT4 DNA-damage-inducible transcript 4 -0.0165147
LCORL ligand dependent nuclear receptor corepressor-like -0.0165031
BHLHE40 basic helix-loop-helix family, member e40 -0.0164749
TMF1 TATA element modulatory factor 1 -0.0164511
WASF2 WAS protein family, member 2 -0.0163248
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0162172
ZNF654 zinc finger protein 654 -0.0161803
COG5 component of oligomeric golgi complex 5 -0.0161271
AMPD3 adenosine monophosphate deaminase 3 -0.016058
RND3 Rho family GTPase 3 -0.0159845
KDM3A lysine (K)-specific demethylase 3A -0.0159722
MTSS1 metastasis suppressor 1 -0.0159665
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.0158621
CALU calumenin -0.0158595
LMNA lamin A/C -0.0156349
NKTR natural killer cell triggering receptor -0.0155769
RPS13 ribosomal protein S13 -0.0153987
YBX3 Y box binding protein 3 -0.0152945
SUCO SUN domain containing ossification factor -0.0150142
CDC27 cell division cycle 27 -0.0149996
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0147615
ANKRD28 ankyrin repeat domain 28 -0.0146893
HMGB2 high mobility group box 2 -0.0146711
NAP1L1 nucleosome assembly protein 1-like 1 -0.0146673
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0146626