Bentamapimod_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bentamapimod perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bentamapimod_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.355326
IGFBP1 insulin-like growth factor binding protein 1 0.226825
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.165733
IGF2 insulin-like growth factor 2 0.150262
SVIL supervillin 0.132172
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.100337
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0978773
TIMP1 TIMP metallopeptidase inhibitor 1 0.0822694
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0811135
RPS12 ribosomal protein S12 0.0771348
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0757455
FAM107B family with sequence similarity 107, member B 0.0735888
RPL23 ribosomal protein L23 0.0734616
SAMD4A sterile alpha motif domain containing 4A 0.0681223
PDLIM5 PDZ and LIM domain 5 0.0611539
RPL37A ribosomal protein L37a 0.0611512
EXT1 exostosin glycosyltransferase 1 0.0545489
MT2A metallothionein 2A 0.0512911
RPS8 ribosomal protein S8 0.0499525
DTNA dystrobrevin, alpha 0.0455702
RPS19 ribosomal protein S19 0.0454813
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0443178
MBNL1 muscleblind-like splicing regulator 1 0.0435981
CCL20 chemokine (C-C motif) ligand 20 0.0433044
PAWR PRKC, apoptosis, WT1, regulator 0.0429965
DSTN destrin (actin depolymerizing factor) 0.0423992
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0419069
KYNU kynureninase 0.0414176
RACK1 receptor for activated C kinase 1 0.0410778
MBNL2 muscleblind-like splicing regulator 2 0.0410345
FOXP1 forkhead box P1 0.0398432
FTL ferritin, light polypeptide 0.039685
RPL12 ribosomal protein L12 0.0396318
ENO1 enolase 1, (alpha) 0.0395302
CRY1 cryptochrome circadian clock 1 0.0381356
DSPP dentin sialophosphoprotein 0.0366745
CPE carboxypeptidase E 0.0365734
APLP2 amyloid beta (A4) precursor-like protein 2 0.0365069
RPLP0 ribosomal protein, large, P0 0.0359996
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0358243
RPS17 ribosomal protein S17 0.0355998
RPL5 ribosomal protein L5 0.0342929
LDHA lactate dehydrogenase A 0.0335769
RPS3 ribosomal protein S3 0.0335678
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0331651
POTEF POTE ankyrin domain family, member F 0.0326455
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0321642
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0316534
EIF1 eukaryotic translation initiation factor 1 0.0312979
PCBP2 poly(rC) binding protein 2 0.0309572
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0308686
KLF6 Kruppel-like factor 6 0.0308095
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0305971
RPL9 ribosomal protein L9 0.029933
RPS6 ribosomal protein S6 0.0294005
NAP1L1 nucleosome assembly protein 1-like 1 0.0285194
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0285133
KIF21A kinesin family member 21A 0.0284052
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0284038
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.028341
TMSB10 thymosin beta 10 0.0277796
TLE4 transducin-like enhancer of split 4 0.0271802
PALLD palladin, cytoskeletal associated protein 0.0260255
C3 complement component 3 0.0259325
RPL7 ribosomal protein L7 0.0257494
FERMT2 fermitin family member 2 0.0251901
EIF5B eukaryotic translation initiation factor 5B 0.0251251
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0242906
SOX9 SRY (sex determining region Y)-box 9 0.0242387
MYO1E myosin IE 0.0240303
EZR ezrin 0.0238989
RPL18 ribosomal protein L18 0.0235705
RPL31 ribosomal protein L31 0.0232102
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0230386
AHR aryl hydrocarbon receptor 0.0228258
FAT1 FAT atypical cadherin 1 0.0226392
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0225366
DST dystonin 0.0224955
MYADM myeloid-associated differentiation marker 0.0221205
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0218477
TCIM transcriptional and immune response regulator 0.0217562
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0216401
RPL30 ribosomal protein L30 0.0215976
SIK3 SIK family kinase 3 0.0215473
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0214298
ATP5F1E ATP synthase F1 subunit epsilon 0.0212734
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.021085
SON SON DNA binding protein 0.020986
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0208829
USP47 ubiquitin specific peptidase 47 0.0208489
PDGFC platelet derived growth factor C 0.0205351
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0204848
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0204523
DIAPH1 diaphanous-related formin 1 0.0202778
ARID5B AT rich interactive domain 5B (MRF1-like) 0.020243
B2M beta-2-microglobulin 0.0195974
TF transferrin 0.0195486
CLIC4 chloride intracellular channel 4 0.019496
RPS14 ribosomal protein S14 0.0194396
EXOC6B exocyst complex component 6B 0.0192637

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.151846
APOB apolipoprotein B -0.150852
FNDC3B fibronectin type III domain containing 3B -0.133619
