Bentamapimod_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bentamapimod perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bentamapimod_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.183882
B2M beta-2-microglobulin 0.12101
FTL ferritin, light polypeptide 0.0964357
EIF1 eukaryotic translation initiation factor 1 0.0925076
RPS6 ribosomal protein S6 0.0848726
RPL23 ribosomal protein L23 0.084127
RPS19 ribosomal protein S19 0.0700811
RPS3 ribosomal protein S3 0.0598233
TMC5 transmembrane channel-like 5 0.0569474
RPL35A ribosomal protein L35a 0.0514387
IFI27 interferon, alpha-inducible protein 27 0.0499725
LOC102724023 ES1 protein homolog, mitochondrial 0.0485806
RPS8 ribosomal protein S8 0.047935
RPS12 ribosomal protein S12 0.0411692
LCN2 lipocalin 2 0.0409801
RPL19 ribosomal protein L19 0.0395149
AGR3 anterior gradient 3 0.0394875
RPLP1 ribosomal protein, large, P1 0.0393625
MACC1 metastasis associated in colon cancer 1 0.0385842
RPL18 ribosomal protein L18 0.0384099
RPL37A ribosomal protein L37a 0.0382573
RPL12 ribosomal protein L12 0.0382151
S100P S100 calcium binding protein P 0.0381575
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0377588
IFI6 interferon, alpha-inducible protein 6 0.0377226
RPL9 ribosomal protein L9 0.0353213
MBNL2 muscleblind-like splicing regulator 2 0.0349676
RPS27 ribosomal protein S27 0.0319725
RPS17 ribosomal protein S17 0.0318141
RPL26 ribosomal protein L26 0.0301434
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0297977
RPS25 ribosomal protein S25 0.0295299
DSTN destrin (actin depolymerizing factor) 0.0290643
SEC61G Sec61 gamma subunit 0.0281353
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0278267
AKAP9 A kinase (PRKA) anchor protein 9 0.0262818
IFITM3 interferon induced transmembrane protein 3 0.0261553
NDRG1 N-myc downstream regulated 1 0.0249431
POTEF POTE ankyrin domain family, member F 0.0246474
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0241364
RPLP0 ribosomal protein, large, P0 0.0239944
RPL36 ribosomal protein L36 0.0236925
RPS14 ribosomal protein S14 0.0233945
FTH1 ferritin, heavy polypeptide 1 0.0231526
NUPR1 nuclear protein, transcriptional regulator, 1 0.0230875
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0227876
RPL35 ribosomal protein L35 0.0225374
ATF4 activating transcription factor 4 0.0222894
RPL5 ribosomal protein L5 0.0222428
RPS29 ribosomal protein S29 0.0218944
NDUFA4 NDUFA4, mitochondrial complex associated 0.0214719
PTPRK protein tyrosine phosphatase, receptor type, K 0.0213559
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0211118
RPL10A ribosomal protein L10a 0.0210903
S100A11 S100 calcium binding protein A11 0.0208938
HLA-A major histocompatibility complex, class I, A 0.0208133
ASTN2 astrotactin 2 0.0207485
GOLGA4 golgin A4 0.0205383
GSTP1 glutathione S-transferase pi 1 0.0205025
ANXA1 annexin A1 0.0204985
RACK1 receptor for activated C kinase 1 0.0203512
IFITM1 interferon induced transmembrane protein 1 0.0202005
RPS16 ribosomal protein S16 0.0200924
RPL27 ribosomal protein L27 0.0198654
RPL7 ribosomal protein L7 0.0197881
RPL11 ribosomal protein L11 0.0197734
CLDN4 claudin 4 0.0196495
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0194614
RPL30 ribosomal protein L30 0.0193333
LIMA1 LIM domain and actin binding 1 0.0191623
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0187098
DST dystonin 0.0186943
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.018615
DSPP dentin sialophosphoprotein 0.0183773
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0181269
CBX3 chromobox homolog 3 0.0181164
RPL13A ribosomal protein L13a 0.0180937
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0178679
ISG15 ISG15 ubiquitin-like modifier 0.0175757
RPL28 ribosomal protein L28 0.0174639
RPS21 ribosomal protein S21 0.0173909
RPL31 ribosomal protein L31 0.0173631
ENO1 enolase 1, (alpha) 0.0172762
RPL34 ribosomal protein L34 0.0170279
RPS20 ribosomal protein S20 0.0170166
RPS5 ribosomal protein S5 0.0169148
DCAF7 DDB1 and CUL4 associated factor 7 0.0166889
MYADM myeloid-associated differentiation marker 0.0164773
TPT1 tumor protein, translationally-controlled 1 0.0164615
SNRPB2 small nuclear ribonucleoprotein polypeptide B 0.0164447
GDA guanine deaminase 0.0163904
SEC62 SEC62 homolog (S. cerevisiae) 0.0162
SERF2 small EDRK-rich factor 2 0.0161312
NACA nascent polypeptide-associated complex alpha subunit 0.0160687
RPL7A ribosomal protein L7a 0.0160503
RPLP2 ribosomal protein, large, P2 0.016034
RPL37 ribosomal protein L37 0.0158951
TES testin LIM domain protein 0.0158947
EPCAM epithelial cell adhesion molecule 0.0158816
TMF1 TATA element modulatory factor 1 0.0158403

decreased expression

Symbol Name Standardized Value
GMDS GDP-mannose 4,6-dehydratase -0.175458
NPSR1 neuropeptide S receptor 1 -0.163222
