Bentamapimod_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bentamapimod perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bentamapimod_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.219897
VIM vimentin 0.197038
CD44 CD44 molecule (Indian blood group) 0.129711
LOX lysyl oxidase 0.117806
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0900125
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0881804
B2M beta-2-microglobulin 0.085362
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0846464
LDHA lactate dehydrogenase A 0.078559
EXT1 exostosin glycosyltransferase 1 0.0720795
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0690979
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0668562
RPL23 ribosomal protein L23 0.0657237
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0591796
EIF1 eukaryotic translation initiation factor 1 0.0590038
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0583025
ENO1 enolase 1, (alpha) 0.0581127
ANGPTL4 angiopoietin-like 4 0.0574057
ALCAM activated leukocyte cell adhesion molecule 0.0559349
RPS19 ribosomal protein S19 0.0548792
RPS12 ribosomal protein S12 0.0544808
CXCL8 chemokine (C-X-C motif) ligand 8 0.0535972
PARP14 poly (ADP-ribose) polymerase family, member 14 0.053214
RPLP1 ribosomal protein, large, P1 0.0528158
RPS6 ribosomal protein S6 0.0523636
RPS8 ribosomal protein S8 0.0503457
NAP1L1 nucleosome assembly protein 1-like 1 0.0497422
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0492106
RPL31 ribosomal protein L31 0.0482393
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.047396
TIMP1 TIMP metallopeptidase inhibitor 1 0.0462158
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0461731
RPS17 ribosomal protein S17 0.0447768
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0438636
SAMD9 sterile alpha motif domain containing 9 0.0432323
LOC102724023 ES1 protein homolog, mitochondrial 0.0429044
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0427742
ZSWIM6 zinc finger, SWIM-type containing 6 0.0425767
CA12 carbonic anhydrase XII 0.0423275
RPL37A ribosomal protein L37a 0.0422751
RACK1 receptor for activated C kinase 1 0.0419037
FAM107B family with sequence similarity 107, member B 0.0411559
MYO10 myosin X 0.0407676
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0403868
ANKRD28 ankyrin repeat domain 28 0.0402367
LOXL2 lysyl oxidase-like 2 0.0396856
RPL37 ribosomal protein L37 0.0396313
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0396277
RPL11 ribosomal protein L11 0.0391133
TMSB4X thymosin beta 4, X-linked 0.0386841
IFI6 interferon, alpha-inducible protein 6 0.0375945
AADAC arylacetamide deacetylase 0.0374993
RPL12 ribosomal protein L12 0.0366943
MT2A metallothionein 2A 0.036606
NDRG1 N-myc downstream regulated 1 0.0364019
RPL36 ribosomal protein L36 0.0363079
RPS27 ribosomal protein S27 0.0348667
IFI44L interferon-induced protein 44-like 0.0348117
FER fer (fps/fes related) tyrosine kinase 0.0340732
EEF2 eukaryotic translation elongation factor 2 0.033835
RPS3 ribosomal protein S3 0.0335012
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0329648
TNNC1 troponin C type 1 (slow) 0.0325435
BIRC3 baculoviral IAP repeat containing 3 0.0322372
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0320698
NAV2 neuron navigator 2 0.0316461
TFPI2 tissue factor pathway inhibitor 2 0.0315505
RPLP0 ribosomal protein, large, P0 0.0311729
NAV1 neuron navigator 1 0.030925
RPL32 ribosomal protein L32 0.0308561
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0302313
FN1 fibronectin 1 0.0301742
S100A10 S100 calcium binding protein A10 0.030101
STC1 stanniocalcin 1 0.0300677
PKM pyruvate kinase, muscle 0.029999
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0298365
INTS6 integrator complex subunit 6 0.0297694
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0297593
SFTPA2 surfactant protein A2 0.0296684
RPL5 ribosomal protein L5 0.0295817
TAGLN2 transgelin 2 0.0294987
EGFR epidermal growth factor receptor 0.0292033
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0290706
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0286745
ECE1 endothelin converting enzyme 1 0.0285807
RPS29 ribosomal protein S29 0.0282124
RPL30 ribosomal protein L30 0.0279808
SOX9 SRY (sex determining region Y)-box 9 0.0276791
PTPRB protein tyrosine phosphatase, receptor type, B 0.0270111
RPLP2 ribosomal protein, large, P2 0.0268219
LHFPL2 lipoma HMGIC fusion partner-like 2 0.026678
SQSTM1 sequestosome 1 0.0265821
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0264587
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0264263
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0261113
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 0.0260724
EHBP1 EH domain binding protein 1 0.0254364
RPL18 ribosomal protein L18 0.0254055
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0248252
CREB5 cAMP responsive element binding protein 5 0.0248104

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.131139
