Bentamapimod_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bentamapimod perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bentamapimod_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.204156
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.175372
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.124894
RPL23 ribosomal protein L23 0.117298
EIF1 eukaryotic translation initiation factor 1 0.0976798
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0940606
VIM vimentin 0.0852869
RPS6 ribosomal protein S6 0.0797396
B2M beta-2-microglobulin 0.0685037
PTMA prothymosin, alpha 0.0646871
RPS3 ribosomal protein S3 0.0525095
AKAP12 A kinase (PRKA) anchor protein 12 0.0481774
MAP1B microtubule-associated protein 1B 0.0480633
RACK1 receptor for activated C kinase 1 0.0479966
RPL19 ribosomal protein L19 0.0447556
RPLP0 ribosomal protein, large, P0 0.0446986
RPS12 ribosomal protein S12 0.0444606
KTN1 kinectin 1 (kinesin receptor) 0.0427144
RPL36 ribosomal protein L36 0.04263
RPL37A ribosomal protein L37a 0.0395797
TLE4 transducin-like enhancer of split 4 0.0384103
RPLP1 ribosomal protein, large, P1 0.038309
PKM pyruvate kinase, muscle 0.0370499
FTL ferritin, light polypeptide 0.0369191
RPS27 ribosomal protein S27 0.0367896
TMSB10 thymosin beta 10 0.0358302
RPS8 ribosomal protein S8 0.0350569
RPL26 ribosomal protein L26 0.034848
FAM107B family with sequence similarity 107, member B 0.0344227
TRIO trio Rho guanine nucleotide exchange factor 0.0341177
TBX2 T-box 2 0.0339431
RPL27 ribosomal protein L27 0.0334602
PABPC1 poly(A) binding protein, cytoplasmic 1 0.03322
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0330643
RPL35A ribosomal protein L35a 0.0329661
IFI16 interferon, gamma-inducible protein 16 0.0324263
RPL30 ribosomal protein L30 0.0323198
RPS19 ribosomal protein S19 0.0319699
MATR3 matrin 3 0.0305957
GNAS GNAS complex locus 0.0301247
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0294377
RPL12 ribosomal protein L12 0.0292147
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.028417
RPS17 ribosomal protein S17 0.0280965
RPLP2 ribosomal protein, large, P2 0.0280863
S100A6 S100 calcium binding protein A6 0.0275961
ITPRID2 ITPR interacting domain containing 2 0.0274704
EEF2 eukaryotic translation elongation factor 2 0.0273329
DSTN destrin (actin depolymerizing factor) 0.0268256
PCBP2 poly(rC) binding protein 2 0.0263207
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0263102
TOP1 topoisomerase (DNA) I 0.0259004
NAP1L1 nucleosome assembly protein 1-like 1 0.0257109
RPS11 ribosomal protein S11 0.0255669
RPL32 ribosomal protein L32 0.0254008
VEGFA vascular endothelial growth factor A 0.0251328
GATA3 GATA binding protein 3 0.0251217
RPS4X ribosomal protein S4, X-linked 0.0250854
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0249617
CXXC5 CXXC finger protein 5 0.0247631
PRRC2C proline-rich coiled-coil 2C 0.0247559
RPL34 ribosomal protein L34 0.0244114
EEF1G eukaryotic translation elongation factor 1 gamma 0.0242823
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0242367
LMNA lamin A/C 0.0241999
CALD1 caldesmon 1 0.0241902
RPS27A ribosomal protein S27a 0.0238556
H3-3B H3.3 histone B 0.023828
FXR1 fragile X mental retardation, autosomal homolog 1 0.0238233
RPL7 ribosomal protein L7 0.023804
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0233868
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0231801
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0229604
MEF2A myocyte enhancer factor 2A 0.0227943
MACF1 microtubule-actin crosslinking factor 1 0.0227686
RPS25 ribosomal protein S25 0.0227529
RPS24 ribosomal protein S24 0.0226736
SET SET nuclear proto-oncogene 0.0226283
RPS14 ribosomal protein S14 0.0225241
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.022496
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0222442
SEPTIN7 septin 7 0.0217995
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.021643
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0215284
ANGPTL4 angiopoietin-like 4 0.0215006
NRIP1 nuclear receptor interacting protein 1 0.0213246
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.021318
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0211136
LOC102724023 ES1 protein homolog, mitochondrial 0.0210659
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0210069
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0209654
RPL9 ribosomal protein L9 0.0209019
FMN1 formin 1 0.0208014
HLA-A major histocompatibility complex, class I, A 0.0207929
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0204901
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0204711
FHL2 four and a half LIM domains 2 0.0203172
ANXA2 annexin A2 0.0203133
NFE2L2 nuclear factor, erythroid 2-like 2 0.0203087
ACTG1 actin gamma 1 0.020256

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.18066
LSAMP limbic system-associated membrane protein -0.174517
IGF2 insulin-like growth factor 2 -0.100687