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.1426
CEMIP cell migration inducing protein, hyaluronan binding -0.127062
FGFR2 fibroblast growth factor receptor 2 -0.11646
MAML2 mastermind-like 2 (Drosophila) -0.105916
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0931174
FLNB filamin B, beta -0.0696235
EHBP1 EH domain binding protein 1 -0.0607406
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0573034
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0571409
ACTN4 actinin, alpha 4 -0.055643
ASPH aspartate beta-hydroxylase -0.0555145
KRT8 keratin 8, type II -0.0531526
PDIA3 protein disulfide isomerase family A, member 3 -0.0526712
AHNAK AHNAK nucleoprotein -0.0525584
EMP1 epithelial membrane protein 1 -0.0520271
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0515946
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0506938
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0486441
TNIK TRAF2 and NCK interacting kinase -0.0479544
PDIA4 protein disulfide isomerase family A, member 4 -0.0479074
PRKCA protein kinase C, alpha -0.0474538
ANXA2 annexin A2 -0.0471547
H1-0 H1.0 linker histone -0.0468325
ITGA6 integrin, alpha 6 -0.0462818
FAT1 FAT atypical cadherin 1 -0.0458515
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0455802
CANX calnexin -0.0454812
BCL2L1 BCL2-like 1 -0.0452139
TMEM123 transmembrane protein 123 -0.0406243
FNDC3B fibronectin type III domain containing 3B -0.0370991
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0354278
CUX1 cut-like homeobox 1 -0.0348728
ANLN anillin, actin binding protein -0.0346311
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0345675
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0336174
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0323959
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0319979
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0312882
SAMD12 sterile alpha motif domain containing 12 -0.0305356
LPP LIM domain containing preferred translocation partner in lipoma -0.0303275
RBM39 RNA binding motif protein 39 -0.0301607
IARS1 isoleucyl-tRNA synthetase 1 -0.0299803
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0298998
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0298607
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0293944
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0293307
MSI2 musashi RNA-binding protein 2 -0.0292202
KLHL29 kelch-like family member 29 -0.0290459
SHB Src homology 2 domain containing adaptor protein B -0.0290171
ZFAND3 zinc finger, AN1-type domain 3 -0.0289157
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0281302
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0280482
MECOM MDS1 and EVI1 complex locus -0.0276767
ANKRD11 ankyrin repeat domain 11 -0.0265742
NHSL1 NHS-like 1 -0.0261707
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0260638
DLC1 DLC1 Rho GTPase activating protein -0.0259758
RAD51B RAD51 paralog B -0.0256738
CAPN8 calpain 8 -0.0255661
NF1 neurofibromin 1 -0.0254058
TFRC transferrin receptor -0.025391
YAP1 Yes-associated protein 1 -0.0252549
MYH9 myosin, heavy chain 9, non-muscle -0.025242
EXOC4 exocyst complex component 4 -0.0250639
TCF12 transcription factor 12 -0.0248831
VCL vinculin -0.0247421
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0244968
DENND1A DENN/MADD domain containing 1A -0.0244286
MPRIP myosin phosphatase Rho interacting protein -0.0243519
WARS1 tryptophanyl-tRNA synthetase 1 -0.0241201
TRPS1 trichorhinophalangeal syndrome I -0.0241132
ATXN1 ataxin 1 -0.0239999
SEPTIN9 septin 9 -0.0238323
ECT2 epithelial cell transforming 2 -0.0236177
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0235322
FBXO11 F-box protein 11 -0.0235248
ACACA acetyl-CoA carboxylase alpha -0.0232953
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0231056
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0230378
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0229026
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0227905
ANO1 anoctamin 1, calcium activated chloride channel -0.0224458
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0220272
KRT7 keratin 7, type II -0.0218361
TNRC18 trinucleotide repeat containing 18 -0.0217157
CTBP2 C-terminal binding protein 2 -0.0213797
BIRC6 baculoviral IAP repeat containing 6 -0.0213416
CD46 CD46 molecule, complement regulatory protein -0.0210696
KDM4C lysine (K)-specific demethylase 4C -0.0210033
FAF1 Fas (TNFRSF6) associated factor 1 -0.0210014
SULF2 sulfatase 2 -0.0209366
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.02085
INSIG1 insulin induced gene 1 -0.0208209
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0207648
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0207432
CDK13 cyclin-dependent kinase 13 -0.0207407
TPM4 tropomyosin 4 -0.0206389
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0206313