Bentamapimod_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bentamapimod perturbation in Hs 766T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Bentamapimod_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.116775
B2M beta-2-microglobulin 0.114785
MT2A metallothionein 2A 0.103658
MBNL2 muscleblind-like splicing regulator 2 0.0828494
ANXA1 annexin A1 0.0687742
CD44 CD44 molecule (Indian blood group) 0.0560071
ESYT2 extended synaptotagmin-like protein 2 0.0558976
RPL12 ribosomal protein L12 0.0547854
RPS8 ribosomal protein S8 0.0520461
SIK3 SIK family kinase 3 0.0518799
IGF2 insulin-like growth factor 2 0.0508057
RPS12 ribosomal protein S12 0.0489981
RPS3 ribosomal protein S3 0.0483228
KTN1 kinectin 1 (kinesin receptor) 0.0477549
RPS19 ribosomal protein S19 0.0465571
EIF1 eukaryotic translation initiation factor 1 0.0457826
MBNL1 muscleblind-like splicing regulator 1 0.0453986
RAI14 retinoic acid induced 14 0.0452277
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0450316
JMJD1C jumonji domain containing 1C 0.0448365
ANKRD12 ankyrin repeat domain 12 0.0444686
EZR ezrin 0.0436041
DUSP6 dual specificity phosphatase 6 0.0434602
KLF5 Kruppel-like factor 5 (intestinal) 0.0411016
IFITM3 interferon induced transmembrane protein 3 0.0407914
HLA-A major histocompatibility complex, class I, A 0.0403221
PRRC2C proline-rich coiled-coil 2C 0.0397788
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0382492
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0376899
TXNIP thioredoxin interacting protein 0.037575
DST dystonin 0.0372171
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.036869
PALM2AKAP2 PALM2 and AKAP2 fusion 0.036144
DSTN destrin (actin depolymerizing factor) 0.0352942
NAMPT nicotinamide phosphoribosyltransferase 0.0352742
APLP2 amyloid beta (A4) precursor-like protein 2 0.0350246
PCBP2 poly(rC) binding protein 2 0.0349615
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0345861
RPS27 ribosomal protein S27 0.0345239
MT1E metallothionein 1E 0.0342641
RPS6 ribosomal protein S6 0.0328249
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0326129
RPL11 ribosomal protein L11 0.0325202
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.032038
IFITM1 interferon induced transmembrane protein 1 0.0319109
MDK midkine (neurite growth-promoting factor 2) 0.0317812
NAP1L1 nucleosome assembly protein 1-like 1 0.0313374
RPL5 ribosomal protein L5 0.0308384
CSTB cystatin B (stefin B) 0.0307365
TES testin LIM domain protein 0.0295276
RPL18 ribosomal protein L18 0.0295231
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.029493
SFTPA2 surfactant protein A2 0.0293833
RPL23 ribosomal protein L23 0.0292543
LDHA lactate dehydrogenase A 0.0290376
RAB2A RAB2A, member RAS oncogene family 0.0289235
ANKRD28 ankyrin repeat domain 28 0.0278685
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 0.0275821
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0272517
RPL26 ribosomal protein L26 0.0269594
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0264715
FTL ferritin, light polypeptide 0.0263815
RACK1 receptor for activated C kinase 1 0.0262472
EXT1 exostosin glycosyltransferase 1 0.0262353
ANGPTL4 angiopoietin-like 4 0.0262339
SLK STE20-like kinase 0.0258747
TAGLN2 transgelin 2 0.0255706
SON SON DNA binding protein 0.0254193
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0252191
MSN moesin 0.0251772
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0250068
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0248608
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0246623
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0245264
ZFP36L1 ZFP36 ring finger protein-like 1 0.0237524
NFIB nuclear factor I/B 0.0234509
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0233516
RPLP0 ribosomal protein, large, P0 0.0232833
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0230629
PUM1 pumilio RNA-binding family member 1 0.0227251
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.0227141
SRRM1 serine/arginine repetitive matrix 1 0.0226757
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0225798
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 0.0225602
GOLGB1 golgin B1 0.0225285
SLTM SAFB-like, transcription modulator 0.0225034
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0220044
ARHGAP21 Rho GTPase activating protein 21 0.021987
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0219748
CSNK1A1 casein kinase 1, alpha 1 0.0215814
AKAP9 A kinase (PRKA) anchor protein 9 0.0215501
LARP7 La ribonucleoprotein domain family, member 7 0.0214952
RPS14 ribosomal protein S14 0.0213808
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0213202
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0210173
EFNA5 ephrin-A5 0.0210148
ARRDC3 arrestin domain containing 3 0.020853
ITPRID2 ITPR interacting domain containing 2 0.0205646
ANO6 anoctamin 6 0.0204967
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0202682

