Bentamapimod_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bentamapimod perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bentamapimod_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.188935
PSD3 pleckstrin and Sec7 domain containing 3 0.141503
MT2A metallothionein 2A 0.137149
TP63 tumor protein p63 0.131532
CD44 CD44 molecule (Indian blood group) 0.111479
RPS8 ribosomal protein S8 0.0940116
RPL12 ribosomal protein L12 0.0914984
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0895205
RPS12 ribosomal protein S12 0.0862058
RPL31 ribosomal protein L31 0.0784794
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0780065
RPL37A ribosomal protein L37a 0.0775585
RPS3 ribosomal protein S3 0.0756502
HLA-B major histocompatibility complex, class I, B 0.0752788
TMSB10 thymosin beta 10 0.0711588
ZDHHC14 zinc finger, DHHC-type containing 14 0.071031
RPL36 ribosomal protein L36 0.0672658
RPL23 ribosomal protein L23 0.0668198
RPS19 ribosomal protein S19 0.0659763
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0651186
DST dystonin 0.0625302
RPL26 ribosomal protein L26 0.0619037
CADM2 cell adhesion molecule 2 0.0603038
SP100 SP100 nuclear antigen 0.0592605
FTL ferritin, light polypeptide 0.0574423
RUNX1 runt-related transcription factor 1 0.0570859
RACK1 receptor for activated C kinase 1 0.0565253
ENO1 enolase 1, (alpha) 0.0552537
RPS27A ribosomal protein S27a 0.0541629
B2M beta-2-microglobulin 0.053817
RPL37 ribosomal protein L37 0.0525907
RPS6 ribosomal protein S6 0.052531
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0524701
HDAC9 histone deacetylase 9 0.0508838
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.049827
RPS17 ribosomal protein S17 0.0481179
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.047093
DNER delta/notch-like EGF repeat containing 0.0453311
BIRC3 baculoviral IAP repeat containing 3 0.0451202
RPLP1 ribosomal protein, large, P1 0.043804
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0434155
TNS3 tensin 3 0.043325
RPLP2 ribosomal protein, large, P2 0.0430586
HLA-A major histocompatibility complex, class I, A 0.0429233
TPT1 tumor protein, translationally-controlled 1 0.0425095
MT1E metallothionein 1E 0.0420475
DPYD dihydropyrimidine dehydrogenase 0.0418919
RPS27 ribosomal protein S27 0.0416555
CSMD3 CUB and Sushi multiple domains 3 0.0413492
JUN jun proto-oncogene 0.0409365
RPL35A ribosomal protein L35a 0.0408661
KTN1 kinectin 1 (kinesin receptor) 0.0401266
RPL19 ribosomal protein L19 0.0400306
EHBP1 EH domain binding protein 1 0.0400235
WWTR1 WW domain containing transcription regulator 1 0.0371899
RPL18 ribosomal protein L18 0.0368213
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.036098
RNF213 ring finger protein 213 0.0339936
RPL27 ribosomal protein L27 0.0335414
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0333921
EGFR epidermal growth factor receptor 0.0332456
NPAS2 neuronal PAS domain protein 2 0.0329511
NAP1L1 nucleosome assembly protein 1-like 1 0.0329048
ZSWIM6 zinc finger, SWIM-type containing 6 0.0325113
EEF1G eukaryotic translation elongation factor 1 gamma 0.0322539
LOC102724023 ES1 protein homolog, mitochondrial 0.0321536
PODXL podocalyxin-like 0.0312617
BICD1 bicaudal D homolog 1 (Drosophila) 0.0310923
PLSCR1 phospholipid scramblase 1 0.031091
LDHA lactate dehydrogenase A 0.0309069
RPL36A ribosomal protein L36a 0.0302454
SOX9 SRY (sex determining region Y)-box 9 0.0300991
RPS25 ribosomal protein S25 0.0300431
RPL9 ribosomal protein L9 0.0299596
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0297872
TSC22D1 TSC22 domain family, member 1 0.0297725
IFI6 interferon, alpha-inducible protein 6 0.0293829
NEK10 NIMA-related kinase 10 0.0293368
INTS6 integrator complex subunit 6 0.0293007
IFITM1 interferon induced transmembrane protein 1 0.0292621
RPS14 ribosomal protein S14 0.0287482
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0283957
MYOF myoferlin 0.0283213
EPHA4 EPH receptor A4 0.0280698
RPS29 ribosomal protein S29 0.0275282
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0271423
CMIP c-Maf inducing protein 0.026936
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0269333
RPL11 ribosomal protein L11 0.0267637
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0266383
RPS20 ribosomal protein S20 0.0264261
TTC3 tetratricopeptide repeat domain 3 0.0263222
RPL7A ribosomal protein L7a 0.0262775
PRELID2 PRELI domain containing 2 0.0261649
RPL30 ribosomal protein L30 0.025978
RPL38 ribosomal protein L38 0.0258905
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0256885
HOMER1 homer scaffolding protein 1 0.0254048
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0253713
ARL4C ADP-ribosylation factor-like 4C 0.0251202

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.177391
ERRFI1 ERBB receptor feedback inhibitor 1 -0.125264
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.116169
