Bentamapimod_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bentamapimod perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bentamapimod_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0802354
SLTM SAFB-like, transcription modulator 0.0602119
B2M beta-2-microglobulin 0.0452188
TMSB10 thymosin beta 10 0.0444904
IFI6 interferon, alpha-inducible protein 6 0.0431995
CAV1 caveolin 1, caveolae protein, 22kDa 0.0427592
LMO7 LIM domain 7 0.041922
SEC61G Sec61 gamma subunit 0.0411542
RPLP1 ribosomal protein, large, P1 0.0405142
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0403226
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0391797
MYO1E myosin IE 0.0349134
MYOF myoferlin 0.0318048
S100A10 S100 calcium binding protein A10 0.0314812
TES testin LIM domain protein 0.0310239
RPL12 ribosomal protein L12 0.0306967
CXCL8 chemokine (C-X-C motif) ligand 8 0.0297007
EGFR epidermal growth factor receptor 0.029616
EIF1 eukaryotic translation initiation factor 1 0.0292934
S100P S100 calcium binding protein P 0.028324
LOC102724023 ES1 protein homolog, mitochondrial 0.0272867
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0261078
ELL2 elongation factor, RNA polymerase II, 2 0.0246079
RPS3 ribosomal protein S3 0.0243107
RPL34 ribosomal protein L34 0.0242673
RPL35A ribosomal protein L35a 0.0238035
RPS19 ribosomal protein S19 0.0230914
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0225493
AREG amphiregulin 0.022509
CST3 cystatin C 0.0217473
RPL31 ribosomal protein L31 0.0205711
YBX3 Y box binding protein 3 0.0204109
CD163L1 CD163 molecule-like 1 0.0201693
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0196597
IRS2 insulin receptor substrate 2 0.0193911
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0186755
RPL23 ribosomal protein L23 0.0184734
RPLP0 ribosomal protein, large, P0 0.0183709
RPS27 ribosomal protein S27 0.0183512
CIB1 calcium and integrin binding 1 (calmyrin) 0.0180158
RNF213 ring finger protein 213 0.0179156
RPS14 ribosomal protein S14 0.01791
RPS17 ribosomal protein S17 0.0174586
RPS8 ribosomal protein S8 0.017298
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0169947
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0168503
RPL30 ribosomal protein L30 0.0167043
MX1 MX dynamin-like GTPase 1 0.0166649
RPL37A ribosomal protein L37a 0.016616
SP100 SP100 nuclear antigen 0.0163767
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0160278
RPS29 ribosomal protein S29 0.0157599
RPS6 ribosomal protein S6 0.0153803
C15ORF48 chromosome 15 open reading frame 48 0.015314
FOSL1 FOS-like antigen 1 0.0152788
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 0.014766
RACK1 receptor for activated C kinase 1 0.0145929
ALCAM activated leukocyte cell adhesion molecule 0.0143856
CEMIP cell migration inducing protein, hyaluronan binding 0.0141965
TSC22D2 TSC22 domain family, member 2 0.0141032
HLA-B major histocompatibility complex, class I, B 0.0140773
RPL32 ribosomal protein L32 0.0138789
ANKRD12 ankyrin repeat domain 12 0.0138706
RPL35 ribosomal protein L35 0.0137877
RPL11 ribosomal protein L11 0.0137371
S100A11 S100 calcium binding protein A11 0.0137305
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0136123
RPL19 ribosomal protein L19 0.0136076
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0135126
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0132599
KRT18 keratin 18, type I 0.0132434
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0131693
RPS12 ribosomal protein S12 0.013096
NSUN6 NOP2/Sun domain family, member 6 0.0130529
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0130278
CCSER1 coiled-coil serine-rich protein 1 0.0130219
ATP5F1E ATP synthase F1 subunit epsilon 0.0127515
EZR ezrin 0.0125271
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0124271
TPI1 triosephosphate isomerase 1 0.012339
LAMB3 laminin, beta 3 0.0122627
RPL36 ribosomal protein L36 0.012142
BTG1 B-cell translocation gene 1, anti-proliferative 0.0118837
RPLP2 ribosomal protein, large, P2 0.011862
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0118489
SIK3 SIK family kinase 3 0.0118423
RASAL2 RAS protein activator like 2 0.0116466
ASTN2 astrotactin 2 0.0115396
ATF4 activating transcription factor 4 0.0114195
IFI44 interferon-induced protein 44 0.0113409
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0112753
GPC5 glypican 5 0.0112588
MT2A metallothionein 2A 0.0111704
KRT7 keratin 7, type II 0.0110754
LDHA lactate dehydrogenase A 0.0110328
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0107917
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0107858
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0107684
IFI44L interferon-induced protein 44-like 0.0107092
FAM107B family with sequence similarity 107, member B 0.0106978

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.147843
MCTP1 multiple C2 domains, transmembrane 1 -0.116717
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.110595
TXNRD1 thioredoxin reductase 1 -0.0925261
