Bentamapimod_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bentamapimod perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bentamapimod_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.176407
MT2A metallothionein 2A 0.162064
TMSB10 thymosin beta 10 0.118533
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0916944
CD44 CD44 molecule (Indian blood group) 0.0824376
LGALS1 lectin, galactoside-binding, soluble, 1 0.0696989
RPS8 ribosomal protein S8 0.0665181
B2M beta-2-microglobulin 0.0640922
RPL23 ribosomal protein L23 0.0631203
EIF1 eukaryotic translation initiation factor 1 0.0585158
RPS6 ribosomal protein S6 0.0579253
LDHA lactate dehydrogenase A 0.0510957
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.050102
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0473344
RPS19 ribosomal protein S19 0.0469939
IGFBP7 insulin-like growth factor binding protein 7 0.046972
HLA-A major histocompatibility complex, class I, A 0.0444822
RPL35A ribosomal protein L35a 0.0444507
RACK1 receptor for activated C kinase 1 0.0441634
RPL11 ribosomal protein L11 0.0428869
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.040316
RPL37A ribosomal protein L37a 0.0392597
RPL12 ribosomal protein L12 0.039198
RPL36 ribosomal protein L36 0.0379578
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0373268
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0369382
STC1 stanniocalcin 1 0.0369326
ALCAM activated leukocyte cell adhesion molecule 0.0366844
RPL7 ribosomal protein L7 0.0357403
RPL32 ribosomal protein L32 0.0356831
ENO1 enolase 1, (alpha) 0.0354549
RPS3 ribosomal protein S3 0.0353008
FTL ferritin, light polypeptide 0.0340217
S100A9 S100 calcium binding protein A9 0.0326386
RPS12 ribosomal protein S12 0.0321221
TAGLN2 transgelin 2 0.0317682
NAP1L1 nucleosome assembly protein 1-like 1 0.0311971
COL3A1 collagen, type III, alpha 1 0.0302377
CXCL8 chemokine (C-X-C motif) ligand 8 0.0301275
RPL5 ribosomal protein L5 0.030072
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0300277
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0300009
RPL18 ribosomal protein L18 0.0294762
RPS14 ribosomal protein S14 0.0293447
RPL37 ribosomal protein L37 0.0293244
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0283655
TPI1 triosephosphate isomerase 1 0.0281145
RPL26 ribosomal protein L26 0.0279341
IFI6 interferon, alpha-inducible protein 6 0.0275237
MYH9 myosin, heavy chain 9, non-muscle 0.0274527
FAM107B family with sequence similarity 107, member B 0.0269866
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0269752
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0265488
YBX1 Y box binding protein 1 0.0264588
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0264153
TPT1 tumor protein, translationally-controlled 1 0.0263324
RPL9 ribosomal protein L9 0.0256752
RPL31 ribosomal protein L31 0.0254018
EEF2 eukaryotic translation elongation factor 2 0.0249589
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0248758
TIMP1 TIMP metallopeptidase inhibitor 1 0.0241479
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0237706
ANKRD12 ankyrin repeat domain 12 0.0235797
BRD4 bromodomain containing 4 0.0235714
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.023342
RPS27 ribosomal protein S27 0.0231928
PCBP2 poly(rC) binding protein 2 0.0231515
RPS21 ribosomal protein S21 0.0231065
CALR calreticulin 0.0230571
S100A6 S100 calcium binding protein A6 0.0226582
MYO10 myosin X 0.0226489
COL4A1 collagen, type IV, alpha 1 0.0224956
RPS17 ribosomal protein S17 0.0223924
CAVIN1 caveolae associated protein 1 0.0223016
RPLP0 ribosomal protein, large, P0 0.0222509
CCND1 cyclin D1 0.0222184
RPLP2 ribosomal protein, large, P2 0.0219031
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0217643
RPL27 ribosomal protein L27 0.0216399
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0214255
RPL35 ribosomal protein L35 0.0213942
RPS4X ribosomal protein S4, X-linked 0.0207078
RPL30 ribosomal protein L30 0.0204995
SFTPA2 surfactant protein A2 0.0203273
PTMA prothymosin, alpha 0.0201358
MLF1 myeloid leukemia factor 1 0.0200584
SAMD9 sterile alpha motif domain containing 9 0.0200065
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0199524
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0199437
ASPH aspartate beta-hydroxylase 0.0197617
SIK3 SIK family kinase 3 0.0196758
TUBB tubulin, beta class I 0.0196264
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0194792
KLF6 Kruppel-like factor 6 0.0191954
MAP1B microtubule-associated protein 1B 0.0191478
IQGAP1 IQ motif containing GTPase activating protein 1 0.019056
RPL19 ribosomal protein L19 0.0190098
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0188876
AKAP12 A kinase (PRKA) anchor protein 12 0.0185555
IFITM3 interferon induced transmembrane protein 3 0.0183995

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.519579
FN1 fibronectin 1 -0.309003