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.101266
CENPF centromere protein F, 350/400kDa -0.0900393
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0844716
TXNRD1 thioredoxin reductase 1 -0.0806722
PTMA prothymosin, alpha -0.075993
SPAG9 sperm associated antigen 9 -0.0705969
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0697156
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0687746
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0667803
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0659063
SLC38A2 solute carrier family 38, member 2 -0.0637337
GARS1 glycyl-tRNA synthetase 1 -0.0572262
KMT2E lysine (K)-specific methyltransferase 2E -0.0570412
RTN4 reticulon 4 -0.0547031
CANX calnexin -0.0540652
MKI67 marker of proliferation Ki-67 -0.0540066
TMEM41B transmembrane protein 41B -0.0516596
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0488819
KMT2C lysine (K)-specific methyltransferase 2C -0.0460263
ADAM17 ADAM metallopeptidase domain 17 -0.0453145
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0445579
RBM39 RNA binding motif protein 39 -0.0444383
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0432429
NUP58 nucleoporin 58 -0.0430952
XPO1 exportin 1 -0.043066
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0422519
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0420905
RAI1 retinoic acid induced 1 -0.0415167
ADGRG6 adhesion G protein-coupled receptor G6 -0.0413559
SMC4 structural maintenance of chromosomes 4 -0.0412953
TRA2A transformer 2 alpha homolog (Drosophila) -0.0406496
SRPK2 SRSF protein kinase 2 -0.0404857
PDIA3 protein disulfide isomerase family A, member 3 -0.040286
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0397797
OGA O-GlcNAcase -0.0394352
MIS18BP1 MIS18 binding protein 1 -0.0392198
JMJD1C jumonji domain containing 1C -0.0388151
USP34 ubiquitin specific peptidase 34 -0.0383333
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0382525
ANLN anillin, actin binding protein -0.0378546
PUM2 pumilio RNA-binding family member 2 -0.0378405
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0377346
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0362883
KCMF1 potassium channel modulatory factor 1 -0.035543
ANXA1 annexin A1 -0.0354698
ZNF292 zinc finger protein 292 -0.0351995
WDR45B WD repeat domain 45B -0.035129
CCNL1 cyclin L1 -0.033416
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.033045
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.032847
BRWD1 bromodomain and WD repeat domain containing 1 -0.0325502
TPX2 TPX2, microtubule-associated -0.0323272
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0322819
RAB6A RAB6A, member RAS oncogene family -0.0320692
CEP170 centrosomal protein 170kDa -0.031765
ECT2 epithelial cell transforming 2 -0.0315317
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0312441
CKAP5 cytoskeleton associated protein 5 -0.0304225
GOLGA4 golgin A4 -0.0303801
TOP1 topoisomerase (DNA) I -0.0303358
MARCHF6 membrane associated ring-CH-type finger 6 -0.0303195
WSB1 WD repeat and SOCS box containing 1 -0.0299117
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0297336
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0295065
RLF rearranged L-myc fusion -0.029503
SBF2 SET binding factor 2 -0.0292726
MAP4 microtubule-associated protein 4 -0.0291655
CKAP2 cytoskeleton associated protein 2 -0.0291177
RBM25 RNA binding motif protein 25 -0.0291071
WDR26 WD repeat domain 26 -0.0290882
HOOK2 hook microtubule-tethering protein 2 -0.0289197
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0286553
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0286025
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0285898
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0285785
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0282807
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0282533
MATR3 matrin 3 -0.0280731
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0279053
BIRC6 baculoviral IAP repeat containing 6 -0.0278778
MARCHF7 membrane associated ring-CH-type finger 7 -0.0276759
KIF14 kinesin family member 14 -0.0275646
KDM3A lysine (K)-specific demethylase 3A -0.0275532
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0272393
CLTC clathrin, heavy chain (Hc) -0.0271132
ZNF217 zinc finger protein 217 -0.0270528
SETD5 SET domain containing 5 -0.0270505
CDK19 cyclin-dependent kinase 19 -0.0269706
CSDE1 cold shock domain containing E1, RNA-binding -0.0268821
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0268217
PHIP pleckstrin homology domain interacting protein -0.0266925
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.026686
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0266798
FOXJ3 forkhead box J3 -0.0265939
TRA2B transformer 2 beta homolog (Drosophila) -0.0265177
RRM2 ribonucleotide reductase M2 -0.0264743
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0264445