PDE4D phosphodiesterase 4D, cAMP-specific -0.118089
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.102206
RBM39 RNA binding motif protein 39 -0.0969858
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0954077
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0883521
FNDC3B fibronectin type III domain containing 3B -0.0761345
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0740642
GLCCI1 glucocorticoid induced 1 -0.069847
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0670798
SDK1 sidekick cell adhesion molecule 1 -0.0658778
USP34 ubiquitin specific peptidase 34 -0.0644509
KDM2A lysine (K)-specific demethylase 2A -0.0631545
ELL2 elongation factor, RNA polymerase II, 2 -0.0615423
KMT2C lysine (K)-specific methyltransferase 2C -0.0595843
SETD5 SET domain containing 5 -0.0586034
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0585227
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0585206
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0579897
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0536633
NRP1 neuropilin 1 -0.0465853
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0454823
DDIT3 DNA-damage-inducible transcript 3 -0.0453529
PDIA3 protein disulfide isomerase family A, member 3 -0.0442894
SBF2 SET binding factor 2 -0.0433294
RAB1A RAB1A, member RAS oncogene family -0.0424348
NPC1 Niemann-Pick disease, type C1 -0.041441
OGA O-GlcNAcase -0.0408647
WAC WW domain containing adaptor with coiled-coil -0.040765
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0401247
PRELID2 PRELI domain containing 2 -0.0385248
DLG1 discs, large homolog 1 (Drosophila) -0.0384398
SRP54 signal recognition particle 54kDa -0.0383517
SPAG9 sperm associated antigen 9 -0.0381634
GOLGA4 golgin A4 -0.0380113
MRPS6 mitochondrial ribosomal protein S6 -0.0374955
RAD51B RAD51 paralog B -0.0372369
NPEPPS aminopeptidase puromycin sensitive -0.0372276
GPC6 glypican 6 -0.0371564
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.036973
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0369706
VMP1 vacuole membrane protein 1 -0.0368551
HELZ helicase with zinc finger -0.0368496
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0367338
STRN3 striatin, calmodulin binding protein 3 -0.0362177
ZMYND8 zinc finger, MYND-type containing 8 -0.0357206
USP3 ubiquitin specific peptidase 3 -0.0356945
BIRC6 baculoviral IAP repeat containing 6 -0.0356751
ATP13A3 ATPase type 13A3 -0.0346668
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0344486
ITCH itchy E3 ubiquitin protein ligase -0.0337805
FOXO3 forkhead box O3 -0.033702
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0329315
MARCHF6 membrane associated ring-CH-type finger 6 -0.0325066
ZNF292 zinc finger protein 292 -0.0319975
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.0316868
ARF4 ADP-ribosylation factor 4 -0.0312952
CANX calnexin -0.0312882
SUCO SUN domain containing ossification factor -0.0312836
ETV6 ets variant 6 -0.0310533
KDM5B lysine (K)-specific demethylase 5B -0.0306248
PDE8A phosphodiesterase 8A -0.0301673
PTMA prothymosin, alpha -0.029948
KDM3A lysine (K)-specific demethylase 3A -0.0298975
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0298645
ZFAND3 zinc finger, AN1-type domain 3 -0.0297524
ADAM9 ADAM metallopeptidase domain 9 -0.029644
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0296086
OXSR1 oxidative stress responsive 1 -0.0294284
RAB6A RAB6A, member RAS oncogene family -0.0291604
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0291205
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0290268
UGCG UDP-glucose ceramide glucosyltransferase -0.0289336
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0289198
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0286942
SS18 synovial sarcoma translocation, chromosome 18 -0.0286408
TENT5A terminal nucleotidyltransferase 5A -0.0285628
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0282336
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.028056
RUNX2 runt-related transcription factor 2 -0.027925
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0276372
KCMF1 potassium channel modulatory factor 1 -0.0275346
COPA coatomer protein complex, subunit alpha -0.0273952
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0269772
ANKRD11 ankyrin repeat domain 11 -0.0268653
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0268651
PHF21A PHD finger protein 21A -0.0268261
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0265519
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0265061
CCNL1 cyclin L1 -0.0264596
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0264148
PTBP2 polypyrimidine tract binding protein 2 -0.0261685
FAM13A family with sequence similarity 13, member A -0.0257534
NGLY1 N-glycanase 1 -0.0253807
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0251358
RTN4 reticulon 4 -0.0249283
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0247116
ADD3 adducin 3 (gamma) -0.0246607
ZFAND6 zinc finger, AN1-type domain 6 -0.0244185
NRG1 neuregulin 1 -0.0237288