NDRG1 N-myc downstream regulated 1 -0.142879
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.137954
PSD3 pleckstrin and Sec7 domain containing 3 -0.116457
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0750146
COL6A3 collagen, type VI, alpha 3 -0.0742956
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0739129
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.071055
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0645358
FNDC3B fibronectin type III domain containing 3B -0.0551713
CDH13 cadherin 13 -0.0481568
ZBTB20 zinc finger and BTB domain containing 20 -0.0473019
CANX calnexin -0.043045
PDIA3 protein disulfide isomerase family A, member 3 -0.0411882
FBN1 fibrillin 1 -0.0407438
IL6ST interleukin 6 signal transducer -0.0393209
PTK2 protein tyrosine kinase 2 -0.0368736
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0354593
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0348366
DST dystonin -0.034834
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0331607
DPYD dihydropyrimidine dehydrogenase -0.0328808
JARID2 jumonji, AT rich interactive domain 2 -0.0323672
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0320936
SEC24D SEC24 family member D -0.0318428
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0317081
ZFAND3 zinc finger, AN1-type domain 3 -0.0315843
CAMTA1 calmodulin binding transcription activator 1 -0.0312249
EGR1 early growth response 1 -0.0299731
F3 coagulation factor III (thromboplastin, tissue factor) -0.0297508
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0289954
HYOU1 hypoxia up-regulated 1 -0.0281383
SLC38A2 solute carrier family 38, member 2 -0.0281327
SEC31A SEC31 homolog A (S. cerevisiae) -0.027702
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0272179
COL5A1 collagen, type V, alpha 1 -0.0270551
SBF2 SET binding factor 2 -0.0266322
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0265012
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0264945
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0264945
PDE10A phosphodiesterase 10A -0.0262377
TRPS1 trichorhinophalangeal syndrome I -0.0255324
ADAM9 ADAM metallopeptidase domain 9 -0.0246973
HMGA2 high mobility group AT-hook 2 -0.0240374
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0237682
TFG TRK-fused gene -0.0236946
ARF4 ADP-ribosylation factor 4 -0.0236836
ATP13A3 ATPase type 13A3 -0.0236597
GOLGA4 golgin A4 -0.0235163
SPAG9 sperm associated antigen 9 -0.0234339
MTDH metadherin -0.0230954
EXT1 exostosin glycosyltransferase 1 -0.0228606
FBXO32 F-box protein 32 -0.0225656
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0222832
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0221111
PDLIM5 PDZ and LIM domain 5 -0.0220697
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0220507
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0220496
SMYD3 SET and MYND domain containing 3 -0.0215899
AAK1 AP2 associated kinase 1 -0.0213236
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0212682
GLIS3 GLIS family zinc finger 3 -0.0212227
ANO10 anoctamin 10 -0.0211542
TRAM1 translocation associated membrane protein 1 -0.0210287
WASF2 WAS protein family, member 2 -0.0208074
PRR16 proline rich 16 -0.0199778
CLIC4 chloride intracellular channel 4 -0.0199477
PDIA6 protein disulfide isomerase family A, member 6 -0.0196037
CD109 CD109 molecule -0.0189547
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0185815
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0185337
DOCK5 dedicator of cytokinesis 5 -0.0183747
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0183211
PRELID2 PRELI domain containing 2 -0.0178936
COPA coatomer protein complex, subunit alpha -0.0178636
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0176909
QKI QKI, KH domain containing, RNA binding -0.0172963
CADM1 cell adhesion molecule 1 -0.0172395
HELZ helicase with zinc finger -0.0169922
VCL vinculin -0.0167906
RAB1A RAB1A, member RAS oncogene family -0.0166366
KCTD9 potassium channel tetramerization domain containing 9 -0.0165546
AFF4 AF4/FMR2 family, member 4 -0.016545
TENM3 teneurin transmembrane protein 3 -0.016541
LOXL2 lysyl oxidase-like 2 -0.0165115
SKIC3 SKI3 subunit of superkiller complex -0.0163779
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0161003
ARHGAP35 Rho GTPase activating protein 35 -0.0160885
TAPBP TAP binding protein (tapasin) -0.0160286
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0160038
PPARD peroxisome proliferator-activated receptor delta -0.01598
DGKI diacylglycerol kinase, iota -0.0159311
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.0158727
CRYBG3 beta-gamma crystallin domain containing 3 -0.0158402
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0156436
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0156247
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0156082
ACLY ATP citrate lyase -0.0153828
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0153108