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0910214
UBC ubiquitin C -0.0827493
MCL1 myeloid cell leukemia 1 -0.0739549
LRP1B low density lipoprotein receptor-related protein 1B -0.0644285
THSD4 thrombospondin, type I, domain containing 4 -0.0637982
PTPRM protein tyrosine phosphatase, receptor type, M -0.0633943
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0533056
PKM pyruvate kinase, muscle -0.0527623
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0494546
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0471738
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0450103
CANX calnexin -0.0431534
CAMTA1 calmodulin binding transcription activator 1 -0.0415268
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0409257
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0407015
GSK3B glycogen synthase kinase 3 beta -0.0404837
USP34 ubiquitin specific peptidase 34 -0.0401723
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0400016
VCL vinculin -0.0396446
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0389189
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0385393
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.037382
NDRG1 N-myc downstream regulated 1 -0.0367202
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0364241
CES1 carboxylesterase 1 -0.0359776
TNRC6B trinucleotide repeat containing 6B -0.0357347
AHNAK AHNAK nucleoprotein -0.035397
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0352982
BRWD1 bromodomain and WD repeat domain containing 1 -0.0345705
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0341828
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0326743
PDIA3 protein disulfide isomerase family A, member 3 -0.03244
TMEM165 transmembrane protein 165 -0.0322781
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0310141
SOD2 superoxide dismutase 2, mitochondrial -0.0309138
FNDC3B fibronectin type III domain containing 3B -0.030164
BIRC6 baculoviral IAP repeat containing 6 -0.0300728
TBC1D22A TBC1 domain family, member 22A -0.0299554
ANKRD11 ankyrin repeat domain 11 -0.0298187
KDM3A lysine (K)-specific demethylase 3A -0.0297949
NABP1 nucleic acid binding protein 1 -0.0296817
HYOU1 hypoxia up-regulated 1 -0.0291808
MYH9 myosin, heavy chain 9, non-muscle -0.0291242
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0288798
LPP LIM domain containing preferred translocation partner in lipoma -0.0279617
NAMPT nicotinamide phosphoribosyltransferase -0.0279133
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0278764
INTS6 integrator complex subunit 6 -0.0276569
PGK1 phosphoglycerate kinase 1 -0.0275732
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0273963
ZC3H11A zinc finger CCCH-type containing 11A -0.0273117
ZMYM2 zinc finger, MYM-type 2 -0.027155
ACTG1 actin gamma 1 -0.0269936
PDE4D phosphodiesterase 4D, cAMP-specific -0.0268131
PRKCA protein kinase C, alpha -0.0267027
KCMF1 potassium channel modulatory factor 1 -0.0264211
LRP12 low density lipoprotein receptor-related protein 12 -0.026086
MED13L mediator complex subunit 13-like -0.0257395
DOCK5 dedicator of cytokinesis 5 -0.0255435
FOXP1 forkhead box P1 -0.0254955
EFNA5 ephrin-A5 -0.0254044
TRAPPC9 trafficking protein particle complex 9 -0.0253013
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0247548
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0247421
NCOA2 nuclear receptor coactivator 2 -0.0246935
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0243892
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0241412
ZBTB20 zinc finger and BTB domain containing 20 -0.0239083
HDLBP high density lipoprotein binding protein -0.023569
MAML3 mastermind-like 3 (Drosophila) -0.0235558
ZFC3H1 zinc finger, C3H1-type containing -0.0235493
FTH1 ferritin, heavy polypeptide 1 -0.0233787
WDR45B WD repeat domain 45B -0.0233288
CCNL1 cyclin L1 -0.0232251
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0231673
RAB1A RAB1A, member RAS oncogene family -0.0231664
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0230433
TLK1 tousled-like kinase 1 -0.022704
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0226592
OGA O-GlcNAcase -0.022545
BBX bobby sox homolog (Drosophila) -0.0225331
NBAS neuroblastoma amplified sequence -0.0224658
SMYD3 SET and MYND domain containing 3 -0.0222704
UVRAG UV radiation resistance associated -0.0220318
USP9X ubiquitin specific peptidase 9, X-linked -0.0219522
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0219192
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0218958
SOS1 son of sevenless homolog 1 (Drosophila) -0.0217767
SPAG9 sperm associated antigen 9 -0.0217421
PTK2 protein tyrosine kinase 2 -0.0217356
RAB10 RAB10, member RAS oncogene family -0.0215027
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0214625
PLEC plectin -0.0213026
TAS2R14 taste receptor, type 2, member 14 -0.0209875
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0209701
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0209467