VCL vinculin -0.0838889
NREP neuronal regeneration related protein -0.07195
FRMD4A FERM domain containing 4A -0.0637031
NALF1 NALCN channel auxiliary factor 1 -0.0599445
SYT1 synaptotagmin I -0.0556253
MAPK10 mitogen-activated protein kinase 10 -0.0511513
TRIB2 tribbles pseudokinase 2 -0.0506309
MSI2 musashi RNA-binding protein 2 -0.0484847
RAD51B RAD51 paralog B -0.045967
PTPRM protein tyrosine phosphatase, receptor type, M -0.0456708
DNAH14 dynein, axonemal, heavy chain 14 -0.0454715
ZBTB20 zinc finger and BTB domain containing 20 -0.043977
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0428549
THSD4 thrombospondin, type I, domain containing 4 -0.0413825
ZNF804A zinc finger protein 804A -0.0409624
COL3A1 collagen, type III, alpha 1 -0.0404352
CUX1 cut-like homeobox 1 -0.0393677
GPC5 glypican 5 -0.0372529
STK38L serine/threonine kinase 38 like -0.0358182
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0344004
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0341113
DLC1 DLC1 Rho GTPase activating protein -0.0328239
CADM1 cell adhesion molecule 1 -0.0327115
FNDC3A fibronectin type III domain containing 3A -0.0326226
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0325451
GREM2 gremlin 2, DAN family BMP antagonist -0.0322344
TTC17 tetratricopeptide repeat domain 17 -0.0312307
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0304138
RNF150 ring finger protein 150 -0.0300976
MBD5 methyl-CpG binding domain protein 5 -0.0299284
GSE1 Gse1 coiled-coil protein -0.0294514
LRP1B low density lipoprotein receptor-related protein 1B -0.0292661
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0291017
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0288094
IGF1R insulin-like growth factor 1 receptor -0.0286162
ANTXR1 anthrax toxin receptor 1 -0.028575
KCTD16 potassium channel tetramerization domain containing 16 -0.0285715
CANX calnexin -0.0285029
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0283912
CDK6 cyclin-dependent kinase 6 -0.0283594
KCNIP4 Kv channel interacting protein 4 -0.0277198
PBX1 pre-B-cell leukemia homeobox 1 -0.0277053
MEIS2 Meis homeobox 2 -0.0273633
RPTOR regulatory associated protein of MTOR, complex 1 -0.027307
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0270369
PTPRD protein tyrosine phosphatase, receptor type, D -0.0269136
TET1 tet methylcytosine dioxygenase 1 -0.0268202
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0260019
LPP LIM domain containing preferred translocation partner in lipoma -0.0258299
DENND1A DENN/MADD domain containing 1A -0.0257505
RALYL RALY RNA binding protein-like -0.0253554
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0249325
CEP95 centrosomal protein 95kDa -0.0246314
TULP4 tubby like protein 4 -0.0246144
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0236578
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0235351
SBF2 SET binding factor 2 -0.0234102
FNDC3B fibronectin type III domain containing 3B -0.0232522
HM13 histocompatibility (minor) 13 -0.0232105
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0228353
TPM1 tropomyosin 1 (alpha) -0.0227687
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0225721
SMYD3 SET and MYND domain containing 3 -0.0224175
CNTN4 contactin 4 -0.0223825
INTS6 integrator complex subunit 6 -0.0223809
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0221597
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0221071
SPAG16 sperm associated antigen 16 -0.022004
ZC3H11A zinc finger CCCH-type containing 11A -0.0219895
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0216931
IARS1 isoleucyl-tRNA synthetase 1 -0.0216762
UNC5C unc-5 homolog C (C. elegans) -0.0213048
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0212261
NAV2 neuron navigator 2 -0.0209708
PRKCA protein kinase C, alpha -0.0207341
AUTS2 autism susceptibility candidate 2 -0.0205765
FNBP1 formin binding protein 1 -0.0205394
EXT1 exostosin glycosyltransferase 1 -0.0205335
SLC39A11 solute carrier family 39, member 11 -0.0204588
PTPRG protein tyrosine phosphatase, receptor type, G -0.0204282
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0199974
ANK2 ankyrin 2, neuronal -0.0198547
COL1A1 collagen, type I, alpha 1 -0.0197703
THBS1 thrombospondin 1 -0.019754
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.019516
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0195066
BCAS3 breast carcinoma amplified sequence 3 -0.0192688
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0192633
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0191016
VAV2 vav 2 guanine nucleotide exchange factor -0.0190658
EGR1 early growth response 1 -0.0190632
RAP1B RAP1B, member of RAS oncogene family -0.018981
SENP6 SUMO1/sentrin specific peptidase 6 -0.0189397
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0189325
VMP1 vacuole membrane protein 1 -0.0189291
TAS2R14 taste receptor, type 2, member 14 -0.0188598
GLCCI1 glucocorticoid induced 1 -0.0188066