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.338375
TIMP3 TIMP metallopeptidase inhibitor 3 -0.183564
FLNB filamin B, beta -0.173496
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.147798
SULF1 sulfatase 1 -0.102052
TRIO trio Rho guanine nucleotide exchange factor -0.100653
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0973838
DPYD dihydropyrimidine dehydrogenase -0.0967789
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0872508
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0851863
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.078872
AHNAK AHNAK nucleoprotein -0.0746994
ACTN4 actinin, alpha 4 -0.0607319
CEMIP cell migration inducing protein, hyaluronan binding -0.0595773
HSPG2 heparan sulfate proteoglycan 2 -0.0585061
NDRG1 N-myc downstream regulated 1 -0.0580155
SLC35F3 solute carrier family 35, member F3 -0.0563554
RIGI RNA sensor RIG-I -0.0548281
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0525992
LOC112694756 uncharaterized LOC112694756 -0.0482654
PALLD palladin, cytoskeletal associated protein -0.0474069
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0472884
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0466361
BCL2L1 BCL2-like 1 -0.0454816
GRB10 growth factor receptor-bound protein 10 -0.044086
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0435751
CANX calnexin -0.0431569
MECOM MDS1 and EVI1 complex locus -0.0424649
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0423251
ZNFX1 zinc finger, NFX1-type containing 1 -0.0416515
HM13 histocompatibility (minor) 13 -0.0412722
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.040899
PLEC plectin -0.0406584
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0403366
PDIA3 protein disulfide isomerase family A, member 3 -0.0393205
THSD4 thrombospondin, type I, domain containing 4 -0.0390947
H1-0 H1.0 linker histone -0.03894
NEK7 NIMA-related kinase 7 -0.0387743
SLC45A4 solute carrier family 45, member 4 -0.0383652
BCAR3 breast cancer anti-estrogen resistance 3 -0.0381445
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0376932
DOCK5 dedicator of cytokinesis 5 -0.0373617
KRT17 keratin 17, type I -0.037324
ACTG1 actin gamma 1 -0.0372579
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0362586
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0357601
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0356484
CUL4B cullin 4B -0.0350448
FOXO1 forkhead box O1 -0.0348246
PYGL phosphorylase, glycogen, liver -0.0347055
BLCAP bladder cancer associated protein -0.0343718
RIN2 Ras and Rab interactor 2 -0.0342521
C4BPB complement component 4 binding protein, beta -0.0341402
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0340059
PLAT plasminogen activator, tissue -0.0337019
ABI3BP ABI family, member 3 (NESH) binding protein -0.0334852
SLC38A2 solute carrier family 38, member 2 -0.0329916
PGK1 phosphoglycerate kinase 1 -0.0328607
HMGA2 high mobility group AT-hook 2 -0.0328395
ADAM10 ADAM metallopeptidase domain 10 -0.0324757
RBM39 RNA binding motif protein 39 -0.0323623
NIBAN2 niban apoptosis regulator 2 -0.0319601
PKM pyruvate kinase, muscle -0.0317789
RABGAP1L RAB GTPase activating protein 1-like -0.0314266
PSD3 pleckstrin and Sec7 domain containing 3 -0.0310345
ZEB1 zinc finger E-box binding homeobox 1 -0.0310293
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0308842
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0308369
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0304788
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0304465
EMP1 epithelial membrane protein 1 -0.0301377
F3 coagulation factor III (thromboplastin, tissue factor) -0.0300538
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.029412
PDLIM5 PDZ and LIM domain 5 -0.0294079
PRELID2 PRELI domain containing 2 -0.029179
MYO10 myosin X -0.0288283
DGKH diacylglycerol kinase, eta -0.0286419
ANKRD11 ankyrin repeat domain 11 -0.0285242
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0279723
POTEF POTE ankyrin domain family, member F -0.0278508
ANKRD10 ankyrin repeat domain 10 -0.0278428
NRCAM neuronal cell adhesion molecule -0.0273156
NT5C2 5'-nucleotidase, cytosolic II -0.027003
PFN1 profilin 1 -0.0269774
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0269107
ASPH aspartate beta-hydroxylase -0.0266884
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0264804
FN1 fibronectin 1 -0.0259263
ANO1 anoctamin 1, calcium activated chloride channel -0.0258238
TMSB4X thymosin beta 4, X-linked -0.0256155
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0255368
FRMD4B FERM domain containing 4B -0.0255002
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -0.0253631
AFAP1 actin filament associated protein 1 -0.0252798
TM4SF1 transmembrane 4 L six family member 1 -0.0251706
APOL2 apolipoprotein L, 2 -0.0249424
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0248076
SEC24D SEC24 family member D -0.0247852
KIAA1217 KIAA1217 -0.0246458
MTAP methylthioadenosine phosphorylase -0.0244456