SLC38A2 solute carrier family 38, member 2 -0.118788
EHBP1 EH domain binding protein 1 -0.111032
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.106133
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0975015
EML4 echinoderm microtubule associated protein like 4 -0.0922539
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0904114
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0895704
MAML2 mastermind-like 2 (Drosophila) -0.0869463
APOA2 apolipoprotein A-II -0.0806866
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0790121
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0788903
TM4SF1 transmembrane 4 L six family member 1 -0.0750514
GPC3 glypican 3 -0.0749706
ZMYND8 zinc finger, MYND-type containing 8 -0.0735695
ELL2 elongation factor, RNA polymerase II, 2 -0.0732222
TPT1 tumor protein, translationally-controlled 1 -0.071706
RBM39 RNA binding motif protein 39 -0.0711516
TMEM123 transmembrane protein 123 -0.0706378
CP ceruloplasmin (ferroxidase) -0.0650739
NPAS2 neuronal PAS domain protein 2 -0.0648828
PEG3 paternally expressed 3 -0.0639056
FBF1 Fas (TNFRSF6) binding factor 1 -0.0602971
GMDS GDP-mannose 4,6-dehydratase -0.0565769
A2M alpha-2-macroglobulin -0.055897
TRIM26 tripartite motif containing 26 -0.0555504
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0550912
NKD1 naked cuticle homolog 1 (Drosophila) -0.0521748
DLC1 DLC1 Rho GTPase activating protein -0.0471489
ATP10A ATPase, class V, type 10A -0.0421972
ITGA1 integrin, alpha 1 -0.0417096
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0406116
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0402657
MSI2 musashi RNA-binding protein 2 -0.0395744
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0387283
SESTD1 SEC14 and spectrin domains 1 -0.0386207
SDC4 syndecan 4 -0.038592
PTPRM protein tyrosine phosphatase, receptor type, M -0.0385188
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0384106
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0378115
RUNX1 runt-related transcription factor 1 -0.0363093
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0355478
KDM3A lysine (K)-specific demethylase 3A -0.0351018
ZFHX3 zinc finger homeobox 3 -0.0349748
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0340803
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0337207
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.032989
STAU1 staufen double-stranded RNA binding protein 1 -0.0327952
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0327077
OSMR oncostatin M receptor -0.0326691
NDRG1 N-myc downstream regulated 1 -0.0325561
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0316052
LRMDA leucine rich melanocyte differentiation associated -0.0313054
ZFAND3 zinc finger, AN1-type domain 3 -0.0310774
MBNL3 muscleblind-like splicing regulator 3 -0.0309142
MALT1 MALT1 paracaspase -0.0306414
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0298579
EPAS1 endothelial PAS domain protein 1 -0.029804
NHSL1 NHS-like 1 -0.0293844
MTUS1 microtubule associated tumor suppressor 1 -0.0292954
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0292803
KDM7A lysine (K)-specific demethylase 7A -0.029238
LAMA4 laminin, alpha 4 -0.0287124
ARHGAP5 Rho GTPase activating protein 5 -0.0284477
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0280427
NINL ninein-like -0.0280332
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0278516
BIRC6 baculoviral IAP repeat containing 6 -0.0277409
TM9SF3 transmembrane 9 superfamily member 3 -0.0277048
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0276418
DOK6 docking protein 6 -0.0271342
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0269279
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0269071
PRKCA protein kinase C, alpha -0.0266733
FRMD5 FERM domain containing 5 -0.0266104
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0264482
IGF2R insulin-like growth factor 2 receptor -0.0263346
TCF12 transcription factor 12 -0.026273
NPR2 natriuretic peptide receptor 2 -0.0260024
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.025998
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.025593
H1-0 H1.0 linker histone -0.0254312
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0253894
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0253326
DOCK5 dedicator of cytokinesis 5 -0.0250038
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0248702
DNAH17 dynein, axonemal, heavy chain 17 -0.024699
DENND4A DENN/MADD domain containing 4A -0.0246601
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0245437
GLG1 golgi glycoprotein 1 -0.0245184
OSBPL10 oxysterol binding protein-like 10 -0.0244844
CYTH1 cytohesin 1 -0.0241671
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.024144
RAB1A RAB1A, member RAS oncogene family -0.0241299
PATJ PATJ crumbs cell polarity complex component -0.0241017
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0238976
NPEPPS aminopeptidase puromycin sensitive -0.0237833
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0236767